SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Gaozu Liao,Peng Xu,Ping Lu,Xiaojiao Qing,Zhanjiang Yu,Yu Chang,Weirui Chen,Yiming Tang,Jing Wang,Xi Wang,Xukai Li,Laisheng Li,Dehua Xia
Single Co atoms dispersed on CMK-3 was synthesized and employed as efficient catalyst to degrade APAP in O 3 /PMS process. The results of morphology and structure characterization indicated that the as prepared catalyst possessed uniform array of mesoporous channel structure with a long-range. Co atoms were single atomic dispersed in CMK-3 skeleton with the form of CoN 4 coordination. The BET surface area and average pore diameter of 3.6% SA Co/CMK-3 were measured as 956 m 2 /g and 3.6 nm, respectively. For APAP degradation by 3.6% SA Co/CMK-3 + PMS/O 3 process, TOC removal efficiency reached to 60% and 78.9% in initial 1 min and 15 min, respectively. The influence of initial pH was investigated and demonstrated that APAP could be efficiently mineralized in a wide pH range. In addition, high mineralization rates were also achieved for other refractory organics (nitrobenzene and sulfamethoxazole). Radical quenching experiments and ESR indicated that SO 4 •− , •OH and 1 O 2 were all responsible for APAP degradation. DFT simulations elucidated that single Co atoms and N-heteroatoms on 3.6% SA Co/CMK-3 served as dual reaction sites for PMS and O 3 decomposition, which enhanced the ROS generation and APAP mineralization.
研究领域:
环境科学
·
催化
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Jinrong Ning,Guodong Zheng,Yi Cai,Yunguang Hu,Yiqi Liu,Enping Lai,Baizhong Chen,Yujie Liu,Ziqi Liang,Jijun Fu,Minyan Wei
Purpose APAP-induced liver injury (AILI) is a common cause of acute liver failure (ALF). Nobiletin (NOB) is a potential hepatoprotective agent for the treatment of APAP-induced liver injury. However, the poor solubility and low bioavailability of NOB hinders its application. In this study, a novel self-assembly nano-drug delivery system of nobiletin (solid dispersion of NOB, termed as NOB/SD) was developed based on solid dispersion technology to improve the bioavailability and hepatoprotective ability of NOB for APAP-induced liver injury therapy.Methods The optimized NOB/SD system was constructed using the amphiphilic copolymers of Soluplus and PVP/VA 64 via hot melt extrusion technology (HME). NOB/SD was characterized by solubility, physical interaction, drug release behavior, and stability. The bioavailability and hepatoprotective effects of NOB/SD were evaluated in vitro and in vivo.Results NOB/SD maintained NOB in matrix carriers in a stable amorphous state, and self-assembled NOB-loaded nanomicelles in water. Nanostructures based on solid dispersion technology exhibited enhanced solubility, improved release behavior, and promoted cellular uptake and anti-apoptosis in vitro. NOB/SD displayed significantly improved bioavailability in healthy Sprague Dawley (SD) rats in vivo. Furthermore, NOB/SD alleviated the APAP-induced liver injury by improving anti-oxidative stress with reactive oxygen species (ROS) scavenging and nuclear factor erythroid 2-related factor 2 (Nrf2) activation.Conclusion These results suggested that NOB/SD could be considered as a promising hepatoprotective nano-drug delivery system for attenuating APAP-induced acute liver injury with superior bioavailability and efficient hepatoprotection, which might provide an effective strategy for APAP-induced acute liver injury prevention and treatment.
研究领域:
药学
·
药理学
·
药物递送系统
·
肝病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Qing Yao,Yingying Tang,Sheng Dai,Lihui Huang,Zewei Jiang,Shiming Zheng,Meng Sun,Yitianhe Xu,Ruijie Lu,Tuyue Sun,Huirong Huang,Xinyu Jiang,Xiaomin Yao,Guangyong Lin,Longfa Kou,Ruijie Chen
Acute liver failure (ALF) is a severe liver disease caused by many reasons. One of them is the overdosed acetaminophen (APAP), which is metabolized into N -acetyl-p-benzoquinone imine (NAPQI), an excessive toxic metabolite, by CYP2E1, resulting in excessive reactive oxygen species (ROS), exhausted glutathione (GSH), and thereafter hepatocyte necrosis. N -acetylcysteine is the Food and Drug Administration-approved drug for detoxification of APAP, but it has limited clinical application due to the short therapeutic time window and concentration-related adverse effects. In this study, a carrier-free and bilirubin dotted nanoparticle (B/BG@N) is developed, which is formed using bilirubin and 18 β -Glycyrrhetinic acid, and bovine serum albumin (BSA) is then adsorbed to mimic the in vivo behavior of the conjugated bilirubin for hitchhiking. The results demonstrate that B/BG@N can effectively reduce the production of NAPQI as well as exhibit antioxidant effects against intracellular oxidative stress via regulating the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signal axis and reducing the production of inflammatory factors. In vivo study shows that B/BG@N can effectively improve the clinical symptom of the mice model. This study suggests that B/BG@N own increases circulation half-life, improves accumulation in the liver, and dual detoxification, providing a promising strategy for clinical ALF treatment.
研究领域:
药理学
·
纳米技术
·
肝病学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）