DESIGNED MONOMERS AND POLYMERS
·
2018
·
IF 1.37
Yong-Fu Li,Hong-Tao Tang,Si-Jing Zhou
The β-cyclodextrin-acrylamide (CDM-AM) copolymer was prepared from acrylamide and β-CD maleate (CDM) using 60Co γ-ray irradiation method. The optimized preparation conditions for the CDM-AM copolymer are as follows: CDM:AM mass ratio of 1:1; irradiation dose of 4 kGy; and using 20 mL of DMF water solution. The yield rate of CDM-AM was 75% in grams using these synthetic conditions. The effects of the CDM-AM copolymer on the solubility and fungicidal activity of natamycin (NM) and carbendazim (MBC) were investigated. The stability constant of NM·CDM-AM and MBC·CDM-AM complexes at 303 K were of 13,446.06 M−1 and 2595.3 M−1, respectively. The complexes were characterized using phase solubility diagrams, NMR spectra and FT-IR spectra. The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone.
研究领域:
药学
·
高分子化学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Tinglei Liu,Chen Ding,Kejing Gao,Jingsheng Zhou,Wei-Guang Yang,Shuai Zhou,Yuxuan Lin,Hao-Yu Zhao,Zhong-Zhen Yu,Dongzhi Yang
High filtration loss of the oil-based drilling fluids restricts their application in reservoirs production at high temperature and high pressure. In this work, modified nano-microsphere P(AM-co-AA)/PSt filtration reducers are designed to reduce filtration loss by excellent dispersion in oil medium, excellent water-absorption swelling and auxiliary emulsification and prepared by inverse phase emulsion polymerization using acrylamide, acrylic acid and styrene, followed by modification with stearyl trimethyl ammonium chloride. The modified nano-microspheres absorb water to reach an equilibrium swelling rate of 950%. Additionally, the water contact angle increases to 70.3° and the temperature resistance reaches up to 240 o C. The permeability of the filter cake can be decreased through the utilization of swelling microspheres to plug tiny cracks, as well as by intertwining organo-montmorillonite sheets with polymer chains detaching from weakly crosslinked microspheres. Especially, due to their excellent dispersion in the oil medium, the microspheres gather at the oil-water interface, thereby stabilizing the emulsification state of oil-based drilling fluids. These two points are conducive to reducing filtration loss. After thermal aging for 16 h at 180 o C, oil-based drilling fluid by adding 4% microspheres exhibits a low filtration loss volume of 7.8 mL at 180 o C and 3.5 MPa. These hydrophilic nano-microspheres with a partially alkylated structure have a considerable practical application prospect as filtration loss reducers of oil-based drilling fluids.
研究领域:
石油工程
·
材料科学
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产品关联
DOI
高影响因子
Gels
·
2025
·Vol. 11
·期 10
·766
·
IF 5.3
Ning Wang,Ming He,Longjiao Wang,Chuanjie Lei,Linyufan Xiao,Yingjie Li,Shuan Liu
An optical fiber sensor based on a HEMA/AM/SA interpenetrating polymer network (IPN) hydrogel is proposed for monitoring the concentration of Pb2+. The Fabry–Perot interference cavity is constructed from a single-mode fiber, a ceramic ferrule, and an IPN hydrogel layer. P (HEMA co AM)/SA IPN hydrogel films were prepared by a step-by-step crosslinking method, which had good mechanical properties, swelling properties, and Pb2+adsorption capacity. The Pb2+concentration changes cause the interference spectrum shift of the sensor. By monitoring the wavelength shift under different Pb2+concentrations, the sensor sensitivity in the range of 0~1 ppm Pb2+concentration in solution is 5.0743 nm/ppm with 0.994 linearity. The influence of different proportions of IPN hydrogel on the performance of the sensor was studied. In the range of 10–90% HEMA, higher sensitivity is obtained by a small weight ratio of HEMA/AM. The sensor stability, repeatability, selectivity, dynamic response, and temperature response are also investigated in experiments. Experimental results demonstrate that the proposed sensor exhibits good stability, sensitivity, repeatability, and selectivity. Owing to its compact structure, straightforward fabrication, low cost, and good sensing performance, this sensor shows strong potential for application in monitoring Pb2+concentrations.
研究领域:
生物医学工程
·
环境监测
·
传感器技术
·
功能材料
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2024
·
IF 4.5
Yaya Feng,Tongda Lei,Shiyang Chen,Mengli Jin,Qian Zhang,Fenge Li,Xipeng Li,Jie Fan
This paper describes a temperature-responsive composite nanofibrous membrane by blending of the P(NIPAM-AM-ABP) (PNAA) nanofiber and the wool keratin (WK) nanofiber. The photo crosslinkable PNAA with the LCST value of 38.1 °C was obtained by free radical copolymerization of the temperature sensitive N-Isopropylacrylamide (NIPAM) monomer, the hydrophilic monomer Acrylamide (AM), and the photo crosslinkable monomer 4-Acryloyloxybenzophenone (ABP). Keratin was extracted from waste wool fiber by reduction method. The PNAA nanofiber (PNAA-NF) and the keratin nanofiber (WK-NF) were electoral spun separately by two-needle parallel spinning, and the obtained composite nanofiber membrane was then crosslinked by UV irradiation and heat treatments to prepare the PNAA/WK nanofiber membrane (PNAA/WK-NFM) with good water tolerance. The result indicated that the photo cross-linkable temperature sensitive PNAA with the LCST of 38.1 °C was successfully synthesized. The obtained PNAA/WK-NFM has a good fibrous morphology and excellent water tolerance. The composite nanofiber membrane showed good reversible temperature sensitivity and temperature responsive drug releasing property due to the PNAA. By combining of the PNAA-NF and WK-NF, the mechanical property of the PNAA/WK-NFM was greatly enhanced in both dry and wet states, and the slow drug releasing property of the membrane was further improved. In-vitro cell culture experiments indicated that the PNAA/WK-NFM has a good biocompatibility with no cytotoxicity. These findings suggested that the PNAA/WK-NFM has a potential application in temperature responsive drug releasing biomaterials.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
·
药剂学
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产品关联
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 52
·32988-32995
·
IF 3.361
Yinlei Lin,Shuoqi Wang,Sheng Sun,Yaoheng Liang,Yisheng Xu,Huawen Hu,Jie Luo,Haichen Zhang,Guangji Li
Introducing double physical crosslinking reagents (i.e., a hydrophobic monomer micelle and the LAPONITE® XLG nano-clay) into the copolymerization reaction of hydrophilic monomers of N,N-dimethylacrylamide (DMAA) and acrylamide (AM) is reported here by a thermally induced free-radical polymerization method, resulting in a highly tough and rapid self-healing dual-physical crosslinking poly(DMAA-co-AM) hydrogel. The mechanical and self-healing properties can be finely tuned by varying the weight ratio of nanoclay to DMAA. The tensile strength and elongation at break of the resulting nanocomposite hydrogel can be modulated in the range of 7.5–60 kPa and 1630–3000%, respectively. Notably, such a tough hydrogel also exhibits fast self-healing properties, e.g., its self-healing rate reaches 48% and 80% within 2 and 24 h, respectively.
研究领域:
材料科学
·
高分子化学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2020
·
IF 3.333
Yong Dong,Liqin Cao,Yongxia Yang,Xiujuan Wu,Jide Wang
Removing dyes and antibiotics from wastewater remains the current requirement for a global health problem. The ionic macroporous adsorbent is an efficient solution to this problem. Herein, a novel sulfonated TiO 2 /poly(acrylamide- co -2-acrylamido-2-methylpropanesulfonic acid) [TiO 2 /P(AM- co -AMPS)] macroporous composite monolith was first prepared by copolymerization of AM and AMPS in m TiO 2 -costabilized CO 2 -in-water Pickering high internal phase emulsions (HIPEs). The composite monoliths were characterized using XRD , SEM, confocal laser scanning microscopy , EDS mapping, FTIR, TGA , and mercury injection methods. The mechanical properties of the TiO 2 /P(AM- co -AMPS) HIPE were also evaluated. The void diameter could be adjusted by changing the density of carbon dioxide and the amount of m TiO 2 . The equilibrium swelling ratios of TiO 2 /P(AM- co -AMPS) with different contents of crosslinking agent of 2, 5, and 10 wt% (AM+AMPS) were 93, 37, and 19 g/g, respectively. TiO 2 /P(AM- co -AMPS) was used to remove methylene blue (MB) and tetracycline (TC) for evaluating the adsorptive properties of the composite monoliths. Results indicated that the main adsorption driving force was the electrostatic attraction between −SO 3 − and MB/TC. Adsorption experiments were conducted using a batch technique. The adsorption capacities of TiO 2 /P(AM- co -AMPS) for MB and TC were 1660 and 1128 mg/g in a wide pH range of 3–10. The equilibrium saturation point could be reached after 90 min for MB and 360 min for TC. Thereafter, the removal of MB and TC by gravity-driven separation was presented. The breakthrough curve and reuse evaluation for the removal of MB/TC were also studied in detail.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2021
·
IF 4.598
Qingfu Ban,Yan Li,Yusheng Qin,Yaochen Zheng,Jie Kong
Hyperbranched star copolymers are important soft materials that have been employed for aqueous self-assembly and bioapplication, but their one-pot one-batch synthesis strategy and relevant topology are rarely discussed. In this contribution, we produce hyperbranched star poly(vinyl ether ester)s (mPEG- hb -PVEEs) amphiphiles with multimodal molecular weight distribution via one-pot one-batch Am+Bn+C1 (m ≥ 2, n ≥ 3) step-growth polymerization. Based on the topological analysis of these hyperbranched star copolymers, a convenient expression of the number ratio of monomeric structural units (N A /N B ) is deduced to describe the cyclic defect of intramolecular cyclization only by using proton nuclear magnetic resonance spectroscopy. The introduction of long-chain terminators and the change in the molar feed ratio of A 2 :B 3 :C 1 considerably affect the N A /N B so as to give rise to increased influence of number of macromolecules and decreased influence of intramolecular cyclization, which are then responsible for an aqueous self-assembly behavior of mPEG- hb -PVEEs amphiphiles. Overall, this study opens new possibilities for the precise description of intramolecular cyclization and controllable synthesis of hyperbranched star copolymers via one-pot Am+Bn+C1 step-growth polymerization.
研究领域:
高分子科学
·
材料科学
·
化学工程
·
生物技术
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DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
·
2024
·Vol. 53
·期 4
·1-16
·
IF 5.7
Zailin Fu,Dingsheng Wang,Caiyun Zheng,Minghua Xie,Yifang Chen,Yi Zhou,Yan Huang,Ying Song,Weiyong Hong
Calcium overload, a notable instigator of acute pancreatitis (AP), induces oxidative stress and an inflammatory cascade, subsequently activating both endogenous and exogenous apoptotic pathways. However, there is currently lack of available pharmaceutical interventions to alleviate AP by addressing calcium overload. In the present study, the potential clinical application of liposome nanoparticles (LNs) loaded with 1,2‑bis(2‑aminophenoxy)ethane‑N,N,N',N'‑tetraacetic acid tetrakis (acetoxymethyl ester) (BAPTA‑AM), a cell‑permeant calcium chelator, was investigated as a therapeutic approach for the management of AP. To establish the experimental models in vitro, AR42J cells were exposed to high glucose/sodium oleate (HGO) to induce necrosis, and in vivo, intra‑ductal taurocholate (TC) infusion was used to induce AP. The findings of the present study indicated that the use of BAPTA‑AM‑loaded LN (BLN) effectively and rapidly eliminated excessive Ca2+ and reactive oxygen species, suppressed mononuclear macrophage activation and the release of inflammatory cytokines, and mitigated pancreatic acinar cell apoptosis and necrosis induced by HGO. Furthermore, the systemic administration of BLN demonstrated promising therapeutic potential in the rat model of AP. Notably, BLN significantly enhanced the survival rates of rats subjected to the TC challenge, increasing from 37.5 to 75%. This improvement was attributed to the restoration of pancreatic function, as indicated by improved blood biochemistry indices and alleviation of pancreatic lesions. The potential therapeutic efficacy of BLN in rescuing patients with AP is likely attributed to its capacity to inhibit oxidative stress, prevent premature activation of zymogens and downregulate the expression of TNF‑α, IL‑6 and cathepsin B. Thus, BLN demonstrated promising value as a novel therapeutic approach for promptly alleviating the burden of intracellular Ca2+ overload in patients with AP.
研究领域:
药理学
·
医学
·
纳米技术
·
细胞生物学
·
炎症
·
胃肠病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2021
·Vol. 28
·期 7
·1-13
·
IF 3.097
Yao Qi,Lan Hai,Li Xin,Chen Youyi
Organic–inorganic interpenetrating network poly (acrylic acid- co -acrylamide) IPN-P(AA-co-AM) polymer sphere with core–shell structure has been synthesized by modified suspension polymerization, which the core is high cross-linked and shell is light cross-linked, respectively. The dispersed phase (water phase) and continuous phase (oil phase), as well as core and shell crosslinking agent are screened based on the water absorption capacity of the polymer spheres. In addition, SiO 2 is applied to endow polymer spheres with excellent thermal and water absorption properties. FTIR, TG, SEM, and XPS analyze the chemical structure, thermal properties, morphology and surface element of polymer spheres, respectively. Particularly, the forming mechanism of polymer spheres and water absorption dynamic model are discussed in detail. The results show that the Organic–inorganic IPN-P(AA-co-AM) polymer spheres are successfully synthesized. The polymer spheres could be wrapped effectively when the SiO 2 content up to 2%. Compared to polymer spheres without SiO 2 , the thermal stability is greatly improved. The optimum core and shell crosslinking agent are pentaerythritol triacrylate (PETA) and sodium alginate, respectively. The maximum absorption capacity of polymer spheres for distilled water and 0.9wt% sodium chloride can up to 922.22 g/g and 93.87 g/g, respectively. Finally, the water absorption of IPN-P(AA-co-AM) polymer spheres dynamic model is closed to second-order.
研究领域:
高分子科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2023
·Vol. 19
·期 17
·2206936
·
IF 13.3
Jiahui Yan,Yanan Wang,Jingwen Zhang,Xiaohu Liu,Liangmin Yu,Zhiyu He
Calcium overload and ROS overproduction, two major triggers of acute kidney injury (AKI), are self-amplifying and mutually reinforcing, forming a complicated cascading feedback loop that induces kidney cell “suicide” and ultimately renal failure. There are currently no clinically effective drugs for the treatment of AKI, excluding adjuvant therapy. In this study, a porous silicon-based nanocarrier rich in disulfide bond skeleton (<50 nm) is developed that enables efficient co-loading of the hydrophilic drug borane amino complex and the hydrophobic drug BAPTA-AM, with its outer layer sealed by the renal tubule-targeting peptide PEG-LTH. Once targeted to the kidney injured site, the nanocarrier structure collapses in the high glutathione environment of the early stage of AKI, releasing the drugs. Under the action of the slightly acidic inflammatory environment and intracellular esterase, the released drugs produce hydrogen and BAPTA, which can rapidly eliminate the excess ROS and overloaded Ca 2+ , blocking endoplasmic reticulum/mitochondrial apoptosis pathway (ATF4-CHOP-Bax axis, Casp-12-Casp-3 axis, Cyt-C-Casp-3 axis) and inflammatory pathway (TNF-α-NF-κB axis) from the source, thus rescuing the renal cells in the “critical survival” state and further restoring the kidney function. Overall, this nanoparticle shows substantial clinical promise as a potential therapeutic strategy for I/R injury-related diseases.
研究领域:
纳米技术
·
药学
·
肾脏生理学
·
分子生物学
·
治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xiancai Jiang,Siqi Wei,Jinquan Wang
Hydrogel electrolytes are ideal for flexible wearable electronic devices because of their high ionic conductivity, flexibility, and biocompatibility. However, some problems, such as poor mechanical properties, low conductivity, and lack of adhesivity, are encountered in the process of hydrogel preparation and application, which restrict the further development of hydrogel electrolytes. In this study, PVA was used as the first network, and P(AM-co-AMPS) as the second network to prepare a double-network hydrogel electrolyte. Laponite and Na2SO4 were introduced into the hydrogel during hydrogel formation as the nanofiller and salt with the salting-out effect to enhance its mechanical properties. The hydrogel electrolyte with high toughness (1663 kJ·m–3), adhesivity (77 kPa), and ionic conductivity (1.7 S·m–1) was obtained. In addition, the hydrogel electrolyte also has excellent antifatigue performance. In the 10 consecutive tensile cycles, the tensile strength does not decay. Due to the high adhesivity of the hydrogel electrolyte, a symmetrical all-solid-state supercapacitor was assembled with a tight interface between the hydrogel electrolyte and the AC/CNT composite electrode. The supercapacitor has a high specific capacitance of 186.1 mF·cm–2 at the current density of 1 mA·cm–2. In addition, the capacitor has good flexibility and can withstand bending at various angles. The hydrogel electrolyte also has excellent strain sensing performance, with an ultrafast tensile response time (0.17 s) and high sensitivity factor (GF = 10.01). Finally, the self-powered sensor system composed of a supercapacitor as the power supply device and hydrogel electrolyte as the sensing part was obtained and applied to human motion monitoring, which provides a potential application in the integrated flexible electronic system.
研究领域:
材料科学
·
电化学
·
纳米技术
·
柔性电子
·
可穿戴设备
·
能源存储
·
传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yanan Wang,Huichao Wei,Keyang Li,Liru Liu,Yingfei Zhu,Xinyuan Wang,Jiahui Yan,Liangmin Yu,Xuefeng Yan,Zhiyu He
Calcium overload in hepatocytes mediates the crosstalk and amplification loop with oxidative stress and severe inflammation that initiate pro-apoptotic and necrotic signaling pathways in acute liver injury (ALI). In this study, an N-acetylgalactosamine-modified amphiphilic dextran-silibinin conjugate (GalNAc-Dex-Sil) with ROS-sensitive phenylboronic acid (PBA) linkage was synthesized. The as-prepared amphiphilic polymer was self-assembled into GalNAc-Dex-Sil nanoparticles, which efficiently encapsulated the membrane-permeable calcium chelator BAPTA-AM (BA), achieving GalNAc-mediated hepatocyte-specific targeting and ROS-responsive release in injured hepatocytes through PBA cleavage. Accordingly, a single low-dose injection of formulation (BA: 150 μg·kg −1 ) significantly alleviated hepatocyte oxidative stress and inflammation, rescued dying hepatocytes, prevented further hepatocyte damage, and ultimately restored liver function in the ALI mouse model by 1) rapidly and effectively eliminating the overloaded calcium and scavenging excessive ROS via released BA to block the feed-forward vicious cycles of the cell damage, 2) inhibiting the inflammatory cascade by decreasing the expression of the key factor of the NF-κB/NLPR3 axis, 3) inhibiting the key branch of the mitochondrial apoptotic pathway (Cyt C/Bcl-2 family/caspase-3 axis) and death receptor pathway (TNFα/Caspase-8 axis), and 4) stabilizing hepatocyte membranes through the synergistic hepatoprotective effect of silibinin. Taken together, this formulation exhibited great potential as a potent and effective ALI treatment strategy.
研究领域:
药理学
·
纳米技术
·
肝病学
·
炎症
·
细胞凋亡
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）