Science China-Chemistry
·
2020
·Vol. 63
·期 12
·1777-1784
·
IF 6.356
Ma Xiaoshuang,Ma Guanyu,Qin Lubing,Chen Guangxu,Chen Shaowei,Tang Zhenghua
Despite the recent progress on controllable synthesis of alkynyl-protected Au nanoclusters, the effective synthetic means are very limited and the cluster formation process still remains puzzling. Here, we develop a novel synchronous nucleation and passivation strategy to fabricate Au 36 (PA) 24 (PA=phenylacetylenyl) nanoclusters with high yield. In Au 36 (PA) 24 formation process, Au 22 (PA) 18 as key intermediate was identified. Meanwhile, Au 22 (PA) 18 can be synthesized under a low amount of reductant, and by employing more reductants, Au 22 (PA) 18 can turn into Au 36 (PA) 24 eventually. Moreover, the structure evolution from Au 22 (PA) 18 to Au 36 (PA) 24 is proposed, where four Au 13 cuboctahedra can yield one Au 28 kernel. Finally, the ratiocination is verified by the good accordance between the predicted intermediate/product ratio and the experimental value. This study not only offers a novel synthetic strategy, but also sheds light on understanding the structural evolution process of alkynyl-protected Au nanoclusters at atomic level.
研究领域:
材料科学
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纳米技术
·
化学
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产品关联
DOI
高影响因子
Cell Chemical Biology
·
2023
·
IF 8.6
Xueyang Jin,Xuben Hou,Xue Wang,Ming Zhang,Jinyao Chen,Minghui Song,Jiaozhen Zhang,Hongbo Zheng,Wenqiang Chang,Hongxiang Lou
Summary Filamentation is an important virulence factor of the pathogenic fungus Candida albicans . The abolition of Candida albicans hyphal formation by disrupting sterol synthesis is an important concept for the development of antifungal drugs with high safety. Here, we conduct a high-throughput screen using a C . albicans strain expressing green fluorescent protein-labeled Dpp3 to identify anti-hypha agents by interfering with ergosterol synthesis. The antipyrine derivative H55 is characterized to have minimal cytotoxicity and potent inhibition of C . albicans hyphal formation in multiple cultural conditions. H55 monotherapy exhibits therapeutic efficacy in mouse models of azole-resistant candidiasis. H55 treatment increases the accumulation of zymosterol , the substrate of C-24 sterol methyltransferase (Erg6). The results of enzyme assays, photoaffinity labeling , molecular simulation, mutagenesis , and cellular thermal shift assays support H55 as an allosteric inhibitor of Erg6. Collectively, H55, an inhibitor of the fungal-specific enzyme Erg6, holds potential to treat C . albicans infections.
研究领域:
微生物学
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药理学
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分子生物学
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DOI
PubMed
高影响因子
JOURNAL OF PLANT GROWTH REGULATION
·
2022
·Vol. 42
·期 4
·2162-2175
·
IF 4.64
Chen Chen,Chen Hong,Han Chao,Liu Zemao,Yu Fangyuan,Wu Qikui
Due to the increasing demand for biofuel feedstock production, Styrax tonkinensis , as a woody oilseed tree species, has received much more attention. However, the effects of various plant growth regulators on its seed development haven’t been explored deeply. Here, we applied 24-epibrassinolide (EBL) and methyl jasmonate (MJ) on the whole trees, and the aim of our study was to explore their effects on seed development of S. tonkinensis as well as seed chemical compositions, especially seed lipid metabolism. The results showed that EBL and MJ promoted the seed development, which was reflected in the increase of fresh and dry weight, as well as transverse and longitudinal diameter. The concentration of crude fat (CF) exhibited an ‘increase–decrease-increase’ trend, and the peak appeared at 70 days after flowering. EBL (in concentration of 5 μM, EBL5) and MJ (in concentration of 200 μM, MJ200) had the most significant effect on the accumulation of CF and the CF content in single seed. In addition, the activities of enzymes related to fatty acid (FA) synthesis were also higher under the two treatments. 12 FAs were detected using gas chromatography-mass spectrometry, among which palmitic acid, oleic acid, and linoleic acid were the main components. EBL5, EBL10, and MJ200 favored the accumulation of soluble sugar, especially in the middle and late stages. The starch concentration in seeds was lower, but it significantly increased after the application of EBL5. Furthermore, our results demonstrated that EBL and MJ enhanced SOD and POD activity while decreased MDA content. We highlighted that EBL and MJ promoted seed development of S. tonkinensis , affected seed chemical compositions and contributed to the accumulation of CF and FA.
研究领域:
植物科学
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生物化学
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农业
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DOI
高影响因子
Pharmaceuticals
·
2024
·Vol. 17
·期 3
·291
·
IF 4.3
Nannan Kang,Jun Ma,Yuling Hu,Rongrong Di,Lei Wang,Xuanling Zhang,Yisheng Lai,Yu Liu
Background: Breast cancer is a commonly diagnosed cancer worldwide. Human MutT homolog 1 (MTH1) is found to be elevated in breast tumors and cancer cells need MTH1 for survival. Pharmacological inhibition of MTH1 may be potentially beneficial in the treatment of breast cancer. Methods: MA−24 was screened by malachite green colorimetric assay for MTH1 inhibitors and the kinetic characteristics of MA−24 were assessed. The features of MA−24’s binding with MTH1 were ascertained through molecular docking, and the cytotoxic activity of MA−24 was validated in vitro and in vivo. Target engagement assays, comet assay, and Western blot confirmed the intracellular target and mechanism of MA−24. Results: MA−24 shows potent antitumor bioactivity both in vitro and in vivo. MA−24 competitively inhibited the MTH1 and further induced DNA strand breaks, leading to increased apoptosis of cancer cells depending on the upregulation of the cleaved-caspase 3–cleaved-PARP axis. In particular, MA−24 exhibited a powerful efficacy and safety in vivo (tumor growth inhibition rate: 61.8%). Conclusions: MA−24 possesses a broad spectrum of breast cancer cytotoxicity and offered valuable insights for overcoming the challenges of chemotherapy-related toxicity, which holds great potential for the further development MA−24 as an anti-cancer drug.
研究领域:
肿瘤学
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药理学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 24
·10873-10883
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IF 2.7
Yunxia Shi,Hui Duan,Meiyan Du,Xia Kong,Ke Xue,Guang Lu,Qingyun Liu
In this work, 2(3),9(10),16(17),23(24)-octamethoxyphthalocyanine (Pc(OH)8) was first used to modify Cu/CuFe2O4(Cu/CFO) nanospheres, and Pc(OH)8–Cu/CFO nanocomposites with enhanced peroxidase mimetic enzyme activity was obtained compared to the performance of Cu/CFO alone. SEM, XRD, and XPS were used to study the surface morphology, phase composition and elemental analysis of the newly synthesized Pc(OH)8–Cu/CFO. Using TMB as the chromogenic substrate, Pc(OH)8–Cu/CFO accelerate the oxidation process of chromogenic substrate 3,3′,5,5′- tetramethylbenzidine (TMB) by hydrogen peroxide in three minutes. The catalytic oxidation mechanism of Pc(OH)8–Cu/CFO on TMB was comprehensively investigated through free radical and fluorescence probe experiments. Based on the excellent catalytic performance of the composite materials, a simple and fast colorimetric sensing platform for the colorimetric detection of H2O2 and glutathione (GSH) was constructed in the range of 0.6–5 mM and 2–10 μM with detection limits (LODs) of 0.35 mM and 0.55 μM, respectively. In addition, using Pc(OH)8–Cu/CFO colorimetric detection for GSH has a lower detection limit, good selectivity and high sensitivity, which is expected to become an ideal material for GSH colorimetric detection.
研究领域:
材料科学
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纳米技术
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分析化学
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生物传感器
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产品关联
DOI
高影响因子
Nature Communications
·
2020
·Vol. 11
·期 1
·1-7
·
IF 12.121
Liu Xu,Xu Wen Wu,Huang Xinyu,Wang Endong,Cai Xiao,Zhao Yue,Li Jin,Xiao Min,Zhang Chunfeng,Gao Yi,Ding Weiping,Zhu Yan
The discovery of atomically precise nanoclusters is generally unpredictable, and the rational synthesis of nanoclusters guided by the theoretical design is still in its infancy. Here we present a de novo design of Au 36 (SR) 24 nanoclusters, from theoretical prediction to experimental synthesis and characterization of their physicochemical properties. The crystal structure of an Au 36 (SR) 24 nanocluster perfectly matches the simulated structural pattern with Au 4 tetrahedral units along a two-dimensional growth. The Au 36 (SR) 24 nanocluster indeed differs from its structural isomer whose kernel is dissected in an Au 4 tetrahedral manner along a one-dimensional growth. The structural isomerism in the Au 36 (SR) 24 nanoclusters further induces distinct differences in ultrafast electron dynamics and chirality. This work will not only promote the atomically precise synthesis of nanoclusters enlightened by theoretical science, but also open up exciting opportunities for underpinning the widespread applications of structural isomers with atomic precision.
研究领域:
纳米材料科学
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物理化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2014
·Vol. 90
·期 5
·947-954
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IF 2.494
Yunfang Chen,Jianzhang Fang,Shaoyou Lu,Weicheng Xu,Zhang Liu,Xiaoxin Xu,Zhanqiang Fang
BACKGROUND Chlorophenols (CPs) are organic pollutants and are most widespread in the aqueous environment. Photocatalytic degradation of organic compounds has been extensively studied as a potential technology for water treatment. In this study, BiOI/Bi 2 WO 6 hierarchical heterostructure with flower-like morphology was synthesized by a facile method using a one-step hydrothermal approach. The catalytic activities of the photocatalysts were tested by the degradation of 2,4-DCP under visible-light irradiation and the photocatalysis mechanism of BiOI/Bi 2 WO 6 was investigated. RESULTS The as-prepared catalysts exhibited the characteristic peaks of BiOI and Bi 2 WO 6 . The photocatalytic activities, which were evaluated by degradation of 2,4-DCP under visible light irradiation, were enhanced significantly by BiOI/Bi 2 WO 6 hierarchical heterostructures with different molar ratios of BiOI to Bi 2 WO 6 . CONCLUSIONS BiOI/Bi 2 WO 6 hierarchical heterostructure significantly enhanced the photocatalytic activity. The optimum percentage of BiOI was 10%. The optimal initial pH value of 2,4-DCP was determined to be pH 8. The possible reaction mechanisms were discussed on the basis of the calculated energy band positions. © 2014 Society of Chemical Industry
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Jianguo Wang,Meng Chen,Xiangkun Elvis Cao,Xianglei Liu,Peidong Wei,Qiao Xu,Haichen Yao,Enda Ci,Qingfeng Zhang,Shushan Lv,Yang Tian,Yongliang Li
Thermal energy, encompassing both heating and cooling demands, accounts for the largest share of global energy consumption. Harvesting thermal energy from the environment, including the Sun and darkness, holds promise for decarbonizing thermal sectors, but suffers from low efficiency and intermittency. Here, inspired by ginkgo leaves featuring wax-coated vertical palisade cells, a 24-h bidirectional thermal energy harvesting approach is developed by integrating spectrally selective aerogels with anisotropic composite phase change materials (CPCMs). During daytime, sunlight is captured, converted into heat, and stored in anisotropic CPCMs with high axial thermal conductivity (24.16 W·m −1 ·K −1 ) and an anisotropy ratio of 3.7. Under one-sun irradiation, a high solar thermal energy storage efficiency of 87.5% with a peak temperature of 382.3 K is achieved by leveraging spectrally selective aerogels exhibiting “greenhouse effects”. At night, a maximum radiative cooling power of 118.8 W·m −2 is attained, enabling cold energy storage at a temperature 4.0 K below ambient. The proposed leaf-inspired device operates continuously over 24 h, delivering annual thermal energy savings of 5321.4 MJ·m −2 ·yr −1 , outperforming standalone solar thermal and radiative cooling systems by 44.8% and 223.3%, respectively. This bioinspired bidirectional energy harvesting strategy employing both solar and outer space resources, establishes a promising approach toward a carbon-neutral thermal energy supply.
研究领域:
可再生能源
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热工工程
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材料科学
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可持续技术
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仿生学
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产品关联
DOI
PubMed
高影响因子
XENOBIOTICA
·
2024
·
IF 1.3
Li Shao,Jiajia Mo,Qinlong Xu,Guangwei He,Chunyu Xing,Zhaoxing Chu
HY-072808 is a novel phosphodiesterase 4 inhibitor clinically used for topical atopic dermatitis treatment. Cytochrome P450 enzymes are involved in transforming it into major metabolite ZZ-24. An efficient UPLC–MS/MS method was established to detect HY-072808 and ZZ-24 in plasma and skin tissues of minipigs.One-step protein precipitation was performed with acetonitrile. Subsequently, elution was served with a methanol and water gradient containing 0.1% formic acid for 3.5 min. The plasma and skin tissue concentrations of HY-072808 and ZZ-24 showed good linearity from 0.200 to 200 ng/mL.The experimental minipigs exhibited low systemic exposure and bioavailability of 3.1–7.6% after transdermal application of 1–4% HY-072808 ointment. Multiple topical administrations over seven consecutive days showed a minor accumulation in systemic exposure, with accumulation factors of 2.3 and 4.0 for HY-072808 and ZZ-24, respectively.The distribution of HY-072808 ointment among different cortical layers in minipigs was studied for the first time. Following transdermal application of 2% HY-072808 ointment, the concentration in plasma and skin tissues in the order of epidermis > dermis > subcutaneous tissue ≈ subcutaneous muscle ≈ plasma; at 48 h after the administration, the epidermis and dermis still had a high concentration of the drug.
研究领域:
药理学
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皮肤病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD AND CHEMICAL TOXICOLOGY
·
2020
·
IF 4.679
Zhouya Bai,Xiaojun Huang,Jinxia Meng,Lijiao Kan,Shaoping Nie
The nutritive peculiarities and original distribution of 24 Chinese cowpeas cultivars, achieved from Jiangxi, Jilin, Shanxi and Shaanxi provinces in China, were evaluated. Their nutritional components were determined and nutrient characteristics were discussed. Principal component analysis (PCA) was applied to classify the cowpea samples based on their nutrient composition. The results discovered that the proximate composition varied among 24 cowpeas in protein (17.30–27.23%), fat (1.87–3.14%), high level of dietary fiber (29.49–38.54%) and resistant starch (3.18–31.33%). The total tocopherol varied from 74.20 to 187.07 μg/g. PCA results presented that the 24 cowpeas cultivars were automatically grouped with provinces of origin, indicating a relationship between nutrient composition and cultivating religion for cowpeas. The results of this study provide us the information on the nutrients characteristic of current cowpeas in China, and give a guideline on cowpea cultivating optimization and processing.
研究领域:
食品科学
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植物营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Research Express
·
2019
·Vol. 7
·期 1
·016506
·
IF 1.449
Syed Adil Shah,Kuo-Juei Hu,Muhammad Naveed,Syed Niaz Ali Shah,Shengyong Hu,Siqi Lu,Fengqi Song
Bimetallic noble metal nanoclusters (NCs) are an emerging topic of metal clusters due to their distinguishing characteristics compared to monometallic clusters. Doping of different noble atoms in other clusters is an effective strategy for tailoring their functionalities for specific applications and synergistic effects. Obtaining single-heteroatom doping is desirable but still very challenging to date. Herein, 2,4-dimethylbenzenthiol (2,4-DMBT) protected Ag/Au alloy NCs (ca. 2-3 nm) were synthesized via a wet chemical one-pot process. The effect of the number of Au atoms in Ag NCs on their optical properties and bandgap was investigated. We found that the change of the absorption peak positions of the Ag NCs was influenced by the presence of Au atoms. Besides, we found that the HOMO-LUMO peak has appeared without a significant change in cluster size during synthesis. Ag/Au alloy NCs are characterized by UV–visible spectroscopy, transmission electron microscopy (TEM) and scanning electron transmission microscopy (STEM).
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
Progress in Natural Science-Materials International
·
2024
·
IF 4.8
Mengxia Ma,Zhaoyang Li,Xu Yan,Yanli Mao,Chaohai Wang,Haiyan Kang,Qun Yan,Jieqiang Zhou,Zhongxian Song,Dandan Pang
Magnetic flower-like α-Fe 2 O 3 @N–C particles were synthesized by hydrothermal self-assembly method and oxygen-limited carbonisation in a glycerol and ethanol solution system using glucose as the carbon source, iron nitrate as the magnetic source and particle skeleton and urea as the nitrogen source. Four hydrothermal temperatures of 120 °C, 140 °C, 160 °C and 180 °C were used to modulate the adsorbent structure. Hydrothermal temperature of 140 °C, solution pH = 7, and a dosage of 0.06 g are the optimum conditions. The adsorption capacity of 2,4-dichlorophenol (2,4-DCP) onto MC-2 was determined as 108.556 mg g −1 at 25 °C. Experiments show that the adsorbents all fitted well to the Langmuir isothermal adsorption model and the quasi-secondary kinetic model, and the adsorption behaviour was dominated by monolayer chemisorption . The adsorption process was heat absorbing and spontaneous. Raman and XRD analysis showed that the adsorbent had a stable α-Fe 2 O 3 skeleton and carbon layers. FTIR and XPS analysis showed that the adsorbent had hydrogen bonding , electrostatic interaction and π-π bonding to 2,4-dichlorophenol.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）