EUROPEAN POLYMER JOURNAL
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2025
·
IF 6.3
Ze Xu,Dan Shou,Wenrong Cai,Junyao Li,Datong Wu,Tao Jiang,Yong Kong
6-Deoxy-6-arginine grafted chitosan (DAC) is cross-linked with dibenzaldehyde-functionalized polyethylene glycol (DF-PEG) via the acylhydrazone (–N=CH–) bonds, which can be utilized for the encapsulation of metformin (MET). The resultant injectable DAC/DF-PEG/MET (DDM) hydrogels highlight well-behaved antibacterial and anti-inflammatory activity as well as self-healing capability. More interestingly, the DDM hydrogels exhibit appealing dynamic self-degradability. The electrostatic attraction between DAC and DF-PEG is significantly weakened at slightly alkaline surface (pH 7.0–8.0) that is the characteristic of skin wounds, resulting in the swelling of the hydrogels and the release of MET. As the wounds gradually get healed, the skin tissue turns to be weakly acidic (pH 4.0–6.0), leading to the hydrolysis of the –N=CH– bonds between DAC and DF-PEG. Therefore, the DDM hydrogels can be dynamically self-degraded during the wound healing process. Owing to the injectability and self-healing properties, the DDM hydrogels are suitable for use as the wound dressing for the wounds in any shape. The developed DDM hydrogels also display excellent hemocompatibility and cytocompatibility, indicating that they might be a potential wound dressing for skin wounds.
研究领域:
生物材料学
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医学
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药剂学
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组织工程
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产品关联
DOI
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2018
·
IF 2.559
Xin-Chun Zhang,Hong-Feng Liang,Xiao-Dong Luo,Hua-Jun Wang,Ai-Ping Gu,Chun-Ye Zheng,Qiao-Zhen Su,Jun Cai
Neuroinflammation plays a critical role in the process of neurodegenerative disorders, during which microglia , the principal resident immune cells in the central nervous system, are activated and produce proinflammatory mediators. Yin-Yang 1 (YY1), a multi-functional transcription factor, is widely expressed in cells of the immune system and participate in various cellular processes. However, whether YY1 is involved in the process of neuroinflammation is still unknown. In the present study, we found that YY1 was progressively up-regulated in BV2 microglial cells stimulated with lipopolysaccharide (LPS), which was dependent on the transactivation function of nuclear factor kappa B (NF-κB). Furthermore, YY1 knockdown notably inhibited LPS-induced the activation of NF-κB signaling and interleukin-6 (IL-6) expression in BV-2 cells, but not mitogen-activated protein kinase (MAPK) signaling. Moreover, YY1 strengthened p65 binding to IL-6 promoter by interacting with p65 but decreased H3K27ac modification on IL-6 promoter, eventually increasing IL-6 transcription. Taken together, these results for the first time uncover the regulatory mechanism of YY1 on IL-6 expression during neuroinflammation responses and provide new lights into neuroinflammation.
研究领域:
神经科学
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免疫学
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分子生物学
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DOI
PubMed
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2020
·Vol. 60
·期 4
·710-716
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IF 1.917
Hui Fang,Denghui Li,Fangjuan Wu,Xiangfang Peng,Anlin Chen,Lingjie Zhang,Sheng Chen
Polyamide 6/boron nitride (PA6/BN) composites were synthesized via anionic ring-opening polymerization using ε-caprolactam as the monomer and functional boron nitride (f-BN) as the thermal conductive filler. Besides the homopolymerized PA6, some PA6 molecule chains would grow from the f-BN sheets through the “grafting from” strategy. Compared with unfunctional hexagonal BN (h-BN), the introduction of f-BN not only improved the dispersion of f-BN in the matrix but also enhanced the interface bonding between f-BN and PA6. The homogeneous dispersion of f-BN in the PA6/f-BN composite favored the formation of the continuous thermal conductive paths or network at a low f-BN loading, and the good interface bonding reduced the phonon scattering in the interface, which improved the thermal conductivity (TC) of the PA6/f-BN composite by 66.0% compared with that of the pure PA6, when only 5 wt% f-BN was added. In contrast, with the same content of unfunctional h-BN loading, the TC of the corresponding composite merely improved by 29.7%. Moreover, Young's modulus and yield strength of PA6/f-BN composites had increased obviously with the introduction of f-BN, whereas those of PA6/h-BN composites showed small fluctuation with the same contents of BN. POLYM. ENG. SCI., 60:710–716, 2020. © 2020 Society of Plastics Engineers
研究领域:
材料科学
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高分子化学
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产品关联
DOI
高影响因子
CHEMISTRY OF NATURAL COMPOUNDS
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2020
·Vol. 56
·期 5
·821-826
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IF 0.653
Shao Jin,Zhao Tong,Ma Hui-Ping,Jia Zheng-Ping,Jing Lin-Lin
A convergent synthesis route of 6-hydroxygenistein (6-OHG) was reported, starting from cheap and readily available biochanin A, via methylation, bromination, methoxylation, and demethylation. The structure of the products was confirmed by MS, IR, 1 H NMR, and 13 C NMR analysis. The antiradical activity of 6-OHG was determined using six different methods, namely, DPPH assay, ABTS assay, nitric oxide assay, superoxide assay, reducing power assay, and phosphomolybdenum assay using ascorbic acid (V C ) as positive control. The results show that 6-OHG possesses similar or greater antiradical activity than V C . In conclusion, 6-OHG can be useful as an antioxidant agent.
研究领域:
有机化学
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药物化学
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天然产物化学
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DOI
高影响因子
Polymers
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2019
·Vol. 11
·期 2
·364
·
IF 3.164
Ya Liu,Gaokai Zhang,Xupin Zhuang,Sisi Li,Lei Shi,Weimin Kang,Bowen Cheng,Xianlin Xu
In this work, a nylon 6 nanofibrous membrane was prepared via solution blowing technology and followed hot-press as scaffold for nanofiltration. The structure and properties of the hot-pressed nylon 6 nanofibrous membrane (HNM) were studied the effect of hot-pressing parameters and areal densities. Then an ultra-thin polyamide (PA) active layer was prepared by interfacial polymerization on HNM. The effects of nanofibrous scaffolds on the surface properties of ultra-thin nanofiltration membranes and their filtration performance were studied. Results showed that the nylon 6 nanofibers prepared at a concentration of 15 wt % had a good morphology and diameter distribution and the nanofibers were stacked more tightly and significantly reduced in diameter after hot pressing at 180 °C under the pressure of 15 MPa for 10 s. When the porous scaffold was prepared, HNM with an areal density of 9.4 and 14.1 g/m2has a better apparent structure, a smaller pore size, a higher porosity and a greater strength. At the same time, different areal densities of HNM have an important influence on the preparation and properties of nanofiltration membranes. With the increase of areal density, the uniformity of HNM increased while their surface roughness and pore size decreased, which is beneficial to the establishment of PA barrier layer. With areal density of 9.4 and 14.1 g/m2, the as-prepared nanofiltration membrane has a smoother surface and more outstanding filtration performance. The pure water flux is 13.1 L m−2h−1and the filtration efficiencies for NaCl and Na2SO4are 81.3% and 85.1%, respectively.Keywords:solution blowing;nylon 6 nanofibrous membrane;scaffold;nanofiltration
研究领域:
材料科学
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纳米技术
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膜技术
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产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
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2016
·Vol. 34
·期 4
·399-406
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IF 1.811
Wang Zhi-liang,Xu Jia-li,Yuan Qian,Shibraen Mahmoud H. M. A.,Xu Jian,Yang Shu-guang
Hydrothermal processing of polyamide 6 (PA6) with the presence of lanthanum chloride (LaCl 3 ) was studied in the temperature region from 160 °C to 250 °C. PA6 will be dissolved in the superheated water when temperature is above 160 °C. And as PA6 is dissolved, hydrolysis will happen, which makes PA6 chains degrade. By adding LaCl 3 in the hydrothermal environment, the PA6 hydrolysis will intensify, especially when the hydrothermal temperature is higher than 200 °C. When the hydrothermal system cools down, the hydrolyzed PA6 segments will crystallize from the solution or remain dissolved in the solution depending on molecular weight. In addition, the hydrolyzed compound of LaCl 3 would affect the crystallization of PA6 segments with proper size, and γ phase would be presented.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
ACS Omega
·
2023
·
IF 4.1
Ying Fan,Ran Cen,Peihui Shan,Carl Redshaw,Hang Cong,Xin Xiao,Qingmei Ge
The supramolecular assembly of symmetrical tetramethylcucurbit[6]uril (TMeQ[6]) and 2-picolylamine (AMPy) has been investigated via various techniques, including ultraviolet–visible (UV–vis) and nuclear magnetic resonance spectroscopy, isothermal titration calorimetry (ITC), and X-ray crystallography. The results indicated that TMeQ[6] could encapsulate the AMPy guest molecule to form a stable inclusion complex. The rotational restriction of the guest in the cavity of TMeQ[6] resulted in a large negative value of entropy. The X-ray crystal structure of the 1:1 inclusion complex between TMeQ[6] and AMPy revealed that AMPy exists in the elliptical cavity of TMeQ[6].
研究领域:
化学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
·
2018
·Vol. 2018
·期 11
·1321-1325
·
IF 2.882
Jia-Rui Wu,Chun-Yu Wang,Yan-Chun Tao,Yan Wang,Chunju Li,Ying-Wei Yang
Graphical The facile synthesis of a diverse range of [2]biphenyl-extended pillar[6]arenes is described. Among the compounds generated is the first water-soluble version, bearing eight pyridinium moieties; this compound showed strong binding capabilities towards some sulfonate anion guests in aqueous solution and holds great potential for the detection or separation of anionic naphthalenesulfonates through rapid precipitation. The facile design and synthesis of a series of extended pillar[6]arene derivatives is described. In particular, the first water-soluble version bearing eight pyridinium moieties (CWBpP6) showed strong binding capabilities towards certain guest compounds with sulfonate groups. Significantly, CWBpP6 could uptake 2,6-naphthalene-disulfonate from water due to the rapid precipitation upon host–guest complexation, which indicates the potential of CWBpP6 as a promising detection and separation agent for naphthalene sulfonate substrates in water. This provides a possibility for further development of extended pillararenes in selective cargo precipitation as well as sensing and detection of analytes.
研究领域:
超分子化学
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有机合成
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材料科学
✓ 已验证
DOI
高影响因子
Polymers
·
2018
·Vol. 10
·期 8
·872
·
IF 2.935
Yongxian Zhao,Chen Ma,Shijie Cheng,Wei Xu,Yuejuan Du,Yansong Bao,Zuojie Xiao
Maleic anhydride (MAH)–divinyl benzene (DVB) multi-monomer melt-grafting onto isotactic polybutene-1 (iPB-1) was carried out in a torque rheometer. The effects of dicumyl peroxide (DCP), MAH, and DVB concentrations, and temperature, on the reaction, were investigated. The optimized conditions were 170 °C, DVB/MAH = 4:6 (mass ratio). DVB as a comonomer enhanced the grafting degree (Gd) and grafting efficiency (Ge) of iPB-g-MAH better than styrene. The initiator DCP had little effect on Gd as its concentration over 0.2 phr, but the grafts’ melt flow rate (MFR) increased significantly, and relative molecular weight decreased remarkably with increased DCP concentration. With increasing Gd, the contact angle of grafts with water decreased, and there was a larger crystallization rate. The study of iPB-1 and iPB-g-MAH (Gd = 1.5%)-modified polyamide 6 (PA6) showed that iPB-g-MAH had an obviously toughening effect on PA6. With increasing iPB-g-MAH concentration, the blends of impact strength and elongation at break increased obviously, tensile strength decreased slightly, and MFR decreased prominently, which greatly slowed the processing degradation of PA6. The properties of iPB-1/PA6 blends deteriorated. Both DSC curves and SEM micrographs confirmed that PA6/iPB-g-MAH blends had much better compatibility than PA6/iPB. The reason was that the anhydride group in iPB-g-MAH reacted with amide group in PA6 to improve the compatibility between two phases, and iPB-g-MAH is an excellent modifier for PA6.Keywords:isotactic polybutene-1;maleic anhydride;divinyl benzene;polyamide 6;modification
研究领域:
材料科学
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高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTAL GROWTH & DESIGN
·
2012
·
IF 4.72
Lin-Lin Xu,Jia-Mei Chen,Yan Yan,Tong-Bu Lu
An antitumor drug, 6-mercaptopurine monohydrate, has a low oral bioavailability (about 16%) due to its poor aqueous solubility. To improve its solubility, two cocrystals of 6-mercaptopurine with 4-hydroxybenzoic acid (1) and 2,4-dihydroxybenzoic acid (2), as well as two salts with piperazine in 1:1 (3) and 2:1 (4) stoichiometry, respectively, were obtained and characterized by infrared spectra, powder and single crystal X-ray diffraction. The structures of 1–4 are assembled via N–H(pyrimidine)···O(carboxyl), N–H(pyrimidine)···N(imidazole), O–H(carboxyl)···S, O–H(hydroxyl)···N(imidazole), N–H(pyrimidine)···S, O–H(carboxyl)···O(carboxyl) and N–H(piperazine)···N(imidazole) hydrogen bonds. After the formation of cocrystals and salts, the solubility of 6-mercaptopurine monohydrate is much improved, and the apparent solubility values of 1–4 in the phosphate buffer of pH 6.8 are approximately 1.6, 2.0, 14.0, and 4.2 times as large as that of 6-mercaptopurine monohydrate. Interestingly, 3 transformed to 4 at 40 °C/75% RH within one month.
研究领域:
药学
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药物化学
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DOI
高影响因子
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
·
2015
·Vol. 2015
·期 31
·6806-6810
·
IF 3.065
Li Liu,Yuhang Yao,Xuefang Zhang,Ce Hao
Graphical A highly ordered 3D framework from 1,5-naphthalenedisulfonate (1,5-NDS) and cucurbit[6]uril (CB[6]) is synthesized, wherein the 1,5-NDS anions act as linkers to connect the CB[6] units together through C–H ··· O H-bonds. The fluorescence wavelength of the assembly structure is blueshifted relative to that of 1,5-NDS and the fluorescence intensity is decreased, which are ascribed to the formed H-bonds. A highly ordered 3D framework from 1,5-naphthalenedisulfonate (1,5-NDS) and cucurbit[6]uril was synthesized and structurally determined by single-crystal X-ray diffraction analysis. The crystal structure demonstrates that the 1,5-NDS anions act as linkers to connect the cucurbit[6]uril units together through C–H ··· O hydrogen bonds between the 1,5-NDS anions and cucurbit[6]uril. Furthermore, with 1,5-NDS as the fluorophore, the fluorescence properties of the corresponding assembly structure were investigated in the solid state. Relative to that observed for 1,5-NDS, the assembly exhibited a blueshift in the fluorescence wavelength from λ = 406 to 340 nm along with decreased fluorescence intensity. Theoretical calculations were in good agreement with the experimental results and disclosed that the fluorescence mechanism of the assembly structure could be ascribed to the hydrogen bonds formed between the 1,5-NDS anion and cucurbit[6]uril.
研究领域:
化学
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材料科学
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产品关联
DOI
高影响因子
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2017
·Vol. 96
·期 3
·739-748
·
IF 1.356
Chun Xi Qin,Cheng Lin,Jie Tang,Zhen Hao Xi,Ling Zhao
Nylon 6 extract concentrate, namely, wastewater produced from industrial nylon 6 extraction unit, was hydrolyzed in subcritical water to efficiently decrease the cyclic dimer (CD) content. The CD equilibrium conversion reached a maximum when the initial water content ranged from 0.40 to 0.45 g/g; specifically, a CD conversion of 94.3 % was achieved at the hydrolysis temperature of 543 K and an initial water content of 0.40 g/g. A kinetic model including both acid- and base-catalyzed mechanisms was developed. The model predictions were in good agreement with the experimental results. The hydrolysis reaction constants increased significantly with increasing subcritical water content. By considering the effects of subcritical water on the individual reaction constants, the kinetic model could reproduce the experimental results over a wide range of initial water contents. Hopefully, the developed kinetic model will be applied in the design of a novel nylon 6 extract liquor recycling process.
研究领域:
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）