INDUSTRIAL CROPS AND PRODUCTS
·
2026
·
IF 6.4
Xuanzheng Li,Liqin Huang,Yunlong Wang,Mingzhen Zhang,Bingchen Han,Xianju Huang,Yuebin Ge
Essential oil of Artemisia argyi leaf (AAEO), derived from a well-known herb plant species of Compositae family, is extensively used to develop healthcare products in traditional medicine and incense for its aromatic odour. In an effort to address the main challenges associated with essential oil, i.e., high volatilization and poor sustainability, we have screened and prepared solidified AAEO powders using six carriers with distinct structural characteristics, including non-porous fumed silica, functionalized mesoporous silica, magnesium aluminometasilicate and calcium carbonate, two ordinary excipients including starch and β-cyclodextrin (β-CD). Substantial evaluation was conducted on the volatilization stability, mechanical property and biological activity as well. Compared to starch and β-CD, more excellent solid-state properties for 350FCP-, S244-, US2-AAEO displayed on dry, loose appearance and high loading amount, extremely reduced weight loss and alleviated the volatilization by TG, DSC and kinetic analysis. BET and BJH methods were employed to evaluate the surface area and pore characteristic of the mesoporous materials microstructure. The solidification of AAEO effectively reduced the volatilization, thus improved the potential stability of volatile oil, particularly for S244 at high temperature. 350FCP- and S244-AAEO powders reflected a significant improvement on the flowability, packability and tabletability, while US2-AAEO behavior was much sensitive to AAEO loading content. This was likely attributed to its spherical morphology with SEM and greater distribution of hydrogen-containing molecules by LF NMR analysis. Through GC-MS analysis of components and antibacterial activity against E. coli , 350FCP- and S244-AAEO especially proved to alleviate the volatilization rate of 23 major ingredients, such as thujone, eucalyptol, caryophyllene, and germacrene D, and simultaneously prolonged the antibacterial effect over 7 days. These comprehensive assessments provided the strong protection for the volatile stability and sustained biological activity to utilize a feasible porous silica material for developing technique for essential oils.
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Journal of Materials Research and Technology-JMR&T
·
2020
·
IF 5.289
Ting-Ting Li,Jiaxin Li,Yue Zhang,Jun-Li Huo,Shu Liu,Bing-Chiuan Shiu,Jia-Horng Lin,Ching-Wen Lou
Medical wound dressing with natural antibacterial efficacy is an important issue. However, few studies on Artemisia argyi oil based wound dressing have been studied because of the volatility of the Artemisia argyi oil. In this study, Artemisia argyi oil -microcapsules (AAO-MC)/PVC fibrous membrane were fabricated through emulsification-internal gelation and electrospinning method. The membranes were characterized by SEM, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and particle diameter, hydrophilicity, breathability, water vapor transmission rate (WVTR), and antibacterial performance were evaluated. The results show that AAO-MC microcapsules excellent stability, and the slow-release property. Moreover, the prepared AAO-MC/PVC fibrous membrane indicated good WVT (72.47 g/(m²·h)), high hydrophilicity (30.5°), and outstanding antibacterial rate (94.3%). This study provides a new strategy to prepare microcapsule nanofibrous membrane with excellent performance and is suggested to be a promising candidate for medical wound dressings.
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RSC Advances
·
2025
·Vol. 15
·期 57
·49432-49440
·
IF 4.6
Lili Feng,Anyuan Ye,xuemei Yu,Zhihua Chen
Natural dyes commonly exhibit low dye uptake and inferior color fastness in textile applications, making the utilization of mordants necessary for enhancing dyeing performance. However, ecological toxicity and low biocompatibility are the drawbacks of traditional metal mordants. This study proposed an eco-friendly alternative by employing Phyllanthus emblica (PE) as natural mordant, and systematically explored its enhancement mechanism and mordanting effects on silk dyed with Artemisia argyi dye. The results demonstrated that the addition of PE extract under the dyeing conditions (pH 4, 90 °C, 30 min) significantly enhanced the color depth of silk fabric, as indicated by an increase in the K/S value from 2.82 to 5.05. The color fastness was also improved, with both washing and rubbing fastness increasing by approximately 0.5 grades. Furthermore, the dyed fabric exhibited excellent antibacterial activity, achieving a 93.03% bacteriostatic rate against Staphylococcus aureus. This study provides new insights for developing eco-functional textiles through sustainable dyeing processs.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Miao Dazhuang,Suo Xiaopeng,Geng Xinqian,Yang Ying,Wang Gaoming,Zhou Yang,Jia Yunhe,Yang Shuofei,Li Heping,Li Gaohua
Diabetic wounds are characterized by persistent inflammation, impaired angiogenesis, and delayed tissue regeneration, yet effective strategies to regulate the pathological immune microenvironment remain limited. Here, integrated single-cell transcriptomics and multi-omics analyses revealed significant enrichment of endoplasmic reticulum stress (ERS)-related signaling in pro-inflammatory macrophages within diabetic wounds, suggesting a potential mechanism driving chronic inflammation. To target this process, we developed an injectable dynamic hydrogel (GPOK-2@EVs) incorporating Artemisia argyi-derived extracellular vesicles (EVs) for localized immunomodulatory therapy. The hydrogel was formed through dual dynamic crosslinking between phenylboronic acid-modified gelatin and oxidized konjac glucomannan, providing self-healing capability, injectability, tissue adhesion, and pH/ROS-responsive degradation for sustained EV release. In vitro experiments demonstrated that GPOK-2@EVs exhibited excellent biocompatibility and effectively reprogrammed macrophages toward an anti-inflammatory phenotype, accompanied by reduced inflammatory cytokine secretion, alleviated ERS activation, decreased ROS accumulation, and improved mitochondrial integrity. GPOK-2@EVs significantly enhanced endothelial angiogenic activities, including cytoskeletal remodeling, tube formation, and migration. In a diabetic mouse wound model, GPOK-2@EVs accelerated wound closure, promoted granulation tissue formation and collagen deposition, enhanced vascularization, and suppressed inflammatory and ERS responses. These findings demonstrate that EV-loaded dynamic hydrogels can modulate the inflammatory microenvironment and promote diabetic wound regeneration, providing a promising biomaterial strategy for chronic wound therapy. Graphical GPOK-2@EVs hydrogel promotes wound healing through ROS-responsive EV release, macrophage modulation, inflammatory cytokine reduction, and enhanced angiogenesis.
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高影响因子
Journal of Cleaner Production
·
2024
·
IF 9.7
Hong Chen,Jinxin Li,Xinglei Chen,Likun Mei,Shumin Feng,Pengfei Duan,Huixia Cai,Kaili Qu,Jingyi Zhang,Yuhuan Miao,Dahui Liu
Nanotechnology contributes to the development of biopesticides with reduced toxicity, increased stability, improved biosafety, and higher activity against targets. It has demonstrated great potential as a solution for practical applications of essential oils. Herein, the HLB method developed two Artemisia argyi essential oil-loaded nanoemulsions (AEOnano). Further systematically optimizing the ratio led to small droplet size (<200 nm) and low PDI (<0.3). As anticipated, the AEOnano demonstrated robust physical stability when subjected to various stressors. Notably, both indoor and outdoor pot experiments demonstrated that AEOnano outperformed ordinary A. argyi essential oil aqueous emulsions (AEOAE) in weed control. These nanoemulsions allowed a 2–4 times reduction in AEO dosage while maintaining the same weed-killing efficacy. The superior improvement attributed to the nanoemulsions enhanced leaf-wetting capability, improved leaf retention, and resistance to wash-off. In addition, biosafety assessment indicated that AEOnano did not affect the plants ( Artemisia argyi , Chrysanthemum morifolium , cotton), which provide orientation for its practical application. Therefore, this study introduces a promising approach to enhance the effectiveness of AEO-based herbicides, which will have a broad application prospect in sustainable agriculture.
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ULTRASONICS SONOCHEMISTRY
·
2026
·
IF 10.2
Nina Bao,Xinyuan Zhao,Lele Li,Marwan M.A. Rashed,Weifeng Yuan
This study presents an efficient and environmentally sustainable technique for extracting flavonoids from Artemisia argyi folium, employing natural deep eutectic solvents combined with ultrasound-assisted extraction (NADESs-UAE). Among the ten DES systems evaluated, the Choline Chloride-Lactic Acid mixture (ChCl-LA, molar ratio 1:1, designated as DES-3) yielded the highest extraction of 93.39 mg of rutin equivalents (RE) per gram of dry weight (DW). This was much higher than the yields obtained with traditional 60% ethanol or water extraction methods. Response surface methodology (RSM) was used to optimize key extraction variables, including water content, extraction time, temperature, and liquid-to-solid ratio. Optimal conditions included 51.5 g/100 g water content, 56 min extraction time, and an extraction temperature of 59 °C. The liquid-to-solid ratio reached 48 mL/g under optimized conditions. Under these conditions, the predicted flavonoid yield was 99.27 mg RE/g DW, whereas the experimental value was 98.71 ± 0.66 mg RE/g DW, confirming the model’s reliability. Kinetic investigations demonstrated that the extraction process followed a pseudo-second-order kinetic model, indicating enhanced diffusion-assisted mass transfer under ultrasonic cavitation conditions. Scanning electron microscopy (SEM) analysis revealed that DES-3 induced pronounced cellular disruption, thereby facilitating enhanced flavonoid extraction. Fourier-transform infrared (FT-IR) spectroscopy further confirmed the presence of strong hydrogen-bonding interactions between ChCl-LA and flavonoid compounds. Compared with conventional solvent systems, the ChCl-LA extract exhibited superior antioxidant activity, including DPPH radical-scavenging activity (959.98 ± 9.59 mg Trolox/g DW), as well as enhanced α-glucosidase inhibition (91.8% at 125 μg/mL) and antibacterial activity. Furthermore, treatment with AAF extracts effectively improved strawberry firmness and enhanced POD activity during storage, thereby prolonging strawberry shelf life. Overall, the findings demonstrate that NADESs-UAE represents a promising green extraction strategy for the efficient recovery and practical utilization of flavonoids from Artemisia argyi folium.
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SEPARATION SCIENCE AND TECHNOLOGY
·
2021
·
IF 2.475
Jia-Lun Zhong,Nadeem Muhammad,Shun-Quan Chen,Li-Wei Guo,Jia-Sheng Li
The essential oils of Artemisia argyi Lévl. et Vant were extracted and separated using three methods, hydrodistillation (HD), supercritical fluid extraction (SFE), and SFE coupled molecular distillation (SFE-MD). Various extraction parameters of SFE were optimized by process modeling of Hansen solubility parameters which are 30 MPa, temperature 45°C, no co-solvents, extraction time 2 h, and flow rate of 90 kg/h. The essential oils obtained by HD and SFE-MD have similar major compositions. The antimicrobial activities were examined according to the agar well diffusion method and the minimum inhibition concentrations against Staphylococcus aureus and Escherichia coli were compared.Abbreviations A. argyi, Artemisia argyi; CFU, Colony Forming Unit; DMSO, dimethylsulfoxide; E. coli, Escherichia coli; GC-MS, Gas Chromatography-Mass Spectrometer; HD, hydrodistillation; HSP, Hansen solubility parameters; MIC, minimum inhibition concentration; OSE, organic solvents extraction; RSM, response surface methodology; SCCO2, supercritical-CO2; SFE, supercritical fluid extraction; SFE-MD, SFE coupled molecular distillation; SMILES, Simplified Molecular Input Line Entry Syntax; S. aureus, Staphylococcus aureus;
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
·
2025
·Vol. 113
·期 6
·e37937
·
IF 3.9
Yiyang Xu,Ying Li,Zixuan Ye,Cheng Wang,Pengfei Cui,Shuwen Zhou,Lin Qiu,Jianhao Wang
Wound bacterial infection deteriorates with antibiotic misuse, boosting bacterial drug resistance, threatening human health. Therefore, combining natural antibacterials with efficient broad-spectrum materials offers new solutions. Artemisia argyi is a kind of medicinal plant distributed in Asia, known for its rich biological active compounds. With the advancement of modern analytical technology, Artemisia argyi has shown excellent antibacterial and anti-inflammatory potential, particularly Artemisia argyi essential oil (AAEO) which is considered to be the most active substance in Artemisia argyi. However, its practical application is limited due to its poor water solubility, strong volatility, high sensitivity to light and heat, and its irritating odor. Zeolitic imidazolate framework-8 (ZIF-8) is a type of metal–organic framework material (MOF) with good biocompatibility, simple synthesis, high porosity, and antimicrobial activity. ZIF-8 can be used as an ideal vehicle for the preparation of antibacterial materials. In this study, we loaded AAEO onto ZIF-8 to successfully develop AAEO@ZIF-8 antibacterial nanomaterial. The bactericidal ability and antibacterial mechanism of AAEO@ZIF-8 were evaluated through in vitro experiments such as bacterial coating, Live/Dead staining, and crystal violet staining. It was confirmed that AAEO@ZIF-8 had significant antibacterial activity against both Staphylococcus aureus and Escherichia coli . In in vivo experiments, the wound model using C57BL/6 male mice was established, and wound tissue staining with Gram, CD31 + immunohistochemistry, H&E, and Masson staining was performed to evaluate the antibacterial activity of AAEO@ZIF-8. The results showed that AAEO@ZIF-8 exhibited the best wound repair performance in the model. These findings suggested that AAEO@ZIF-8 is a novel and effective antimicrobial nanomaterial targeting pathogenic bacteria. This study successfully transformed the storage mode of AAEO from liquid to solid, providing a promising strategy for the application of AAEO in the treatment of wound bacterial infections.
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FITOTERAPIA
·
2023
·
IF 3.4
Nan Zhang,Junwei Zhang,Weiqi Cui,Deqiao Wu,Jingxian Zhang,Bo Wei,Lingbo Qu,Xia Xu
Artemisia argyi H.Lév. & Vaniot, a traditional Chinese medicine with a history spanning over two millennia, has been extensively used in folk medicine to treat dysmenorrhea, uterine bleeding and inflammation. Recent studies have demonstrated that the essential oil extracted from Artemisia argyi H.Lév. & Vaniot, known as AAEO, exhibits significant anti-tumor properties against liver and lung cancers. There is a scarcity of research on the potential impact of AAEO on pancreatic cancer (PC) cells. In this study, UPLC-MS/MS-based metabolomics method was established to evaluate the effect of AAEO on the proliferation of PC cells. The differential compounds included 5-oxoproline, glutamate, γ-glutamylcysteine, glutathione, arachidonic acid, adrenal acid and linoleic acid were detected by metabolomics, enriching in the γ-glutamyl cycle and polyunsaturated fatty acid metabolism, which were closely related to ferroptosis. Meanwhile, AAEO dramatically increased the levels of intracellular iron ion via up-regulation of TFR1, augmented reactive oxygen species and malondialdehyde in a dose-dependent manner by down-regulation of γ-glutamyl cycle through decreasing expressions of SLC7A11. Additionally, β-caryophyllene oxide, one of the main components of AAEO, could covalently bind to Cys in SW1990 cells to form a conjugate Cpo-Cys, resulting in the inhibition of glutathione synthesis. Importantly, the ferroptosis inhibitor deferoxamine significantly blocked the inhibitory effect of AAEO on SW1990 cells. Meanwhile, β-caryophyllene oxide, dihydro-β-ionone and α-bisabolol had strong binding force with GPX4, SLC7A11 and TFR1, respectively. These findings showed that AAEO induced ferroptosis via regulation of γ-glutamyl cycle by SLC7A11 and iron disorders by TFR1. Our study discovered AAEO as a potential therapeutic approach to induce ferroptosis to prevent or treat PC.
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MOLECULES
·
2023
·Vol. 28
·期 5
·2022
·
IF 4.6
Ting Zhang,Dingrong Wan,Yuanyuan Li,Sisi Wang,Xiuteng Zhou,Fatemeh Sefidkon,Xinzhou Yang
TheArtemisia argyiLévl. et Van. growing in the surrounding areas of Qichun County in China are called Qiai (QA). Qiai is a crop that can be used both as food and in traditional folk medicine. However, detailed qualitative and quantitative analyses of its compounds remain scarce. The process of identifying chemical structures in complex natural products can be streamlined by combining UPLC-Q-TOF/MS data with the UNIFI information management platform and its embedded Traditional Medicine Library. For the first time, 68 compounds in QA were reported by the method in this study. The method of simultaneous quantification of 14 active components in QA using UPLC-TQ-MS/MS was reported for the first time. Following a screening of the activity of QA 70% methanol total extract and its three fractions (petroleum ether, ethyl acetate, and water), it was discovered that the ethyl acetate fraction enriched with flavonoids such as eupatilin and jaceosidin had the strongest anti-inflammatory activity, while the water fraction enriched with chlorogenic acid derivatives such as 3,5-di-O-caffeoylquinic acid had the strongest antioxidant and antibacterial activity. The results provided the theoretical basis for the use of QA in the food and pharmaceutical industries.Keywords:Artemisia argyiLévl. et Van.;UPLC-MS;quantification;anti-inflammatory;antioxidant
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Pharmaceuticals
·
2026
·Vol. 19
·期 4
·640
·
IF 5.7
Zeting Tan,Rongshun Liang,Adam Junka,Haoxuan Sun,Jie Jiang,Haojia Ma,Shisong Fang,Yanfang Sun
Background: Respiratory syncytial virus (RSV) is a leading global pathogen of acute lower respiratory tract infection, posing significant risks to infants, the elderly, and immunocompromised patients.Artemisia argyiLevl.et Vant Extract (AALE) and its active components have a variety of pharmacological effects, but their anti-RSV potential remains unclear. The aim of this study is to investigate the anti-RSV activity of AALE and parthenolide and its underlying mechanisms.Methods: Cell counting kit-8 (CCK-8) assay was used to determine the anti-RSV activities of AALE and parthenolide. Time-of-addition assay and phase of action analysis were used to explore the effect of drugs on the viral replication cycle. Quantitative polymerase chain reaction (qRCR), immunofluorescence (IF) and Western blot (WB) were used to investigate the effects of AALE and parthenolide on RSV-F gene and protein and on RIG-I/TLR-3 pathway related molecules in vitro. In vivo antiviral efficacy was verified by hematoxylin–eosin (HE) staining for lung histopathology, quantitative real-time PCR (qPCR) quantification of RSV-F, RIG-I, TLR-3, IRF3, IL-6, and IFN-β gene expression in lung tissues, and enzyme-linked immunosorbent assay (ELISA) for serum IL-6 and IFN-β levels.Results: AALE exhibited the strongest anti-RSV activity among the extracts (SI = 27.6), while parthenolide was the most potent monomeric compound (SI = 8.19). In vitro, both AALE and parthenolide were effective in the co-treatment and post-treatment models, reducing RSV-F gene and F protein levels in infected cells. Furthermore, they alleviated RSV infection by regulating RIG-I and TLR-3 pathway-related genes and proteins. In vivo, AALE and parthenolide suppressed lung index and RSV proliferation, attenuated lung injury, and down-regulated RIG-I, TLR-3, IRF3, IL-6, and IFN-β expression in the lungs of RSV-infected mice.Conclusions: AALE and its component parthenolide can inhibit the invasion and replication of RSV, making it a potential candidate for the treatment of RSV-related diseases.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Fanglin Liu,Yongqiang Pang,Dexiang Liu,Qianwen Cao,Ying Rong,Xinglin Liao,Qiman Jiang,Peirong Xu,Di Chen,Xia Xu
In this study, Artemisia argyi essential oil (AAEO), extracted from the leaves of Artemisia argyi , was employed as a green extraction solvent for in-syringe kapok fiber-supported liquid-phase microextraction (KF-SLME) of hydrophobic compounds in aqueous samples. The wheat of natural kapok fiber as the support medium was 2 mg, and the optimum volume of the extraction solvent AAEO was 12.5 μL. The volume of green desorption solvent 75 % ethanol was 100 μL, which realized a highly environmentally friendly sample preparation method. By simply pulling and pushing the syringe plunger five times, the extraction process enabled rapid and convenient enrichment of analytes while removing most interferences. Coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS), the AAEO-based in-syringe SLME method was applied as a proof-of-concept study to determine triazole fungicides (TFs) residues in fruit juices, herbal oral liquids and herbal extract granules. Employing in-syringe KF-SLME prior to LC-MS/MS detection significantly reduced the limits of quantification (LOQs) by 5–50-fold. The integrated AAEO-based in-syringe KF-SLME-LC-MS/MS method demonstrated satisfactory linearity (R 2 ≥ 0.995), accuracies (86.5 %–115.1 %), and precisions (1.2 %–12.7 %) using an isotope calibration method. Furthermore, three greenness assessment metrics uniformly highlighted its outstanding environmental friendliness. The proposed method offers competitive advantages in terms of its environmentally friendly approach, detection sensitivity, analysis cost, and operational convenience.
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危险品化学品经营许可证（带存储）