Journal of Biomedical Nanotechnology
·
2022
·Vol. 18
·期 1
·158-165
·
IF 3.641
Wang Ruizhi,Zhou Guofeng,Yang Yuchan,Wang Shiqing,Gao Shanshan,Gao Dongmei,Wang Xiaolin
The advantages of deep tissue penetration and the high spatial accuracy of photothermal therapy have been widely studied. Gold, as a photothermal material, has received particular attention. Different sizes and shapes of gold have been studied and characterized for their varying photothermal
properties. The core–shell structure of gold nanoparticles and silica enhances the photothermal conversion through the coupling effect between gold clusters on the material’s surface. With excellent photothermal conversion performance, the core–shell nanoparticles can quickly
reach 40 °C in 200 s under the irradiation of 808 nm, 1.5 W·cm−2. The highest conversion temperature of these nanoparticles is 56 °C, and the photothermal conversion rate is 45%. In vitro cell experiments displayed that NPs with targeted function can
efficiently aggregate in prostate cancer cells and effectively kill cells. In vitro experiments showed that the tumor cells of mice after photothermal treatment completely disappeared after 15 days, which fully demonstrated the potential of the nanoparticles for targeted photothermal
therapy.
研究领域:
癌症治疗
·
纳米技术
·
材料科学
·
生物医学工程
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DOI
PubMed
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 38
·22616-22621
·
IF 3.119
Liren Wang,Han Wang,Yanming Liu,Xinyu Wang,Peng Tao,Wen Shang,Benwei Fu,Chengyi Song,Tao Deng
This paper introduces an approach to synthesize bimetallic nanoparticles under an alternating temperature field in aqueous solution. During the synthesis, pyro-catalytic barium titanate is used as the substrate to reduce the metallic ions dispersed in the solution due to the generated charges at the surface of pyro-materials under temperature oscillation. Chloroauric acid and potassium tetrachloroplatinate are used as precursors to produce gold/platinum bimetallic nanoparticles through a pyro-catalytic process. Transmission electron microscopy characterization, in combination with energy dispersive X-ray spectroscopy mapping, demonstrates that the bimetallic nanoparticle is composed of an Au core and Au/Pt alloy shell structure. Compared to the conventional approaches, the pyroelectric synthesis approach demonstrated in this work requires no toxic reducing agents and waste heat can be used as a thermal energy source in the synthesis. Hence, it offers a potential “green” synthetic method for bimetallic nanoparticles.
研究领域:
材料科学
·
纳米技术
·
催化化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Xinglu Jiang,Yiwu. Qin,Jun Zhou,Wenjin Chen,Beibei Xie,Hailun Zhou,Kangjing Li,Chunyun Liang,Cong Liu,Ao Long,Shufang Zhuo,Yigeng Liu,Fengyuan Zhou
As exposed to heavy metals, they can bind to biomacromolecules and damage these molecular structures, thereby seriously threatening human's health，for example. Hence, to study the mechanism of interaction between heavy metals and biomacromolecules plays an important role in protecting human health from heavy metal hazards. Here, ssDNA and E. coli lysates were severed as biomacromolecules to analyze their molecular structure changes as exposed to gold (Au) ion and other heavy metal ions, such as Pb 2 + , Cd 2+ , Cr 2+ and Hg 2+ . Gold nanoparticles coated by E. coli lysates (ECL-Au NPs) have been produced in the process of reducing the toxicity of Au(III) by E. coli lysates. As simultaneously exposed to heavy metal ions and sunlight, Au(III) ion can be generated from ECL-Au NPs to rapidly cleave DNA through cycling between Au(0) and Au(III). Meanwhile, the electron transfers also occur in the biomacromolecules from E. coli lysates, and it must cause their structure destruction as well. In conclusion, as exposed to multiple heavy metals, sunlight can enhance the synergetic damage of biomacromolecules by heavy metals. This study provides not only a new tool for DNA cleavage, but also a new mechanism of DNA and proteins damage caused by heavy metal pollution.
研究领域:
环境科学
·
分子生物学
✓ 已验证
DOI
高影响因子
FOOD AND AGRICULTURAL IMMUNOLOGY
·
2021
·
IF 3.101
Xiaofeng Wang,Yongfeng Chen,Runze Yu,Ruiqiang Wang,Zhixiang Xu
In this paper, a sensitive biomimetic enzyme-linked immunoassay (BELISA) method based on an Au@Pt@Au composite nanozyme label was developed for histamine (HA) detection. A molecular imprinted polymer prepared directly on the 96-well plate served as a biomimetic antibody. A BELISA method was developed for HA standard solutions at concentrations ranging from 0.01 to 100.00 mg/L. Under optimal conditions, the novel BELISA method had a low limit of detection (0.069 mg/L) and high sensitivity (7.20 mg/L). The HA spiked in yellow rice wine and liqueur samples were detected by this BELISA method with the recoveries ranging from 84.28% to 108.82%. There was no significant difference of the results between the BELISA method and HPLC for the detection of HA in the red and white grape wine samples.
研究领域:
分析化学
·
生物传感器
·
食品科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2024
·
IF 4
Junhui Du,Haibin Liu,Hongshuo Chen,Chuanjin Cui,Wensi Zhang,Xuechao Zhang,Zhang Bin
A competitive electrochemical aptamer biosensor for the selective detection of Pb 2+ was developed in this study. The PAMAM@Au hybrid materials and the bioprobe MB-GNPs-ssDNA were synthesized with chemical methods . Modified electrode with carboxylated graphene oxide was prepared via electrodeposition . PAMAM@Au was immobilized on the modified electrode using the EDC/NHS crosslinker, and aptamer (Apt) was bound to PAMAM@Au hybrid materials using the glutaraldehyde crosslinker. The assembly of MB-GNPs-ssDNA/Apt/PAMAM@Au/GO/SPCE biosensors was achieved through immobilizing bioprobe onto electrodes, based on the theory of aptamer-complementary chain reactions. The fabricated biosensor was characterized through electrochemical experiments, SEM, AFM , TEM, XPS and FTIR . The biosensor's performance was evaluated in a series of Pb 2+ aqueous solutions by differential pulse voltammetry (DPV), and the results demonstrated this biosensor had excellent repeatability, stability, and specificity. The detection range spanned from 0.5 pM/L to 500 nM/L, with a detection limit of 5 fM/L. Consequently, the proposed biosensor can serve as a reliable analytical tool for the sensitive detection of lead ions .
研究领域:
生物化学
·
分析化学
✓ 已验证
DOI
高影响因子
ChemSusChem
·
2022
·Vol. 15
·期 13
·e202200092
·
IF 9.14
Xiaohong Hu,Zhijian Li,Haiyong Wang,Haosheng Xin,Song Li,Chenguang Wang,Longlong Ma,Qiying Liu
Graphical Ring-opening : Au/ZrO 2 catalysts with excellent ring-opening hydrogenolysis ability are developed for the selective hydrogenolysis of 5-hydroxymethylfurfural and furfural to produce 2-hexanol and pentanol (1-pentanol and 2-pentanol). The Au-O−Zr interfaces with Lewis acid and metal functionalities play key roles for obtaining the target products with high yield. 2-Hexanol (2-HOL) is a versatile biomass-derived platform molecule for synthesis of liquid transportation fuels, lubricants, or detergents. Herein, a one-step preparation of 2-HOL using 5-hydroxymethylfurfural (HMF) as a substrate was reported for the first time. Several Au-based catalysts supported on different metal oxides were prepared to explore the relationship between carrier and catalytic activity. The results showed that the highest 2-HOL yield of 65.8 % was obtained at complete HMF conversion over the 5 %Au/ZrO 2 catalyst. The 5 %Au/ZrO 2 catalyst exhibited excellent durability after five consecutive recycling runs, while confirming its remarkable ring-opening hydrogenolysis on other biomass-derived furanics, furfural, with a total yield of 1-pentanol and 2-pentanol of 67.4 %. The distinguished ring-opening hydrogenolysis performance of the Au/ZrO 2 catalyst originated from a synergistic effect between the interfacial Au-O-Zr oxygen vacancies-induced Lewis acidic sites (activating C−OH/C=O bonds) and metallic Au (activating H 2 ). This work provides a possibility for producing 2-HOL from HMF with high yield, expanding the sustainable application of lignocellulosic biomass.
研究领域:
催化
·
化学工程
·
可再生能源
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绿色化学
✓ 已验证
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Yueshan Xu,Daoxiong Wu,Peilin Deng,Jing Li,Junming Luo,Qi Chen,Wei Huang,Chong Michael Shim,Chunman Jia,Zhongxin Liu,Yijun Shen,Xinlong Tian
The direct methane (CH 4 ) oxidation to high value-added C1 chemicals is a great promising strategy to explore the CH 4 resource utilization. However, the low activity and selectivity of catalytic performance remains a great conundrum due to the difficulty to activate the C H bond and the unmanageable over oxidation. Herein, Pd x Au y nanowires (NWs) with various Pd/Au atomic ratios are presented as ideal models to explore the atomic-level effect of PdAu atoms for the direct CH 4 oxidation. The influence of reaction parameters are systematically investigated, and Pd 9 Au 1 NWs display a maximum yield of 2890.3 μmol g −1 h −1 with 99% selectivity for the liquid C1 oxygenated products. This enhanced performance is attributed to the combination of one-dimensional structure and the synergistic effect from the suitable portion of Au on Pd sites, which regulates bond strength between adsorbed radicals (•OH, •OOH, •CH 3 ) and PdAu atoms, confirmed by the density function theory calculations.
研究领域:
催化
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Jiaojiao Fang,Jiaqi Li,Yukai Chen,Jiale Cheng,Chengyang Zhu,Junjie Mao
CO2-selective photoreduction to value-added products is ideal, but its practical application suffers from weak photogenerated carrier separation and insufficient multielectron transport. Herein, we constructed the tricomponent AuNPs@SnO2–AuNCs hybrid by decorating Au nanoclusters (AuNCs) on the Au nanoparticle (AuNPs)@SnO2 core–shell structure. AuNC–NP dual coupling endowed AuNPs@SnO2–AuNCs with an excellent CO yield of 64.8 μmol g–1 h–1 during CO2 photoreduction, which was higher than the role of separate application of AuNCs (25.3 μmol g–1 h–1) and AuNPs (16.0 μmol g–1 h–1). It was mainly attributed that the coaction of AuNPs and AuNCs not only enhanced the visible light absorption capacity but also improved the photogenerated carrier separation/migration. As a result, the electron-rich AuNCs induced from plasmonic AuNPs and photoexcited SnO2 promoted the photocatalytic CO2-to-CO performance. This work provides a new perspective to design multicomponent photocatalysts for highly efficient CO2 conversion.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Yingying Zhong,Qing Wang,Zi-Jian Chen,Hongwu Wang,Suqing Zhao
Background In vitro screening strategies based on the inhibition of α-glucosidase (GAA) activity have been widely used for the discovery of potential antidiabetic drugs, but they still face some challenges, such as poor enzyme stability, non-reusability and narrow range of applicability. To overcome these limitations, an in vitro screening method based on GAA@GOx@Cu-MOF reactor was developed in our previous study. However, the method was still not satisfactory enough in terms of construction cost, pH stability, organic solvent resistance and reusability. Thence, there is still a great need for the development of in vitro screening methods with lower cost and wider applicability. Results A colorimetric sensing strategy based on GAA/(Au–Au/IrO 2 )@Cu(PABA) cascade catalytic reactor, which constructed through simultaneous encapsulating Au–Au/IrO 2 nanozyme with glucose oxidase-mimicking and peroxidase-mimicking activities and GAA in Cu(PABA) carrier with peroxidase-mimicking activity, was innovatively developed for in vitro screening of GAA inhibitors in this work. It was found that the reactor not only exhibited excellent thermal stability, pH stability, organic solvent resistance, room temperature storage stability, and reusability, but also possessed cascade catalytic performance, with approximately 12.36-fold increased catalytic activity compared to the free system (GAA + Au–Au/IrO 2 ). Moreover, the in vitro GAA inhibitors screening method based on this reactor demonstrated considerable anti-interference performance and detection sensitivity, with a detection limit of 4.79 nM for acarbose. Meanwhile, the method owned good reliability and accuracy, and has been successfully applied to the in vitro screening of oleanolic acid derivatives as potential GAA inhibitors. Significance This method not only more effectively solved the shortcomings of poor stability, narrow scope of application, and non-reusability of natural enzymes in the classical method compared with our previous work, but also broaden the application scope of Au–Au/IrO 2 nanozyme with glucose oxidase and peroxidase mimicking activities, and Cu(PABA) carrier with peroxidase mimicking activity, which was expected to be a new generation candidate method for GAA inhibitor screening.
研究领域:
生物技术
·
催化
·
药物发现
·
酶学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 20
·13808-13816
·
IF 3.9
Min Yang,Jian Wang,Xuan Xue,Hechun Jiang
It is imperative to develop a rapid detection method for Hg2+ due to its harm to human health and the ecological environment. In this research, CuO/Au@Cu3(BTC)2 was synthesized through reducing HAuCl4 by CuxO@Cu3(BTC)2, which was obtained by reducing Cu3(BTC)2 with hydrazine hydrate. The oxidase-mimic activity of CuO/Au@Cu3(BTC)2 can be enhanced by Hg2+ through forming a Au–Hg alloy. Therefore, a colorimetric method was designed for Hg2+ detection with a linear relationship in the 0.05–25 μM range and a limit of detection of 9.7 nM. This strategy exhibited a strong selectivity to Hg2+ and was applied in a real water sample with reliable recoveries. This work provides a possibility for the rapid detection of Hg2+.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 42
·32897-32901
·
IF 3.84
Miaolin Yin,Lifang Zhao,Qin Wei,He Li
A simple, rapid and sensitive detection method by the naked eye for melamine in dairy products is reported. Within 60 min, melamine can be detected as low as 0.4 μM by UV-vis spectrometric or naked eye observation, which is far below the melamine safety limit in the USA and EU.
研究领域:
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2023
·Vol. 19
·期 38
·2302302
·
IF 13.3
Zhao He,Jian Zhu,Xin Li,Guo-Jun Weng,Jian-Jun Li,Jun-Wu Zhao
In this paper, Au@Ag nanopencil is designed as a multimodality plasmonic nanoprobe based on asymmetric etching for the detection of SCN − and ClO − . Au@Ag nanopencil with Au tip and Au@Ag rod is prepared by asymmetric tailoring of uniformly grown silver-covered gold nanopyramids under the combined effect of partial galvanic replacement and redox reaction. By asymmetric etching in different systems, Au@Ag nanopencil exhibits diversified changes in the plasmonic absorption band: O 2 •− facilitated by SCN − etches Au@Ag rod from the end to the tip, causing a blue shift of the localized surface plasmon resonance (LSPR) peak as the aspect ratio decreases; while the ClO − can retain Au@Ag shell and etch Ag within rod from the tip to the end, causing a redshift of the LSPR peak as the coupling resonance weakens. Based on peak shifts in different directions, a multimodality detection of SCN − and ClO − has been established. The results demonstrate the detection limits of SCN − and ClO − are 160 and 6.7 n m , and the linear ranges are 1–600 µ m and 0.05–13 µ m , respectively. The finely designed Au@Ag nanopencil not only broadens the horizon of designing heterogeneous structures, but also enriches the strategy of constructing multimodality sensing platform.
研究领域:
纳米材料
·
分析化学
·
生物传感
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）