CATALYSIS LETTERS
·
2019
·Vol. 149
·期 8
·2110-2118
·
IF 2.372
Gao Menghui,Yang Yanzhao,Guo Jinxin
The hindrance of ligands chain arising from colloidal nanoparticle (NPs) surface in the process for different kinds of colloidal Au NPs catalyzed reduction of 4-nitrophenol (4-NP) is presented. The hindrance around Au NPs is controlled by varying the length of chain ligands coated on Au NPs. As the length of the ligand chain shortens, the catalytic activity of colloidal Au NPs got significant promotion for the 4-NP reduction reaction. Till inorganic sulfide ion as surface ligand, the catalytic activity of Au@S 2− NPs reached the top. Moreover, by grafting different organic chain ligands of quaternary ammonium salts into Au@S 2− NPs to vary the length of ligands, we can realize the regulation of catalytic reaction rate during the procedure of the reduction of 4-NP. In particular, Au@S 2− NPs also exhibited excellent catalytic cycle stability. Graphical Abstract
研究领域:
纳米材料科学
·
催化化学
✓ 已验证
DOI
高影响因子
npj Science of Food
·
2025
·Vol. 9
·期 1
·1-9
·
IF 7.8
Ye Xiang,Chen Wen,Yan Fujie,Zheng Xiaodong,Tu Pengcheng
In late-stage type 2 diabetes mellitus (T2DM), impaired islet β cell function leads to absolute insulin deficiency, thereby disrupting blood glucose homeostasis. GLP-1, an incretin hormone, stimulates insulin secretion from islet β cells post-meals. This study investigated the effects of anthocyanin cyanidin-3-O-glucoside (C3G) on GLP-1 secretion using STC-1 (intestinal endocrine L cells) and NIT-1 (islet β cells). In a co-culture system, C3G treatment increased GLP-1 secretion in STC-1 cells, promoting insulin release in NIT-1 cells under high glucose. Mechanistically, C3G activated the PPARβ/δ-β-catenin-TCF-4 pathway in STC-1 cells, enhancing PG precursor transcription and GLP-1 synthesis.Inhibiting PPARβ/δ with GSK0660 blocked this C3G-induced upregulation. Overall, C3G stimulates GLP-1 secretion from intestinal L cells via this pathway, indirectly boosting insulin release from β cells. These findings enhance T2DM mechanism understanding and suggest the potential of C3G in GLP-1-based T2DM therapy.
研究领域:
分子生物学
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代谢疾病研究
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药理学
✓ 已验证
DOI
PubMed
高影响因子
ACS Omega
·
2024
·
IF 3.7
Weiming Gao,Dingwu Jiang,Yiming Zhang,Yao Li,Zhilong Xu,Runxi Han,Hao Tian,Hufei Dai,Qijing Lu,Cuiping Li
Detoxification of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) with high efficiency and dynamic performance is challenging for a polymeric catalyst. Herein, a series of conjugated microporous polyanilines (CMPAs), capable of efficiently catalytically reducing 4-NP, were synthesized based on the Buchwald–Hartwig cross-coupling reaction mechanism. By adjusting the types of linkers and the molar ratios of linker to core, CMPAs with different Brunauer–Emmett–Teller (BET) specific surface areas and reduction degrees were obtained and used as the catalysts in reducing 4-NP. The ultrahigh catalytic reduction efficiency (K = 141.32 s–1 g–1, kapp = 0.00353 s–1) was achieved when using CMPA-3-0.7 as the catalyst (prepared with 4,4′-diaminodiphenylamine as the linker and a 0.7:1 molar ratio of linker to core). The catalytic reduction performance exhibited a strong correlation with the reduction degree and BET specific surface area of CMPAs. Furthermore, they also exhibit excellent cycling stability and dynamic performance. The coexistence of a microporous structure and high BET specific surface area endowed CMPAs with an increased number of catalytic active centers. The reversible redox transformation of CMPAs in the presence of NaBH4 and air enabled self-healing (the oxidation units in CMPAs were reduced to reduction units by NaBH4, and the newly generated reduction unit in CMPAs was subsequently oxidized to its original state by the O2 in the air), leading to the reduction reaction of 4-NP proceeded continuously and stably. The aforementioned factors resulted in the high efficiency of CMPAs for reducing 4-NP to 4-AP, enhancing the practical application prospects of CMPAs in the detoxification of 4-NP wastewater.
研究领域:
材料科学
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环境科学
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催化化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
HIGH PERFORMANCE POLYMERS
·
2021
·
IF 2.161
Kai Ma,Hanzhou Jiang,Guofei Chen,Wei Wang,Yonggang Zhang
Several polyimides were prepared via two-step polycondensation from novel 2,5-furandicarboxylic acid–based diamine, 2,5-bis[4-(4-aminophenoxy)benzoyl]furan, with commercial dianhydrides. The chemical structures of the monomers and polymers were characterized by FT-IR and NMR in detail, respectively. The polyimides exhibited high performances with 5 wt% weight loss temperatures of over 410 oC, glass transition temperatures of over 214 oC, and tensile strengths and Young’s moduli of up to 130 MPa and 3.2 GPa, respectively. The thermal crosslinking mechanism was studied by FT-IR, Raman spectroscopy, and model reaction analysis, which showed the Diels–Alder reaction between the furan group and diphenylethylene group was the main reaction. The crosslinked polyimide films showed improved solvent resistance, and thermal and mechanical properties.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
CRYSTENGCOMM
·
2014
·Vol. 16
·期 33
·7667-7672
·
IF 3.858
Tingting Zhang,Yan Yang,Xiaojun Zhao,Jiangtao Jia,Hongmin Su,Hongming He,Jingkai Gu,Guangshan Zhu
The pharmaceutical cocrystal approach can be used to modify the properties of paliperidone. We report here two novel cocrystals, paliperidone 4-hydroxybenzoic acid cocrystal (1, 1 : 1, w/w) and paliperidone 4-aminobenzoic acid cocrystal (2, 1 : 1, w/w), with CCDC numbers of 855981 and 948923, which were constructed using paliperidone with 4-hydroxybenzoic acid and 4-aminobenzoic acid, respectively. The experimental results of the dissolution studies revealed that both 1 and 2 showed much faster dissolution rates than the original active pharmaceutical ingredient (API) in simulated gastric fluid media (pH = 1.2). The pharmacokinetic (PK) studies of 1, 2 and the original API were conducted using beagle dogs. 1 has a slightly higher maximal serum concentration, and both of the cocrystals presented considerably faster absorption rates after a single-dose oral administration to beagle dogs compared to the original API. Observed improvements suggested their potential application to the treatment of acute schizophrenia.
研究领域:
药剂学
·
药物化学
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生物医学
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2018
·Vol. 8
·期 3
·141
·
IF 3.504
Guangyin Fan,Xiaojing Li,Caili Xu,Weidong Jiang,Yun Zhang,Daojiang Gao,Jian Bi,Yi Wang
Developing highly efficient and recyclable catalysts for the transformation of toxic organic contaminates still remains a challenge. Herein, Titanium Carbide (Ti3C2) MXene modified by alkali treatment process was selected as a support (designated as alk-Ti3C2X2, where X represents the surface terminations) for the synthesis of Pd/alk-Ti3C2X2. Results show that the alkali treatment leads to the increase of surface area and surface oxygen-containing groups of Ti3C2X2, thereby facilitating the dispersion and stabilization of Pd species on the surface of alk-Ti3C2X2. The Pd/alk-Ti3C2X2catalyst shows excellent catalytic activity for the hydrodechlorination of 4-chlorophenol and the hydrogenation of 4-nitrophenol in aqueous solution at 25 °C and hydrogen balloon pressure. High initial reaction rates of 216.6 and 126.3 min−1·gpd−1are observed for the hydrodechlorination of 4-chlorophenol and hydrogenation of 4-nitrophenol, respectively. Most importantly, Pd/alk-Ti3C2X2exhibits excellent stability and recyclability in both reactions without any promoters. The superior property of Pd/alk-Ti3C2X2makes it as a potential material for practical applications.Keywords:palladium;titanium carbide;catalytic transformation;4-chlorophenol;4-nitrophenol
研究领域:
材料科学
·
环境科学
·
催化化学
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Jie Shi,Yuting Xiong,Junyan Li,Baolei Gao,Guangyan Qing,Qianying Sheng,Minbo Lan
Protein methylation has attracted increasing attention due to its significant regulatory roles in various biological processes. However, the diversity of methylation forms, subtle differences between methylated and nonmodified sites, and their ultralow abundances pose substantial challenges for capturing and isolating methylated peptides from biological samples. Herein, we develop a chromatographic method that utilizes 4-sulfonylcalix[4]arene (SC4A) as a mobile phase additive and Click-Maltose as the stationary phase to separate methylated/nonmethylated peptides through the adsorption of the SC4A-K(Me3) complex. By utilization of the interaction between calix[4]arene cavities and trimethylated lysine residues, methylated peptides could be specifically separated from peptide samples. This method significantly improves the signal-to-noise ratio (S/N), even in samples containing a 10-fold excess of bovine serum albumin (BSA) trypsin digests. Additionally, we successfully enriched 12 methylated peptides from histone digests. This study paves the way for the selective enrichment of lysine methylated peptides in post-translational modification proteomics (PTMs), enhancing both the capture efficiency and selectivity of methylated peptides and providing robust technical support for subsequent proteomics research.
研究领域:
蛋白质组学
·
生物化学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2013
·Vol. 18
·期 4
·4158-4169
·
IF 2.428
Luhui Ren,Xue Du,Mengnan Hu,Chaoqun Yan,Taigang Liang,Qingshan Li
An asymmetric synthesis of a series of novel 4-methyl-(3'S,4'S)-cis-khellactone derivatives3a–ois reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR and MS. Their cytotoxic activity was evaluated by the MTT assay against three selected human cancer cell lines: HEPG-2 (human liver carcinoma), SGC-7901 (human gastric carcinoma), LS174T (human colon carcinoma). Some compounds showed high inhibitory activity against these human cancer cell lines. Among them, compound3aexhibited strong cytotoxicity, with IC50values ranging from 8.51 to 29.65 μM. The results showed that 4-methyl-cis-khellactone derivatives withS,Sconfiguration could be a potential antitumor agents.Keywords:4-methyl-(3'S,4'S)-cis-khellactone derivatives;asymmetric synthesis;antitumor activity
研究领域:
药物化学
·
肿瘤学
·
有机合成化学
✓ 已验证
DOI
PubMed
高影响因子
ACS Omega
·
2020
·
IF 2.87
Chunmei Xiao,Jianming Lin
The contamination of water systems by heavy metals greatly threatens human health and ecological safety. An efficient adsorbent is critical for the removal of these contaminants. In this work, magnetic Ni3Si2O5(OH)4 nanotubes (NTs) have been synthesized via in situ hydrothermal reduction and further functionalized by grafting poly(4-vinyl pyridine) (P4VP) brushes on its surface via atom transfer radical polymerization. Characterizations by Fourier transform infrared, X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, and X-ray photoelectron spectroscopy proved that P4VP was successfully grafted on the surface of magnetic Ni3Si2O5(OH)4 NTs. The resultant Ni3Si2O5(OH)4-g-P4VP NTs are efficient nanosorbents for removing Cr(VI) anions from water. The Cr(VI) adsorption capacity of Ni3Si2O5(OH)4-g-P4VP NTs reaches 1.49 mmol/g at a pH of 3. The pseudo-second-order kinetic model and the Freundlich isothermal model are suitable to describe the adsorption process. The analysis using Weber–Morris and Boyd models indicates that both intraparticle diffusion and external film diffusion affect the Cr(VI) adsorption process. The adsorption enthalpy is estimated to be 18.37 kJ/mol. More than 90% of the Cr(VI) adsorption capacity of the Ni3Si2O5(OH)4-g-P4VP NTs remains after eight adsorption and desorption cycles.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
·
2023
·Vol. 48
·期 12
·16471-16482
·
IF 2.9
Zainuddin Muhd Izzudin Fikry,Ahmad Abdul Latif,Subramaniam Reasmyraj R.
Carbon dioxide (CO 2 ) separation with membrane technology has become the focus of researchers over the past decades due to its lower energy consumption and cheaper alternative. Mixed matrix membrane (MMM) of poly(4-methyl-1-pentene) (PMP) with nano fumed silica particles was studied to determine the feasibility of using MMM to separate CO 2 from nitrogen (N 2 ) gas. The critical concentration of PMP (7 wt%) was utilized to form the membrane in this study in order to ensure the polymer chain entanglement occurs to form a dense structure. Agglomeration of particle can be observed on the surface with scanning electron microscopy (SEM) imaging with 10 and 15 wt% of nano fumed silica loading in PMP matrix. This observation is further confirmed with energy-dispersive X-ray (EDX) mapping across the cross-sectional area which shows clustered nano fumed silica particle with loading of 10 and 15 wt%. With 7.5 wt% filler loading and at 1 bar, the MMM seems to give the best gas permeance performance with CO 2 permeance of 4.62 GPU (100.54 Barrer) and N 2 permeance of 0.20 GPU (4.31 Barrer) which makes the highest ideal selectivity to be about 23, which was the highest ideal selectivity achieved in this study. Meanwhile, when the pressure was increased from 1 to 7 bar, the CO 2 permeability increased almost linearly followed by a steady decline in CO 2 /N 2 ideal selectivity.
研究领域:
膜技术
·
气体分离
·
高分子科学
·
纳米复合材料
·
环境工程
✓ 已验证
DOI
高影响因子
LIQUID CRYSTALS
·
2013
·
IF 1.959
Lina Zhang,Xinbing Chen,Fengqi Zhao,Xuezhong Fan,Pei Chen,Zhongwei An
Three series of 2-(4′-alkoxybiphenyl-4-yl)-1H-benzimidazole derivatives (nM-x), which possessed 5-nitrobenzimidazole (nM-N series), benzimidazole (nM-H series) or 5-methylbenzimidazole (nM-M series) units at the end of the molecule, were synthesised and characterised by infrared, 1H- and 13C-nuclear magnetic resonance spectra, electrospray ionisation-mass spectrometry and elemental analysis. Their phase transition behaviour was investigated by differential scanning calorimetry, polarising optical microscopy and X-ray diffraction. All the compounds exhibited enantiotropic smectic mesophases with wide temperature domains for a carbon number in the alkoxy chain from 6 to 16, where the mesophase ranges were 14–91°C and 17–99°C during heating and cooling processes for the nM-N compounds, 7–25°C and 8–49°C for the nM-H compounds and 48–81°C and 52–85°C for the nM-M compounds, respectively. The effect of the length of alkoxy chain on mesomorphic properties was discussed. The nM-N and nM-M exhibited a much wider mesophase range whether during heating or cooling process than the corresponding nM-H series, especially for the longer terminal chain (n > 8), which indicated that the substituent in the benzimidazole moiety was helpful in increasing the mesophase stability.
研究领域:
有机化学
·
材料科学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 18
·10272-10281
·
IF 3.049
Yide Xia,Ying Liu,Nannan Shi,Xungao Zhang
In this article, the catalyst Au/γ-Fe2O3@hydroxyapatite (Au/γ-Fe2O3@HAP) consisting of Au nanoparticles supported on the core–shell structure γ-Fe2O3@HAP was prepared through a deposition–precipitation method. The catalyst was characterized by transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, N2 adsorption–desorption and atomic absorption spectrometry. The as-prepared Au/γ-Fe2O3@HAP exhibited excellent performance for the reduction of 4-nitrophenolate (4-NP) to 4-aminophenolate (4-AP) in the presence of NaBH4 at room temperature. Thermodynamic and kinetic data on the reduction of 4-NP to 4-AP catalyzed by the as-prepared catalyst were studied. The as-prepared catalyst could be easily separated by a magnet and recycled 6 times with over 92% conversion of 4-NP to 4-AP. In addition, the as-prepared catalyst showed excellent catalytic performance on other nitrophenolates. The TOF value of this work on the reduction of 4-NP to 4-AP was 241.3 h−1. Au/γ-Fe2O3@HAP might have a promising potential application on the production of 4-AP and its derivatives.
研究领域:
材料科学
·
化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）