Polymers
·
2020
·Vol. 12
·期 2
·326
·
IF 3.426
Qiwen Yong,Jinming Chang,Qi Liu,Feng Jiang,Daidong Wei,Haijun Li
Matt polyurethane coating was successfully prepared through the synergistic effect of castor oil and phenolic epoxy resin into polyurethane backbone. The formation mechanism may be ascribed to the modulus mismatch between the partially modified epoxy polyurethane and partially unmodified polyurethane. Scanning electron microscopy (SEM) was used to observe the micro-rough surface morphologies. Atomic force microscopy (AFM) and three-dimensional (3D) surface profilometer were applied to calculate a series of surface roughness parameters in different dimensions, such asSa,Sq,Sp,Sv,Sz,Sku,Ssk, etc. The exciting results of this paper—the correlation of surface roughness on measurement length and gloss—are explored in detail. It reveals the extrinsic property of measured roughness with measurement length and provides guidance for what kind of incident angle gloss meters (20°, 60°, and 85°) best describe the gloss of matt polyurethane coating.
研究领域:
材料科学
·
表面工程
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DOI
高影响因子
Small Methods
·
2017
·Vol. 2
·期 2
·1700298
·
IF 0
Cai Shen,Guohong Hu,Ling-Zhi Cheong,Shiqiang Huang,Ji-Guang Zhang,Deyu Wang
Lithium dendrite growth is one of the most challenging problems affecting the safety performance of lithium-ion batteries (LIBs). It causes low Coulombic efficiency as well as safety hazards for LIBs. Understanding the evolution process of Li-dendrite growth at the nanoscale is critical for solving this problem. Herein, an in situ electrochemical atomic force microscopy (EC-AFM) investigation of the initial Li deposition in ethylene carbonate (EC)-based and fluoroethylene carbonate (FEC)-based electrolytes on graphite anodes is reported. These results show that the solid electrolyte interphase (SEI) formed from the FEC-based electrolyte can suppress Li-dendrite growth. The FEC-based electrolyte induces formation of LiF-rich SEI films, which are harder and denser than those formed in an EC-based electrolyte. Due to its better mechanical properties and larger resistance, the SEI layer formed from the FEC-based electrolyte is sufficient to prevent reduction of Li + ions and deposition of Li + ions on the anode surface. These results demonstrate that EC-AFM is a powerful in situ technique for the study of lithium-dendrite growth.
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DOI
Journal of CO2 Utilization
·
2026
·
IF 8.6
Xinxin Fan,Zhian Fang,Yanting Ouyang,Lu Qian,Xiyue Li,Xiaoyu Chen,Biying Xie,Chunyi Wang,Tiejun Lu,Long Xi,Zhenwen Qiu,Alan Xiaodong Zhuang,Qingguo Li
Improving drug loading and dissolution of poorly water-soluble active pharmaceutical ingredients (APIs) remains a major challenge in formulation development. Here, we integrate atomic force microscopy (AFM) adhesion-force profiling with supercritical antisolvent fluidized-bed (SAS-FB) technology to establish a predictive framework for drug–carrier selection. Enzalutamide (ENZ), a highly crystalline and poorly soluble biopharmaceutics classification system (BCS) Class II compound, was used as a stringent model drug. Single-particle force spectroscopy measurements quantified nanoscale interaction forces between SAS-processed ENZ microcrystals and seven carrier materials. Among these, lactose T70 exhibited the highest adhesion force, which strongly correlated with its superior encapsulation efficiency (EE = 92.7 %) under identical SAS-FB processing conditions. Statistical analysis revealed a robust linear relationship between mean adhesion force and EE (R² = 0.94453), identifying adhesion force as a quantitative predictor of drug deposition efficiency. This predictive capability was further validated using three additional model compounds (naringenin, dihydromyricetin, and luteolin). Comprehensive physicochemical characterization (SEM, PSD, EDS, DSC, XRD, FT-IR, and ¹H NMR) confirmed effective deposition of ENZ onto lactose T70, particle-size reduction, preserved chemical integrity, and SAS-induced polymorphic transformation. The optimized ENZ@SAS-FB(T70) formulation achieved a 5.5-fold increase in dissolution compared with unprocessed ENZ, attributed to uniform coating, enhanced wetting, and improved dispersion of micronized drug on the carrier surface. Collectively, this study establishes AFM-guided carrier screening as a mechanistic and efficient strategy for optimizing SAS-FB formulations. By linking nanoscale adhesion forces to macroscopic encapsulation outcomes, this framework offers a generalizable approach for accelerating the development of high-performance formulations for poorly soluble APIs.
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高影响因子
Journal of Physical Chemistry C
·
2024
·
IF 3.3
Da Shu,Ruipeng Fan,Songyou Yao,He Jiang,Xiaoyue Zhang,Yue Zheng
Understanding the rotor dynamics within metal–organic frameworks (MOFs) is fundamental to the desired amphidynamic application. However, in-depth investigation has been hindered due to the inadequacy of current characterization tools. In this paper, a technique based on infrared-combined atomic force microscopy (AFM-IR) was developed, in which the infrared spectrum can be obtained under tip bias and tip force with nanometer resolution. The tip bias induced variation in infrared spectra of the Cu2(fbdc)2(dabco) film demonstrates that full width at half-maximum of the vibration–rotation coupling mode is competent for rotor speed characterization. Stalling of dipolar rotor speed in the Cu2(fbdc)2(dabco) film is observed under both tip bias and tip force, which indicates the electrical and mechanical controllability of MOF rotor dynamics. On this basis, the rotor behavior of few-layer MOF films is investigated to reveal the influence of self-assembled molecule stress on rotor dynamics. It is found that the rotor rotation is activated progressively as the film grows and self-assembled molecule stress releases. Our results pave the avenue for direct study of rotor dynamics within MOF films at the nanoscale.
研究领域:
材料科学
·
化学
·
物理学
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DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2020
·
IF 7.864
Yuyao Zhang,Xiaoying Zhu,Baoliang Chen
The surface hydrophobicity and its heterogeneity are essential physicochemical properties of functional materials and environmental media, which directly influence many critical processes, such as the adsorption capacity of absorbents, water/fertilizer retention of soil and oil–water separation performances of membranes. The conventional method to characterize the surface hydrophobicity is based on the water/air/oil contact angle, which could only analyze the macroscale local hydrophobicity of the surfaces. Until now, it is impossible to profile two-dimensional surface hydrophobicity recognition in the nanoscale. Here we utilized an atomic force microscopy (AFM)-based chemical force spectroscopy to measure the topography and the local adhesion forces in the nanoscale. A novel approach is established to exploit adhesion forces to extract the hydrophobic attractions, enabling mapping of the surface hydrophobicity of environmental media in the nanoscale, which was validated by studying synthetic self-assembled monolayers of known composition. The new method was then applied to directly measure the hydrophobicity of porous biochar particles, to profile two-dimensional nanoscale hydrophobicity images of graphene oxide, and to observe the in situ variations of the graphite surface hydrophobicity in the adsorption process of benzylamine, which cannot be monitored by the conventional methods. The advantages of direct observations of the surface hydrophobicity recognition from a single AFM image dynamically and quantitatively may provide an in-depth insight into the surface hydrophobicity in the nanoscale.
研究领域:
材料科学
·
环境科学
·
表面化学
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
·
2020
·
IF 3.422
Peiwen Li,Jin Zhou,Wang Li,Huan Wu,Jinrong Hu,Qihan Ding,Shouqin Lü,Jun Pan,Chunyu Zhang,Ning Li,Mian Long
Background Liver sinusoidal endothelial cells (LSECs) display unique fenestrated morphology. Alterations in the size and number of fenestrae play a crucial role in the progression of various liver diseases. While their features have been visualized using atomic force microscopy (AFM), the in situ imaging methods and off-line analyses are further required for fenestra quantification. Methods Primary mouse LSECs were cultured on a collagen-I-coated culture dish, or a polydimethylsiloxane (PDMS) or polyacrylamide (PA) hydrogel substrate. An AFM contact mode was applied to visualize fenestrae on individual fixed LSECs. Collected images were analyzed using an in-house developed image recognition program based on fully convolutional networks (FCN). Results Key scanning parameters were first optimized for visualizing the fenestrae on LSECs on culture dish, which was also applicable for the LSECs cultured on various hydrogels. The intermediate-magnification morphology images of LSECs were used for developing the FCN-based, fenestra recognition program. This program enabled us to recognize the vast majority of fenestrae from AFM images after twice trainings at a typical accuracy of 81.6% on soft substrate and also quantify the statistics of porosity, number of fenestrae and distribution of fenestra diameter. Conclusions Combining AFM imaging with FCN training is able to quantify the morphological distributions of LSEC fenestrae on various substrates. Significance AFM images acquired and analyzed here provided the global information of surface ultramicroscopic structures over an entire cell, which is fundamental in understanding their regulatory mechanisms and pathophysiological relevance in fenestra-like evolution of individual cells on stiffness-varied substrates.
研究领域:
生物医学工程
·
细胞生物学
·
显微技术
·
机器学习
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Hui Chen,Bo Jiang,Chunyang Zou,Zhichao Lou,Junlong Song,Wenjuan Wu,Yongcan Jin
Nonproductive adsorption of cellulase onto the residual lignin in substrate seriously hinders the enzymatic hydrolysis. To understand how lignin structure affects lignin-cellulase interaction, the carbohydrate-binding module (CBM) functionalized atomic force microscope tip was used to measure CBM-lignin interaction by single-molecule dynamic force spectroscopy in this work. The results showed that sulfonated lignin (SL) has the greatest adhesion force to CBM (4.74 nN), while those of masson pine milled wood lignin (MWL), poplar MWL and herbaceous MWLs were 2.85, 1.03 and 0.27–0.61 nN, respectively. It provides direct quantitative evidence for the significance of lignin structure on lignin-cellulase interaction. The CBM-MWLs interaction decreased sharply to 0.054–0.083 nN while SL was added, indicating the primary mechanism of SL promoting lignocellulose hydrolysis was significantly reducing the nonproductive adsorption of substrate lignin on cellulase. Finally, the “competitive adsorption” mechanism was proposed to interpret why SL effectively promotes the enzymatic hydrolysis of lignin-containing substrates.
研究领域:
生物化学
·
生物物理学
·
材料科学
·
酶学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Zhanli Geng,Wenjie Han,Limin Zhou,Shichun Zhang,Wandong Bai,Binyu Zhao,Yue Shen
Unveiling the dynamic adsorption behavior of collectors at the solid-liquid interfaces of soluble salts is crucial for understanding flotation mechanisms. Here, utilizing in-situ fluid atomic force microscopy (AFM) imaging, we directly visualized the dynamic adsorption behavior of octadecylamine hydrochloride (ODH) on KCl surfaces in saturated brine, incorporating dispersion agitation, rapid collector-mineral collision and static adsorption. We observed dynamic ODH particles and flat layers with a reduced modulus on the KCl surface in brine. The scratching experiment confirmed that these structures originated from adsorption rather than precipitation. Force spectroscopy provided a quantitative measurement of their thickness, which was found to be dependent on the ODH concentration. After removing the brine, the KCl surface exhibited small particles, crater-shaped aggregates, and island-shaped monolayers (hemimicelles). The prevalence of these hemimicelles suggests the formation of ordered ODH multilayers in the static liquid environment, while the crater-shaped structure likely stemmed from ruptured ODH-covered nanobubbles. Based on these observations, we propose a novel adsorption mechanism tailored to the rapid collision and static adsorption: initiated by aggregate adsorption, followed by molecular rearrangement and multilayer adsorption. The first direct in-situ visualization of collector adsorption behavior on water-soluble salts confirms the dominant role of colloidal particles and nanobubbles in the adsorption process, establishing a critical link connecting adsorption theory to industrial flotation practice.
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DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Jiayi Wu,Lun Lu,Rui Wang,Liuyi Pan,Baoliang Chen,Xiaoying Zhu
Microplastics and antibiotics were frequently detected in the effluent of sand filtration, while the presence of microplastics may change the interactions between the antibiotics and the quartz sands. However, the influence of microplastics on the transport of antibiotics in sand filtration has not been revealed. In this study, ciprofloxacin (CIP) and sulfamethoxazole (SMX) were respectively grafted on AFM probes to determine the adhesion forces to the representative microplastics (PS and PE) and the quartz sand. CIP and SMX exhibited low and high mobilities in the quartz sands, respectively. Compositional analysis of the adhesion forces indicated that the lower mobility of CIP in sand filtration columns could be attributed to the electrostatic attraction between the quartz sand and CIP compared with repulsion for SMX. Moreover, the significant hydrophobic interaction between the microplastics and the antibiotics could be responsible for the competitive adsorption of the antibiotics to the microplastics from the quartz sands; meanwhile, the π-π interaction further enhanced the adsorption of PS to the antibiotics. As a result of the high mobility of microplastics in the quartz sands, the carrying effect of microplastics enhanced the transport of antibiotics in the sand filtration columns regardless of their original mobilities. This study provided insights into the mechanism of the microplastics on enhancing the transport of antibiotics in sand filtration systems from the perspective of the molecular interaction.
研究领域:
环境科学
·
化学
·
材料科学
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DOI
高影响因子
MINERALS ENGINEERING
·
2019
·
IF 3.315
Wenjie Zou,Lu Gong,Jun Huang,Mingfei Pan,Zhenzhen Lu,Chunbao Sun,Hongbo Zeng
Selective flocculation is an efficient separation method for processing fine coal. In this work, one type of hydrophobically modified polyacrylamide, poly(AM-NaAA-C 16 DMAAC) (HMPAM), was synthesized and used as flocculants of coal. The adsorption and interaction of HMPAM on model coal surface under the influence of KCl concentration were compared with a commercial polyacrylamide (PAM) using quartz crystal microbalance with dissipation monitoring (QCM-D), multi-angle laser light scattering (MALLS) and atomic force microscope (AFM). The QCM-D results showed that the adsorption amounts of both PAM and HMPAM on model coal surface increased with increasing KCl concentration, and the amount of HMPAM was much higher than that of PAM in 100 mM KCl solution. This result could be due to the fact that the high salinity (e.g., 100 mM KCl) led to the compressed conformation of the polymers and significantly compressed electric double layer repulsion. The conformational changes were determined using MALLS. The AFM force measurement results showed that the adhesion between the polymers and model coal surface increased with increasing the KCl concentrations due to the compressed electric double layer, and the average adhesion of PAM was about one order of magnitude smaller than that of HMPAM. Such difference was mainly ascribed to the hydrophobic attraction between the hydrophobic chain of HMPAM and model coal surface. Meanwhile, the attractive hydrophobic interaction between the hydrophobic chains induced the formation of multiple layers of HMPAM, which was in consistence with the QCM-D results. The fundamental insights into the interaction mechanisms of HMPAM/PAM on model coal surface will benefit the rational development of effective polymer additives for fine coal preparation.
研究领域:
矿物加工工程
·
界面化学
·
高分子化学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Jiqiang Wang,Yongda Yan,Shunyu Chang,Yimin Han,Yanquan Geng
Lysozyme plays an important role in the innate immune system of animal or human body, thus, it is vital to detect it using a high sensitivity and efficiency approach in clinic. Nanostructure-based Surface-enhanced Raman scattering (SERS) substrate is often employed to detect biomolecules. In this study, a nanodots array structure, which was utilized as a micro-nano hybrid SERS substrate, was fabricated using second-scan scratching strategy with AFM-probe. The dependence of the nanodots structure on the machining parameters such as applied normal loads and scratching angles were investigated. The effects of the nanostructure feature sizes and the Au film thickness on the measured SERS spectra that tested using Rhodamine 6G (R6G) were studied. In addition, different drying temperatures and concentrations of NaNO 3 solution were used to study the absorption manner of lysozyme on an Ag substrate. The SERS spectra of a binary protein mixture, which includes lysozyme and insulin, were also investigated based on the fabricated nanostructures. Results showed that the substrates fabricated using AFM nanomachining approach may promote the SERS application in biologic field.
研究领域:
生物医学
·
纳米技术
·
光谱学
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产品关联
DOI
高影响因子
Petroleum Science
·
2023
·
IF 5.6
Zhong-Zheng Xu,Ming-Wei Zhao,Yi-Ning Wu,Jia-Wei Liu,Ning Sun,Zi-Zhao Wang,Yi-Ming Zhang,Lin Li,Cai-Li Dai
The membrane method based on adaptive wettability shows great advantages in oil-water separation. At present, researches focus on the excellent application performance of the membrane material, while the quantitative analysis of interactions in oil-water separation is rarely recognized. Herein, we constructed an adaptable wettability membrane with multiple polymer networks by polydopamine (PDA) and mussel-inspired amphiphilic polymer. Based on the Owens three-probe liquid method, the surface energy of the modified membrane was verified to meet the adaptive wettability conditions, with surface energies ( γ S ) of 147.6 mJ m −2 (superhydrophilic/underwater superoleophobic) and 49.87 mJ m −2 (superhydrophobic/superoleophobic), respectively. The adhesion or repulsion of the membrane to the oil phase under different conditions during the separation process was quantified by the chemical probe AFM technique. In addition, the oil-water selective separation mechanism was further analyzed in a simplified membrane microchannel model. The results show that the different wetting produces capillary additional pressure in opposite directions, resulting in different energies to be overcome when the oil or water passes through the microchannels, thus achieving selective separation.
研究领域:
材料科学
·
环境科学
·
界面化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）