JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Wang Daifang,Shen Ligong,Liu Wenjun,Cao Xiao,Wang Qianwen
This article introduces a novel unlabeled surface-enhanced electrochemiluminescence (SEECL) sensor for malachite green (MG) detection. The SEECL sensor was prepared by modifying the Ru(bpy) 3 2+ doped gold-SiO 2 core–shell nanocomposites (Au@SiO 2 -Ru(bpy) 3 2+ ) on the gold electrode. Ru(bpy) 3 2+ of nanocomposites can not only emit electrochemiluminescence (ECL) with electrochemical reaction, but also induce the local surface plasmon resonance (LSPR) of gold core. That is beneficial to enhance the ECL signa of sensor. However, in the existence of MG, the luminescence of sensor would be quenched by the fluorescence resonance energy transfer (FRET) between MG and Ru(bpy) 3 2+ . In this paper, both fluorescence and ECL of the Au@SiO 2 -Ru(bpy) 3 2+ were investigated for MG detection. And the results show that the SEECL sensor has high sensitive to MG. Under the optimal experimental conditions, the minimum detection concentration could be achieved about 1.0 nM of MG, which fully meets the China national standard detection requirements of veterinary drug residue in seafood.
研究领域:
分析化学
·
环境科学
·
食品安全
✓ 已验证
DOI
PubMed
高影响因子
Polymers
·
2022
·Vol. 14
·期 21
·4772
·
IF 4.967
Ruizhi Wang,Nan Du,Liang Jin,Wufei Chen,Zhuangxuan Ma,Tianyu Zhang,Jie Xu,Wei Zhang,Xiaolin Wang,Ming Li
Bladder cancer and prostate cancer are the most common malignant tumors of the genitourinary system. Conventional strategies still face great challenges of high recurrence rate and severe trauma. Therefore, minimally invasive photothermal therapy (PTT) has been extensively explored to address these challenges. Herein, fluorescent Au nanoparticles (NPs) were first prepared using glutathione as template, which were then capped with SiO2shell to improve the biocompatibility. Next, Au nanoclusters were deposited on the NPs surface to obtain[email protected]2@Au NPs for photothermal conversion. The gaps between Au nanoparticles on their surface could enhance their photothermal conversion efficiency. Finally, hyaluronic acid (HA), which targets cancer cells overexpressing CD44 receptors, was attached on the NPs surface via 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) chemistry to improve the accumulation of NPs in tumor tissues. Photothermal experiments showed that NPs with an average size of 37.5 nm have a high photothermal conversion efficiency (47.6%) and excellent photostability, thus exhibiting potential application as a PTT agent. The temperature of the NPs (100 μg·mL−1) could rapidly increase to 38.5 °C within 200 s and reach the peak of 57.6 °C with the laser power density of 1.5 W·cm−2and irradiation time of 600 s. In vivo and in vitro PTT experiments showed that the NPs have high biocompatibility and excellent targeted photothermal ablation capability of cancer cells. Both bladder and prostate tumors disappeared at 15 and 18 d post-treatment with[email protected]2@Au NPs, respectively, and did not recur. In summary,[email protected]2@Au NPs can be used a powerful PTT agent for minimally invasive treatment of genitourinary tumors.Keywords:genitourinary system;bladder cancer;prostate cancer;photothermal therapy;hyaluronic acid;Au nanoparticles
研究领域:
纳米技术
·
癌症研究
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材料科学
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生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Conghui Liu,Haifeng Dong,Nianqiang Wu,Yu Cao,Xueji Zhang
Reactive oxygen species generation efficiency of photosensitizers and hypoxia microenvironment in solid tumor hamper photodynamic therapy (PDT) efficacy. Here, we introduce an efficient inorganic photosensitizer by incorporating plasmonic gold metal nanostructures into Cu2O semiconductors for PDT. By utilizing the plasmon-induced resonance energy transfer (PIRET) process from Au to Cu2O, Au@SiO2@Cu2O (ASC) demonstrates a high singlet oxygen quantum yield of 0.71 under a 670 nm laser irradiation. The ASC is loaded into oxygen self-enriched perfluorohexane (PFH) droplets and coated with liposome (Lip) to form Lip(ASC/PFH) nanocomposites. The achieved Lip(ASC/PFH) shows considerable anticancer efficacy for in vitro cancer cells and in vivo tumor growth. The proposed oxygen self-enriched PIRET-PDT concept has significant implication in PDT design.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2019
·
IF 3.683
Xinbing Jiang,Ben Q. Li,Xiaoli Qu,Huan Yang,Jinyou Shao,Hongmei Zhang
This paper discusses synthesis and application of dual functional SiO2@Au@SiO2@QD composite nanoparticles for integrated intracellular heating with temperature motoring. The particles are of multilayered concentric structure, consisting of Au nanoshells covered with quantum dots, with the former for infrared heating through localized surface plasma resonance while the later for temperature monitoring. The key to integrate plasmonic-heating/thermal-monitoring on a single composite nanoparticle is to ensure that the quantum dots be separated at a certain distance away from the Au shell surface in order to ensure a detectable quantum yield. Direct attachment of the quantum dots onto the Au shell would render the quantum dots practically functionless for temperature monitoring. To integrate quantum dots into Au nanoshells, a quantum quenching barrier of SiO2 was created by modifying a Stöber-like process. Materials, optical and thermal characterization was made of these composite nanoparticles. Cellular uptake of the nanoparticles was discussed. Experiments were performed on simultaneous in vitro heating and temperature monitoring in a cell internalized with the dual-functional SiO2@Au@SiO2@QD composite nanoparticles.
研究领域:
纳米技术
·
材料科学
·
生物医学工程
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2019
·
IF 2.961
Lin Lin,Zhipeng Yu,Zhezhe Wang,Zhuohong Feng,Feng Huang,Lili Huang,Qionghua Dai,Fengfen Zhang,Zhiqiang Zheng
Au@SiO 2 /NaYF 4 :Tb 3+ ,Yb 3+ @NaYF 4 nanocomposites are acquired by combining Au@SiO 2 nanorods with ligand-free NaYF 4 :Tb 3+ ,Yb 3+ @NaYF 4 nano-particles in water solution due to the electrostatic attraction. Plasmon-enhanced upconversion (UC) and quantum-cutting (QC) are both obtained and optimized in these nanocomposites by adjusting SiO 2 shell thickness and concentrations of Au@SiO 2 . While the thickness of SiO 2 shell is 35 nm, the enhancement factor of UC and QC reaches maximum as 1.91 and 3.47 times, respectively. The nanocomposites may be applied in biological fluorescence label, super-resolution imaging and solar cells, etc.
研究领域:
纳米技术
·
光学
·
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
FOOD CONTROL
·
2016
·
IF 3.388
Ruoping Li,Guanghong Yang,Jingliang Yang,Junhe Han,Junhui Liu,Mingju Huang
A simple and rapid method to detect melamine in liquid milk by Surface-enhanced Raman Scattering (SERS) technique was presented. The pretreatment procedure of milk samples only contains hydrochloric acid treatment and twice centrifugation. In order to reduce the distortion about the Raman signals originating from charge transfer and electronic tunnelling effect, SiO 2 shell-isolated gold nanoparticles (Au@SiO 2 NPs) instead of Au NPs were employed to enhance signal intensity. Aggregation occurs when the Au@SiO 2 NPs colloid is mixed with the melamine solution or the treated milk containing melamine. Different from aggregated Au NPs, these aggregated Au@SiO 2 NPs on Cu substrate can undistortedly enhance the Raman signals of melamine using surface plasma effect. Quantitative analysis was tried and the results showed a good linearity (R 2 ≈ 0.99) when the melamine concentration was between 0.5 mgL −1 and 5 mgL −1 . The detection sensitivity satisfies the requirement of the Codex Alimentarius Commission and this method can be practically used for melamine detection in milk.
研究领域:
食品安全
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Xueyuan Li,Yang Xu,Yuxia Chen,Chen Wang,Jingjing Jiang,Jiangtao Dong,Hua Yan,Xuezhong Du
This paper reports dual enhanced electrochemiluminescence (ECL) of CdS quantum dot (QD)-decorated aminated Au@SiO2 core/shell (Au@SiO2-NH2/CdS) superstructures. A maximum ECL emission of the Au@SiO2-NH2/CdS superstructures (Au core, ca. 55 nm) with a silica shell of 38 nm was 35-fold stronger than that of the counterparts (containing neither Au cores nor amino groups) with H2O2 as a coreactant. The fold of ECL enhancement is the largest, and the optical path of maximum ECL enhancement is the longest reported so far. The larger the Au cores in the superstructures, the stronger the ECL emission of CdS QDs was. Two types of ECL enhancement mechanisms were clearly proposed for the dual enhanced ECL of the Au@SiO2-NH2/CdS superstructures. One was the electromagnetic field enhancement induced by localized surface plasmon resonance of Au cores, and the other was the chemical enhancement from amino groups modified on the silica surface involved in the ECL process in the assistance of H2O2. It is the first time to put forward the new concept of chemical enhanced ECL that was directly related to the participation of other chemicals, which caused a decrease in the difference in the redox potential between emitters and coreactants for the increase of their redox currents. The constructed ECL platform was demonstrated to have promising applications in highly sensitive detection of glutathione (GSH), and the response mechanism of GSH was also explored.
研究领域:
分析化学
·
材料科学
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纳米技术
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Gangrong Chen,Yongtao Yuan,Ming Lang,Zeping Lv,Weilin Ma,Naiting Gu,Hong Liu,Jingzhong Fang,Haibin Zhang,Yuntao Cheng
Herein, we report a facile and straightforward synthetic strategy for preparing flexible NH 3 sensors with high performance and application prospects. Interestingly, core–shell Au@SiO 2 nanocrystals (NCs) doped polyaniline (PANI) were innovatively employed as the sensitive material and the NH 3 sensors were constructed via a simple droplet-evaporation self-assembly process on the polyimide substrates. Experimental results show that the well-designed NH 3 sensor with ∼ 20 wt% of Au@SiO 2 NCs doping PANI exhibited high sensitivity, flexibility and combined reproducibility at room temperature: the device’s detection limit of NH 3 reached a 10 ppb level; the device’s concentration deviation induced by large-angle and cycled bending could be kept within 0.6 ppm, and the maximum response variation was less than 2.7% through 30 days of monitoring; Additionally, the designed NH 3 sensor does have insusceptibility to the ambient relative humidity (from 48% to 66%). Indeed the sensing mechanism of our NH 3 sensor was discussed from the Au@SiO 2 NCs doped PANI structure, the crucial role of abundant hydroxyl (–OH) functional groups, and the catalytic activity of Au NPs. Overall, this study demonstrates an alternative and effective pathway to fabricate high-performance and applicable NH 3 sensors, which may be conducive to further application for environmental NH 3 detection and human kidney disease diagnosis.
研究领域:
材料科学
·
环境科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
VIBRATIONAL SPECTROSCOPY
·
2021
·
IF 2.507
Yuqian Liu,Lei Lei,Yeyu Wu,Yuyun Chen,Jun Yan,Weiwei Zhu,Xuecai Tan,Qi Wang
The quantitative determination of malachite green (MG) is of great importance in aquatic product safety. Although it has been testifying that sea urchin-like gold nanoparticles (SGNPs) have good enhancement effect, the practical application remains challenging for surface-enhanced Raman spectroscopy (SERS) due to poor stability. Here, sea urchin-like Au@SiO 2 nanoparticles (SG@SiO 2 NPs) is designed and synthesized through a controllable and surfactant-free hydrothermal method to improve its stability. The morphology of SG@SiO 2 NPs and the SiO 2 shell thickness were adjusted to obtain good SERS performance. The SERS signal intensity was linear for MG, crystal violet (CV) and methylene blue (MB) at 1619 cm −1 , 1623 cm −1 and 1627 cm −1 over the concentration range of 10 −5 -10 −9 M, 10 −5 -10 −9 M and 10 −5 -10 −8 M, respectively. The substrate was easily used for MG detection with limit of detection (LOD) as low as 1.5 × 10 −9 M. The recovery of MG added to several tilapia fillets samples at different concentrations ranged from 90 % to 110 %. Results indicated that SERS substrate can be used for the determination of trace amounts of MG in tilapia and demonstrated the potential of SG@SiO 2 NPs SERS substrate in food analysis fields.
研究领域:
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Yujiang Gou,Xinglan Fu,Jian Zhang,Jingyu Jiang,Yuehua Huang,Shixiang Ma,Chunjiang Zhao,Guanglin Li
The detection of heavy metals in soil is of great scientific significance for food security and human health. However, traditional detection methods are complicated, time-consuming, and labor-intensive. Herein, we developed a novel method using Au@SiO 2 nanoparticles (NPs) and surface microstructure combined with laser-induced breakdown spectroscopy (Au@SiO 2 NPs-SMS-LIBS) for the rapid detection of lead (Pb), chromium (Cr), and copper (Cu) in soil samples. The surface microstructures and Au@SiO 2 NPs were prepared to improve detection sensitivity and stability. The limits of detection (LODs) for Pb, Cr, and Cu were 0.36 mg/kg, 0.32 mg/kg, and 0.28 mg/kg, respectively, with relative standard deviations (RSDs) of 5.47–6.72 %. The mechanisms of spectral performance enhancement of LIBS detection were thoroughly investigated. Furthermore, the stacking combination model was developed to improve quantitative accuracy, with the correlation of the prediction set (R p 2 ) for Pb, Cr, and Cu being 0.9285, 0.8625, and 0.9160, respectively. This work offers a very promising solution to improve the sensitivity, stability, and accuracy of heavy metal detection. The developed method holds great application potential for large-scale soil assessments and real-time heavy metal pollution monitoring.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Yanping Guo,Jichun Zhu,Dongxing Kou,Wenhui Zhou,Zhengji Zhou,Shengjie Yuan,Yafang Qi,Yuena Meng,Litao Han,Zhi Zheng,Sixin Wu
The kesterite Cu2ZnSn(S,Se)4 (CZTSSe) solar cells have shown a continuous rise in power conversion efficiencies in the past years. However, the encountered interfacial problems with respect to charge recombination and extraction losses at the CdS/CZTSSe heterojunction still hinder their further development. In this work, an additional plasmonic local electric field is imposed into the CdS/CZTSSe interface through the electrostatic assembly of a two-dimensional (2D) ordered Au@SiO2 NP array onto an aminosilane-modified surface absorber. The interfacial electric properties are tuned by controlling the coverage particle distance, and the finite-difference time domain (FDTD) simulation demonstrates that the strong near-field enhancement mainly occurs near the p-n junction interface. It is shown that the imposed local electric field leads to interfacial electrostatic potential (Velec) augmentation and improves the charge extraction and recombination processes. These electric benefits enable remarkable improvements in open-circuit voltage (Voc) and short-circuit current (Jsc), leading to the cell efficiency being increased from 10.19 to 11.50%. This work highlights the dramatic role of the plasmonic local electric field and the use of the 2D Au@SiO2 NP array to modify a surface absorber instead of the extensively used ion passivation, providing a new strategy for p-n junction engineering in kesterite photovoltaics.
研究领域:
材料科学
·
光伏技术
·
纳米技术
·
电气工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 9
·1-11
·
IF 6.408
Zhai Hongguo,Wang Yue,Yin Jiaqi,Zhang Yuhao,Guo Qi,Sun Xia,Guo Yemin,Yang Qingqing,Li Falan,Zhang Yanyan
MXene@Au as the base and Au@SiO 2 as signal amplification factor were used for constructing an ultrasensitive “on–off” electrochemiluminescence (ECL) biosensor for the detection of Pb 2+ in water. The use of MXene@Au composite provided a good interface environment for the loading of tris(2,2-bipyridyl)ruthenium(II) (Ru(bpy) 3 2+ ) on the electrode. Based on resonance energy transfer, the Au (core) SiO 2 (shell) (Au@SiO 2 ) nanoparticles stimulate electron transport and promote tripropylamine (TPrA) oxidation. The luminescence effect of Au@SiO 2 was five times that of AuNPs and SiO 2 nanomaterials alone, and the ECL intensity was greatly improved. In addition, Pb 2+ activated the aptamer to exert its endonuclease activity, which realized the signal cycle amplification in the process of Pb 2+ detection. When Pb 2+ was added, the ECL signal weakened, and the Pb 2+ concentration was detected according to the decreased ECL intensity. Under optimized experimental conditions, this aptamer sensor for Pb 2+ has a wide detection range (0.1 to 1 × 10 6 ng L −1 ) and a low detection limit (0.059 ng L −1 ). The relative standard deviation (RSD) of the sensor is 0.39–0.99%, and the recovery of spiked standard is between 90.00 and 125.70%. The sensor shows good selectivity and high sensitivity in actual water sample analysis. This signal amplification strategy possibly provides a new method for the detection of other heavy metal ions and small molecules. Graphical abstract
研究领域:
分析化学
·
环境科学
·
材料科学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）