POLYMER
·
2019
·
IF 3.771
Jiemei Zhou,Chenxu Zhang,Cailong Shen,Yong Wang
Block copolymers (BCPs) are interesting precursors to nanoporous films with well-defined and tunable porosities. So far, BCPs with polystyrene (PS) as the majority block are predominantly used, hindering the using of produced nanoporous films at elevated temperatures. Herein, we propose to use BCPs with poly (styrene- alt - N -phenylmaleimide) (P( S - alt -NMI)) as the majority block to develop thermally stable nanoporous films considering that this alternative copolymer has a much higher glass transition temperature than PS. We synthesized BCPs of poly (2-dimethylaminoethyl methacrylate) (PDMAEMA) and P( S - alt -NMI) (PDMAEMA- b -P( S - alt -NMI)) with four different block ratios by reversible addition-fragmentation chain transfer (RAFT) polymerization. The swelling behaviors of these BCPs in various solvents were investigated, and we found that nanoporosities will be generated in the BCP films following the mechanism of selective swelling induced pore generation when single solvents or solvent pairs having strong affinity to PDMAEMA and moderate affinity to P( S - alt -NMI) were used as the swelling agents. The pore sizes and porosities of thus-produced nanoporous films can be flexibly tuned by changing the compositions of the BCPs and the swelling conditions. Because of the excellent thermal stability of P( S - alt -NMI) blocks the nanoporous BCP films exhibited excellent thermal tolerance and they maintained intact at a temperature as high as 158 °C while the PS-based BCPs started to deform at the temperature of 75 °C. This thermal tolerance is very much desired in many applications, for example, high-temperature disinfection for medical purposes.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Naizhen Zhou,Xiaoe Ma,Wanjun Hu,Pengfei Ren,Youliang Zhao,Tianzhu Zhang
The extracellular matrix (ECM) affects cell behaviors, such as survival, proliferation, motility, invasion, and differentiation. The arginine-glycine-aspartic acid (RGD) sequence is present in several ECM proteins, such as fibronectin, collagen type I, fibrinogen, laminin, vitronectin, and osteopontin. It is very critical to develop ECM-like substrates with well-controlled features for the investigation of influence of RGD on the behavior of tumor cells. In this study, poly(ethylene glycol) (PEG)-crosslinked poly(methyl vinyl ether- alt -maleic acid) (P(MVE- alt -MA)) hydrogels (PEMM) with different RGD contents were synthesized, fully characterized, and established as in vitro culture platforms to investigate the effects of RGD content on cancer stem cell (CSC) enrichment. The morphology, proliferation, and viability of SK-OV-3 ovarian cancer cells cultured on hydrogels with different RGD contents, the expression of CSC markers and malignant signaling pathway-related genes, and drug resistance were systematically evaluated. The cell aggregates formed on the hydrogel surface with a lower RGD content acquired certain CSC-like properties, thus drug resistance was enhanced. In contrast, the drug sensitivity of cells on the higher RGD content surface increased because of less CSC-like properties. However, the presence of RGD in the stiff hydrogels (PEMM2) had less effect on the stemness expression than did its presence in the soft hydrogels (PEMM1). The results suggest that RGD content and matrix stiffness can lead to synergetic effects on the expression of cancer cell stemness and the epithelial-mesenchymal transition (EMT), interleukin-6 (IL-6), and Wnt pathways.
研究领域:
生物材料
·
癌症生物学
·
细胞生物学
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2010
·
IF 3.019
Xiaoya Liu,Chenglin Yi,Ye Zhu,Yiqun Yang,Jinqiang Jiang,Zhenggang Cui,Ming Jiang
A new type of copolymer containing two alternating segments, poly-(styrene- alt -maleic anhydride)- co -poly (7-(4-vinylbenzyloxyl)-4-methylcoumarin- alt -maleic anhydride) P(St- alt -MAn)-co-P(VM- alt -MAn)(PSMVM), was prepared. The copolymer self-assembled into nanoparticles with internal microphase structures in water because the hydrophilicity of segment P(VM- alt -MAn) is higher than that of P(St- alt -MAn). The particle size, morphology, ζ potential and surface properties and their dependence on the pH and slat concentrations were studied with a combination of techniques. The nanoparticles of PSMVM showed surface activity and pH sensitivity for producing Pickering oil-in-water emulsions. The emulsion volume increased and the size of oil/water droplet decreased with increasing salt concentration. Furthermore, cross-linked nanoparticles (CLPs) were obtained by photo-dimerization of the pendent coumarin groups in PSMVM under UV irradiation. The emulsions produced by using the CLPs as emulsifiers showed even better stability upon standing. Solid oil-phase droplets were obtained by preparation of CLPs-stabilized Pickering emulsions with an oil phase of styrene containing the initiator AIBN followed by the polymerization of styrene. Thus, the enrichment and aggregation of the CLPs on the emulsion droplets was visible because the solid droplets remained unchanged during the SEM sample preparation.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
MACROMOLECULES
·
2019
·
IF 5.997
Meng Wang,Wei-Wei Bao,Wen-Ying Chang,Xu-Man Chen,Bao-Ping Lin,Hong Yang,Er-Qiang Chen
In recent years, sequence-controlled side-chain liquid crystal polymers (SCLCPs) have gained extensive interest because mesogenic units with different lengths and distributions can form various ordered sequences, which further endow LCP materials with diverse functions. In this manuscript, a side-chain side-on maleimide-containing monomer 2,5-bis-(4-butoxy-benzoyloxy)-benzoic acid 6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexyl ester (Y1801) and a side-chain end-on styrene-containing monomer 4′-[6-(4-vinyl-phenoxy)-hexyloxy]-biphenyl-4-carbonitrile (Y1802) are combined in one single macromolecular chain and orderly polymerized in an alternative sequence to form an alternating copolymer Poly(Y1801-alt-Y1802). The chemical structure and alternating sequence of Poly(Y1801-alt-Y1802) are confirmed by GPC and NMR techniques. The combination of DSC, POM, and WAXS data indicates that, although the side-on homopolymer PY1801 and the end-on homopolymer PY1802 both exhibit the nematic phase, their alternating copolymer Poly(Y1801-alt-Y1802) shows an interdigitated smectic A phase, a compromised molecular arrangement instead. In addition, a strong fluorescence emission of Poly(Y1801-alt-Y1802) is observed, which might provide this novel alternating-structured liquid crystal polymer with potential applications in luminescent materials and devices.
研究领域:
高分子化学
·
材料科学
·
液晶物理
·
功能高分子
·
光电功能材料
✓ 已验证
DOI
高影响因子
CURRENT TOPICS IN MEDICINAL CHEMISTRY
·
2024
·
IF 2.9
Su Hongbing,Lei Hong,Cao Ling,Zhou Xiaoying,Liu Yumeng,Li Ying,Yan Lili,Shaowa Lv,Wang Yanhong,Guan Qingxia
Background: Self-emulsifying nano-phase of traditional Chinese medicine are a research
hotspot. Xiao-Chai-Hu decoction is a commonly used compound decoction in clinical practice,
which is of great research significance. The aim of this study was to isolate and characterize
the self-emulsifying nano-phase and other phases of Xiao-Chai-Hu decoction, and to study the effects
of each phase on acute liver injury.
Methods: The liquid medicine was prepared employing centrifugation followed by dialysis. Single-
factor investigation methodology was utilized to optimize the preparation parameters for both
phases. Characterization of the formulated phase involved analyses such as surface morphology assessment,
measurement of nanoparticle size and Zeta potential using an analyzer, observation of
the Tyndall effect, conducting diffusion and dilution tests, examination under a microscope, and
structural visualization via transmission electron microscopy (TEM). Furthermore, an acute liver
injury model was established in rats through intraperitoneal injection of D-Galactosamine (D-Gal-
N). To assess hepatic function and oxidative stress status, serum levels of alanine aminotransferase
(ALT) and aspartate aminotransferase (AST), superoxide dismutase (SOD) activity, and
malondialdehyde (MDA) content in liver tissue were quantified. The liver coefficients for each
group were calculated as an additional parameter. For histopathological evaluation, liver tissue sections
from the experimental group were stained with Hematoxylin and Eosin (H&E) and examined
microscopically under light conditions. These revisions aim to enhance clarity, correct minor
grammatical errors (such as capitalization of “HE” to “H&E”), and ensure a smoother flow of
information without altering the scientific content of your original text.
Results: Successful establishment and separation of four distinct phases were achieved, including
the self-emulsifying nano-phase, precipitation phase, suspension phase, and true solution phase.
The self-emulsifying nano-phase was characterized as spherical particles with an average diameter
of approximately 100 nm. Pharmacodynamic assessments revealed that both Xiao-Chai-Hu decoction
and its self-emulsifying nano-phase significantly reduced liver coefficients and alanine aminotransferase
(ALT) levels compared to controls (P<0.05). However, no statistically significant differences
were observed in regards to aspartate aminotransferase (AST) concentrations, malondialdehyde
(MDA) content, or superoxide dismutase (SOD) activity between the treatment groups
and control (P>0.05). These findings indicate that both Xiao-Chai-Hu decoction and its self-emulsifying
nano-formulation ameliorated D-GalN-induced acute liver injury, albeit without statistically
distinguishable efficacy between them (P>0.05).
Conclusion: The presence of a self-emulsifying nano-phase within Xiao-Chai-Hu decoction is
confirmed, and this nano-phase emerges as a therapeutically efficacious component in mitigating
acute liver injury.
研究领域:
中药学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2015
·
IF 2.858
Guangpu Liu,Xinquan Liu,Yongchun Zhang,Fang Zhang,Ting Wei,Min Yang,Kaiming Wang,Yongjie Wang,Na Liu,Huiling Cheng,Zhongxi Zhao
Jujube polysaccharides have been proved to have various bioactivities. This study was designed to evaluate the chemical composition and hepatoprotective function of the polysaccharides extracted from Zizyphus jujube cv. Huanghetanzao (HJP). The composition of HJP was determined as heteropolysaccharides with galactose and arabinose being the main components. The pretreatment of mice with HJP significantly ( p < 0.01) reduced the activities of serum hepatic AST, ALT, and LDH induced by CCl 4 or acetaminophen (APAP) while the commercial liver-injury treatment drug silybin did not show any prevention effects. Mechanistic study results indicate that the administration of the CCl 4 - or APAP-injured mice with HJP enhanced SOD and GSH-Px and decreased MDA, indicating that anti-oxidation and detoxification could be the pathways for the liver protection observed. In addition, the liver prevention and treatment effects of HJP on the liver damage induced by CCl 4 or APAP obtained from the liver enzyme analyses were confirmed by the hepatic histopathology studies in mice. Therefore, HJP could be used as a prevention and treatment agent for liver injury induced by liver toxic chemicals and drugs.
研究领域:
食品科学与工程
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
iScience
·
2021
·
IF 5.458
Zhizheng Zhao,Qiang Che,Kexin Wang,Mohamed E. El-Khouly,Jiaxuan Liu,Yubin Fu,Bin Zhang,Yu Chen
Polymer memristors are preeminent candidates for low-power edge computing paradigms. Poly[chalcogenoviologen- alt -triphenylamine] (PCVTPA) has been synthesized by direct coupling of chalcogeno-viologen as electron acceptor and 4-(bromomethyl)-N-(4-(bromo-methyl)phenyl)-N-phenylaniline as electron donor. The introduction of chalcogen atoms (S, Se, Te) into viologen scaffolds can greatly improve electrical conductive, electrochemical, and electrochromic properties of the materials when compared with the conventional viologens. Taking PTeVTPA as an example, the as-fabricated electronic device with a configuration of Al/PTeVTPA/ITO exhibits excellent multilevel storage and history-dependent memristive switching performance. Associated with the unique memristive behavior, the PTeVTPA-based device can not only be used to emulate the synaptic potentiation/depression, the human's learning and memorizing functions, and the transition from short-term synaptic plasticity to long-term plasticity but also carry out decimal arithmetic operations as well. This work will be expected to offer a train of new thought for constructing high-performance synaptic biomimicking and neuromorphic computing system in the near future.
研究领域:
材料科学
·
神经科学
·
电子工程
✓ 已验证
DOI
PubMed
高影响因子
Polymer Chemistry
·
2025
·Vol. 16
·期 42
·4686-4695
·
IF 3.9
Ranran Gao,Qu Wang,Qian Li,Chenchi Hua,Xiaoning Guo,Li Wang,Wantai Yang
Stimuli-responsive aggregation-induced emission (AIE) active polymers hold great promise for a wide range of future applications. In the present work, an efficient post-polymerization modification approach was developed to synthesize AIE-active polymers with commercial poly(ethylene-alt-maleic anhydride) (PEM) as the parent polymer and 2-(4-(1,2,2-triphenylvinyl)phenoxy)ethan-1-amine as a model modification reagent. By performing hydrolysis, amidation, or esterification reactions on the maleic anhydride groups, we obtained four types of tetraphenylethylene-appended PEM derivatives successfully. The PEM derivatives displayed wide range-tunable pH-responsive emission characteristics as well as CO2- and H2O2-responsive photoluminescence depending on the functional side groups introduced. These intriguing results highlight the effectiveness and importance of post-polymerization modification in obtaining highly customizable structures and ‘signaling’ performance in stimuli-responsive AIE-active polymers.
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9
Mengjie Qian,Zhiguo Yan,Man Xu,Cunwen Wang,Yanbo Li
Synthesis of nanofiltration membranes with antifouling performance using simple and green methods is crucial for nanofiltration membrane development. This work presents a novel type of poly (methyl vinyl ether- alt -maleic anhydride) (PMVE-MA) based composite nanofiltration membrane with promising anti-fouling performance. The membranes were synthesized by co -depositing mixed solutions of PMVE-MA and amino silane coupling agents on porous polyethersulfone (PES) supports, followed by thermal annealing. The selective layer was formed on the PES support through nucleophilic addition of amines to anhydrides, coupling with silane hydrolysis-condensation under acid catalysis. The performance of the membranes was adjusted by controlling the concentration of PMVE-MA, the concentration of sulfuric acid, and the mass ratio of PMVE-MA to amino silane coupling agents. Under an optimal condition, a tight (PMVE-MA)-APTES/PES membrane with water permeance of 7.9 L m −2 h −1 bar −1 and a MWCO of 330 Da was obtained. The rejection of Na 2 SO 4 of the membrane reached 92 %. The anti-fouling test under filtration of bovine serum protein (BSA) showed the membrane had a high-water flux recovery rate of 99.3 %, indicating an excellent antifouling performance. This work highlights the potential of using PMVE-MA as a material for antifouling nanofiltration membrane design.
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产品关联
DOI
高影响因子
RSC Advances
·
2014
·Vol. 5
·期 2
·1564-1570
·
IF 3.708
Wei Wei,Ting Wang,Chenglin Yi,Jingcheng Liu,Xiaoya Liu
Branched copolymer self-assembled micelles, based on amphiphilic branched poly(styrene-alt-maleic anhydride) (BPSMA) synthesized by a one-pot method, are prepared and employed as particulate emulsifiers to stabilize the white oil-in-water Pickering emulsions. The influences of micelle concentration, branching degree, salinity, and oil type on the emulsifying performance of self-assembled micelles are comprehensively investigated, and the distinction between BPSMA micelles and linear poly(styrene-alt-maleic anhydride) (LPSMA) self-assembled micelles on the micellar structure and emulsifying performance is also studied. The results show that the branched structure of the copolymer plays an important role in emulsification. The emulsifying performance of BPSMA micelles is superior to that of LPSMA micelles, reflected in the emulsifying efficiency and the long-term stability of emulsions. It is attributed to the much better structural stability of BPSMA micelles compared to LPSMA micelles, which is probably due to the postponing of hydrolyzing of maleic anhydride and ionization of carboxyl to some extent caused by the introduction of the branched structure in copolymers. It is also worth noting that, salinity has a great effect on the emulsifying performance of LPSMA micelles, but little impact on that of BPSMA micelles. Additionally, BPSMA micelles can also well stabilize the oil-in-water emulsions with some other types of natural oils. Thus the findings are not only of theoretical interest but also of great practical application in the cosmetics area.
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产品关联
DOI
高影响因子
POLYMER SCIENCE SERIES B
·
2020
·Vol. 62
·期 4
·368-374
·
IF 0.976
Qian Zhao,Zhan Yi-Kai,Liu Yu-Fei,He Min,Gong Yong-Ji
Abstract Poly( N -(3-carboxyphenyl)maleimide- alt -styrene) with superior heat-resistance was synthesized by free radical copolymerization and its structure was confirmed by FTIR and NMR spectroscopy. To show the advantages in heat-resistance of the synthesized copolymers, the thermal properties of poly( N -phenylmaleimide- alt -styrene) and poly( N -phenylmaleimide- alt -maleic anhydride) with similar structures were determined. DSC/TG analysis showed that the synthesized copolymer exhibited the better thermal properties than two other copolymers due to the formation of a chemically crosslinked three-dimensional network during heating.
研究领域:
高分子化学
·
材料科学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Jiayi Xin,Ziyang Song,Bo Zheng,Jiawen Hu,Changwen Zhao,Dong Chen,Wantai Yang
In recent years, synthetic polymers have become integral to modern society, but their improper disposal has led to significant environmental challenges. Therefore, it is of great significance to investigate the environmental impact of polymer waste. Herein, we conducted comprehensive research on the biodegradability of poly(styrene-alt-maleic anhydride) (PSM) when exposed to soil and microbes, as well as its toxic effects on soybean seedlings and Eisenia fetida. The biodegradation process of PSM was thoroughly evaluated using respirometry tests, Fourier transform infrared spectroscopy, gel permeation chromatography, weight loss analysis, and bacterial reproduction tests. After 90 days of incubation in soil, the mineralization ratio of PSM reached 15%, and the weight-average molecular weight gradually decreased from 28.0 to 14.5 kg/mol in the first 14 days. Additionally, PSM experienced a 50% degradation by Pseudomonas aeruginosa after 30 days. In terms of phytotoxicity, PSM showed slight effects on the morphology of soybean seedlings while inducing oxidative stress in roots. The toxic effects of PSM on Eisenia fetida were investigated using both filter paper and soil contact methods. The filter paper contact test showed that the LC50 value was above 1000.0 μg/cm2 at 48 h, while the soil contact test indicated an LC50 value of 93.34 g/kg at 7 days. In conclusion, PSM demonstrates excellent biodegradability and low biotoxicity, suggesting great potential for emerging environmental applications.
研究领域:
环境科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）