Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 45
·9316-9323
·
IF 6.331
Danling Cheng,Jiali Gong,Peng Wang,Jingyi Zhu,Ningyue Yu,Jinhua Zhao,Qin Zhang,Jingchao Li
Photothermal therapy (PTT) has shown great promise for cancer treatment via light-triggered heat generation, while the anticancer efficacy of sole PTT is often limited. In this study, we report the use of radionuclide 131I-labeled gold nanoframeworks (131I-AuNFs) for radiotherapy-combined second near-infrared (NIR-II) PTT of breast cancer. AuNFs synthesized via a simple reduction approach are surface functionalized with polydopamine and poly(ethylene glycol), followed by labeling with 131I. The formed 131I-AuNFs with a high photothermal conversion efficacy and stable radioactivity can effectively accumulate into subcutaneous 4T1 mouse models as confirmed by in vivo single photon emission computed tomography (SPECT) imaging. Upon 1064 nm laser irradiation of tumors, local heat is generated for NIR-II PTT, which combines with radiotherapy to achieve a much higher therapeutic efficacy relative to sole treatment. As such, 131I-AuNFs-mediated radiotherapy-combined NIR-II PTT results in the effective inhibition of the growth of subcutaneous tumors. This study thus provides a facile nanoplatform for effective combination cancer therapy.
研究领域:
肿瘤学
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纳米医学
·
放射医学
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DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·
IF 12.6
Liang Maolin,Fan Longfei,Zhang Suming,Chen Hua,Dong Xuexue,Hu Lin,Wang Guanglin,Yang Kai,Pei Pei,Zhu Ran
The efficacy of radiotherapy for brain tumors is limited by tumor cell radio-resistance and the immunosuppressive microenvironment, which often counteracts the immunogenic effects of radiation-induced antitumor responses. To address this, we developed statherin-enriched engineered outer membrane vesicles (OMVs), co-labeled with the radionuclide 131 I and loaded with the metabolic inhibitor methotrexate (MTX), termed 131 I-O/M-P, to enable integrated radiotoxicity, metabolic intervention, and immune activation. Upon delivery of 131 I-O/M-P to the tumor site, 131 I promptly emits β-rays that induce DNA double-strand breaks, triggering immunogenic cell death (ICD) and the release of damage-associated molecular patterns (DAMPs), thereby initiating antitumor immune responses. Subsequently, the released MTX is internalized by tumor cells, where it inhibits dihydrofolate reductase (DHFR), blocks nucleotide synthesis, impairs DNA repair capacity, and exacerbates DNA damage accumulation, thereby further promoting apoptosis and immune activation. Meanwhile, the intrinsic adjuvant properties of OMVs synergize with the ICD response to enhance T cell activation and infiltration. In both subcutaneous and orthotopic brain tumor mouse models, 131 I-O/M-P significantly enhanced CD8 + T cell infiltration, reduced T cell exhaustion phenotypes, and suppressed tumor growth. In summary, we present a temporally coordinated radio-metabolic-immunotherapy strategy, offering a novel therapeutic approach for advancing radio-immunotherapy in brain tumors. Graphical abstract
研究领域:
肿瘤学
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纳米医学
·
免疫治疗
·
放射生物学
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癌症代谢
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DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2019
·Vol. 319
·期 3
·1119-1125
·
IF 1.186
Wang Yunhan,Song Hu,Wang Guanquan,Yang Xia,Wang Jing,Wei Hongyuan
In this study, we successfully synthesized polyethylene glycol (PEG) and folic acid (FA) co-functionalized graphene quantum dots (GQDs) to improve the biocompatibility and tumor-targeting ability of GQDs simultaneously, and labeled GQDs–PEG–FA with 131 I for biological behavior evaluation. The in vitro properties, biodistribution and SPECT imaging of 131 I-GQDs–PEG–FA were investigated. The uptake of 131 I-GQDs–PEG–FA at tumor sites can be clearly examined via SPECT imaging, which can ascribe to enhanced permeability and retention effect and active targeting effect of FA to folate receptors. The results indicate that 131 I-GQDs–PEG–FA can be used as a radioactive probe for detection of tumor cells overexpressing folate receptor.
研究领域:
放射学
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核医学
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分子影像
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生物材料
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癌症研究
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DOI
高影响因子
Nature Biomedical Engineering
·
2018
·Vol. 2
·期 8
·611-621
·
IF 0
Chao Yu,Xu Ligeng,Liang Chao,Feng Liangzhu,Xu Jun,Dong Ziliang,Tian Longlong,Yi Xuan,Yang Kai,Liu Zhuang
Radiation therapy for cancer can lead to off-target toxicity and can be ineffective against hypoxic solid tumours and distant metastases. Here, we show that intratumoral injection, in mouse and rabbit xenografts and in patient-derived mouse xenografts, of a sodium alginate formulation containing catalase (Cat) labelled with the therapeutic 131 I radioisotope enables long-term relief of tumour hypoxia and complete tumour elimination at low radioactivity doses. On injection, the soluble polysaccharide rapidly transforms into a hydrogel in the presence of endogenous Ca 2+ , fixing 131 I-Cat within the tumours. We also show that local radiotherapy with a formulation that includes the immunostimulatory CpG oligonucleotide combined with systemic checkpoint-blockade therapy using an anti-CTLA-4 antibody leads to metastasis inhibition and protection against tumour rechallenge. The local therapy, which uses only biocompatible components, might enable new strategies for local tumour treatments that can be combined with systemic therapeutic responses, for the inhibition of tumour metastasis and the prevention of tumour recurrence in patients with advanced-stage cancer.
研究领域:
肿瘤学
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免疫学
·
放射医学
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产品关联
DOI
PubMed
Nanoscale Research Letters
·
2017
·Vol. 12
·期 1
·1-8
·
IF 2.833
Wang Haiyan,Sheng Weizhong
Herein, folic acid (FA) conjugated Poly(d,l-lactide-co-glycolide) (PLGA)-lipid composites (FA-PL) were developed as nanocarriers for the targeted delivery of insoluble anti-cancer drug paclitaxel (PTX), resulting FA-PLP nanoparticles. Furthermore, 131 I, as a radioactive tracer, was used to label FA-PLP nanoparticles (FA-PLP- 131 I) to evaluate their cell uptake activity, in vivo blood circulation, and biodistribution. The FA-PLP- 131 I nanoparticles had a spherical morphology with great stability, a narrow size distribution (165.6 and 181.2 nm), and −22.1 mV in average zeta potential. Confocal laser scanning microscopy indicated that the targeting molecule FA promotes PLP- 131 I uptake by melanoma B16F10 cells, which was further confirmed by the cell incorporation rate via 131 I activity detection as measured by a gamma counter. FA-PLP- 131 I without PTX (FA-PL- 131 I) shows minor cytotoxicity, good biocompatibility, while FA-PLP- 131 I was demonstrated to have efficient cell viability suppression compared to free PTX and PLP- 131 I. Following intravenous injection, the blood circulation half-life of free PTX ( t
1/2 = 5.4 ± 0.23 h) was prolonged to 18.5 ± 0.5 h by FA-PLP- 131 I. Through FA targeting, the tumor uptake of FA-PLP- 131 I was approximately 4.41- and 12.8-fold higher compared to that of PLP- 131 I and free PTX- 131 I, respectively. Moreover, following 40 days of treatment, FA-PLP- 131 I showed an improved tumor inhibition effect compared to free PTX and PLP- 131 I, with no relapse and no remarkable systemic in vivo toxicity. The results demonstrate that the 131 I-labeled PLGA-lipid nanoparticle can be simultaneously applied for targeted drug delivery and reliable tracking of drugs in vivo.
研究领域:
药学
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肿瘤学
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纳米医学
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DOI
PubMed
高影响因子
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
·
2025
·
IF 0.9
Jiaojiao Zuo,Jing Kang,Jingjing Hong,Jingwen Li,Yi Fang,Chunyi Liu,Minhao Xie,Zhengping Chen
Dopamine transporter (DAT) is closely associated with neurodegenerative diseases such as Parkinson's disease (PD). To develop an in vivo stable radioligand targeting DAT, we synthesized a novel iodine-131-labeled tropane analog [ 131 I] 1 with deuteration on both the N -fluoropropyl and 2 β -carbomethoxy positions of the tropane scaffold and then biologically compared with the previously reported analog [ 131 I]FP-CIT-d 6 with deuteration only on the N -fluoropropyl group. The radioligand [ 131 I] 1 was obtained via a radioiodine-destannylation reaction with a radiochemical yield of ~95%, a radiochemical purity of > 99% and a molar activity of 12.72 GBq/μmol. [ 131 I] 1 exhibited a high in vitro binding affinity for DAT with an IC 50 value of 2.2 nM. Metabolic stability studies demonstrated that [ 131 I] 1 displayed superior in vivo stability compared with [ 131 I]FP-CIT-d 6 . Biodistribution studies revealed that [ 131 I] 1 had better DAT affinity, specificity, and a higher target-to-background ratio than [ 131 I]FP-CIT-d 6 . Ex vivo autoradiography and blocking experiments validated the selective and reversible binding of [ 131 I] 1 to DAT and superiority to [ 131 I]FP-CIT-d 6 . These preliminary results suggest that deuterated radioligand [ 131 I] 1 , with enhanced in vivo stability and higher target-to-background ratio, is a promising DAT probe, warranting the development and application of 123 I-labeled counterpart ([ 123 I] 1 ) for SPECT imaging in DAT-related disorders.
研究领域:
医学影像学
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神经生物学
·
放射化学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Haidong Shen,Surui Chen,Chonghai Zhang,Teng Liu,Yugui Tao,Lin Hu,Kai Yang
Radioisotope therapy (RIT) is one of clinical treatment for tumors, which can not only directly kill tumor cells, but also enhance anti-tumor immune response by inducing tumor cell immunogenic cell death (ICD). However, significant challenges for RIT are the low radiolabeling efficiency, as well as tumor targeting issues. Bacterial outer membrane vesicles (OMVs), which are natural nano-vesicles secreted by Gram-negative bacteria, are now garnering significant attention in cancer therapy due to their tumor-targeting and immunotherapeutic potential. Herein, we construct an engineering delivery platform based on OMVs to achieve efficient labeling of radioactive iodine and improve radio-immunotherapy ( 131 I-STATH-OMV-PEG). Firstly, high tyrosine-rich protein statherin (STATH) is integrated onto the surface of OMVs (STATH-OMV) through bioengineered technology. The obtained STATH-OMV is coated with polyethylene glycol (PEG) and then labeled with radionuclide iodine-131 ( 131 I-STATH-OMV-PEG), which exhibit excellent radiolabeling efficiency due to the integration of STATH. More importantly, 131 I-STATH-OMV-PEG could also boost DC maturation and produce anti-tumor cytokines, thereby enhancing the systemic anti-tumor immune response induced by RIT. Additionally, 131 I-STATH-OMV-PEG could inhibit orthotopic colon cancer, induce systemic immune memory effect and prevent tumor invasion. In summary, this study proposes an OMV-centered RIT delivery system that ensures proficient labeling of 131 I, thereby amplifying the therapeutic effect of RIT and opening up a promising approach for tumor radio-immunotherapy.
研究领域:
肿瘤学
·
放射生物学
·
免疫疗法
·
纳米技术
·
癌症治疗
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DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2018
·Vol. 316
·期 1
·363-368
·
IF 1.181
Song Hu,Wang Guanquan,Wang Jing,Wang Yunhan,Wei Hongyuan,He Jiaheng,Luo Shunzhong
Porphyrin derivatives are usually used for photodynamic therapy (PDT) and labeled with raidonuclide for radiopharmaceuticals. In this work, 5,10,15,20-tetrakis (4-hydroxyphenyl) porphyrin (TPPOH) and 5,10,15,20-tetrakis (4-aminophenyl) porphyrin (TPPNH 2 ) were labeled by 131 I. 131 I-TPPOH and 131 I-TPPNH 2 were cultured with SMMC-7721 and HL-7702 cells for affinity test. The results show high uptake ratios of SMMC-7721 than HL-7702. 131 I-TPPOH and 131 I-TPPNH 2 were performed radionuclide therapy (RNT) and PDT via tumor in situ injection. At 14 days post injection, the volumes of tumors injected 131 I-TPPOH and 131 I-TPPNH 2 diminished 64 ± 11 and 54 ± 10%, respectively. The therapeutic effect is better than either single PDT or single RNT. The combination therapy of PDT and RNT could be a more effectual method for cancer therapy.
研究领域:
肿瘤学
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核医学
·
药理学
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Jinglang Gong,Beijia Wang,Huihui Liu,Pinghua Cheng,Xiaolian Sun,Dan Su
Cerenkov radiation-induced photodynamic therapy (CR-PDT) addresses the tissue penetration limitations of traditional photodynamic therapy for deep-seated tumors. However, continuous phototoxicity in normal tissues and inefficient tumor accumulation of co-delivery of radionuclides and photosensitizer remain the main challenges to the therapy efficacy of lung cancer. Here, we developed a novel pulmonary delivered 131 I-labeled GSH-responsive chlorin e6 (Ce6)-conjugated Bovine Serum Albumin (BSA) nanoassembly ( 131 I-CBA ) for efficient and selective tumor therapy in orthotopic lung cancer. The 131 I-CBA, with a stable diameter of around 150 to 200 nm, were designed to show minimal phototoxicity in normal tissues due to the aggregation-caused quenching (ACQ). Under tumor intracellular reductive glutathione (GSH) conditions, the dissociation of nanosystem happened, restoring the quenched photoactivity of Ce6 to produce singlet oxygen. After pulmonary delivery in orthotopic lung cancer, 131 I-CBA showed high lung accumulation and great tumor inhibition capability with excellent biosafety. We believe that this pulmonary delivered 131 I-labeled GSH-responsive nanosystem could provide a promising strategy for lung cancer.
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Jie An,Xinyi He,Huizhu Ma,Yanglei Li,Yayuan Li,Xinyu Zhang,Qizhi Shuai,YinMeng Wang,Wen Liu,Weihua Li,Hongliang Wang,Zhifang Wu,Sijin Li
Radionuclide therapy (RNT) is an effective method for the clinical precise treatment of cancer. However, the uneven dose distribution and rapid metabolism of nuclides limit the effective killing of tumors. To overcome the limitations of radionuclide therapeutic approaches, combining different therapeutic strategies to treat cancer has manifested great promise in basic and clinical research. Here, a new combination therapy strategy was developed to combine radionuclide therapy, sonodynamic therapy and photothermal therapy (RNT-SDT-PTT) under radionuclide imaging guided achieve highly effective combination therapy. We prepared a polydopamine-modified Au nanostar (AN), then loaded with the acoustic sensitizer protoporphyrin (IX) and labeled with diagnostic ( 99m Tc) or therapeutic ( 131 I) radionuclides ( 131 I/ 99m [email protected] /IX) for the precise diagnosis and treatment of pancreatic cancer. After intratumor administration, single photon emission computed tomography imaging showed that the nanocarriers were mostly retained in the tumor compared to free radionuclide. As well as using near-infrared light to trigger PTT and ultrasound with high penetration depth to activate IX to generate reactive oxygen species achieved SDT of tumor. The ultimate significantly improved the inhibitory effects by the RNT-SDT-PTT combined therapy for pancreatic cancer. Therefore, this study proposes an effective radionuclide combination therapy regimen consisting of three widely used treatments, offering promising prospects for the future of oncology.
研究领域:
肿瘤学
·
核医学
·
诊疗一体化
·
纳米技术
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Xia Yang,Jing Wang,Zhikai Ding,Qingchuan Lin,Liangang Zhuo,Wei Liao,Yan Zhao,Yue Feng,Yue Chen,Hongyuan Wei,Yuchuan Yang
Hyaluronan (HA) have been widely used as the ideal biomaterials. It is important to understand their degradation and distribution for better optimization. From a new aspect of using radiotracers, we designed the HA-tyramine-bisphosphonate derivative for dual-labelling with two radionuclides ( 99m Tc and 131 I) simultaneously for in vitro and in vivo tracking. This dual-radiolabelled HA derivative can still be non-covalently crosslinked by hydroxyapatites to form injectable gel. The excellent properties of the gel, such as robust, biodegradable, and self-healing capacity were maintained. We firstly proved the possibility to distinguish different radionuclides in the degraded gel using the high-resolution gamma-ray spectrometry. The radiolabelled gel showed lower toxicity than pure hydroxyapatites against various cell lines, while the in vivo results proved that the 99m Tc/ 131 I-labelling of the gel was safe and stable enough for imaging and quantitatively tracking. The present method can also be applied for the development of dual-radiolabelled gels from other polysaccharides.
研究领域:
生物材料
·
放射药学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）