EUROPEAN JOURNAL OF MEDICAL RESEARCH
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2026
·Vol. 31
·期 1
·902
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IF 4.8
Ma Yang,Ying Yiyang,Huang Zanche,Zhang Qin,Ren Ning
Background Laser-assisted hatching (LAH) has been reported to improve implantation and pregnancy rates, yet its efficacy and safety profile require rigorous evaluation. To assess the impact of LAH on pregnancy-related outcomes and safety metrics within Assisted Reproductive Technologies (ART) procedures, we conducted a systematic review and meta-analysis. Methods Electronic databases were searched from inception to November 30, 2023. Studies, comparing LAH with other hatching methods or no intervention within ART frameworks, were included. The quality of the included studies was rigorously evaluated using the Risk of Bias In Non-randomized Studies-of Interventions (ROBINS-I) tool with a Weighted Cohen’s kappa coefficient (κ). Summative data, subgroup analyses, and evaluation of heterogeneity were analyzed via Stata 15. Results 47 eligible studies were included, covering 24,876 couples. When comparing the effectiveness of LAH to other methods or no intervention, the results revealed enhancements in implantation and clinical pregnancy rates. For implantation rates, the pooled effect size showed an OR of 1.22 (95% CI 1.09–1.36), indicating a modest improvement with LAH. As for clinical pregnancy rates, LAH was associated with an OR of 1.12 (95% CI 1.03–1.22), demonstrating its positive impact. However, term delivery rates showed a modest but statistically detectable improvement, with an OR of 1.07 (95% CI 1.01–1.14), and sensitivity analysis revealed this effect to be study-dependent. The abortion rate remained statistically unchanged with LAH, OR 0.95 (95% CI 0.85–1.06; P = 0.34; I 2 : 0%). Subgroup analyses, particularly focusing on age and embryo status (fresh vs. frozen), elucidated some of the observed heterogeneity, offering a deeper understanding of LAH's varying impacts across different patient demographics and treatment specifics. Conclusion LAH represents a valuable adjunct in ART, particularly beneficial for specific patient groups. It modestly improves implantation and clinical pregnancy rates without compromising safety. However, its effect on term delivery is small, sensitive to individual studies, and uncertain overall. Graphical
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COMPOSITES PART B-ENGINEERING
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2024
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IF 12.7
Gang Qiao,Yuyang Zhao,Pan Wang,Dongshuai Hou,Binmeng Chen
The morphology of interface hydration products is crucial as it directly determines the interface mechanics. Inspired by the fishing nets, we employed photo-grafted active copolymer Poly(vinylpyrrolidone-co-acrylic acid) on the inert glass fibers. Providing a template for PVP-co-PAA maintains its regulatory capability in cement paste. For the first time, ordered nanomesh-like hydrated calcium silicate (CSH) with average pore diameter of 30 nm are developed in cement paste. The interface strength and energy absorption increased by 90 % and 253 %, respectively. XPS and SEM revealed that the multi-scale regulation mechanisms originated from the preferential adsorption and stable dispersion of Ca 2+ result from the strong electronegativity and steric hindrance of pyrrolidone rings. CSH nuclei (60 nm) dispersed well on fiber templates, stacked along fiber surfaces, without collapse or tilt, intertwined into nanomesh. Nanomesh-like CSH in cement paste holds significant potentials for the improvement of mechanical properties of fiber-cement interfaces, contributing to construction sustainability.
研究领域:
建筑材料学
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界面化学
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
He Jiang,Haoliang Wei,Xinkai Li,Yijun Zhang,Tingjiang Lu,Feili Li,Shuang Song,Yan Yu,Meilan Pan,Weiting Yu
The widespread discharge of halogenated organic pollutants (HOPs) in wastewater brings significant risks to the environment and human health due to potent high toxicity, antibacterial activity, and strong biodegradation resistance. Adsorbed atomic hydrogen (H* ads )-mediated electrocatalytic hydrodehalogenation (EHDH) has been recognized as an efficient strategy for HOPs removal through selectively breaking carbon-halogen bonds. In this work atomic Pd uniformly anchored on molybdenum disulfide (denoted as Pd-MoS 2 ) was synthesized through a facile hydrothermal method and found with state-of-the-art specific activity in florfenicol (FLO) removal via the H* ads -mediated EHDH process. Pd-MoS 2 completely dehalogenated (∼100 %) FLO within 30 min at a rate constant of 0.15 min −1 , which was 6.0, 6.5 and 33.1 times the value of MoS 2 , Pd/C and carbon paper samples, respectively. Notably, the toxicity of the wastewater was reduced to 1/6 of its original value after the treatment. Moreover, Pd-MoS 2 presented superior catalytic stability in five successive cycles. Furthermore, Pd-MoS 2 was also robust in complex water environment with practical applicability for industrial wastewater treatment. A dual-active-center mechanism with enhanced H* ads production capacity and the improved H* ads utilization efficiency was contributed to the increased EHDH activity on Pd-MoS 2 .
研究领域:
环境科学
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材料科学
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化学工程
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Weihua Zou,Yujiao Zhang,Naike Zou,Delin Sun
A delignified longitudinal-cutting poplar veneer-based epoxy resin composite (TLPE) with excellent transmittance, haze, flexibility and wood fiber art texture, that was prepared by delignifing longitudinal-cutting poplar veneer (LPV) and filling the delignified LPV with epoxy resin (ER). The TLPE has retained the porous structure and wood fiber art texture of LPV due to the fact that it is not completely filled with resin. The changed benzene skeleton and the ether (C-O-C) were found in the TLPE, that should be due to the chemical combination between the benzene of filled ER and the cellulose of delignified LPV, and the chemical reaction between the benzene and the cellulose yielded the C-O-C. Parts of the TLPE that are completely filled with the ER, that can reach a transmittance of approximately 90 % and a haze of approximately 90 %. Moreover, due to the combined action between the fibril of delignified LPV and the ER, the TLPE has high refractive index fluctuation in the perpendicular direction of fiber and excellent flexibility (the elongation at break: 15 %). When the TLPE is used as the building material, the TLPE can provide a comfortable lighting effect after the light passes through it, it can also accommodate various streamlined and natural artistic shapes with wood fiber art texture in buildings, and it can also achieve a balance between science and art in the building through its optical, styling, and textural advantages.
研究领域:
材料科学
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林产化学加工工程
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高影响因子
Journal of CO2 Utilization
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2023
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IF 7.7
Weiting Yu,Sizhuo Chen,Jieyun Zhu,Zhiqiao He,Shuang Song
Electrochemical CO 2 reduction reaction (CO 2 RR) towards CO is considered as one of the most promising routes to alleviate carbon emissions and achieve a carbon-neutral cycle. In this work, a highly dispersed Ag-BTC catalyst (BTC refers to the 1,3,5-benzenetricarboxylate ligand) with abundant catalytically active sites has been synthesized via a facile one-step hydrothermal method. Efficient, highly selective, and stable electrochemical reduction of CO 2 into CO has been achieved on the Ag-BTC electrocatalyst. The faradaic efficiency of CO production from the CO 2 RR is around 95%, which is within the range of highest values reported to date. A correlation between the structure of the Ag-BTC electrode and its enhanced catalytic performance has been established through the combination of characterization results and electrochemical measurements. Furthermore, a lower Gibbs free energy change (∆G) for the rate-determining step regarding the formation of intermediate COOH ads also leads to the superior catalytic performance of CO 2 RR on Ag-BTC.
研究领域:
材料科学
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电化学
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高影响因子
BIOMATERIALS
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2022
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IF 15.304
Zhifang Li,Chunmei Wang,Chen Dai,Ruizhi Hu,Li Ding,Wei Feng,Hui Huang,Yin Wang,Jianwen Bai,Yu Chen
Chemodynamic therapy represents a distinct anti-tumor strategy by activating intratumoral chemical catalytic reactions to produce highly toxic reactive oxygen species (ROS) from non-/limited-toxic nanocatalysts . However, the low efficacy of ROS generation still remains a major challenge for further clinical translation. Herein, a liposomal nanosystem which simultaneously encapsulated copper peroxide nanodots (CPNs) and artemisinin (ART) was constructed for autophagy-enhanced and ferroptosis-involved cancer cell death owing to Cu-based dual catalytic strategy. To be specific, the CPN components, served as a H 2 O 2 self-supplying platform, release H 2 O 2 and Cu 2+ under acidic tumor environment and endogenously generate . OH via Fenton-like reaction (catalytic reaction I). In addition, Cu 2+ species catalyze ART components to produce ROS radicals (catalytic reaction II), further augmenting the intracellular oxidative damage and lipid peroxide accumulation, leading to cancer cell death. Specifically, ART also acted as a potent autophagy inducer increasing the level of intracellular iron pool through degradation of ferritin , which could promote cancer cell ferroptosis , producing the best antineoplastic effect. After accumulation into the tumor sites, ultrasound irradiation was applied to trigger the release of CPNs and ART from liposomal nanosystems, and amplify the efficacy of catalytic reaction for maximum therapeutic effect. Both in vitro and in vivo therapeutic outcomes suggest the outstanding autophagy-augmented ferroptosis-involved cancer-therapeutic efficacy, which was further corroborated by transcriptome sequencing. In this work, Cu was firstly proven to trigger ART to produce ROS species, but also provide a TME-responsive nanoplatform for potentially suppressing tumor growth by autophagy-augmented ferroptosis-involved cancer nanotherapy.
研究领域:
纳米医学
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癌症治疗
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生物医学工程
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药学
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DOI
PubMed
高影响因子
ACS Applied Nano Materials
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2024
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IF 5.3
Yahui Zhang,Xia Huang,Jiachang Chen,Jiyuan Li,Shen Zhou,Junying Chen
Quantitative analysis of harmful patina components on the surface of bronzeware is crucial as patina can corrode artifacts. Surface-enhanced Raman spectroscopy (SERS) has a common application in surface analysis. However, there exists an absence of documented investigations concerning the quantitative analysis of detrimental patina, particularly the chloride patina. To achieve high sensitivity in targeting harmful patina, we report a fabrication method for constructing Ag/Au alloys in the pores and on the surface of UiO-66 (zirconium 1,4-dicarboxybenzene metal–organic framework) nanomaterials, resulting in Ag/Au/UiO-66 nanoparticle monolayers formed by self-assembly at the oil–water interface. By incorporating them onto the surface of PVA hydrogel, we obtained SERS sensor devices with excellent flexibility, outstanding optical transparency, and ultrahigh activity. These sensor devices efficiently sample irregular surfaces and detect micrometer-scale specimen. They significantly enhance the Raman characteristic peaks of measured objects, facilitating precise analysis of the patina composition on the surface of bronze artifacts. The Raman peak at 118 cm–1 was boosted from 367 to 11,909 for detecting harmful patina, and the enhancement factor of the SERS substrate was calculated to be 3.6 ×1010 for detecting the Raman peak of rhodamine 6G (R6G), which could be easily detected at 610 cm–1 at a concentration of 10–13 mol/L (M). The Raman peaks at 610 cm–1 from the SERS substrate could also be readily detected. By grafting the organic fluorescent group amino-MQAE onto the surface of Ag/Au/UiO-66 nanoparticles (NPs), the content of harmful patina on the surface of bronze artifacts treated for different durations was indirectly determined. These results indicate the successful construction of the Ag/Au alloy on the surface of UiO-66 NPs, resulting in SERS sensor devices with excellent flexibility, optical transparency, and ultrahigh sensitivity.
研究领域:
材料科学
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考古学
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光谱学
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高影响因子
JOURNAL OF CONTROLLED RELEASE
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2023
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IF 10.8
Huihui Liu,Qing Wang,Jingru Guo,Kai Feng,Yiling Ruan,Zhihao Zhang,Xin Ji,Jigang Wang,Tao Zhang,Xiaolian Sun
Cerenkov radiation induced photodynamic therapy (CR-PDT) can tackle the tissue penetration limitation of traditional PDT. However, co-delivery of radionuclides and photosensitizer may cause continuous phototoxicity in normal tissues during the circulation. 5-aminolevulinic acid (ALA) which can intracellularly transform into photosensitive protoporphyrin IX (PpIX) is a cancer-selective photosensitizer with negligible side effect. However, the hydrophilic nature of ALA and the further conversion of PpIX to photoinactive Heme severely hinder the therapeutic benefits of ALA-based PDT. Herein, we developed an 89 Zr-labeled, pH responsive ALA and artemisinin (ART) co-loaded liposome ( 89 Zr-ALA-Liposome-ART) for highly selective cancer therapy. 89 Zr can serve as the internal excitation source to self-activate PpIX for CR-PDT, and the photoinactive Heme can activate the chemotherapeutic effect of ART. The 89 Zr-ALA-Liposome-ART exhibited excellent tumor inhibition capability in subcutaneous 4T1-tumor-bearing Balb/c mice via CR-PDT and chemotherapy. Combined with anti-PD-L1, the 89 Zr-ALA-Liposome-ART elicited strong antitumor immunity to against tumor recurrence.
研究领域:
药学
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放射肿瘤学
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纳米技术
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免疫疗法
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DOI
PubMed
高影响因子
Theranostics
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2024
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IF 12.4
Yan-Hang Wang,Xin Chen,Yi-Zhen Bai,Peng Gao,Zhuo Yang,Qiang Guo,Ying-Yuan Lu,Jiao Zheng,Dan Liu,Jun Yang,Peng-Fei Tu,Ke-Wu Zeng
The hypothalamus plays a fundamental role in controlling lipid metabolism through neuroendocrine signals. However, there are currently no available drug targets in the hypothalamus that can effectively improve human lipid metabolism. In this study, we found that the antimalarial drug artemether (ART) significantly improved lipid metabolism by specifically inhibiting microglial activation in the hypothalamus of high-fat diet-induced mice. Mechanically, ART protects the thyrotropin-releasing hormone (TRH) neurons surrounding microglial cells from inflammatory damage and promotes the release of TRH into the peripheral circulation. As a result, TRH stimulates the synthesis of thyroid hormone (TH), leading to a significant improvement in hepatic lipid disorders. Subsequently, we employed a biotin-labeled ART chemical probe to identify the direct cellular target in microglial cells as protein kinase Cδ (PKCδ). Importantly, ART directly targeted PKCδ to inhibit its palmitoylation modification by blocking the binding of zinc finger DHHC-type palmitoyltransferase 5 (ZDHHC5), which resulted in the inhibition of downstream neuroinflammation signaling. In vivo, hypothalamic microglia-specific PKCδ knockdown markedly impaired ART-dependent neuroendocrine regulation and lipid metabolism improvement in mice. Furthermore, single-cell transcriptomics analysis in human brain tissues revealed that the level of PKCδ in microglia positively correlated with individuals who had hyperlipemia, thereby highlighting a clinical translational value. Collectively, these data suggest that the palmitoylation of microglial PKCδ in the hypothalamus plays a role in modulating peripheral lipid metabolism through hypothalamus-liver communication, and provides a promising therapeutic target for fatty liver diseases.
研究领域:
神经科学
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代谢学
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药理学
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分子生物学
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内分泌学
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PubMed
高影响因子
危险品化学品经营许可证（带存储）