EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
·
2017
·Vol. 2017
·期 46
·6980-6985
·
IF 2.834
Xin-Xin Wang,Kai Chen,Fang-Fang Shen,Yuan Wang,Yun-Qian Zhang,Zhu Tao,Hang Cong
Graphical Three novel hydroxylated hexamethylcucurbit[3,3]urils (Q[ n ]s), namely {(OH)Me 6 Q[3,3], (OH) 2 Me 6 Q[3,3], and (OH) 3 Me 6 Q[3,3]} have been prepared by the parent symmetrical hexamethylcucurbit[3,3]uril (Me 6 Q[3,3]) through a photochemical method, and further chemical modification could afford novel supramolecular assemblies for new applications. Mono-, di, and tri-hydroxylated hexamethylcucurbit[3,3]urils (Q[ n ]s), {(OH)Me 6 Q[3,3], (OH) 2 Me 6 Q[3,3], and (OH) 3 Me 6 Q[3,3]}, have been prepared through a photochemical method whereby limited hydroxyl group(s) can be directly introduced on the parent symmetrical hexamethylcucurbit[3,3]uril (Me 6 Q[3,3]). These three hydroxylated Me 6 Q[3,3]s have been characterized by means of NMR, MS, and X-ray crystallographic techniques. Further chemical allylation of these hydroxylated Me 6 Q[3,3]s has also been performed.
研究领域:
有机化学
·
超分子化学
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DOI
高影响因子
Pharmacogenomics & Personalized Medicine
·
2021
·
IF 3.912
Xikun Wu,Weichong Dong,Haoran Li,Xiuling Yang,Yiran Jin,Zhiqing Zhang,Ye Jiang
Purpose To perform therapeutic drug monitoring (TDM) of total and free plasma valproic acid (VPA) concentrations in pediatric patients with epilepsy and to analyze related factors.Patients and Methods Pediatric epileptic patients treated in 2015–2019 in our hospital were assessed. Total and free plasma VPA concentrations were obtained by UPLC and LC-MS/MS, respectively. Regression analysis was performed to examine the associations of free plasma VPA with total plasma VPA and plasma protein binding rate. The impacts of individual situation, CYP2C9 genotype, and drug combination on VPA concentration were examined.Results Of the 251 patients, 81 had lower total concentrations than effective therapeutic levels; 86 and 31 patients had infections and central nervous system dysplasia, respectively. VPA’s daily doses and free drug concentrations were significantly lower in the CYP2C9 *3/*3 genotype group versus the CYP2C9 *1/*3 and CYP2C9 *1/*1 groups (P<0.05). Free and total VPA concentrations were linked by Y = 0.0004 X2 + 0.042 X + 0.3035 (r=0.6981); VPA plasma protein binding rate and free VPA concentration were related by Y = 0.0003 X2 - 0.0127 X + 0.9777 (r=0.8136). Both total and free VPA concentrations were significantly decreased in patients simultaneously administered phenobarbital, meropenem and biapenem (P<0.05), with therapeutic failure after meropenem/biapenem co-administration.Conclusion Free VPA amounts have nonlinear relationships with total VPA amounts and plasma protein binding rate in epileptic children. Additionally, CYP2C9 *3/*3 expression affects VPA metabolism. Since phenobarbital affects VPA metabolism, TDM is recommended. Meanwhile, carbapenem-co-administration with VPA should be prohibited.
研究领域:
医学
·
药理学
·
遗传学
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DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Letao Guo,Mei Yang,Lixia Yang,Mei Han,Wenna Tang,Guangwen Chen
3-(3-Pyridyl)acrylic acid is a key cap motif in chidamide and related analogues. Conventional strategies, including Knoevenagel condensation, Horner-Wadsworth-Emmons reactions, and Heck couplings, suffer from limitations such as direct pyridine utilization, phosphorus-containing waste, or reliance on expensive palladium catalysts. Here, we presented a scalable, streamlined three-step platform for the synthesis of 3-(3-pyridyl)acrylic acid from ethyl acetate and 3-pyridine aldehyde. The process integrates sequential continuous-flow aldol condensation and hydrolysis with batch dehydration, coupled with online intermediate separation units. Each module was engineered to meet the kinetic and operational requirements of the subsequent step, thereby minimizing overall residence time. The aldol condensation, which typically requires cryogenic conditions and exhibits pronounced scale-up effects in batch reactors, was intensified in microreactors through precise residence time control, enabled room-temperature condensation to afford the β-hydroxy ester intermediate in 99% yield with a productivity of 116 g/h within 1.1 s. In the hydrolysis module, where the rate was constrained by mass transfer in the heterogeneous system, ethanol was introduced as a co-solvent to enhance phase interaction, enabling continuous-flow hydrolysis to deliver the β-hydroxy sodium salt intermediate in > 99% yield with a productivity of 88 g/h within 1 min at 60 °C. Subsequent batch dehydration, conducted at high concentration to maximize the reaction rate and optimized according to the upstream hydrolysis conditions, afforded 3-(3-pyridyl)acrylic acid in 96% yield (84% overall), producing 76 g/batch at 120 °C within 1 h. The product was isolated with ∼ 100% high performance liquid chromatography purity by simple pH-triggered precipitation, eliminating the need for recrystallization.
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LANGMUIR
·
2023
·
IF 3.9
Yu Zhang,Lu Wang,Ning Ma,Yizhen Wan,Xueyi Zhu,Weiping Qian
Nonspecific adsorption (NSA) seems to be an impregnable obstacle to the progress of the biomedical, diagnostic, microelectronic, and material fields. The reaction path of bioconjugation can alter the surface charge distribution on products and the interaction of bioconjugates, an ignored factor causing NSA. We monitored exacerbated NSA introduced by a 1-ethyl-3-(3-(dimethylamino)propyl) carbodiimide (EDC) addition reaction, which cannot be resistant to bovine serum albumin (BSA) or polyethylene glycol (PEG) antifouling coating and Tween-20. And the negative effects can be minimized by adding as low as 7.5 × 10–6 M N-hydroxysulfosuccinimide (sulfo-NHS). We applied ordered porous layer interferometry (OPLI) to sensitively evaluate the NSA that is difficult to measure on individual particles. Using the silica colloidal crystal (SCC) film with Fabry–Perot fringes as in situ and real-time monitoring for the NSA, we optimized the surface chemistry to yield a conjugate surface without variational charge distribution. In this work, we propose a novel approach from the perspective of the reaction pathway to minimize the NSA of solely EDC-induced chemistry.
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PubMed
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2018
·Vol. 85
·期 3
·506-513
·
IF 1.745
Fei Zhifang,Yang Zichun,Chen Guobing,Li Kunfeng
Abstract Polyimide cross-linked silica aerogels with different weight percentages of polyimide were prepared through sol–gel technology and supercritical CO 2 fluid drying technology. Tetraethoxysilane (TEOS) was used as a silica source precursor, 3-aminopropyltriethoxysilane (APTES) end-capped polyimide was used as a cross-linking agent, derived from 3, 3′, 4, 4′-biphenyltetracarboxylic dianhydride (BPDA) and 4, 4′-oxydianiline (ODA). The acid produced during the imidization process catalyzed the hydrolysis reaction without additional catalyst. After condensation reaction catalyzed by ammonium hydroxide solution, the polyimide cross-linked silica gels were obtained and then dried in supercritical CO 2 . The polyimide cross-linked silica aerogels have low density (0.132~0.187 g/cm 3 ), high specific surface area (623–741 m 2 /g), low thermal conductivity (0.0306~0.0347 W/m K at room temperature), relatively high compressive strength (1.03~3.82 MPa) and high thermal decomposition temperature (360 °C). This research provided a simple and efficient method that used the polyimide as a strengthening phase to improve the mechanical properties of TEOS-based silica aerogels.
研究领域:
材料科学
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化学工程
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高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Li Huang,Shangying Qin,Yuanjin Xu,Shiqi Cheng,Jin Yang,Yilin Wang
MnO 2 nanosheets (MnO 2 NSs) were prepared and used as both oxidant of 3, 3′, 5, 5′- tetramethylbenzidine (TMB) and recognizer of UA, a simple colorimetric approach for sensitive detection of uric acid (UA) was established. In the medium of weak acid, MnO 2 NSs exhibited strong oxidation capacity and could oxidize colorless TMB to generate a blue oxidation product (oxTMB) with an absorbance signal. However, the introduction of UA could inhibit MnO 2 NSs - mediated TMB oxidation and reduce the formation of oxTMB, resulting in the blue fading and the absorbance weakening. Under the conditions of incubation time 20 min, pH 3.0, TMB 0.5 mM, and MnO 2 NSs 50 μM, the decrease in absorbance was linearly dependent on UA concentration in the range of 0.5–30.0 μM with a detection limit of 0.21 μM. Furthermore, the approach has been applied for determining UA in human urine samples with recoveries between 93.1 and 102.4 % and relative standard deviation less than 3.0 %.
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JOURNAL OF MOLECULAR STRUCTURE
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2021
·
IF 3.196
Chenli Wei,Zeyu Guo,Yongjie Li,Jie Huang
A new nitrogen-rich energetic complex Cd(DMF) 2 BTZAF (1) (DMF= N,N-Dimethylformamide, H 2 BTZAF= 3, 3′-bis(1H-tetrazol-5-yl)-4, 4′-azofurazan) was first synthesized by the reaction of Cd(NO 3 ) 2 ·4H 2 O with 4-amino-3-(5-tetrazolate)-furazan. The compound 1 was characterized by elemental analysis and FT-IR spectrum analysis, respectively. The crystal structure of complex 1 was determined by single-crystal X-ray diffraction. It revealed that 1 crystallizes in the monoclinic space group P2 1 /c. A Cd 2+ ion is coordinated by four N atoms and two O atoms to form a distorted octahedral structure. Among them, four nitrogen atoms are from the four BTZAF 2− ions and the other two oxygen atoms are from two DMF molecules. Moreover, the thermal decomposition behavior of compound 1 was studied with DSC and TG-DTG methods. The non-isothermal kinetic parameters of compound 1 was calculated by Kissinger's method and Ozawa-Doyle's method. In addition, the thermal safety performance and the impact sensitivity of complex 1 were measured and calculated, and the results showed that the synthetic compound has good insensitivity and stability.
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ACS Omega
·
2018
·
IF 0
Xin-Xin Wang,Fei-Yang Tian,Kai Chen,Yun-Qian Zhang,Zhu Tao,Qian-Jiang Zhu
In the present work, we selected hexamethylcucurbit[3,3]uril (Me6Q[3,3]) as a building block and obtained two Me6Q[3,3]-based porous supramolecular assemblies from neutral water (A) and aqueous HCl solutions (B), respectively. Both Me6Q[3,3]-based assemblies are constructed of Me6Q[3,3] molecules through the typical outer surface interaction of cucurbit[n]urils, as well as hydrogen bonding between latticed water molecules and portal carbonyl oxygens of Me6Q[3,3]. The assemblies present different porous structure features and exhibit different adsorption properties for eight common volatile organic compounds. However, the two porous assemblies exhibit similar adsorption properties for certain fluorophore dyes, including rhodamine B (G1), fluorescein (G2), and pyrene (G3), and form solid colored fluorescent compounds, some of which exhibit responses to the selected volatile organic compounds.
研究领域:
化学
·
材料科学
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PubMed
Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 23
·8526-8534
·
IF 6.1
Fang Xu,Jialin Zheng,Dai-Huo Liu,Ao Wang,Zhenjiang Li,Chunyan Xu,Mengqin Song,Beinuo Zhang,Zhengyu Bai,Zhongwei Chen
Manganese dioxide is considered an ideal cathode candidate material for aqueous zinc-ion batteries. However, its poor conductivity and nanostructural degeneration impede its further application. Herein, a 3 × 3 tunnel-structured τ-MnO2 cathode material was synthesized through the addition of excessive Mg2+. During its preparation, a portion of Mg2+ was embedded into the 3 × 3 tunnel of τ-MnO2 to stabilize the microstructure, while another portion of Mg2+ formed a new phase, i.e., Mg2(OH)3Cl·4H2O, adjoining τ-MnO2, resulting in a cathode material with heterointerface synergy between τ-MnO2 and Mg2(OH)3Cl·4H2O. The charge arrangement of the heterointerface between τ-MnO2 and Mg2(OH)3Cl·4H2O enabled more active sites and accelerated ion-diffusion kinetics. The introduction of Mg2(OH)3Cl·4H2O increased the proportion of Mn(IV) and suppressed the structural instability caused by Jahn–Teller distortion, thereby improving the electrochemical performance of the τ-MnO2 cathode (capacity retention of 86.7% after 1800 cycles at 1 A g−1).
研究领域:
材料科学
·
电化学
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Kayode Hassan Lasisi,Temitope Fausat Ajibade,Kaisong Zhang
The desirability of acid-resistant nanofiltration (NF) membranes having superior acid stability with good separation performance for industrial acid wastewater treatment and reclamation is currently in high demand. Here, we presented a new sulfonated-based acid-resistant NF membrane prepared by the crosslinking and participation action of 3,3′-diaminodiphenyl sulfone (DDS) via the synthesis of branched polyethyleneimine (BPEI) and 1,3-benzenedisulfonyl chloride (BDSC). By optimizing the preparation conditions, the BP-DDS/BD membrane exhibited an improved pure water flux of 13.4 L m −2 h −1 bar −1 and a MgCl 2 rejection of 97.3% for 1000 ppm. It also shows desirable rejection (>90%) and adsorption capacities for selected heavy metals. In addition, an excellent pressure resistance at different operating bars was achieved. Benefiting from the strong and stable S O bond present in DDS, the optimized BP-DDS/BD membrane displayed an outstanding acid stability at different acid immersion conditions while also maintaining impressive long-term stability of 240 h after 30 days acid exposure period. The polysulfonamide (PSA)-based NF membrane presented in this work therefore demonstrated viable and promising usefulness in wastewater treatment containing acid and heavy metal ions removal.
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高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Shimeles Addisu Kitte,Fuad Abduro Bushira,Tesfaye Refera Soreta
Efficient coreactants are of high importance in electrochemiluminescence sensing. Herein, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide was demonstrated as an effective coreactant for tris(2,2′-bipyridine)ruthenium(II) electrochemiluminescence system for the first time. The new electrochemiluminescence system showed a good sensing performance for H 2 O 2 on the basis of quenching of the electrochemiluminescence intensity. It allows the detection of H 2 O 2 in the dynamic range of 0.5–200 µM. The limit of detections for H 2 O 2 was 0.33 µM ( 3σ/m ). In addition, the developed ECL system exhibited satisfactory recoveries for H 2 O 2 sensing in real samples.
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高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Xiaopeng Zhang,Lin Chen,Longzhu Li,Xiaoming Yan,Junjiang Bao,Ning Zhang,Gaohong He
The introduction of guest metal molecules into metal–organic frameworks (MOFs) is an outstanding method to prepare dual-atom catalysts (DACs) with good oxygen reduction reaction (ORR) activity. However, most of the MOF-derived dual-atom catalysts reported to date exhibit a microporous structure and, therefore, suffer from the underutilization of active sites and poor mass transfer. This study employed NH2-MIL-101 as a precursor to form defect-bearing mesoporous Fe-NC via one-step pyrolysis for adsorbing [Co(en)3]3+, followed by secondary pyrolysis to generate Fe–Co binuclear site catalysts. The mesopores of NH2-MIL-101 are beneficial to [Co(en)3]3+ introduction and can improve the mass transfer of the ORR. Furthermore, the elevated nitrogen content within the [Co(en)3]3+ complex facilitates the co-coordination of Fe and Co with nitrogen, thereby enhancing the formation of Fe–Co diatomic sites. As a result, the obtained FeCo-NC-40 catalyst showed excellent ORR performance with a half-wave potential of 0.915 V (vs RHE). In addition, the liquid-phase Zn–air battery employing FeCo-NC-40 as the cathode catalyst demonstrated a peak power density of 178.13 mW·cm–2 and achieved a discharge specific capacity of 806.13 mAh·g–1 at 10 mA·cm–2, and there was no significant decay in stability for 10 days of continuous cycling.
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高影响因子
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