JOURNAL OF MATERIALS CHEMISTRY
·
2011
·Vol. 22
·期 2
·520-526
·
IF 5.101
Benlin Hu,Fei Zhuge,Xiaojian Zhu,Shanshan Peng,Xinxin Chen,Liang Pan,Qing Yan,Run-Wei Li
A new polyimide bearing the functional pendant 9-phenyl-9H-carbazole moieties, poly[2,2-(4,4′-di(N-benzyloxycarbazole)-3,3′-biphenylene)propane-hexafluoroisopropylidenediphthalimide] (6F-BAHP-PC PI), has been designed as a functional material for resistance memory devices. The ITO/6F-BAHP-PC PI/Ag memory device exhibits nonvolatile resistive switching (RS) with a high ON/OFF ratio (>106), long retention time (>6 × 104 s), good endurance, and low power consumption (∼100 μW). In situconductive atomic force microscopy measurements show that the RS of 6F-BAHP-PC PI originates from the formation/rupture of nanoscale conducting filaments.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Shuo Tian,Jiaping Lin,Wei Chen,Dianping Tang,Yang Ou
The development of rapid and sensitive CA19–9 (carbohydrate antigen 19–9) analytical methods for early screening of potential patients, especially in clinical situations, is important for controlling the progression of pancreatic cancer. Herein, a new photoelectrochemical (PEC) immunoassay has been devised for the ultrasensitive detection of CA19–9 using gold nanoparticle-modified ultrathin ZnIn 2 S 4 nanosheets (Au-UZNS) as the photoactive substrate. Notably, the alkaline phosphatase (ALP) labeled on the detection antibody (ALP-dAb) serves as the signal amplifier that catalyzes the production of large amounts of ascorbic acid (AA) after the sandwiched immunoreaction. The generated AA is an outstanding electron donor, thereby improving the intensity of the photoactive substrate. Under the optimized parameters, the Au-UZNS-based PEC immunosensor displays an excellent response to CA19–9 ranging from 0.01 to 500 U mL −1 with a limit of detection (LOD) of 4.7 mU mL −1 . Generally, the CA19–9 levels in the serum of high-risk pancreatic cancer patients range from 120 to 400 U mL −1 , while the levels in normal humans range from 0 to 40 U mL −1 . Therefore, the exceptionally low LOD value of the proposed method is sufficient to meet the threshold for clinical detection and holds significant potential for further application.
研究领域:
分析化学
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生物分析化学
·
纳米技术
·
生物医学工程
·
癌症诊断
✓ 已验证
产品关联
DOI
高影响因子
Communications Biology
·
2024
·Vol. 7
·期 1
·1-16
·
IF 5.2
Ren Huihong,Zhang Yujuan,Huang Wei,Xu Haiyan,He Weixiong,Hao Nan,Zhang Cong
Photothermal therapy (PTT) is a cancer-targeted treatment approach.The occurrence of tumors may be related to microbial infections (Viruses, bacteria, fungi, etc.), which probably provokes anti-tumor immunity. However, T cells in the context of cancer become exhausted and dysfunctional. Galectin-9 (Gal-9) is highly expressed in normal tissues and associates with body immune tolerance, and was firstly evidenced with much higher expression on the primary solid tumors than CD80/86 (B7) and CD274 (PD-L1) here, which suggests that Gal-9 may be a key factor in inhibiting the anti-tumor immunity, and its receptor T cell immunoglobulin and mucin domain 3 (TIM-3) was discovered on the cytotoxic T lymphocytes (CTL) with high expression as well based on the single cell analysis. The immune checkpoint communications showed that the Gal-9/TIM-3 axis played the most vital role on negatively regulating the anti-tumor immunity of CTL for melanoma. Then, we used a novel transdermal photothermal nanosensitizer (FSGG) loading Gal-9 siRNA (FSGG/siGal-9) for knocking the tumor cells down Gal-9 to block the Gal-9/TIM-3 axis and prohibit CTL exhaustion synergizing PTT against melanoma, which evidenced good effects on inhibiting tumor growth and enhancing anti-tumor immunity, named “photothermal immunotherapy”. This paper provides a new perspective for tumor prevention and treatment.
研究领域:
肿瘤学
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免疫学
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纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
HIGH PERFORMANCE POLYMERS
·
2013
·
IF 0.85
Ling Xiao,Dechao Sun,Tianli Niu,Youwei Yao
Two novel phosphrous–nitrogen-containing flame retardants (3) and (4) were successfully synthesized from two steps: condensation reaction between 4-aminopenol and 1,4-phthaladehyde (or 4,4′-biphenyldicarboxaldehyde) and addition reaction between the above condensation compounds and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide. The structures of (3) and (4) were characterized by Fourier transform infrared, nuclear magnetic resonance, and mass spectroscopy methods. The results show that (3) and (4) can serve as co-curing agents of diaminodiphenylmethane (DDM) for the curing reaction of epoxy resin. The epoxy thermosets-containing DDM and (3) or (4) exhibit moderate changes in glass transition temperature, thermal stability, and show improvement in flame retardancy: UL94 V-0 grade can be obtained when phosphorus content of the epoxy thermoset is only 1.0%; the limiting oxygen index of epoxy resin system containing (4) reaches 40.9 when phosphorus content is up to 1.5%.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2019
·
IF 6.864
Zhenghong Guo,Zilu Wang,Zhengping Fang
Fullerene (C 60 ) is readily to capture chain radicals and delays the scission of macromolecular chains during the degradation or combustion of polymers, because of its high reactivity with free radicals. In this work, C 60 was functionalized with 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO), trying to combine their free radical-trapping effects both in gaseous phase and in condensed phase. Through an addition reaction between C 60 and DOPO, DOPO has decorated onto the surface of C 60 via P–H bond at the molar ratio of 1:1. From the images of transmission electron micrographs (TEM) and scanning electron microscopy (SEM), the introduction of DOPO onto C 60 surface prevented C 60 from clumping together and achieved a looser morphology. Thermogravimetry (TG), differential scanning calorimetry (DSC) and cone calorimetry measurements showed that compared with pristine C 60 , DOPO- d -C 60 further increased the anti-oxidative properties and restrained the combustion process of polypropylene .
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
ANALYST
·
2024
·Vol. 149
·期 24
·5784-5790
·
IF 3.6
Yi-Xuan Li,Yu-Xuan Dai,Ju-Zheng Wang,Jérome Chauvin,Xue-Ji Zhang,Serge Cosnier,Robert S. Marks,Dan Shan
The concentration of zinc ions in semen is significantly correlated with sperm viability and male fertility. In this work, a reliable ratiometric fluorescence probe (ZIF-9-TCPP) based on the efficient Förster resonance energy transfer (FRET) process between two luminophores, benzimidazole (BIM) and meso-tetra (4-carboxyphenyl) porphyrin (TCPP) for Zn2+ detection has been constructed, where the emissions of BIM and TCPP are used as reference and detection signals. The proximity of BIM and TCPP in one framework (ZIF-9-TCPP) and the overlapped spectra between BIM and TCPP afford the attainment of a highly efficient FRET (around 90% efficiency). Efficient FRET improves the fluorescence intensity of porphyrin to enhance the sensitivity of detection. The unique spectral shift resulting from Zn2+ binding to the porphyrin ring ensures the selectivity of detection. In addition, the response mechanism of the proposed ratiometric probes to Zn2+ has been investigated. This work provides a convenient way to design an efficient FRET system and a promising method for sperm mobility detection.
研究领域:
生物化学
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生殖医学
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2020
·Vol. 138
·期 3
·49698
·
IF 2.52
Yao Xu,Jinhao Sun,Lijun Qian,Juan Li
Polydopamine (PDA) was prepared by using dopamine which has good charring ability. The PDA was used as an environmentally friendly flame retardant and combined with 9,10-dihydro-9-oxo-10-phosphaphenanthrene-10-oxide (DOPO) to improve the flame retardancy of epoxy (EP) resin. The flame retardancy and thermal stability of EP composites were researched by UL-94 vertical burning, limiting oxygen index (LOI), cone calorimetry tests, and thermal gravimetric analyzer. Adding DOPO alone requires 6% to make EP obtain the UL-94 V0. If DOPO and PDA are combined, only 4% is needed to make EP obtain the UL-94 V0, which suggests that there is good synergistic effect between them. Moreover, the peak of heat release rate of EP/DOPO/PDA composites is less than that of EP/DOPO composites. The reactions among EP, DOPO, and PDA reduce the release of combustible gases at the early stage of degradation; at the same time, DOPO volatilize to the gas phase, quench the free radicals, and the combustion can be stopped. In addition, due to the decrease of the amount of PDA/DOPO, the EP composite can get a higher glass transition temperature, but due to the aggregation of PDA in EP, the tensile property of EP composite decreases.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Brain Sciences
·
2022
·Vol. 12
·期 5
·571
·
IF 3.333
Chao Song,Chao Gao,Zhenxin Wang
(1) Background: Chemotherapy-induced cognitive impairment (CICI) is often observed in cancer patients and impairs their life quality. Grape-seed-orientated procyanidin has been shown to have anti-inflammatory and neuroprotective effects, yet its effects in preventing CICI have not been investigated. (2) Method: Adult male mice received 2.3 mg/kg cisplatin or saline injections for three cycles consisting of five daily injections followed by 5 days of rest. Procyanidin or saline was administered 1 h prior to cisplatin treatment. Cognitive testing, gelatin zymography, and blood–brain-barrier (BBB) penetration tests were performed after treatment cessation. RAW264.7 cells were treated by stimulated supernatant of SHSY5Y cells. In addition, high-mobility group protein B1 (HMGB1) expression and MMP-9 activity were tested. (3) Results: Repeated cisplatin treatment increased BBB penetration, MMP-9 activity, impaired performance in contextual fear conditioning, and novel object recognition tasks. The knockout of MMP-9 rescues cognitive impairment and cisplatin-induced upregulation of HMGB1 in SHSY5Y cells. HMGB1/TLR4/IP3K/AKT signaling contributes to the increased MMP-9 activity in RAW264.7 cells. Procyanidin treatment attenuates MMP-9 activity, BBB damage, and CICI. (4) Conclusions: The results indicated that MMP-9 activation and BBB disruption is involved in CICI. Procyanidin may effectively alleviate the harmful effects of cisplatin.Keywords:cisplatin;chemotherapy;MMP-9;RAW264.7 cells;procyanidin;blood–brain barrier (BBB);chemotherapy-induced cognitive impairment (CICI)
研究领域:
肿瘤学
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神经科学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 39
·15700-15705
·
IF 3.069
Yan Lei,Limei Yu,Maochang Shen,Shikang Luo,Zhanxian Gao
A series of ionic liquids (ILs) were synthesized and their Hammett acidities (H0) were determined using 4-nitroaniline as the indicator. The relationship among IL's structure, the acid strength, and the catalytic performance in the condensation reaction of 9-fluorenone with phenol was discussed. The effective H0 range of ionic liquids that can catalyse the condensation reaction was obtained. Moreover, the catalysis of the mercapto compound co-catalyst was also systematically studied. According to the analysis of how the structure of the sulfydryl co-catalyst affects the percent conversion of 9-fluorenone and the selectivity of BHPF, a mechanism for the reaction in the IL–thiol cooperative catalytic system was proposed. The present work gave a clear clue to design novel IL catalysts for the synthesis of BHPF.
研究领域:
有机化学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
Molecular Catalysis
·
2020
·
IF 3.687
Fanfan Yue,Ao Hu,Xinhuan Lu,Chenlong Wang,Haijun Pan,Haifu Zhang,Lu Yang,Qinghua Xia,Dan Zhou,Yongde Xia
Benzimidazole and metal cobalt salts were employed in the synthesis of Co-ZIF-9 by solvothermal crystallization. Highly active catalysts for selective hydrogenation of carbonyl compounds were developed. The optimal nanocatalyst Co-ZIF-350 manifested remarkable activity and selectivity for the hydrogenation of cyclohexanone under mild conditions. Catalytic conversion of cyclohexanone reached the highest over the catalyst of Co-ZIF-9-pyrolyzed at 350 °C for 2 h, in which the conversion of cyclohexanone was 100 % and the selectivity of cyclohexanol was ＞99 % at 50 °C. A wide scope of ketones/aromatic aldehydes could be selectively reduced to the corresponding alcohols with high yields. Importantly, the nanocatalyst Co-ZIF-350 presented good tolerance of substrates with various functional groups under mild conditions.
研究领域:
催化化学
·
材料科学
✓ 已验证
DOI
高影响因子
NEUROPHARMACOLOGY
·
2025
·
IF 4.6
Yue Xin,Tianyue Guan,Guanglu Wang,Yannan Xiang,Mengxin Li,Yikun Zhao,Panpan Zhao
Sepsis is a severe systemic infection that leads to multiple organ dysfunction and high mortality, making it one of the primary causes of death in ICU patients. Sepsis also induces septic encephalopathy (SAE), resulting in acute and long-term cognitive impairments. Research indicates that inhibiting BBB damage, anti-inflammatory, and antioxidant responses are critical therapeutic directions for SAE. Monotropein (Mon), the main active component of the traditional Chinese medicine Epimedium, possesses various pharmacological effects, including antioxidant properties. This study aims to explore the protective effects and potential targets of Mon in SAE. Firstly, the GEO database was utilized to screen for highly expressed genes, identifying matrix metalloproteinase-9 (MMP9) as a target. Drug target reverse screening using Schrodinger software confirmed MMP9 as a potential therapeutic target for Mon. Subsequently, in vitro experiments using an LPS-stimulated BV-2 and HUVECs co-culture model examined the interaction between Mon and MMP9. A CLP-induced mouse model was employed to investigate Mon's role in SAE. Results indicate that MMP9 is highly expressed in SAE and promotes its progression. Mon targets MMP9, enhancing its protein stability and exerting anti-inflammatory, improved vascular permeability, and barrier protective effects. Mon alleviates brain tissue damage, BBB disruption, and synaptic loss induced by CLP, increases antioxidant enzyme activity to eliminate ROS, and suppresses sepsis-induced oxidative stress, thereby mitigating CLP-induced cognitive impairment in mice. In conclusion, Mon targets MMP9, exerting anti-inflammatory, antioxidant, and barrier protective effects, alleviating SAE. Mon may serve as a potential natural therapeutic agent for treating sepsis-induced brain dysfunction.
研究领域:
药理学
·
神经科学
·
免疫学
·
生物信息学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2022
·Vol. 33
·期 20
·205402
·
IF 3.953
Tianyang Li,Zhikun Xu,Shuangyan Lin
Rational design and controllable synthesis of metal-organic frameworks nanosheets is critical for electrochemical catalysis. Herein, a carnation-like ZIF-9 nanostructure made of nanosheets is grown on nickel foam (ZIF-9/NF) by a simple one-step solvothermal method, the morphology evolution and the electrocatalytic oxygen evolution properties have been investigated by controlling the solvothermal time. The binder-free ZIF-9-d/NF (60 h, solvothermal time is 60 h) electrode delivers efficient electrocatalytic oxygen evolution reaction activity with low overpotentials of 312 and 337 mV at 50 and 100 mA cm−2, respectively. Furthermore, ZIF-9-d/NF (60 h) exhibits excellent stability without obvious attenuation for at least 30 h at 200 mA cm−2. The excellent performances can be attributed to the combination of the highly exposed active sites in the ZIF-9-d nanosheets, as well as the effective electron conduction and mass transfer. This work provides much possibilities for ZIF-9 nanosheets as binder-free electrode for electrocatalyst.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）