BIOCONJUGATE CHEMISTRY
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2016
·
IF 4.5
Jianbo Li,Dawei Jiang,Baoliang Bao,Yulin He,Lei Liu,Xuemei Wang
Self-assembled DNA nanostructures, as a new type of nanocarriers, have shown great potential in molecular imaging probes. DNA bipyramid nanostructures (DBNs), as a classic kind of DNA nanostructure, can be precisely constructed through the unparalleled base-pairing precision of oligonucleotide strands. DBNs were prepared by self-assembly of six oligonucleotides with equal molar amounts in a single annealing step, and purified by high performance liquid chromatography (HPLC). DBNs were stable in 10% FBS as well as 80% mouse serum for at least 8 h. To prepare 99mTc-labeled DBNs, N-hydroxysuccinimidyl S-acetylmercaptoacetyl triglycinate (Sacetyl-MAG3-NHS ester) tagged single-stranded DNA (ssDNA) was first radiolabeled with Tc-99m, and DBNs with an overhang were assembled and then hybridized with 99mTc-ssDNA to prepare 99mTc-labeled DNA bipyramid nanostructures (99mTc-MAG3-DBNs). DBNs were radiolabeled, with the radiochemical purity being over 90%. The plasma half-life of 99mTc-MAG3-DBNs in normal KM mice was about 6 min. The biodistribution and SPECT/CT imaging were conducted with 99mTc-MAG3-DBNs in KM mice, and both showed that 99mTc-MAG3-DBNs mainly concentrated in the intestine, liver, and kidneys, and there was also prominent uptake in the gallbladder and bladder. We successfully obtained a new class of SPECT molecular probes based on this DNA polyhedron structure.
研究领域:
核医学
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分子影像
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生物化学
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放射学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Dingyang Chen,Zhaoli Liu,Shuying Li,Xiaofei Jing,Yuyang Tian,Wei Hu,Fengchao Cui,Rui Zhao,Guangshan Zhu
Developing cationic adsorbents for efficient radioactive pertechnetate ( 99 TcO 4 − ) removal from water is of great significance in both nuclear fuel management and nuclear-related environmental treatment fields. However, tremendous efforts should be taken to improve the comprehensive performance of the adsorbent materials. Herein, novel cationic electrospun nanofibers were synthesized via the blending electrospinning from the branched polyethylenimine based solution and the following quaternization reaction by benzyl bromide. Consequently, abundant specific anion traps with hydrophobic microenvironment were constructed on the fibers. The obtained fiber adsorbents were systematically investigated to remove perrhenate (ReO 4 − ) ions (the nonradioactive surrogate for TcO 4 − ), which exhibit satisfying adsorption performance in several aspects: high adsorption capacity (943 mg g −1 ), fast kinetics (30 min), good removal depth (distribution coefficient = 1.1 × 10 6 mL g −1 ), large dynamic column adsorption volume (1540 bed volume), and excellent ReO 4 − capture from solution with high ionic strength or acidity/alkalinity. The adsorption performance surpassed all macroscopic shapeable adsorbents and many powdery advanced porous materials, owing to their abundant adsorption sites, tailored anion traps and macroscopic fibrous structures. Overall, this work gives a useful insight into designing novel adsorbents for effective TcO 4 − /ReO 4 − capture.
研究领域:
材料科学
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环境科学
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核能工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Mengnan Huang,Lixin Kan,Wenyan Zhao,Yuejiao Wang,Ying Xiong,Weijun Shan,Zhenning Lou
99 Technetium ( 99 Tc) is one of the most dangerous radioactive isotopes in the legacy nuclear waste, and harmful to the environment and human health. Effectively removing it remains a long-term challenge. Herein a resin-like imidazolium-based ionic liquid polymer (DVB-2C 8 VEIMBr) was prepared for selective adsorption of TcO 4 − (ReO 4 − as an alternative for laboratory operation). It is manifested that DVB-2C 8 VEIMBr integrates high adsorption capacity (313.28 mg·g −1 ) and selectivity (90.68% in 6000 times excess of SO 4 2− ions). A real-scenario experiment exhibits DVB-2C 8 VEIMBr can remove up to 93% of TcO 4 − from the simulated Hanford LAW scrubber solution. More importantly, DVB-2C 8 VEIMBr displays super acid and alkaline resistance and stability after immersing for 8 months under extreme conditions of 3 M HCl and 2 M NaOH. It can also effectively separate rhenium from molybdenum solution in the range of 3 M HCl - pH 2. Additionally, it still showed perfect regeneration performance after 10 cycles. In particular, this work demonstrates the feasibility of imidazolium-based ionic liquid adsorbents in the TcO 4 − or ReO 4 − immobilization process, which can be applied to capture these radioactive oxygen anions under high acid and high alkali conditions.
研究领域:
环境科学
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放射化学
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材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
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2010
·Vol. 15
·期 4
·591-599
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IF 3.415
Zhu Hua,Huang Liliang,Zhang Yuanqing,Xu Xiaoping,Sun Yanhong,Shen Yu-Mei
To develop technetium- and rhenium-labeled nonsteroidal estrogen imaging agents for estrogen receptor (ER) positive breast tumors, two groups of rhenium and technetium cyclofenil derivatives were synthesized and characterized. The binding affinities of the rhenium complexes for ERs were determined. The tricarbonyl rhenium complex showed the highest binding affinity for ERs (81.2 for ERβ, 16.5 for ERα). Tricarbonyl technetium cyclofenil complexes were obtained in high radiochemical purity and radiochemical yields. The results of studies of their octanol/water partition and in vitro stability are presented. These results demonstrate that these radiolabeled cyclofenil derivatives may be considered as potential breast cancer imaging agents.
研究领域:
医学影像学
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药物化学
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肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Hongfei Sun,Xinying Lei,Jingxuan Xu,Minjia Yan,Tao Wen,Xinyue Zhang,Congcong Shen,Zilong Wang,Xi Lin Wu
Radioactive iodine (I 2 , CH 3 I) and pertechnetate (TcO 4 − ), both byproducts of uranium and plutonium fission processes, make up the majority of long half-life radionuclide waste from nuclear power plants. Imidazolium-based cationic polymeric networks (CPN-tib- x ) were rationally designed by modulating benzyl bromide substituents to optimize electrostatic potential distribution and steric hindrance. Representatively, CPN-tib-1 exhibited high efficiency in simultaneous removal of volatile and aqueous I 2 via charge-transfer complexes, affording both adsorption capacities of 5.11 and 1.71 g g −1 , respectively. CPN-tib-3 demonstrated superior CH 3 I uptake (1.54 g g −1 ) through N-methylation at nonionic N sites, surpassing most imidazolium-based materials. More significantly, CPN-tib-2 achieved the highest ReO 4 − (TcO 4 − surrogate) adsorption capacity (921.9 mg g −1 ) as well as fast kinetics through strong anion exchange and electrostatic attraction, maintaining >60 % efficiency even in simulated Hanford low-activity waste (LAW). The impressive ReO 4 − adsorption performance of CPN-tib-2 was attributed to the synergistic effects arising between steric hindrance and densely imidazolium-N + sites. The structure-adsorption performance relationships highlighted the synergy of charge density, steric accessibility, and binding site geometry in governing selective adsorption. This work provides a versatile platform for designing multifunctional polymers tailored for nuclear waste remediation, offering insights into balancing electrostatic and steric effects for efficient radionuclide sequestration.
研究领域:
核化学
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环境工程
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高分子化学
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放射化学
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材料科学
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污染控制
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Jiaqing Huang,Xiaoyong Xia,Jiajia Li,Liang Liu,Chunyue Xu,Jinkai Qiu,Cheng Lian,Qingfeng Xu,Jianmei Lu
The extraction of TcO 4 - from nuclear wastewater via adsorption-based methods is recognized as a highly promising strategy but confronted with significant challenges due to the harsh conditions often encountered, such as highly acidic or alkaline environments, elevated ionic strengths, and intense radiation fields. In this work, we have designed and synthesized a triazine-tri-imidazole based cationic covalent organic polymer, CTFT, with covalent triazine frameworks (CTF) as the structural building blocks and tri-imidazole-based (TIB) units as the connecting motifs. This highly conjugated polymer successfully overcomes the aforementioned challenges and exhibits remarkable ReO 4 - (a non-radioactive substitute to TcO 4 - ) uptake capabilities across five critical performance metrics simultaneously: ultrafast adsorption kinetics (equilibrium reached within 0.5 min), exceptional resistance to strong acids and bases (4 M HNO 3 and 4 M NaOH), high selectivity towards ReO 4 - (80.5 %, 5000 × over SO 4 2- ), superior radiation resistance (400 kGy γ-rays), and outstanding recyclability (20 cycles, 95.6 % retention). Additionally, CTFT achieves a high ReO 4 - removal efficiency in simulated Hanford waste (85.3 %, 10 g/L). Experimental and theoretical calculation results demonstrate that strong electrostatic interactions and affinity exist between imidazolium cation and ReO 4 - . This finding provides a potential design strategy for developing polymers with high durability in the field of nuclear environmental remediation.
研究领域:
环境修复
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高分子化学
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核化学
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材料科学
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放射化学
·
废物处理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）