CHEMOSPHERE
·
2017
·
IF 4.208
Zhenzhen Huang,Piao Xu,Guiqiu Chen,Guangming Zeng,Anwei Chen,Zhongxian Song,Kai He,Lei Yuan,Hui Li,Liang Hu
This study investigated the influence of silver ions (Ag + ) on the cytotoxicity of silver nanoparticles (AgNPs) in Phanerochaete chrysosporium and noted the degree of extracellular secretions in response to the toxicant's stress. Oxalate production was elicited with moderate concentrations of 2,4-dichlorophenol (2,4-DCP) and AgNPs reaching a plateau at 10 mg/L and 10 μM, respectively. Increased oxalate accumulation was accompanied by higher activities of manganese peroxidase (MnP) and lignin peroxidase (LiP). However, the secretion of oxalate, MnP and LiP was significantly inhibited owing to Ag + incorporation into AgNP solution. Production of extracellular polymeric substances (EPS) significantly elevated with an increase in 2,4-DCP concentrations; however, after 24 h of exposure to 100 mg/L 2,4-DCP, an obvious decrease in EPS occurred, indicating that part of EPS could be consumed as carbon and energy sources to ameliorate biological tolerance to toxic stress. Furthermore, AgNP-induced “particle-specific” cytotoxicity was substantially enhanced with additional Ag + as evidenced by its significant negative impact on cellular growth, plasma membrane integrity, and morphological preservation compared with AgNPs at equal Ag concentration.
研究领域:
微生物学
·
环境科学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2022
·
IF 3.915
Nan Jin,Jingwen He,Chenyuan Wu,Zejun Chen,Yuling Li,Jianmin Chen,Jianhu Lin
The aim of this study was to explore the function of glycyrrhizic acid (GA) in an anti-psoriatic dermal delivery, whereby GA is originally designed as the matrix agent, with curcumin (Cur) as the active agent and silica as the drug carrier. Formulations with different GA proportions were prepared and named W-GA (without GA), L-GA (13% w/w GA) and H-GA (26% w/w GA). The results showed that GA had no significant effect on the physical characteristics, such as particle size and amorphous state, as exhibited by scanning electron microscopy and x-ray diffractograms, respectively. Compared with W-GA and L-GA, H-GA resulted in 10% less photodegradation of Cur after storage for one month, 0.45 μg more penetrated Cur in the epidermis, 2-fold higher viscosity, fewer signals of imiquimod-induced psoriasiform skin lesions and less histological morphological changes. The findings showed that H-GA significantly inhibited expression of interleukin 17 A in the dermis, and interleukin IL-23 in the epidermis, compared with Cur raw drug powder (RDP), whereas L-GA had no significant effect on the expression. These results indicated that a high GA proportion results in superior anti-psoriatic efficacy. Therefore, Cur-loaded silicas with approximately 26% GA are recommended as the superior formulation for the treatment of psoriasis.
研究领域:
药剂学
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皮肤病学
·
药物递送系统
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 11
·6335-6344
·
IF 4.682
Liu Lingling,Zhou Shu,Luo Liping,Zheng Jingjing,Ji Lijun
Ag@C fibres with porous silver structure were synthesized with a surface-hydrolyzed polyacrylonitrile (PAN) fibre as a template and by a hydrazine hydrate reduction and carbonization process. The composition and structure of the Ag@C fibres were characterized with a scanning electron microscope, an X-ray diffractometer, a Fourier transform infrared spectrometer, an X-ray photoelectron spectrometer, a Raman spectrometer, and a thermogravimetric analyser. The porous structure of the silver shell combined with carbon was conducive to the release of silver ions and suppressed the loss of silver nanoparticles from the surface of the carbon fibres. The Ag@C fibres showed excellent antibacterial performance. When the dosage of Ag@C fibres prepared with a silver nitrate solution of 0.5 mol/L was 1 mg, 2 mg, 4 mg and 8 mg, the bacterial inactivation rate to Staphylococcus aureus was 97.98%, 99.89%, 99.99%, and 99.99% in 12 h, respectively. The loss of viability only decreased to 80% when 1 mg of Ag@C fibres were used for antimicrobial activity test after five times of recycling. The Ag@C fibres have a broad application prospect in producing fabric products of antibacterial fields. Graphical abstract
研究领域:
材料科学
·
微生物学
✓ 已验证
DOI
高影响因子
Current Pharmaceutical Analysis
·
2020
·Vol. 16
·期 6
·763-773
·
IF 0.923
Yaro Peter,Nie Jing,Xu Mingcheng,Zeng Kui,Zeng Su
Background: Terpene lactones are major components of ginkgo biloba extract which are used in cardiovascular and degenerative diseases. To study the involvement of transporters in the transport/disposition of ginkgolides A, B, C, and bilobalide, a bioanalytical assay was developed by
LCMS/ MS system for the quantitation of intracellular levels of terpene lactones in cells expressing organic cation transporter 2 (OCT2). Methods: The assay involved an optimized simple sample handling with methyl tert-butyl ether for liquid-liquid extraction and reconstitution in modified
dissolution solution. Pretreatment of samples with 50 μM ascorbic acid and the addition of ascorbic acid and formic acid in dissolution solution significantly reduced matrix effect and stabilized the postpreparative samples. Separations were performed by Zobrax RRHD column (extend-C18 1.8μm,
3.0 x 100mm) and acetonitrile gradient elution. The analysis was carried out in the negative ion scan mode using multiple reaction monitoring. Results: The method was validated for linearity (concentration range of 20-5000nM), accuracy (±13.1%), precision (<11.0%), recovery
(94.31–105.9%), matrix effect (93.8-111.0%) and stability. Finally, the method was applied in the determination of intracellular concentrations of ginkgolides A, B, C, and bilobalide in Madin-Darby canine kidney (MDCK-mock) and MDCK-OCT2 cells in uptake study. Conclusion: The developed
method was successfully validated. Results suggest that OCT2 is involved in the renal disposition of ginkgolide A, B, and bilobalide. This method would foster the study of transport mediated activity via the interaction of ginkgolides and bilobalide with cellular systems.
研究领域:
药理学
·
分析化学
·
药物代谢
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Lufa Yang,Shuai He,Zongyi Shang,Jie Zou,Yaoyue Yang,Zhigang Zhao,Dan Xiao,Caixia Zhou
The Zn-Ag and Zn-Ag/air hybrid batteries are challenged by the low conductivity and capacity of Ag electrode materials. How to further optimize and tune the surface electronic structure of Ag nanomaterials has become an important topic in the improvement of Ag electrode materials. Herein, the silver nanobelts (Ag NBs) materials were prepared by a fast and simple redox replacement reaction. The special nanobelts structure, with the key surface features of the gully-like morphology, raised Ag mounds and superlattice fringes, are beneficial to tune the surface electron structure and thereby increase the conductivity and electrochemical performance of Ag NBs. As a consequence, the assembled Zn-Ag battery exhibits favorable electrochemical performance in view of the specific capacity of 380.9 mAh g Ag −1 . In addition, the hybrid Zn-Ag/air battery shows two-step voltage plateaus of 1.83 and 1.55 V in the Zn-Ag reaction, as well as a voltage plateau of 1.23 V corresponding to the Zn-air reaction. The hybrid battery maintains a high energy efficiency of 76.9% and high rate capabilities, demonstrating an excellent energy-saving feature of this battery. The insights gained from this work may be beneficial for designing the highly-efficient Ag catalysts for electrochemical energy storage.
研究领域:
材料科学
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能源存储
·
电化学
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2016
·Vol. 6
·期 6
·119
·
IF 2.69
Hongru Ma,Jinfeng Zeng,Steven Harrington,Lei Ma,Mingze Ma,Xuhong Guo,Yanqing Ma
Silver nanowires-silver nanoparticles-graphene nanosheets (AgNWs-AgNPs-GN) hybrid nanomaterials were fabricated through a hydrothermal method by using glucose as a green reducing agent. The charge carriers of AgNWs-AgNPs-GN passed through defect regions in the GNs rapidly with the aid of the AgNW and AgNP building blocks, leading to high electrical conductivity of electrically conductive adhesives (ECA) filled with AgNWs-AgNPs-GN. The morphologies of synthesized AgNWs-AgNPs-GN hybrid nanomaterials were characterized by field emission scanning electron microscope (FESEM), and high resolution transmission electron microscopy (HRTEM). X-ray diffraction (XRD) and laser confocal micro-Raman spectroscopy were used to investigate the structure of AgNWs-AgNPs-GN. The resistance of cured ECAs was investigated by the four-probe method. The results indicated AgNWs-AgNPs-GN hybrid nanomaterials exhibited excellent electrical properties for decreasing the resistivity of electrically conductive adhesives (ECA). The resistivity of ECA was 3.01 × 10−4Ω·cm when the content of the AgNWs-AgNPs-GN hybrid nanomaterial was 0.8 wt %.Keywords:hydrothermal;nanosilver;graphene;resistivity;electrically conductive adhesives
研究领域:
材料科学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
Materials Research Express
·
2020
·Vol. 7
·期 8
·085403
·
IF 1.929
Yanqin Xu,Jie Liu,Shumin Guan,Aotong Dong,Yuan Cao,Changguo Chen
pH-sensitive Ag/AgO/carboxymethyl chitosan (CMCS) bacteriostatic hydrogels and Ag/AgO/CMCS/Aspirin (ASP) carrier hydrogels were prepared by Ag/AgO in situ precipitation method, and the effects of swelling, degradation, drug release and antibacterial properties of hydrogels were studied. The network of Ag/AgO/CMCS/ASP drug-loaded gels produced was mainly cross-linking by hydrogen bonding and intermolecular forces, and the cross-linking silver was mainly present in the elemental Ag and Ag2+ states. Under the condition of buffer solution pH = 7.4, the cumulative release amount of Ag/AgO/CMCS/ASP drug-loaded gel was 75.20% within 12 h, and the inhibition rate of Gram-negative Escherichia coli (E. coli) reached the maximum of 92.32%, which had broad application prospects in the medical field.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF FOOD PROCESSING AND PRESERVATION
·
2022
·Vol. 46
·期 10
·e16896
·
IF 2.609
Dan-Feng Zhang,Zhi-E Zhou,Juan Du,Xiao-Ning Liao,Gao-Ding Xu,Yan-Ping Hong,Jian-Hua Xiong
Lonicera japonica Thunb. leaves were used to biosynthesize silver nanoparticles (AgNPs), while its antibacterial and antifungal properties were investigated. Reaction conditions of AgNPs which characterized were optimized. The maximum absorption wavelength of the AgNPs was located about 400 nm, with a spherical shape and a particle size of 14.87 ± 4.07 nm. Produced AgNPs showed effective antibacterial activities against tested bacterial strains. Minimal inhibitory concentrations and minimum bactericidal concentrations of the AgNPs were 0.25 and 0.5 mg/ml for Escherichia coli ( E. coli ), and 0.5 and 1.0 mg/ml for Staphylococcus aureus , respectively. According to the mechanism study, AgNPs generated morphological changes in E. coli and disrupted membrane integrity. Furthermore, AgNPs which showed effective dose-dependent inhibitory effects against Penicillium citrinum could suppress the growth of fungal mycelium on citrus peels. Conclusively, AgNPs generated by this facile and green method showed effective antimicrobial activity, which is promising in food processing and preservation. Practical applications Silver nanoparticles have attracted enormous attention because of their intrinsic properties which are advantageous in many applications, especially in agriculture and food industry. Silver nanoparticles were synthesized by medicine food homology plants Lonicera japonica Thunb. leaves for the first time, which was a green synthesis method. Synthesized AgNPs showed good antibacterial and antifungal properties, which has the potential use in citrus preservations.
研究领域:
植物学
·
微生物学
·
食品科学
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2019
·
IF 6.35
Qinlei Liu,Yao Lin,Jing Xiong,Li Wu,Xiandeng Hou,Kailai Xu,Chengbin Zheng
A disposable, instrument-free, height readout paper-based analytical device (HR-PAD) based on a paper strip inkjet-printed with CdTe quantum dots (QDs) was developed for the sensitive speciation analysis of Ag+ and silver nanoparticles (AgNPs). When the paper strip is immersed into a sample solution, capillary action draws it through the surface and any Ag+ in the solution quenches the fluorescence of CdTe QDs via a cation exchange reaction between Ag+ and the CdTe QDs, with the height of the quenched band being proportional to the concentration of Ag+. In contrast, fluorescence quenching cannot be observed when only AgNPs are present in solution. Thus, the concentration of AgNPs can be obtained by subtracting the Ag+ content from the total silver determined by the HR-PAD after digestion with HNO3. Under optimized conditions, the methodology provides high selectivity, sensitivity, and accuracy for the detection of Ag+ or AgNPs in various samples, even at concentrations as low as 0.05 mg L–1. Precisions of 4.5% and 2.2% RSDs were achieved at concentrations of 1 mg L–1 and 7 mg L–1 of Ag+, respectively. Compared to conventional methods, this approach is inexpensive and user-friendly and eliminates the need for expensive and sophisticated detection instruments. The practicality of the method was demonstrated via the speciation analysis of AgNPs and Ag+ in river water and 12 commercial products with satisfactory results.
研究领域:
分析化学
·
环境科学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2019
·
IF 5.107
Hongbin Yu,Danyang Wang,Bin Zhao,Ying Lu,Xinhong Wang,Suiyi Zhu,Weichao Qin,Mingxin Huo
A ternary dual Z-scheme heterojunction photocatalyst composed of Ag 3 PO 4 , AgBr and g-C 3 N 4 was prepared by a facile chemical deposition method. Scanning electron microscope equipped with energy-dispersive X-ray, X-ray diffraction, diffusive reflective spectrophotometry and X-ray photoelectron spectroscopy were carried out to characterize the morphology, element and structure properties of the photocatalysts. The photocatalytic activity was evaluated by the photoelectrochemical tests and the degradation of tetracycline (TC). The results indicated that the composite Ag 3 PO 4 /AgBr-20%g-C 3 N 4 exhibited the best photocatalytic activity in terms of the photocurrent response and the degradation of TC under visible light irradiation. The degradation rate of TC over the ternary photocatalyst was 0.12 min −1 , which was 2.55 and 3.24 times faster than that over Ag 3 PO 4 /AgBr and Ag 3 PO 4 , respectively. During photocatalysis, metallic Ag could be formed and served as the electron transfer mediator to build the dual Z-scheme heterojunction by bridging the recombination of electrons and holes. By this manner, more efficient separation of photo-generated carriers and better redox ability could be obtained, consequently promoting the photocatalytic activity. Additionally, the trapping experiments verified that O 2 − and h + played prominent roles in the photocatalytic processes, while the impact of OH on the removal efficiency was relatively small.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
ORGANIC ELECTRONICS
·
2020
·
IF 3.31
Jiachen Kang,Kang Han,Xue Sun,Lianping Zhang,Rong Huang,Irfan Ismail,Zhenguo Wang,Changzeng Ding,Wusong Zha,Fangsen Li,Qun Luo,Yuanjie Li,Jian Lin,Chang-Qi Ma
Silver nanowires (Ag NWs) network is an excellent candidate as flexible transparent electrode applying in flexible perovskite solar cells, owing to their excellent electrical and optical properties . However, several problems including large surface roughness, chemical reaction between Ag and perovskite precursor, and migration of Ag limited the application in high performance perovskite solar cells . Aiming to solve these problems, the composite electrode combining the spray coated Ag nanowires and the low-temperature sol-gel zinc oxide was developed in this work. The optimized concentration and annealing temperature of sol-gel ZnO were 0.45 M and 150 °C. The introduction of zinc oxide with suitable concentration caused slight impact on the transmittance and sheet resistant of transparent composite electrode, and promoted mechanical and chemical stability in air relative to the pristine Ag NWs electrode. The use of the composite flexible electrode could decrease the surface roughness of the Ag NWs electrode, passivate the reaction of perovskite and silver electrode, and prevent the migration of Ag. As a consequence, the performance of the flexible device significantly improved from 9.51% to 13.12%. Under the AM 1.5G constant illumination, the optimization device has a remarkably improved stability than pristine device. This study demonstrates that spray Ag NWs as bottom electrode is suitable for flexible perovskite solar cells. Meanwhile, it's an effective method using sol-gel ZnO to construct composite electrode to promote the device performance and stability.
研究领域:
材料科学
·
能源科学
✓ 已验证
DOI
高影响因子
POLYMER SCIENCE SERIES A
·
2020
·Vol. 62
·期 3
·196-204
·
IF 0.968
Ting Gu,Zhu Dayong,Lu Shengjun
Abstract Silver nanoparticles are deposited on aramid fiber surfaces by a three-step process. Calcium chloride/ethanol coarsening of the aramid fiber is followed by surface functionalization with poly(dopamine) and electroless silver plating. The chemical structure and elemental composition of the aramid fibers are determined by X-ray photoelectron spectroscopy and energy dispersive X-ray spectroscopy, respectively. The surface morphology of the modified aramid fibers is investigated by scanning electron microscopy and atomic force microscopy. The crystalline structure and thermal stability of the modified aramid fibers before and after silver plating are analyzed by X-ray diffraction and thermogravimetric analyses. A four-point probe is used to determine the electrical resistivity of the silver-plated aramid fibers. The results show that after the silver plating of the aramid fiber surface, its electrical resistance was reduced. At 20 g/L AgNO 3 , the silver layer on the aramid fiber surface is stable and durable with a high electrical resistivity.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）