POLYMER
·
2025
·
IF 4.5
Kaizhi Gu,Shixiao Yan,Maiping Yan,Xiaoli Shi,Zifan Zhao,Jing Feng
In this paper, Ni-coated YSZ powder and flame-retardant APP were introduced into phenolic resin-epoxy resin composite system by organic-inorganic mixed flame retardant strategy. Through a series of experimental tests, it was found that the TSR (total smoke release), THR (total heat release), total CO production (TCOP) and TCO2P (total CO 2 production) of the composite resin system with the same mass of APP and Ni@YSZ decreased by 53.5 %, 45.8 %, 13.6 % and 45.5 % respectively. The synergistic effect of Ni@YSZ and APP and its product Ni 2 P 2 O 7 improved the formation and structure of carbon layer. Thus, the fire hazard of epoxy resin is reduced, and the situation that a large amount of heat and toxic substances are released by decomposition is improved. In addition, the composite coating achieves an EAB (effective absorption bandwidth) of 1.11 GHz (16.77 GHz–17.88 GHz) in the ku band of electromagnetic waves. When the frequency is 17.60 GHz, the lowest RL (reflection loss) (−17.02 dB) is achieved. This discovery provides a simple and effective idea for developing light stealth and fire protection integrated functional coatings.
研究领域:
材料科学
·
防火与隐身技术
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产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2024
·
IF 6.3
Mei Wan,Congling Shi,Lei Chen,Lei Deng,Yueping Qin,Honglei Che,Jingyun Jing,Junyi Li,Xiaodong Qian
Ammonium polyphosphate (APP) is the most commercially valuable phosphorus-based flame retardant, but poor interaction with the polymer interface limits the flame-retardant efficiency. In this work, a new type of multi-layered nanomaterial coating APP (APP-PEI@MXene@ZIF-67) was prepared and introduced into thermoplastic polyurethane (TPU) polymers by a simple and green assembly strategy. The effects of different loading shells of modified APP on the flame retardancy of TPU composites were investigated, as well as their gas/condensed phase thermal degradation products and their flame-retardant mechanisms. The results showed that APP-PEI@MXene@ZIF-67 was more favorable for catalytic char formation than APP, and the residual char formed by its composites was denser and more continuous. Compared with the pure TPU, the pHRR, THR, pSPR, and TSP of TPU/APP-PEI@MXene@ZIF-67–2BL composites were decreased by 72.75 %, 87.25 %, 59.58 %, and 85.97 %, respectively, which significantly reduced the heat and smoke release during the combustion process. The gas-phase and condensed-phase flame retardant mechanisms synergized to construct a possible approach to address the fire risk and heat/smoke hazards of TPUs and promote the extensive application of TPU polymers.
研究领域:
材料科学
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高分子科学
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消防安全工程
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产品关联
DOI
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·1-13
·
IF 3.9
Chen Juanli,Wei Chuanfei,Zhang Yingchao,Chen Qingfa,Li Xuemei,Zhang Wei,Zhang Xiaoping,Han Fabin
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) plaques, leading to neuronal death. Notably, there are no therapeutically efficacious treatments for this disorder. This study investigates the neuroprotective mechanisms of curcumin. In vitro experiments demonstrated that curcumin significantly promoted the proliferation of neural stem cells (NSCs) derived from E16 mouse embryos. Additionally, in the APP/PS1 transgenic mouse model, curcumin improved cognitive function, as evidenced by a shorter escape latency and increased platform crossing frequency in the Morris water maze test and enhanced novel object recognition. Histological analysis showed that curcumin reduced Aβ accumulation in the hippocampal and cortical regions. Molecular studies revealed that curcumin upregulated the expression of BDNF and enhanced phosphorylation of CREB. Collectively, these findings indicate that curcumin exerts neuroprotective effects through multiple mechanisms, including promoting NSC proliferation, reducing Aβ accumulation, and the potential modulation of the BDNF-CREB signaling pathway.
研究领域:
神经科学
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药理学
·
细胞生物学
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分子生物学
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神经退行性疾病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2024
·
IF 4.8
Hui-Han Ma,Jia-Yi Zheng,Yu-Hui Qiu,Shan Su,Fang-Mei Lu,Guang-Liang Wu,Shi-Jie Zhang,Ye-Feng Cai
Ethnopharmacological relevance Alzheimer's disease (AD) is a common type of neurodegenerative disease with the β-amyloid plaques (Aβ) deposition. Previously, Dengzhan Shengmai capsule (DZSM) has been shown to reduce the pathology associated with AD, but the underlying mechanism is unclear. Aim of study This study investigated the potential mechanisms of DZSM against AD. Materials and methods The six-month-old wild-type male mice and APP/PS1 double transgenic male mice were administered 0.9 % saline or DZSM for 8 weeks by gavage. Open field test, new object recognition test, and Morris Water maze test were used to assess spatial learning and memory. Aβ plaques in brains were visualized using ThT staining. Nissl staining, TUNEL staining, and Western blot analyses were used to detect the neuronal function and apoptosis level. The superoxide dismutase (SOD), glutathione peroxidase assay kit (GSH-Px), and malondialdehyde (MDA) kits were performed to assess oxidative stress levels. Then, immunofluorescence and Western blot analysis were applied to evaluate ER stress pathway protein levels. Finally, HT22 cells were treated by Aβ 1-42 with or without DZSM medicated serum. Cell viability was assessed using the CCK-8 assay, and Western blot analysis was applied to evaluate ER stress pathway protein levels. Results Open filed test, new object recognition test and Morris Water maze test showed that DZSM restored cognitive disorders in APP/PS1 mice. Immunohistochemistry and Thioflavin T staining results indicated that DZSM reduced Aβ plaques in the brain. Deeper and denser Nissl bodies were found in APP/PS1 mice after DZSM administration. Besides, APP/PS1 mice treated with DZSM showed a lower level of TUNEL and Bax/Bcl-2 ratio. DZSM improved the acetylcholine (ACh), choline acetyltransferase (ChAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity while reducing acetylcholinesterase (AChE) and malondialdehyde (MDA) activity. In addition, the levels of ER stress pathway containing Phospho-PKR-like ER kinase (P-PERK), phosphorylate eukaryotic initiation factor 2 (P-eIF2α), activating transcription factor 4 (ATF4), glutamine-rich protein 1 (QRICH1), phosphorylate inositol-requiring protein 1α (P-IRE1α), the spliced form of X-box binding protein 1 (XBP1s), activating transcription factor-6 (ATF6) and C/EBP homologous binding protein (CHOP) were decreased by DZSM. CCK-8 results indicated that DZSM medicated serum played cytoprotective effects on Aβ 1-42 -induced HT22 cells. Western blot results suggested DZSM possibly inhibited ER stress pathways in Aβ 1-42 -induced HT22 cells. Conclusion The potential protective mechanism of DZSM on cognitive impairment in AD might be related to ER stress pathways.
研究领域:
神经药理学
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民族药理学
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神经退行性疾病
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药理学
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
Frontiers in Pharmacology
·
2024
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IF 4.4
Liu Bin,Li Faping,Wang Yuxiong,Gao Xin,Li Yunkuo,Wang Yishu,Zhou Honglan
Background: Kidney injuries often carry a grim prognosis, marked by fibrosis development, renal function loss, and macrophage involvement. Despite extensive research on macrophage polarization and its effects on other cells, like fibroblasts, limited attention has been paid to the influence of non-immune cells on macrophages. This study aims to address this gap by shedding light on the intricate dynamics and diversity of macrophages during renal injury and repair.Methods: During the initial research phase, the complexity of intercellular communication in the context of kidney injury was revealed using a publicly available single-cell RNA sequencing library of the unilateral ureteral obstruction (UUO) model. Subsequently, we confirmed our findings using an independent dataset from a renal ischemia-reperfusion injury (IRI) model. We treated two different types of endothelial cells with TGF-β and co-cultured their supernatants with macrophages, establishing an endothelial cell and macrophage co-culture system. We also established a UUO and an IRI mouse model. Western blot analysis, flow cytometry, immunohistochemistry and immunofluorescence staining were used to validate our results at multiple levels.Results: Our analysis revealed significant changes in the heterogeneity of macrophage subsets during both injury processes. Amyloid β precursor protein (APP)-CD74 axis mediated endothelial-macrophage intercellular communication plays a dominant role. In the in vitro co-culture system, TGF-β triggers endothelial APP expression, which subsequently enhances CD74 expression in macrophages. Flow cytometry corroborated these findings. Additionally, APP and CD74 expression were significantly increased in the UUO and IRI mouse models. Immunofluorescence techniques demonstrated the co-localization of F4/80 and CD74 in vivo.Conclusion: Our study unravels a compelling molecular mechanism, elucidating how endothelium-mediated regulation shapes macrophage function during renal repair. The identified APP-CD74 signaling axis emerges as a promising target for optimizing renal recovery post-injury and preventing the progression of chronic kidney disease.
研究领域:
肾病学
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免疫学
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分子生物学
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细胞生物学
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病理生理学
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2019
·Vol. 137
·期 1
·47367
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IF 2.188
Dong Ma,Juan Li
A triazine derivative CC–Cy was synthesized using cytosine (Cy) and cyanuric chloride (CC). The CC–Cy was used as a charring agent and combined with ammonium polyphosphate (APP) to form an intumescent flame-retardant (IFR) system. The IFR system was applied to improve the flame retardancy of polypropylene (PP). Moreover, bisphenol-A bis(diphenyl phosphate) (BDP) was introduced in the IFR system to regulate the suitability between the IFR and PP. The results showed the PP containing 20 wt % APP and 5 wt % CC–Cy achieves the UL-94 V-2 rating. While the PP with 18 wt % APP/CC-Cy (4:1) and 3 wt % BDP obtains the UL-94 V-0 rating indicating the improved flame-retardant efficiency. Thermal degradation behaviors and char morphology both showed that the reactions between APP and CC–Cy promote the formation of char residues, and BDP works in gas phase to enhance the flame retardancy of PP composites. Thus, a synergistic IFR system based on APP, CC–Cy, and BDP is formed, which can protect PP from fire effectively. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 47367.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2023
·
IF 7.5
Jinman Liu,Xue Zuo,Mingjun Huang,Jiansong Fang,Weirong Li,Qing Shi,Qi Wang,Yong Liang
This study aimed to investigate the potential effects of Gomisin B, a natural compound known for its inhibition of CYP3A4, on cognitive dysfunction in APP/PS1 transgenic mice with Alzheimer's disease (AD). Additionally, the study explored the combined effects of Gomisin B and Osthole (OST). The research involved male wild-type (WT) mice and 7-month-old APP/PS1 transgenic AD mice. The assessment of behavioral changes included the use of the open field test (OFT) and the Morris water maze (MWM). OST levels in brain tissue were quantified using LC-MS/MS, while levels of oxidative stress were measured through an assay kit. Neuronal apoptosis was studied using Nissl staining, RT-qPCR, and immunofluorescence. Amyloid plaque clearance was assessed using thioflavine-S (Th-S) staining, RT-qPCR, and ELISA. The results of the study revealed that Gomisin B led to a significant improvement in cognitive dysfunction in APP/PS1 mice. Moreover, the simultaneous administration of OST and Gomisin B demonstrated enhanced therapeutic effects. These effects were attributed to the inhibition of β-site APP-Cleaving Enzyme 1 (BACE1) and oxidative stress by Gomisin B, along with its anti-apoptotic properties. The combined use of OST and Gomisin B exhibited a synergistic impact, resulting in more pronounced anti-oxidant and anti-apoptotic effects. In summary, this study pioneers the exploration of Gomisin B's multifunctional anti-AD properties in APP/PS1 mice. The findings provide a solid groundwork for the development of anti-Alzheimer's drugs based on natural active ingredients.
研究领域:
神经科学
·
药理学
·
神经退行性疾病
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Mingjuan Li,Na Zhao,Chenyao Wang,Yuhao Zou,Xinzhi Chen,Yi Mei
Polymer solid electrolytes (PSEs) are still under the safety risk because of flammability and low mechanical strength. Here a TiO 2 coated piperazine-modified ammonium polyphosphate (TiO 2 @PA-APP) is synthesized and incorporated into poly (ethylene oxide) (PEO)-based PSE membranes to meet the above challenges. The thermal stability and ionic conductivity of PSE membrane incorporated with TiO 2 @PA-APP have been improved. Micro-scale combustion calorimetry experiments indicate a dramatic 70 % decrease in heat release rate, from 919 W g −1 to 267 W g −1 . The lithium symmetric cell demonstrates remarkable durability, operating normally for 500 h with minimal polarization potential across various current densities at 60 °C. The all solid-state LiFePO 4 //Li battery using the cathode-supported TiO 2 @PA-APP/PEO-PSE membrane can reach a high discharge specific capacity of 153 mAh g −1 at 0.1 C and demonstrates good cycle performance, achieving a capacity retention rate of 88 % after 200 cycles at 0.2 C, along with an average coulombic efficiency of 99.24 %. These findings underscore the effectiveness of the TiO 2 @PA-APP flame retardant in fabricating solid-state lithium-ion batteries that provide enhanced safety and exceptional electrochemical performance.
研究领域:
材料科学
·
电化学
·
能源存储
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产品关联
DOI
高影响因子
Journal of Inflammation Research
·
2024
·
IF 4.2
Jiahua Cheng,Wujuan Li,Lanlin Wang,Yu Gao,Yueran Ma,Min Zhou,Tian Yang,Changwu Yue,Long Yan,Yuhong Lyu
Purpose To explore the protective effects and mechanisms of Jiawei Qifuyin on APP/PS1 mice, a model for Alzheimer’s disease (AD).Methods Network pharmacology tools were used to predict anti-AD targets and signaling pathways affected by Jiawei Qifuyin. In vitro studies assessed antioxidant and oxygen radical scavenging abilities, immune cell proliferation, and inflammatory cytokine levels in lipopolysaccharide-induced BV2 microglial cells. Cognitive ability in APP/PS1 mice was evaluated using the Morris Water Maze test. mRNA expression of neuroinflammatory factors, changes in intestinal microbiota, and short-chain fatty acid content were analyzed post-treatment.Results Network pharmacology predicted that Jiawei Qifuyin affects AKT1, TNF-α, and AGE/RAGE pathways. It showed concentration-dependent antioxidant effects and modulated immune cell proliferation. IL-2, IL-6, and TNF-α levels in LPS-induced BV2 cells were significantly reduced. Treated animals exhibited improved cognitive performance, decreased brain amyloid-beta levels, and downregulated expression of IL-1β, IL-6, RAGE, and NF-κB. Significant changes in intestinal microbiota composition and SCFA content were observed.Conclusion Jiawei Qifuyin may enhance immunity and improve cognitive impairment in APP/PS1 mice through regulation of inflammatory factors, gut microbiota, and the gut-brain axis.
研究领域:
神经科学
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药理学
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免疫学
·
微生物学
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产品关联
DOI
PubMed
高影响因子
Frontiers in Pharmacology
·
2024
·
IF 4.4
Liu Wei,Chen Xiao,Zhao Jing,Yang Chen,Huang Guanqin,Zhang Zhen,Liu Jianjun
Alzheimer’s disease (AD) has an increasing prevalence, complicated pathogenesis and no effective cure. Emerging evidences show that flavonoid compounds such as xanthohumol (Xn) could play an important role as a dietary supplement or traditional Chinese herbal medicine in the management of diseases such as AD. This study aims to analyze the target molecules of Xn in the prevention and treatment of AD, and its potential mechanism from the perspective of metabolites. APP/PS1 mice 2- and 6-months old were treated with Xn for 3 months, respectively, the younger animals to test for AD-like brain disease prevention and the older animals to address therapeutic effects on the disease. Memantine (Mem) was selected as positive control. Behavioral tests were performed to assess the course of cognitive function. Urine samples were collected and analyzed by high-performance liquid chromatography (HPLC) with tandem mass spectrometry (MS/MS) coupled with online Compound Discoverer software. Morris Water Maze (MWM) tests showed that Xn, like Mem, had a therapeutic but not a preventive effect on cognitive impairment. The expression levels of urinary metabolites appeared to show an opposite trend at different stages of Xn treatment, downregulated in the prevention phase while upregulated in the therapy phase. In addition, the metabolic mechanisms of Xn during preventive treatment were also different from that during therapeutic treatment. The signaling pathways metabolites nordiazepam and genistein were specifically regulated by Xn but not by Mem in the disease prevention stage. The signaling pathway metabolite ascorbic acid was specifically regulated by Xn in the therapeutic stage. In conclusion, dietary treatment with Xn altered the urinary metabolite profile at different stages of administration in APP/PS1 mice. The identified potential endogenous metabolic biomarkers and signal pathways open new avenues to investigate the pathogenesis and treatment of AD.
研究领域:
神经科学
·
药理学
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代谢组学
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疾病预防与治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALZHEIMERS DISEASE
·
2025
·
IF 3.1
Yanyu Zhai,Kaili Lu,Yuan Yuan,Ziyao Zhang,Lixia Xue,Fei Zhao,Xiaofeng Xu,Hongmei Wang
BackgroundAlzheimer's disease (AD) causes cognitive function disorder and has become the preeminent cause of dementia. Glucagon-like peptide-1 (GLP-1) receptor agonists, semaglutide, have shown positive effects on promoting the cognitive function. However, research about the mechanism of semaglutide as a therapeutic intervention in AD is sparse.ObjectiveThis study was to investigate the therapeutic efficacy of semaglutide in a transgenic mouse model of AD pathology and explored the detailed mechanism by semaglutide modulated neuroinflammatory processes.MethodsMale amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice were treated with semaglutide or vehicle for 8 weeks. Morris water maze test was used to assess the therapeutic efficacy of semaglutide on recognition function. Pathology analysis was performed to detect the deposition of amyloid plaques. High-throughput sequencing analysis was applied to specify the mechanism. Microglia and astrocyte activation were assessed with immunofluorescent staining. Inflammation cytokine levels were evaluated with enzyme-linked immunosorbent assay (ELISA). Related proteins and pathway were evaluated with western blot.ResultsSemaglutide treatment attenuated Aβ accumulation and enhanced cognitive function in APP/PS1 transgenic mice. Through transcriptomic profiling, immunohistochemical staining, and ELISA, semaglutide was substantiated to inhibit the overactivation of microglia and astrocytes, as well as to curtail the secretion of inflammatory mediators. Furthermore, semaglutide robustly activated AMP-activated protein kinase (AMPK) and suppressed the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling cascade, thus reducing the Aβ deposition and dampening the inflammatory cascade.ConclusionsThe results demonstrated that semaglutide mitigated neuroinflammation and decelerated the advance of AD in APP/PS1 transgenic mice.
研究领域:
神经科学
·
药理学
·
分子生物学
·
神经退行性疾病
·
炎症研究
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Fengyi Wang,Daheng Wang,Zhiguang Guo
Functional superamphiphobic coatings have garnered massive concern due to their promising application in oil transportation and anti-contamination, which call for the requirements of mechanical stability and flame retardancy. Herein, a novel superamphiphobic PVT/F-APP-TiO 2 hybrid coating with excellent mechanical stability and flame retardancy was fabricated using fluorinated PVT polymer adhesive and highly fluorinated ammonium polyphosphate/TiO 2 (F-APP-TiO 2 ) particles with hierarchical core-shell structure. The synthetic mechanism, surface structure, chemical composition of the F-APP-TiO 2 particles were investigated by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), respectively. The PVT/F-APP-TiO 2 coatings exhibited excellent superamphiphobicity, anticontamination and self-cleaning property. Good mechanical stability of PVT/F-APP-TiO 2 coatings was verified by mechical damage tests including sand paper abrasion, tape-peeling and water-impacting tests. Further, the PVT/F-APP-TiO 2 coatings showed excellent flame retardancy and self-recovery ability. The PVT/F-APP-TiO 2 coatings with versatile abilities exhibited promising potential to achieve numerous applications in water-oil proof, fireproof and oil transportation materials.
研究领域:
材料科学
·
表面工程
·
涂层技术
·
消防安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）