PHARMAZIE
·
2012
·Vol. 67
·期 5
·426-431
·
IF 1.006
Sun Xiaoyi,Chen Jinliang,Chen Hailiang,Liang Wenquan
The transfection agent polycation polyethylenimine (PEI) has been rarely used to construct liposomes for chemical antitumor drugs. In this study, it was introduced into cisplatin (CDDP) encapsulated neutral liposomes (CDDP-NL) by amphiphilic PEI-cholesterol (PEI-Chol) to investigate
its effect on the antitumor activity in A549 cells. The IC50 was 0.65 ± 0.02, 2.94 ± 0.21 and 2.03 ± 0.15 g/ml for CDDP-cationic liposomes (CDDP-CL), CDDP-NL and free CDDP, respectively. The enhanced anticancer activity was attributed to the addition of PEI-Chol
which influenced cellular processing of CDDP. With the help of inhibitors, we found that besides clathrin dependent and actin dependent uptake pathways, caveolae-mediated endocytosis was involved in the internalization of CDDP-CL. Improved internalization of CDDP was observed. Intracellular
Pt accumulations were 6.5 times and 3 times of those in CDDP-NL and free CDDP groups, respectively. The differences of intracellular location caused by endocytosis routes and lysosomes escape capacity of PEI-Chol was observed by fluorescence colocalization studies. PEI-Chol also decreased
the Pt fraction exported out of cells and extended the cellular Pt retention of CDDP liposomes. In conclusion, cationic modification of liposomes with PEI is a potential and promising way for antitumor drug delivery.
研究领域:
药理学
·
肿瘤学
·
药物递送系统
·
细胞生物学
✓ 已验证
产品关联
DOI
高影响因子
Catalysis Science & Technology
·
2019
·Vol. 10
·期 5
·1248-1255
·
IF 5.726
Lei Wang,Yang Wang,Chang-Wu Zhang,Jing Wen,Xuefei Weng,Lei Shi
Minimizing the use of platinum while maximizing its catalytic activity is attractive but challenging in the development of industrially important platinum catalysts. Herein, using a hexagonal boron nitride (h-BN) nanosheet-supported Pt/Cu cluster catalyst, we report the promotion of the platinum utilization efficiency and catalytic performance for the dehydrogenation of propane. Specifically, as little as 100 ppm platinum exhibits high propane conversion (∼15%) and propylene selectivity (>99%) at a relatively low reaction temperature (520 °C); the formation rate of propylene reaches 7.3 mol molPt−1 s−1, which is about 10 times higher than the best value for the reported Pt/Cu single-atom alloy catalyst. The structural analysis reveals that the abundant fault edges of the h-BN nanosheets and strong bonding of copper with the edge B–O defects maintain the unique geometry of the Pt/Cu cluster, together with the metallic platinum ensemble stabilizing on the top layer of the copper cluster, leading to remarkable improvement in catalytic efficiency. This prominent promotion in catalytic efficiency is also exemplified using other supports including Al2O3, SBA-15 and SiC as counterparts.
研究领域:
材料科学
·
催化化学
✓ 已验证
DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2019
·
IF 2.291
Yucheng Hao,Linbo He,Guangjie Ge,Quanzheng Zhang,Ningjing Luo,Shuping Huang,Haijian Li,Evgeny V. Alekseev
Investigation of the Pt-B-O system reveals the first magnesium platinum borate Mg 3 Pt(BO 3 ) 2 O 2 obtained from the high temperature flux method. The compound crystallizes in the centrosymmetric monoclinic space group C 2/ m (no. 12) with the lattice parameters of a = 16.8073(8) Å, b = 3.10610(1) Å, c = 5.2107(2) Å, and β = 90.546(4)° (Z = 2). The crystal structure of Mg 3 Pt(BO 3 ) 2 O 2 is based upon isolated BO 3 triangles and PtO 6 and MgO 6 octahedra . The PtO 6 octahedra are connected with each other in an edge-sharing manner forming one dimensional (1D) chains. Each of the PtO 6 octahedra links with two BO 3 units to form anionic [Pt(BO 3 ) 2 O 2 ] 6- chains along the b -axis. MgO 6 octahedra are arranged in the form of two dimensional (2D) layers. The 2D MgO 6 layers are further connected by the anionic [Pt(BO 3 ) 2 O 2 ] 6- chains into the 3D framework structure of Mg 3 Pt(BO 3 ) 2 O 2 . The material was experimentally and theoretically characterized in regards to its optical and spectroscopic properties.
研究领域:
材料科学
·
晶体学
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Chao Wang,Hu Zang,Changjiang Liu,Jiahao Wang,Long Kuai,Baoyou Geng
The hydrogen evolution reaction (HER) involves two-step elementary reactions, providing an opportunity to establish dual-site synergistic catalysts. This work demonstrates carbon-supported Pt single atoms and clusters (Pt1+Cs-NPC) as an efficient catalyst for acidic HER, which exhibits an ultralow Tafel slope of 12.5 mV/dec and an overpotential of 24 mV at 10 mA/cm2 with an ultralow platinum content of 3.8 wt %. The Pt mass activity and turnover frequency (TOF) are 10.2 times and 5.4 times that of commercial Pt/C, respectively. The density functional theory (DFT) study shows that the Pt cluster regulates the electronic state structure of the adjacent Pt single atom, so that the ΔGH* at the Pt1 site approaches 0. Moreover, the DFT study confirms that Pt clusters and neighboring Pt single atoms can synergistically catalyze the Tafel step and reduce the energy barrier in forming the H–H bond. At the same time, the platinum cluster reduces the energy barrier of the nearby platinum single-atom site to the Heyrovsky step and accelerates the reaction with hydrated hydrogen ions. Studies have shown that platinum clusters and platinum single-atom composite loading structures exhibit excellent activity for the Volmer–Tafel or Volmer–Heyrovsky reaction paths of HER reactions. This work provides a clear understanding of the synergistic effect of Pt1+Cs-NPC, which provides guidance for developing efficient HER catalysts.
研究领域:
催化化学
·
材料科学
·
能源化学
✓ 已验证
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2010
·
IF 5.429
Shujun Ji,Qingqing Guo,Qiaoli Yue,Lei Wang,Huaisheng Wang,Jinsheng Zhao,Ruixin Dong,Jifeng Liu,Jianbo Jia
Fabrication of sub-monolayer array of Pt nanoparticles (PtNPs) assembled at nucleobases terminated layers and their application into H 2 O 2 and glucose sensing were reported. To prepare such a PtNPs assembly, 3-mercaptopropionic acid (MPA), Zr 4+ , nucleotide-5′-monophosphate (NTMP including guanosine, adenosine, cytidine, uridine-5′-monophosphate, and abbreviations were GMP, AMP, CMP, UMP, respectively) were adsorbed onto Au substrate sequentially to form nucleobases terminated surface and Zr 4+ acted as binder to link carboxylic and phosphoric groups (NTMP/Zr 4+ /MPA/Au). Complexation of cisplatin, cis-Pt(NH 3 ) 2 Cl 2 , with terminated nucleobases and following electrochemical reduction of surface-bound cisplatin gave PtNPs attached surface. Different PtNPs coverage or particle density was obtained depending on the NTMP used and decreased in the order: PtNPs/GMP/Zr 4+ /MPA/Au > PtNPs/AMP/Zr 4+ /MPA/Au > PtNPs/CMP/Zr 4+ /MPA/Au > PtNPs/UMP/Zr 4+ /MPA/Au. The surface loading of Pt was between 160 and 16 ng/cm 2 . The as prepared PtNPs can be used as electrocatalysts for H 2 O 2 sensing (detection limit of H 2 O 2 < 100 nM) and the sensitivity increased with decreasing PtNPs density. After adsorption of glucose oxidase, the modified electrode can be used as enzymatic electrode for glucose sensing and a detection limit of 38.5 μM was achieved. This study provided an example of fabricating PtNP arrays utilising surface complexation of cisplatin with nucleobases. The advantage of this method is that the NP density can be controlled through changing nucleobases or Pt complexes used to obtain suitable kinetics of the complexation reactions. Additionally, the PtNPs sub-monolayer as prepared has high sensitivity for H 2 O 2 sensing even at a very low loading of Pt.
研究领域:
生物化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2023
·Vol. 35
·期 14
·2211790
·
IF 29.4
Xiang Miao,Wenxing Chen,Shuning Lv,Anran Li,Yanhong Li,Qinghua Zhang,Yonghai Yue,Hewei Zhao,Limin Liu,Shaojun Guo,Lin Guo
Precisely tailoring the oxidation state of single-atomic metal in heterogeneous catalysis is an efficient way to stabilize the single-atomic site and promote their activity, but realizing this approach remains a grand challenge to date. Herein, a class of stable single-atomic catalysts with well-tuned oxidation state of Pt by forming Pt Fe atomic bonds is reported, which are supported by defective Fe 2 O 3 nanosheets on reduced graphene oxide (PFARFNs). These as-synthesized materials can greatly enhance the catalytic activity, stability, and selectivity for the diboration of alkynes. The PFARFNs exhibit high conversion of 99% at 100 °C with an outstanding turnover frequency (TOF) of 545 h −1 , and a relatively high conversion of 58% at room temperature (25 °C) with a TOF of 310 h −1 , which has been hardly achieved previously. Through both experimental and theoretical investigation, it is demonstrated that the fast electron transfer from Fe to Pt in Fe–Pt–O atomic sites in PFARFNs can not only stabilize the single-atomic Pt, but also significantly improve their catalytic activity.
研究领域:
催化化学
·
材料科学
·
理论计算
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Minghui Liu,Yutong Zhao,Ming Tian,Kejia Liu,Guoping Hu,Jian Zhang,Tianyan Xue,Tao Qi,Hui Zhang
Platinum group metals (PGMs) are scarce critical materials, and recovering PGMs from spent automotive catalysts (SAC) is economically and ecologically important. However, dissolving the Fe-Si-PGMs alloy derived from SAC is challenging, impeding PGMs recovery. This study aims to develop a more sustainable, efficient, and scalable leaching scheme. We demonstrate efficient leaching of Fe-Si-PGMs alloy using a thermochemical combined with mechanochemical leaching method with a HCl + FeCl 3 + H 2 O 2 solution. Kinetics parameters studies optimize the leaching process. The main obstacles to leaching are the chemical inertness of the alloy and the SiO 2 encapsulation formed. Ultimately, efficient dissolution of 99 % Pd, 95 % Pt and 88 % Rh was achieved, increasing PGMs leaching by 17 % compared to single thermochemical leaching. Additionally, this work remedies the scalability limitations of mechanochemical leaching and provides valuable insights for PGMs recovery.
研究领域:
冶金工程
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Fundamental Research
·
2025
·
IF 6.3
Fengquan Li,Yuan Liu,Yan Dong,Haozhi Wang,Tongzhou Wang,Junda Lu,Wenjie Huang,Xiangqi Chen,Yuanyuan Guo,Xuerong Zheng,Yida Deng
Pt-carbon materials are identified as state-of-the-art electrocatalysts for oxygen reduction reaction (ORR). However, it is still a big challenge to reduce the usage of Pt while maintaining the high efficiency and durability of the catalysts. Herein, we report a topologicallly defective nanoparticle carbon (DPC) supported PtCo nanoparticles (PtCo NPs) catalyst (denoted as PtCo-DPC) with a low Pt loading for efficient ORR. The topological carbon defects with a low work function can serve as anchoring sites to trap and stabilize PtCo NPs for driving ORR. Meanwhile, the presence of topological carbon defects leads to the electron structure regulation and the lattice contraction for the PtCo NPs. The prepared PtCo-DPC demonstrates an increased half-wave potential (E 1/2 , 0.85 V vs. RHE) with a low Pt loading (4.74 μg Pt cm -2 ) and delivers a superior mass activity (MA) with 1.02 A mg pt -1 . Furthermore, the PtCo-DPC maintains a high stability after 100,000 cycles of accelerated durability test (ADT).
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Lijia Zhou,Xiangjiang Dong,Qiang Li,Xianran Xing
We systematically investigated the superconducting properties of 2H-PtxTaS2 (0 ≤ x ≤ 0.08). As the platinum (Pt) content increases, the charge density wave (CDW) in 2H-TaS2, which appears at approximately 75 K, is progressively suppressed and completely disappears in Pt0.06TaS2. Meanwhile, the superconducting transition temperature (Tc) first increases and then decreases, reaching its maximum value of approximately 4.85 K at x = 0.06. This phenomenon suggests a competitive interplay between CDW and superconductivity (SC) in this system. Further measurements of the superconducting parameters of Pt0.06TaS2 indicate that the enhancement of Tc is primarily attributed to an increase in the density of states at the Fermi level.
研究领域:
凝聚态物理
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2020
·
IF 7.489
Ke Li,Jun Xu,Chan Chen,Zhizhog Xie,Dan Liu,Deyu Qu,Haolin Tang,Qiang Wei,Qibo Deng,Junsheng Li,Ning Hu
Electrocatalytic hydrogen evolution reaction (HER) is a green approach to produce high-quality hydrogen fuel . Developing efficient electrocatalyst is the key to realize cost-effective HER. Pt is the state-of-the-art HER catalyst so far. However, the use of Pt for HER is limited by its high cost. Thus, it is essential to lower down the usage of Pt in the electrocatalyst by improving the intrinsic activity of Pt. In this work, we propose to achieve this goal by introducing synergistic interaction between Pt and substrate material (NiS 2 ). The favorable synergy interaction can modify the d band structure of Pt (1 1 1) facet and modulate the hydrogen adsorption on Pt (1 1 1), which enhances the intrinsic electrocatalytic activity of Pt. The effectiveness of this strategy is demonstrated with both experimental and theoretical investigations.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2016
·Vol. 24
·期 1
·676-684
·
IF 2.76
Tu Baosheng,Shi Nian,Sun Wei,Cao Limei,Yang Ji
In this paper, Pt supports on carbon black powder (Vulcan XC-72) were synthesized via a hydrothermal method for selective catalytic reduction (SCR) of NO with H 2 in the presence of 2 vol% O 2 over a wide temperature of 20–300 °C. The results showed that the 3 and 5 wt% Pt/C catalysts resulted in high NO conversion (>90 %) over a temperature range of 120 to 300 °C, and the maximum NO conversion of 98.6 % was achieved over 5 wt% Pt/C at 120 °C. Meanwhile, the influence of SO 2 and H 2 O on the catalyst performance of 3 wt% Pt/C was investigated. The catalysts exhibited good SO 2 poisoning resistance when the SO 2 concentration was lower than 260 ppm. Moreover, a positive effect on NO conversion was detected with the addition of 3 and 5 vol% H 2 O in the feed gas stream.
TEM image and good NO conversion performance of the Pt/C catalysts
研究领域:
催化化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION SCIENCE AND TECHNOLOGY
·
2018
·
IF 1.2
Yan Yan,Qi Wang,Zeyang Xiang,Yanzhao Yang
A reasonable project was presented for the extraction and separation of Pt(IV), Pd(II), Ru(III), and Rh(III) from the mixed imidazolium-based ionic liquids (ILs) [C6mim]Cl, [C6mim][NTf2], and [C6mim][DDTC]. Pt(IV) was first separated from other three platinum group metals with a mixture of [C6mim]Cl and [C6mim][NTf2]. Then, separation of Pd(II) and Ru(III) from Rh(III) was realized by changing the concentration of [C6mim][DDTC]. Back-extraction of Pt(IV), Pd(II), and Ru(III) from loaded hydrophobic phase and the recovery of Rh(III) in aqueous phase were also investigated. Mechanisms between Pd(II)/Ru(III) and [C6mim][DDTC] were further explored using ultraviolet spectrophotometry (UV-Vis), infrared spectrophotometry (FTIR), the method of continuous variations, ab initio quantum chemical studies, and X-ray crystallographic analysis. The results afford more directions for extracting and separating metals by introducing devisable functionalized group into ILs.
研究领域:
化学工程
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）