ANALYTICA CHIMICA ACTA
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2025
·
IF 6
Zhihui Zhong,Qinglei Cui,Tangsheng Guan,Hongyu Wen,Yu-xin Chen,Yu-Xin Ye,Jianqiao Xu,Gangfeng Ouyang
Background Aggregation-induced emission luminogens (AIEgens) exhibit efficient fluorescence in the aggregated state, making them promising candidates for bioimaging applications. However, their inherently hydrophobic structures often lead to uncontrollable aggregation, hindering their delivery to target sites for imaging. Researchers have developed strategies to enhance the water solubility of AIEgens through either structural modification or carrier-based encapsulation. However structural modification methods involve complicated synthesis and macrocycles often show low encapsulation efficiency toward AIEgens. Improving the water solubility of AIEgens for bioimaging requires simple yet effective strategies. Results We report a novel supramolecular encapsulation approach utilizing water-soluble metal–organic cages (MOCs) as host carriers for AIEgens. Encapsulation significantly prevented the aggregation of AIEgens, enabling their uniform dispersion in aqueous matrices. The AIEgens@MOC complex exhibited excellent structural stability across broad ranges of pH (5.0-9.0), temperature (10°C-80°C), and time (over 14 days) prior to bisulfite (HSO 3 - ) stimulation, confirming the stable host–guest interaction. Upon stimulation with HSO 3 - , the disassembly of MOC led to the release of AIEgens, which subsequently aggregated and exhibited significantly enhanced fluorescence within 60 s. The new AIEgens@MOC complex enabled the succeeded visualization of abnormal intracellular HSO 3 - fluctuations ( > 20 μM). Moreover, the low cytotoxicity of AIEgens@MOC facilitated its application as an intracellular imaging probe for HSO 3 - , with the capability of specific lysosomal localization. Significance We have developed a simple and effective strategy to improve the water solubility of AIEgens for bioimaging of important biomarkers in live cells. This method avoided complex chemical modifications, and enabled efficient detection of HSO 3 - in biological systems. By selecting MOCs with appropriate cavity sizes, this strategy is promising to accommodate various AIEgens in the future, offering a generalizable solution to facilitate their bioimaging applications.
研究领域:
超分子化学
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生物成像
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材料科学
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有机电子学
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 18
·10440
·
IF 6.208
Yingxiang Zhai,Jiguo Zhang,Jian Li,Shouxin Liu,Zhijun Chen,Shujun Li
The potential for leakage of liquid electrolytes from magnesium (Mg) batteries represents a large hurdle to future application. Despite this, there are no efficient sensing technologies to detect the leakage of liquid electrolytes. Here, we developed a sensor using laccaic acid (L-AIEgen), a naturally occurring aggregation-induced emission luminogen (AIEgens) isolated from the beetle Laccifer lacca. L-AIEgen showed good selectivity and sensitivity for Mg2+, a universal component of electrolytes in Mg batteries. Using L-AIEgen, we then produced a smart film (L-AIE-F) that was able to sense leakage of electrolytes from Mg batteries. L-AIE-F showed a strong “turn-on” AIE-active fluorescence at the leakage point of electrolyte from model Mg batteries. To the best of our knowledge, this is the first time that AIE technology has been used to sense the leakage of electrolytes.Keywords:laccaic acid;aggregation-induced emission;smart film;detect of Mg2+
研究领域:
材料科学
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化学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Shunni Dong,Qiguang Zang,Zhao-Yu Ma,Meiqi Tang,Zhi-Kang Xu,Jingjing Nie,Binyang Du,Jing Zhi Sun,Ben Zhong Tang
The proposal of the aggregation-induced emission (AIE) effect shines a light on the practical application of luminescent materials. The AIE-active luminescence microgels (TPEC MGs) with photo-induced color-changing behavior were developed by integrating positively charged AIE luminogens (AIEgens) into the anionic network of microgels, where AIEgens of TPEC were obtained from the quaternization reaction between tetra-(4-pyridylphenyl)ethylene (TPE-4Py) and 7-(6-bromohexyloxy)-coumarin. The aqueous suspensions of TPEC MGs exhibit a significant AIE effect following the enhancement of quantum yield. In addition, further increase in fluorescence intensity and blueshift occur at elevated temperatures due to the collapse of microgels. The distinctive photochromic behavior of TPEC MGs was observed, which presents as the transition from orange-yellow to blue-green color under UV irradiation, which is different from TPEC in good organic solvents. The phenomenon of color changing can be ascribed to the competition between photodimerization of the coumarin part and photocyclization of TPE-4Py in TPEC. The photochromic TPEC MG aqueous suspensions can be conducted as aqueous microgel inks for information display, encryption, and dynamic anticounterfeiting.
研究领域:
材料科学
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光学
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产品关联
DOI
PubMed
高影响因子
Advanced Optical Materials
·
2021
·Vol. 9
·期 22
·2101092
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IF 9.926
Min Ge,Shiyan Han,Yanli Ma,Jian Li,Shouxin Liu,Zhijun Chen,Shujun Li
Mechanofluorochromic carbon dot-based aggregation-induced emission luminogens (M-CD-AIEgens) are attracting much attention because of their many potential practical applications. However, the mechanofluorochromic response of current M-CD-AIEgens only occurs under high pressure, which greatly hinders their practical applications. To overcome this shortcoming, more pressure-sensitive M-CD-AIEgens are now developed, which show approximately fivefold enhancement of photoluminescence quantum yield after grinding. This enhancement of photoluminescence is attributed to the weakening of π–π stacking interactions between the carbon dots, which is caused by the grinding process. To illustrate a potential application of their interesting properties, M-CD-AIEgens are incorporated into a poly( e -caprolactone) matrix to prepare self-sensing sustainable plastics, which are able to dynamically sense the external pressure distribution when subjected to strain.
研究领域:
材料科学
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纳米技术
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光电材料
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可持续材料
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2022
·
IF 10.383
Yunxia Wang,Min Ren,Ying Li,Feng Liu,Yu Wang,Zhijun Wang,Liheng Feng
Diseases caused by bacterial infections are increasingly threatening human health. As a major part of the microbial family, Gram-positive bacteria induce severe infections in hospitals and communities. Therefore, developing antibacterial materials that can recognize bacteria and specifically kill them is significant to cope with fatal bacterial infection. To this end, we designed and prepared a series of positively charged photosensitizers with an aggregation-induced emission feature and a type I reactive oxygen species (ROS) generation ability. Based on a molecular engineering strategy, the PS abbreviated to MTTTPy that owns a superior ROS generation ability and red emission in aggregation is obtained by adjusting bridging groups. Due to the unique molecular structure, MTTTPy can sensitively and specifically recognize and light up Gram-positive bacteria through electrostatic adsorption and void permeability. In addition, it can kill 95% of the recognized bacteria at a low concentration of 0.5 μM by generating oxygen-independent ROS under white light irradiation. Both in vitro and in vivo studies verify the sensitive and specific recognition and killing effect of MTTTPy toward Gram-positive bacteria. This work provides superior material-integrated diagnosis and treatment for Gram-positive bacteria-caused infectious diseases and shows potential for addressing bacterial resistance.
研究领域:
材料科学
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生物医学工程
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微生物学
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药学
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DOI
PubMed
高影响因子
MACROMOLECULES
·
2021
·
IF 5.985
Jing Wang,Qian Jiang,Shuang Cao,Chenchen Sun,Yuping Zhang,Yuan Qiu,Hong Wang,Guochuan Yin,Yonggui Liao,Xiaolin Xie
The structure–property relationship of luminescent liquid crystalline polymers (LLCPs) with AIEgens has attracted much attention. However, the effect of the AIEgen configuration on the properties is still unclear because of the difficulty in designing LLCPs with a single configuration. In addition, it is expected that this effect can be amplified through constructing the AIEgen on the backbone of LLCPs. Herein, for the first time, we have synthesized two kinds of main-chain polyesters with a single configuration of an AIEgen, E-PM7 and Z-PM7, via melt polycondensation. Interestingly, E-PM7 shows two coexisting phases of rectangular columnar and smectic liquid crystalline phases, whereas Z-PM7 exhibits no liquid crystalline properties. Moreover, E-PM7 with AIE behavior and liquid crystalline properties can be used to prepare fluorescent patterns printed on flexible films and glass substrates through the photocyclization of AIE units, which endows this kind of material with promising applications ranging from anti-counterfeiting to information storage.
研究领域:
材料科学
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化学
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DOI
高影响因子
Science China-Chemistry
·
2024
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IF 10.4
Chen Pu,Shan Guogang,Nie Qingli,Yan Yuting,Zhang Pengfei,Zhao Zujin,Feng Hai-Tao,Tang Ben Zhong
Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. Herein, two dual-emissive aggregation-induced emission luminogens (AIEgens) with donor-π-acceptor structures were designed and synthesized, namely QT-1 and QF-2 . Both two AIEgens exhibited excitation wavelength-dependence defying the Kasha’s rule, and could stain lipid droplets (LDs) and mitochondria in blue and red fluorescence, respectively. Moreover, thanks to the near-infrared emission and abundant reactive oxygen species (ROS) generation efficiency of QT-1 , it was chosen as a photodynamic therapy agent to selectively kill cancer cells from normal cells. Upon light irradiation, an obvious decrease of mitochondrial membrane potential (MMP) and serious change of mitochondrial shape in cells were observed, which corresponded to the efficient inhibition of tumor growth in vivo . This work afforded a promising strategy for the construction of multicolor emission by tuning anti-Kasha behaviors and expanding their application in dual-organelle targeting-based phototheranostics.
研究领域:
生物化学
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医学影像
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肿瘤学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 9
·1418-1426
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IF 7.571
Hongsen Wang,Yu Wang,Zhaohui Zheng,Fang Yang,Xiaobin Ding,Aiguo Wu
The development of a multifunctional single molecule phototherapeutic agent with excellent fluorescence imaging, photothermal therapy and photodynamic therapy at the same time is still a challenging task, which mainly arises from the low absorbance of the molecule, and the complexity of energy dissipation and molecular design. Herein, four donor–acceptor (D–A) compounds were synthesized by linking triphenylamine (TPA), thiophene/thieno[3,2-b]thiophene and different cyano acceptor structures. In this design, we propose a molecular design strategy to redshift absorption and increase the molar extinction coefficient (ε) by enhancing electron-withdrawing acceptors and enlarging the π-conjugation plane unit. Due to the twisted structure of TPA, these compounds exhibit aggregation-induced emission (AIE) characteristics. Notably, these AIEgens have long emission wavelengths, excellent photostability, biocompatibility, photothermal stability and singlet oxygen (1O2) generation performance. Among them, the photothermal conversion efficiency of a compound (named TCF-SS-TPA NPs) can reach 84.5%. Cellular internalization and therapy showed that TCF-SS-TPA NPs have good biocompatibility, excellent cell bioimaging and cancer phototherapy capabilities in vitro. This study will stimulate the molecular design of multifunctional phototherapeutics to realize effective synergistic cancer therapy.
研究领域:
生物医学工程
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分子设计
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2024
·
IF 15.8
Jiayi Bian,Yingjie Xu,Minghao Sun,Zerui Ma,Hao Li,Changrui Sun,Fei Xiong,Xiaopeng Zhao,Wenjing Yao,Yue Chen,Yuanyuan Ma,Xikuang Yao,Shenghong Ju,Wenpei Fan
Accurate imaging and precise treatment are critical to controlling the progression of pancreatic cancer. However, current approaches for pancreatic cancer theranostics suffer from limitations in tumor specificity and invasive surgery. Herein, a pancreatic cancer-specific phototheranostic modulator (AuHQ) dominated by aggregation-induced emission (AIE) luminogens-tethered gold nanoparticles is meticulously designed to facilitate prominent fluorescence-photoacoustic bimodal imaging-guided photothermal immunotherapy. Once reaching the pancreatic tumor microenvironment (TME), the peptide Ala-Gly-Phe-Ser-Leu-Pro-Ala-Gly-Cys (AGFSLPAGC) linkage within AuHQ can be specifically cleaved by the overexpressed enzyme Cathepsin E (CTSE), triggering the dual self-assembly of AuNPs and AIE luminogens. The aggregation of AuNPs mediated by enzymatic cleavage results in potentiated photothermal therapy (PTT) under near-infrared (NIR) laser irradiation, induced immunogenic cell death (ICD), and enhanced photoacoustic imaging. Simultaneously, AIE luminogen aggregates formed by hydrophobic interaction can generate AIE fluorescence, enabling real-time and specific fluorescence imaging of pancreatic cancer. Furthermore, coadministration of an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with AuHQ can address the limitations of PTT efficacy imposed by the immunosuppressive TME and leverage the synergistic potential to activate systemic antitumor immunity. Thus, this well-designed phototheranostic modulator AuHQ facilitates the intelligent enzymatic dual self-assembly of imaging and therapeutic agents, providing an efficient and precise approach for pancreatic cancer theranostics.
研究领域:
生物医学工程
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癌症治疗
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纳米技术
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成像科学
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免疫学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 41
·9533-9543
·
IF 5.344
Fei Zhang,Zhe Li,Yaoming Liu,Binsheng Yang,Hui Qiao,Jie Chai,Guangming Wen,Bin Liu
Organic light-emitting materials with aggregation-induced emission (AIE) character have experienced a rapid development in imaging, visualization and sensing. In this paper, by installing rotors to an aggregation-caused quenching (ACQ) compound, we constructed an AIE luminogen (AIEgens) system (A2–A4, B1–B3) with wide emission tunability, which covers almost all regions of visible light (400–780 nm). The calculated energy gap of the compounds is consistent with the value of the absorption transition. In the biological experiments, B3 showed excellent lipid droplet (LD) targeting ability in PC12 cells, and higher photostability compared with the commercial LDs bioprobe. Moreover, as a hydrophobic compound, B3 can distinguish blood from a hyperlipidemia patient and normal people. Thus, this study provides a strategy to construct red/NIR fluorescent materials with AIE character, and further apply it to identify the blood of people with hyperlipidemia.
研究领域:
生物化学
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材料科学
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医学影像
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产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2018
·Vol. 10
·期 46
·5486-5492
·
IF 2.073
Yunsuo Kuang,Linfeng Chen,Xike Tian,Yong Li,Liqiang Lu,Chao Yang,Zhaoxin Zhou,Yulun Nie
In this study, three novel fluorophores with aggregation-induced emission effects (AIE) have been synthesized by a new strategy that uses the non-AIE active compound 3,5-dibromobenzaldehyde (DBB) as a core (stator). This new strategy is completely different from the traditional synthetic process of AIE compounds that rely heavily on the modification of the classic existing AIE core such as archetypal silole, tetraphenylethene and distyrylanthracene. The obtained DBB derivatives (S1, S2 and S3) display typical AIE characteristics in which their quantum yields in the solid state are much higher than that in the solution. In addition, the emission can be fine-tuned by varying the rotor on the DBB skeleton, and a significant Stokes shift from 395 nm to 434 nm can be observed with the increase of the conjugate structure from S1 to S3. Furthermore, S1, S2 and S3 showed an exclusively selective turn-on response to As3+, and the detection limits are lower than the guideline of As3+ in drinking water, permitted by the EPA. This study will be instructive in providing a strategy for the synthesis of AIE luminogens, which not only greatly enrich the species of AIE compounds, but also broaden their application.
研究领域:
化学
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材料科学
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环境科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Shengfeng Ye,Wenjing Zhang,Zhaolan Zhai,Shibin Shang,Lixin Huang,He Liu,Zhanqian Song,Jianxin Jiang
Supramolecular hydrogels with aggregation-induced emission (AIE) activity are attracting significant attention due to their unique properties and promising application potential. However, using nonplanar conjugated molecules to self-assemble into ordered nanostructures remains a substantial challenge. In this study, a series of amphiphilic maleopimaric acid-derived Schiff bases (MPASA-R, R = H, 4Cl, 5Cl, 5Br, 5I, and 5-NO 2 ) with AIE characteristics were easily synthesized from rosin. Changing the substituents significantly affected the molecular arrangement and the excited-state molecular motion, thereby altering the photophysical properties and photochromic behaviors of MPASA-R. Notably, MPASA-5Br in the solid state exhibited quick and obvious visualized photochromic behaviors and excellent fatigue resistance, making it an ideal material for encryption-decryption applications. Interestingly, the strong hydrophobic interactions and large geometrical restrictions of the rosin skeleton promoted MPASA-R to self-assemble into chiral nanofibers in alkaline conditions. AIE supramolecular hydrogels were further obtained, the fluorescence properties and mechanical strength of which could be regulated by changing substitutions or concentration. Furthermore, the obtained AIE supramolecular hydrogels exhibited excellent injectable ability and high temperature resistance, which could be shaped on demand and remain unchanged mechanical properties and intense fluorescence at 90 °C. The present work not only provides novel biobased encrypted materials but also proposes an effective strategy based on the strong aggregation of the rosin skeleton for preparing AIE supramolecular hydrogels.
研究领域:
材料化学
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生物医学工程
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产品关联
DOI
高影响因子
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