Energy Storage Materials
·
2024
·
IF 18.9
Baorui Chen,Yuhang Xin,Yingshuai Wang,Xiangyu Ding,Chunyu Jiang,Feng Wu,Hongcai Gao
Sodium-ion batteries (SIBs) show great potential for energy storage due to their good electrochemical properties and intrinsic cost performance, and sodium-ion cathode materials with high capacity and stable structure are the inevitable future development trend. While conventional anionic redox-active layered oxide cathode materials offer the advantage of extra capacity, challenges such as irreversible oxygen release still need to be addressed. Herein, beryllium is successfully introduced into P3-Na x Li y Mn 1-y O 2 series of layered oxide materials for the first time, and the developed P3-Na 0.6 Li 0.2 Be 0.25 Mn 0.675 O 2 (NLBMO) with the modulation of lattice oxygen activity can reach an ultra-high reversible capacity of 212.6 mAh g −1 , significantly surpassing the P3-Na 0.6 Li 0.2 Mn 0.8 O 2 (NLMO, 165.7 mAh g −1 ). Based on a comprehensive comparison with the P3-NLMO, the effect of beryllium on the Mn/O charge complementary mechanism is revealed. Since the strong covalency of beryllium can inhibit the oxidation of excess O through the formation of stable Be-O bonds, while irreversible peroxidation of partially unstable (O 2 ) n − occurs to stimulate more Mn 4+ /Mn 3+ to replace O for charge compensation. As a result, pollution and structural damage caused by O peroxidation are effectively suppressed while achieving ultra-high capacity. In-situ XRD reveals that P3-NLBMO exhibits high structural reversibility during charging and discharging processes, indicating that the formation of Be-O bonds can also further stabilize the crystal structure during cycling. Therefore, beryllium modification strategy proposed in this work provides a novel route to synthesize novel SIBs cathode materials with higher performance.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2021
·
IF 9.811
Runqing Liu,Hongping Wu,Hongwei Yu,Zhanggui Hu,Jiyang Wang,Yicheng Wu
KBe2BO3F2 (KBBF) is the sole nonlinear optical (NLO) crystal that can practically generate deep-ultraviolet (UV) coherent light by a direct second-harmonic generation (SHG) process. However, the toxic BeO and crystal layer habit limit its application. With this background, a new beryllium-free borate, K5Mg2La3(BO3)6 (KMLBO), has been designed and synthesized through a high-temperature solution method. KMLBO crystallizes into the noncentrosymmetric space group P31m (No. 157) and features a three-dimensional framework structure consisting of alveolate [LaBO3]∞ layers further tightly bound via interlayer [BO3]3– groups. KMLBO not only exhibits desirable performances including deep-UV transparency, large SHG (∼3.1 × KH2PO4), and phase-matchability but also overcomes the crystal layer habit of KBBF, demonstrating that it is a potential deep-UV NLO crystal.
研究领域:
材料科学
·
光学
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DOI
高影响因子
JOURNAL OF APPLIED TOXICOLOGY
·
2025
·
IF 2.8
Yaqi Li,Zhanbing Sun,Yuqi Tong,Chenxi Yan,Lian Huang,Zhaohui Zhang
Beryllium and its compounds are classified as carcinogens, and prolonged exposure can trigger chronic beryllium disease. The Janus kinase–signal transducer and activator of transcription (JAK-STAT) signaling is known to play a critical role in the development and progression of numerous diseases. Leukemia inhibitory factor (LIF), a key upstream cytokine of the JAK-STAT pathway, has been implicated in regulating inflammatory responses and epithelial-mesenchymal transition (EMT) in various diseases. However, the specific involvement of the JAK-STAT pathway and LIF in beryllium sulfate (BeSO₄)–induced EMT in human bronchial epithelial (16HBE) cells remains unclear. To investigate the regulatory mechanisms, we examined the effects of BeSO₄ on 16HBE cells and targeted the JAK-STAT pathway using both pharmacological inhibition (niclosamide) and genetic silencing of LIF. Subsequently, we assessed cell morphology, proliferative capacity, inflammatory protein levels, and EMT marker expression. Our findings demonstrated that BeSO₄ exposure inhibited 16HBE cell proliferation and activated the JAK-STAT pathway. Pretreatment with niclosamide significantly mitigated cellular inflammation and the EMT process induced by BeSO₄. Additionally, silencing LIF markedly reduced JAK-STAT pathway activation and decreased the expression of EMT markers. This study uncovers a novel mechanism underlying BeSO₄-induced EMT in 16HBE cells, providing valuable insights into the molecular mechanisms of toxicity induced by beryllium and its compounds.
研究领域:
毒理学
·
细胞生物学
·
呼吸系统疾病
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产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2025
·
IF 3.3
Tong Wu,Lei Kang,Fan Liu,Ruixin Guo,Shu Guo,Tianhong Huang,Shuangyue Shang,Lijuan Liu,Xiaoyang Wang
Cation regulation is a compelling strategy for developing new compounds with optimized crystal structure by atomic-scale manipulation. Herein, we report two new SBBO-like fluoroberyllium borates, SrMgBe₂(BO₃)₂F₂ (SMBBF) and SrZnBe₂(BO₃)₂F₂ (SZBBF). They crystallize in a trigonal system and feature a [Be₃B₃O₆F₃]∞ single layer stabilized by the incorporation of Mg²⁺/Zn²⁺ cations and F⁻ cations. Both compounds exhibit deep-UV absorption edges below 200 nm. Theoretical calculations confirm their potential as deep-UV birefringent materials, with correspinding birefringence values of 0.064 (SMBBF) and 0.063 (SZBBF) at 589 nm, respectively. This work demonstrates the effectiveness of cation regulation in designing novel borate-based optical materials.
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED TOXICOLOGY
·
2024
·
IF 2.7
Xiaodong Liu,Tianyi Jiang,Huiyun Jin,Chenxi Yan,Yuqi Tong,Jiaquan Ding,Yaqi Li,Lian Huang,Zhaohui Zhang
Beryllium sulfate (BeSO 4 ) can cause inflammation through the mechanism, which has not been elucidated. Mitochondrial DNA (mtDNA) is a key contributor of inflammation. With mitochondrial damage, released mtDNA can bind to specific receptors (e.g., cGAS) and then activate related pathway to promote inflammatory responses. To investigate the mechanism of mtDNA in BeSO 4 -induced inflammatory response in 16HBE cells, we established the BeSO 4 -induced 16HBE cell inflammation model and the ethidium bromide (EB)-induced ρ 0 16HBE cell model to detect the mtDNA content, oxidative stress-related markers, mitochondrial membrane potential, the expression of the cGAS-STING pathway, and inflammation-related factors. Our results showed that BeSO 4 caused oxidative stress, decline of mitochondrial membrane potential, and the release of mtDNA into the cytoplasm of 16HBE cells. In addition, BeSO 4 induced inflammation in 16HBE cells by activating the cGAS-STING pathway. Furthermore, mtDNA deletion inhibited the expression of cGAS-STING pathway, IL-10, TNF-α, and IFN-β. This study revealed a novel mechanism of BeSO 4 -induced inflammation in 16HBE cells, which contributes to the understanding of the molecular mechanism of beryllium and its compounds-induced toxicity.
研究领域:
毒理学
·
细胞生物学
·
免疫学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF NUCLEAR MATERIALS
·
2025
·
IF 3.2
Zhangqi Li,Shizhuan Xu,Peng Wang,Jinzhao Zou,Jian Chen,Changqing Cao,Jin Lin
Although uranium trifluoride (UF 3 ) holds promise for applications in molten salt reactors, its high-temperature physicochemical properties in molten salt systems have yet to be thoroughly explored. In this study, the solubility and dissolution kinetics of UF 3 in molten 2LiF-BeF 2 (66–34 mol %, FLiBe) eutectic salt were investigated using the isothermal saturation method within the temperature range of 823 K to 973 K. High-purity UF 3 compacts (∼99.70 %) were synthesized via an optimized solid-phase reaction protocol and subsequent compacting. The UF 3 -saturated FLiBe molten salts were prepared by immerse dissolution of nickel mesh-wrapped UF 3 compacts and bulk uranium in the molten salt, eliminating the filtration step. Experimental findings showed that the dissolution equilibrium of UF 3 in the FLiBe salt was 120 h. The solubility of UF 3 exhibited a linear increase (R 2 > 0.99) from 4.16 wt. % to 12.60 wt. % as the elevation of temperature. Crystallographic analysis confirmed that the typical UF 3 phase was the only uranium-bearing phase throughout the dissolution process, while deconvolution X-ray photoelectron spectroscopy (XPS) verified the exclusive presence of the U 3+ species under all temperature conditions. Notably, the dissolution kinetics conformed to a mass transport control model.
研究领域:
核化学
·
材料科学
·
物理化学
·
能源技术
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED TOXICOLOGY
·
2020
·Vol. 41
·期 8
·1275-1285
·
IF 2.997
Shan Yi,Yan-ping Liu,Xun-ya Li,Xiao-yan Yuan,Ye Wang,Ying Cai,Yuan-di Lei,Lian Huang,Zhao-hui Zhang
Beryllium and its compounds are systemic toxicants that mainly accumulate in the lungs. As a regulator of gene expression, microRNAs (miRNAs) were involved in some lung diseases. This study aimed to analyze the levels of some inflammatory cytokine and the differential expressions of miRNAs in human bronchial epithelial cells (16HBE) induced by beryllium sulfate (BeSO 4 ) and to further explore the biological functions of differentially expressed miRNAs. The profile of miRNAs in 16HBE cells was detected using the high-throughput sequencing between the control groups ( n = 3) and the 150 μmol/L of BeSO 4 -treated groups ( n = 3). Bioinformatics analysis of differentially expressed miRNAs was performed, including the prediction of target genes, Gene Ontology (GO) analysis, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to verify some damage-related miRNAs. We found that BeSO 4 can increase the levels of some inflammatory cytokine such as interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). And BeSO 4 altered miRNAs expression of 16HBE cells and a total of 179 differentially expressed miRNAs were identified, including 88 upregulated miRNAs and 91 downregulated miRNAs. The target genes predicted by 28 dysregulated miRNAs were mainly involved in the transcription regulation, signal transduction, MAPK, and VEGF signaling pathway. The qRT-PCR verification results were consistent with the sequencing results. miRNA expression profiling in 16HBE cells exposed to BeSO 4 provides new insights into the toxicity mechanism of beryllium exposure.
研究领域:
毒理学
·
分子生物学
·
生物信息学
·
细胞生物学
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DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 14
·3590-3597
·
IF 7.779
Qiang Wang,Wen Song,Yang Lan,Liling Cao,Ling Huang,Daojiang Gao,Jian Bi,Guohong Zou
KBe2BO3F2 (KBBF) with a perfect honeycomb hexagonal layered structure is the sole practical deep-ultraviolet (DUV) nonlinear optical material which could generate DUV coherent light through direct frequency doubling. However, the layered growth habit and the toxicity of Be severely hinder its extensive applications. Herein, a non-centrosymmetric fluoride carbonate, KLi2CO3F, was successfully developed via chemical co-substitution with KBBF as the prototype. KLi2CO3F preserves the structural merits of KBBF, containing neatly arranged infinite planar [Li2CO3F2]∞ layers. In particular, compared with the weak interlayer K–F electrostatic attraction in KBBF, KLi2CO3F presents a stronger interlayer binding energy induced by the shorter and stronger Li–F bonds, which effectively overcomes the layered tendency of crystal growth. Simultaneously, KLi2CO3F exhibits a large birefringence of approximately 0.102@546 nm and a short ultraviolet absorption edge down to 190 nm, indicating that it is a promising DUV birefringent material.
研究领域:
材料科学
·
光学
·
晶体学
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DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
PeiChi Liao,Haichang Guo,Hongyu Niu,Ruijie Li,Ge Yin,Lei Kang,Liuchen Ren,Ruicong Lv,Huifeng Tian,Shizhuo Liu,Zhixin Yao,Zhenjiang Li,Yihan Wang,Lina Yang Zhang,U Sasaki,Wenxi Li,Yijie Luo,Junjie Guo,Zhi Xu,Lifen Wang,Ruqiang Zou,Shulin Bai,Lei Liu
The rapid development of modern electronic devices increasingly requires thermal management materials with controllable electrical properties, ranging from conductive and dielectric to insulating, to meet the needs of diverse applications. However, highly thermally conductive materials usually have a high electrical conductivity. Intrinsically highly thermally conductive, but electrically insulating materials are still limited to a few kinds of materials. To overcome the electrical-thermal conductance trade-off, here, we report a facile Pechini-based method to prepare multiple core (metal)/shell (metal oxide) engineered fillers, such as aluminum-oxide-coated and beryllium-oxide-coated Ag microspheres. In contrast to the previous in situ growth method which mainly focused on small-sized spheres with specific coating materials, our method combined with ultrafast joule heating treatment is more versatile and robust for varied-sized, especially large-sized core–shell fillers. Through size compounding, the as-synthesized core–shell-filled epoxy composites exhibit high isotropic thermal conductivity (∼3.8 W m–1 K–1) while maintaining high electrical resistivity (∼1012 Ω cm) and good flowability, showing better heat dissipation properties than commercial thermally conductive packaging materials. The successful preparation of these core–shell fillers endows thermally conductive composites with controlled electrical properties for emerging electronic package applications, as demonstrated in circuit board and battery thermal management.
研究领域:
材料科学
·
电气工程
·
热能工程
·
复合材料
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产品关联
DOI
PubMed
高影响因子
CHEMISTRY OF MATERIALS
·
2025
·
IF 7
Yurui Wang,Xuehua Dong,Wei Zeng,Ling Huang,Zhien Lin,Hongmei Zeng,Guohong Zou
Designing nonlinear optical (NLO) materials that simultaneously exhibit enhanced second-harmonic generation (SHG), moderate birefringence (Δn), and short-wavelength ultraviolet (UV) transparency remains a significant challenge. This study presents a stepwise structural regulation strategy using the International Zeolite Association (ABW)-type zeolite NH4BePO4 (I) as the parent material. By systematically modulating the anionic units, we successfully synthesized two compounds: KBe2(HPO3)2F (II) and NH4Be2(OH)(SeO3)2·H2O (III). Compound III represents a breakthrough, demonstrating an SHG intensity 4.0 times greater than that of KH2PO4, a birefringence of 0.080 at 546 nm, and a UV cutoff at 203 nm. The enhanced optical anisotropy and NLO efficiency of compound III arise from the stereochemically active lone pairs in the [SeO3] groups. By optimizing SHG intensity, short-wavelength UV transparency, and birefringence simultaneously, compound III addresses the key challenge of designing high-performance short-wavelength UV NLO materials. This work not only validates the stepwise regulation strategy but also provides a design framework for achieving balanced NLO performance, paving the way for the development of next-generation optical materials.
研究领域:
材料科学
·
非线性光学
·
无机化学
·
晶体工程
·
光学材料
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产品关联
DOI
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-16
·
IF 17.694
Meng Yun,Chen Lijie,Chen Yang,Shi Jieyun,Zhang Zheng,Wang Yiwen,Wu Fan,Jiang Xingwu,Yang Wei,Zhang Li,Wang Chaochao,Meng Xianfu,Wu Yelin,Bu Wenbo
Bacteria and excessive inflammation are two main factors causing non-healing wounds. However, current studies have mainly focused on the inhibition of bacteria survival for wound healing while ignoring the excessive inflammation induced by dead bacteria-released lipopolysaccharide (LPS) or peptidoglycan (PGN). Herein, a boron-trapping strategy has been proposed to prevent both infection and excessive inflammation by synthesizing a class of reactive metal boride nanoparticles (MB NPs). Our results show that the MB NPs are gradually hydrolyzed to generate boron dihydroxy groups and metal cations while generating a local alkaline microenvironment. This microenvironment greatly enhances boron dihydroxy groups to trap LPS or PGN through an esterification reaction, which not only enhances metal cation-induced bacterial death but also inhibits dead bacteria-induced excessive inflammation both in vitro and in vivo, finally accelerating wound healing. Taken together, this boron-trapping strategy provides an approach to the treatment of bacterial infection and the accompanying inflammation.
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Penglong Wang,Wenbo Guo,Guangrui Huang,Jianhua Zhen,Yini Li,Tong Li,Lu Zhao,Kai Yuan,Xuehao Tian,Xuemei Huang,Yanyan Feng,Haimin Lei,Anlong Xu
Aristolochic acid (AA) has been reported to cause a series of health problems, including aristolochic acid nephropathy and liver cancer. However, AA-containing herbs are highly safe in combination with berberine (Ber)-containing herbs in traditional medicine, suggesting the possible neutralizing effect of Ber on the toxicity of AA. In the present study, in vivo systematic toxicological experiments performed in zebrafish and mice showed that the supramolecule self-assembly formed by Ber and AA significantly reduced the toxicity of AA and attenuated AA-induced acute kidney injury. Ber and AA can self-assemble into linear heterogenous supramolecules (A–B) via electrostatic attraction and π–π stacking, with the hydrophobic groups outside and the hydrophilic groups inside during the drug combination practice. This self-assembly strategy may block the toxic site of AA and hinder its metabolism. Meanwhile, A–B linear supramolecules did not disrupt the homeostasis of gut microflora as AA did. RNA-sequence analysis, immunostaining, and western blot of the mice kidney also showed that A–B supramolecules almost abolished the acute nephrotoxicity of AA in the activation of the immune system and tumorigenesis-related pathways.
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DOI
PubMed
高影响因子
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