Arabian Journal of Chemistry
·
2022
·
IF 6.212
Zhenzhong Zang,Shichun Zhao,Ming Yang,Chengqun Yu,Hui Ouyang,Lihua Chen,Weifeng Zhu,Zheng-gen Liao,Abid Naeem,Yongmei Guan
Honeysuckle is a commonly used Chinese medicine for treating intestinal inflammation and other diseases. Compounds that are absorbed into the blood produce pharmacodynamic effects. However, it is still unclear which compounds in honeysuckle are absorbed into the blood. Thus, the purpose of this study was to investigate the composition and in vivo absorption of active components in honeysuckle in male Sprague-Dawley rats, and develop a controlled release hydrogel system. UPLC-LTQ-Orbitrap-MS was used to determine the active ingredients of honeysuckle in vitro and in vivo . A total of 80, out of which 42 components were found to be absorbed into the blood, which includes flavonoids, iridoids, organic acids and other compounds. FTIR analysis confirmed crosslinking between hydrogel content and drug loading, and TGA and DSC analysis indicated a high thermal stability. XRD analysis showed a decrease in crystallinity following crosslinking, and SEM revealed an irregular and hard surface. The maximum swelling and drug release were observed at pH 7.4 as compared to pH 1.2. The identified blood components can be used to determine Q-markers, while the prepared hydrogels can serve as an effective and promising carrier for the controlled release of honeysuckle extracts.
研究领域:
中药学
·
药剂学
·
分析化学
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Yi Zong,Pan Xu,Haoyu Yue,Xinxue Li
To improve the stability of the polymers applied to profile control in high-temperature and high-salinity reservoirs, a water-soluble graft-copolymer HPMC-g-poly(AM/AA/APEG2400) was synthesized from hydroxypropylmethylcellulose (HPMC), acrylamide (AM), acrylic acid (AA), and allyl polyoxyethylene ether (APEG2400) via free-radical copolymerization using potassium persulfate (KPS) as the initiator. The molecular weight (M w ) of HPMC-g-poly(AM/AA/APEG2400) was controlled by the addition of the chain-transfer agent, sodium formate (SF), to the polymerization medium and was measured by capillary viscometry. Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), proton nuclear magnetic resonance ( 1 H NMR), and scanning electron microscopy (SEM) were performed to characterize the graft-copolymer. The rheological properties of the graft-copolymer were investigated at different salinities and temperatures. The graft-copolymer solution showed better salt resistance, temperature tolerance, and long-term thermal stability than partially hydrolyzed polyacrylamide (HPAM). In addition, hydrogels were prepared using the graft-copolymer with varying M w (346 × 10 4 –1319 × 10 4 ), a crosslinker (hexamethylenetetramine–resorcinol, (HMTA–RC)), and additives (citric acid, (CA), and ammonium phosphate monobasic, (MAP)), and the hydrogels exhibited adequate strength and tunable gelation time. The hydrogels prepared using the graft-copolymer with high M w possessed excellent long-term stabilities with negligible syneresis at 45 °C after 130 d, for the same conditions, the syneresis of conventional hydrogels prepared by HPAM reached approximately 90%.
研究领域:
聚合物化学
·
材料科学
·
石油工程
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Xu-Feng Xia,Ying-Ying Gu,Shi-Ai Xu
In this study, an environment-friendly titanium (Ti) conversion coating was successfully deposited on the aluminum foil AA 8021 in the solution containing hexafluorotitanic acid (H 2 TiF 6 ), and its morphology, composition, growth process, hydrophilicity and corrosion resistance were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), energy dispersive spectroscopy (EDS), X-ray photoelectric spectroscopy (XPS), contact-angle measurements (CAM) and salt spray exposure. The peeling strength between the Ti treated Al foil and the modified polypropylene (PP) film (PP grafted with maleic anhydride, PP- g -MAH) (Al/PP- g -MAH) was measured by T-peeling test. The results show that the Ti conversion coating is a multi-component coating composed primarily of metal oxides (TiO 2 and Al 2 O 3 ) and metal fluoride (AlF 3 ). Ti treated Al foil shows better corrosion resistance than untreated and alkali-cleaned Al foils. The peeling strength of PP- g -MAH film with Ti treated Al foils is approximately 30 times higher than that with untreated Al foils. Thus, Ti treatment is a promising approach to improve the corrosion resistance and peeling strength of aluminum/polymer composite film (Al/P) used in the lithium–ion battery package.
研究领域:
材料科学
·
表面工程
·
电化学
·
能源材料
·
复合材料
·
薄膜技术
·
电池封装技术
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Tinglei Liu,Chen Ding,Kejing Gao,Jingsheng Zhou,Wei-Guang Yang,Shuai Zhou,Yuxuan Lin,Hao-Yu Zhao,Zhong-Zhen Yu,Dongzhi Yang
High filtration loss of the oil-based drilling fluids restricts their application in reservoirs production at high temperature and high pressure. In this work, modified nano-microsphere P(AM-co-AA)/PSt filtration reducers are designed to reduce filtration loss by excellent dispersion in oil medium, excellent water-absorption swelling and auxiliary emulsification and prepared by inverse phase emulsion polymerization using acrylamide, acrylic acid and styrene, followed by modification with stearyl trimethyl ammonium chloride. The modified nano-microspheres absorb water to reach an equilibrium swelling rate of 950%. Additionally, the water contact angle increases to 70.3° and the temperature resistance reaches up to 240 o C. The permeability of the filter cake can be decreased through the utilization of swelling microspheres to plug tiny cracks, as well as by intertwining organo-montmorillonite sheets with polymer chains detaching from weakly crosslinked microspheres. Especially, due to their excellent dispersion in the oil medium, the microspheres gather at the oil-water interface, thereby stabilizing the emulsification state of oil-based drilling fluids. These two points are conducive to reducing filtration loss. After thermal aging for 16 h at 180 o C, oil-based drilling fluid by adding 4% microspheres exhibits a low filtration loss volume of 7.8 mL at 180 o C and 3.5 MPa. These hydrophilic nano-microspheres with a partially alkylated structure have a considerable practical application prospect as filtration loss reducers of oil-based drilling fluids.
研究领域:
石油工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE RESEARCH
·
2016
·
IF 1.817
Hui Zhao,Jun Gao,Ruina Liu,Sanping Zhao
To fabricate thermo- and pH-sensitive hydrogels functionalized with β -cyclodextrin ( β -CD) moieties, β -CD polymer bearing methacrylate (CDP- g -GMA) used as a reactive and functional crosslinker was synthesized, and then copolymerized with N -isopropylacrylamide (NIPAAm) and acrylic acid (AA) in aqueous solution via UV-initiated free radical polymerization. The stimulus-responsiveness of the resultant hydrogels has been carried out by measuring the swelling ratio at different temperatures and pH values. The results showed that the thermo- and pH-sensitivities of the produced hydrogels were significantly dependent on the compositions of the hydrogels, and the dual sensitivities exhibited good reversible process. The interior morphology observed by SEM exhibited that the pore size of the hydrogels could be tailored by pH of the local medium. Using a water-soluble cationic dye methyl violet (MV) as a model drug, MV loading and release profiles of the hydrogels as potential drug controlled release carriers were evaluated. The MV release rate from CD-functionalized hydrogels was much slower than that from the hydrogel without β -CDs at both pH 2.0 and pH 7.4. The release of MV from CD-functionalized hydrogels at pH 2.0 was faster than that at pH 7.4, the release kinetics of MV from the CD-functionalized hydrogels displayed a sustained release profile, and the release mechanism followed Fickian diffusion.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 38
·e52918
·
IF 3.057
Yukun Tian,Yongzhi Hong,Yunlong Wang,Yuan Tian,Zhihao Wang,Meixing Ai,Jun Ma
The emerging stretchable and tough hydrogels find their extraordinary contributions in widespread use. However, the applicability of existing tough hydrogels in harsh environments like highly acidic stomachs has remained a challenge. Here, we develop superior stretchable and tough P(AA -co- AAm)/SiO 2 hybrid hydrogels through radiation-induced polymerization and crosslinking in the presence of acids. The performance of the nanocomposite gels was optimized by altering fabrication variables including acid concentration, monomer composition and absorbed dose. The mechanic tests show that the protonated hybrid hydrogels displayed a high elongation at break (1919%), fracture strength (117 kPa), and compressive strength at 50% strain (126 kPa). These values are superior to those of conventional polyelectrolyte hydrogels and expect to significantly broaden the application. The proposed strategy is quite general and offers an alternative strategy to develop tough hydrogels.
研究领域:
材料科学
·
高分子化学
·
生物医学工程
✓ 已验证
DOI
高影响因子
TALANTA
·
2017
·
IF 4.162
Liping Zhang,Bo Ling,Lun Wang,Hongqi Chen
An upconversion luminescence method was developed for the determination of glutathione (GSH), L -cysteine (Cys) or L -ascorbic acid (AA) based on redox reaction . We synthesized poly(acrylic acid) (PAA)-modified Mn 2+ -doped NaYF 4 :Yb,Tm upconversion nanoparticles (UCNPs), and the luminescence of these UCNPs was effectively quenched due to their carboxyl groups coordinating with Fe 3+ to form a UCNPs/Fe 3+ system. GSH, Cys or AA reduced Fe 3+ to Fe 2+ , which induced the luminescence recovery of the UCNPs. Under the optimized conditions, wide linear concentration ranges from 0.25-300 μM for GSH, 0.5–875 μM for Cys and 0.5–350 μM for AA were found, and the detection limits (3 S/K) were 0.2 μM, 0.5 μM and 0.2 μM, respectively. Thus, the UCNPs/Fe 3+ system was successfully applied for sensing GSH, Cys or AA.
研究领域:
纳米技术
·
分析化学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
OncoTargets and Therapy
·
2022
·
IF 4.345
Yue Jing,Gang Wang,Ying Ge,Minjie Xu,Shuainan Tang,Zhunan Gong
Asiatic acid (AA; 2α,3β,23-trihydroxyurs-12-ene-28-oic acid) is widely used for medicinal purposes in many Asian countries due to its various bioactivities. A series of AA derivatives has been synthesized in attempts to improve its therapeutic potencies. Herein we investigated the anti-tumor activities of N-(2α,3β,23-acetoxyurs-12-en-28-oyl)-l-proline methyl ester (AA-PMe), a novel AA derivative. AA-PMe exhibited a stronger anti-cancer activity than its parent compound AA. AA-PMe inhibited the proliferation of SGC7901 and HGC27 human gastric cancer cells in a dose-dependent manner but had no significant toxicity in human gastric mucosa epithelial cells (GES-1). AA-PMe induced cell cycle arrest in G0/G1 phase and blocked G1-S transition, which correlated well with marked decreases in levels of cyclin D1, cyclin-dependent kinase CKD4, and phosphorylated retinoblastoma protein, and increase in cyclin-dependent kinase inhibitor P15. Further, AA-PMe induced apoptosis of human gastric cancer cells by affecting Bcl-2, Bax, c-Myc, and caspase-3. Moreover, AA-PMe suppressed the migration and invasion of human gastric cancer cells (SGC7901 and HGC27) cells by downregulating the expression of MMP-2 and MMP-9. Overall, this study investigated the potential anti-cancer activities of AA-PMe including inducing apoptosis and suppressing proliferation, migration and invasion of gastric cancer cells, as well as the underlying mechanisms, suggesting that AA-PMe is a promising anti-cancer drug candidate in gastric cancer therapy.
研究领域:
肿瘤学
·
药理学
·
细胞生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Yuqi Yang,Longlong Zeng,Xiaoyan Li,Zaisheng Cai
Glasses such as automobile windshields, mirrors, and lampshades are prone to fogging due to temperature changes, which affects the process of use and even jeopardizes safety. Hydrophilic films can prevent the glass surface from fogging by absorbing condensation droplets. However, the anti-fog film only lasts for a short period because it will gradually dissolve with the moisture increasing, which leads to image distortion. Herein, we propose a hydrophilic/hydrophobic coating to achieve longer anti-fog persistence. The strong interface bonding of the polymer is the key to improving the durability performance of the coating. It prevents interfacial failure and folding caused by fogging conditions. In this paper, a multifunctional coating with good anti-fog and anti-frost properties was prepared using butyl acrylate (BA), acrylic acid (AA) and 4-benzoylphenyl acrylate (BPA) as the polymer monomers . The light transmission of coated glass is up to 90 % even under harsh fogging conditions. The poly(AA- co -BA-co-BPA) can be firmly bonded with the plasma-treated glass plate, which greatly enhances the durability and water resistance of the coating. After being immersed in deionized water for 60 h at room temperature, the coated glass still has a certain anti-fog effect and the light transmittance is maintained at about 85 %. In addition, the anti-fog coating has excellent self-healing properties due to the fact that the carboxyl group in AA can generate hydrogen bonding , so that it can be healed within 15 s with the help of hot water after physical damage. This anti-fog coating has great potential for application in construction, shipbuilding and other industries.
研究领域:
材料科学
·
化学工程
·
高分子科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2021
·Vol. 28
·期 7
·1-13
·
IF 3.097
Yao Qi,Lan Hai,Li Xin,Chen Youyi
Organic–inorganic interpenetrating network poly (acrylic acid- co -acrylamide) IPN-P(AA-co-AM) polymer sphere with core–shell structure has been synthesized by modified suspension polymerization, which the core is high cross-linked and shell is light cross-linked, respectively. The dispersed phase (water phase) and continuous phase (oil phase), as well as core and shell crosslinking agent are screened based on the water absorption capacity of the polymer spheres. In addition, SiO 2 is applied to endow polymer spheres with excellent thermal and water absorption properties. FTIR, TG, SEM, and XPS analyze the chemical structure, thermal properties, morphology and surface element of polymer spheres, respectively. Particularly, the forming mechanism of polymer spheres and water absorption dynamic model are discussed in detail. The results show that the Organic–inorganic IPN-P(AA-co-AM) polymer spheres are successfully synthesized. The polymer spheres could be wrapped effectively when the SiO 2 content up to 2%. Compared to polymer spheres without SiO 2 , the thermal stability is greatly improved. The optimum core and shell crosslinking agent are pentaerythritol triacrylate (PETA) and sodium alginate, respectively. The maximum absorption capacity of polymer spheres for distilled water and 0.9wt% sodium chloride can up to 922.22 g/g and 93.87 g/g, respectively. Finally, the water absorption of IPN-P(AA-co-AM) polymer spheres dynamic model is closed to second-order.
研究领域:
高分子科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
AMERICAN ANTHROPOLOGIST
·
2005
·Vol. 107
·期 2
·247-251
·
IF 0.952
EMILY YATES-DOERR
The 41 films at the 2004 Margaret Mead Film and Video Festival showcased a multiplicity of styles and approaches, thus widening the perspective of “what counts” as ethnographic film. The two main events—A Tribute to Jean Rouch and Native Voices—epitomized the festival's commitment to diversity and creative talent. Despite the festival's awkward location in the American Museum of Natural History, the films tackled challenging political subjects and directly addressed questions of representation. Postscreening musical performances, informational panels, and audience–director discussion sessions shaped the festival itself as an ethnographic experience, as well as being a venue for the year's best documentary films. Festival highlights were Raven Tales: How Raven Stole the Sun (2004), Mr. Patterns (2004), and Beauty Academy of Kabul (2004).
✓ 已验证
DOI
高影响因子
AMERICAN ANTHROPOLOGIST
·
2005
·Vol. 107
·期 2
·252-256
·
IF 0.952
STANISLAV SHECTMAN
International film festivals are entangled spaces in which filmmakers and audiences negotiate aesthetic, ethical, political, and practical traditions and communities. This review of the Second Moscow International Visual Anthropology Film Festival explores some of the differences in ethics, practice, and priorities of anthropological filmmaking between Russia and the West. By providing a brief history of Soviet anthropology and a discussion of the festival's main themes, this review explores some of the historic and contemporary influences shaping the development of (one particular strain of) visual anthropology in post-Soviet Russia.
研究领域:
视觉人类学
·
电影研究
·
文化人类学
·
伦理学
·
后苏联研究
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）