JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Kaixiang Ji,Peilin Wang,Yameng Li,Qiang Ma,Xingguang Su
Phthalate esters, particularly di(2-ethylhexyl) phthalate (DEHP), are widely used plasticizers found in various consumer products, posing significant environmental and health risks due to their endocrine-disrupting effects. In this study, a novel enzyme-free intra-capacitive biofuel cell self-powered sensor (ICBFC-SPS) was developed. The ICBFC-SPS integrated a ternary heterostructure-based capacitive anode and a cathode with a sensing interface into a single-chamber electrolytic cell. The ternary heterostructure based on Ti 3 C 2 T x MXene with ultra-small Au NPs and polypyrrole (PPy) NPs was prepared to provide the efficient glucose oxidation and robust electron production. Furthermore, the charge storage capacity was significantly enhanced through a synergistic combination of the double-layer capacitor mechanism of Ti 3 C 2 T x and the pseudocapacitive behavior of PPy. Additionally, the intercalation of PPy NPs expanded the interlayer spacing, promoting electrolyte ion diffusion and charge transfer. The ICBFC-SPS demonstrated exceptional sensitivity with a linear detection range from 0.05 to 100000 ng/L and a detection limit of 9.51 pg/L for the sensitive and selective detection of DEHP in complex environmental and biological samples. The ICBFC-SPS addresses the limitations of traditional methods by providing a self-powered, highly sensitive, and portable platform for rapid, on-site DEHP detection. This work underscores the potential of self-powered sensors as transformative tools for real-time environmental monitoring and public health protection.
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Analytical Methods
·
2026
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IF 3
Liansheng Ling,chen chen,Yingqing Li,xiaosong Yang,Ji Zhang
Here we report an ultrasensitive dynamic light scattering (DLS) immunosensor for cardiac troponin I (cTnI) leveraging a novel Self-cascading reaction synergistic amplification strategy by using metal organic frameworks (MOF) materials. This synergistic amplification system was designed within combined enzymatic (glucose oxidase, GOD) catalysis, acid-responsive MOF disintegration, Fenton reaction and gold nanoparticles (Au NPs) stability modulation. When the target cTnI was present, sandwich structure was formed between multifunctional probes (Ab-GOD/Fe-MOF) and Ab modified 96-well plates, subsequently occurring self-cascading reactions with further addition of glucose: the glucose was oxidized into gluconic acid (creating an acidic micro-environment) by O2 under the catalysis of MOF - conjugated GOD and produced H2O2, the acidic micro-environment triggered the breakdown of Fe-MOF and the release of Fe2+, reacting with H2O2 via the Fenton reaction to etch the protective DNA layer that modified on Au NPs, enable the salt-induced aggregation of AuNPs. Crucially, the DLS assay achieved a low limit of detection (LOD) of 1.5 × 10-13 g/mL, furthermore, this cascade amplification strategy realized the quantitative detection of cTnI in clinical samples with high sensitivity and specificity.
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ELECTROCHIMICA ACTA
·
2026
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IF 5.8
Leilei Dong,Yuping Wang,Yitong Hao,Jinghui Zhang,Xin Fang,Xueping Ji,Beibei Wang
A three-dimensional (3D) porous PDA–PPY hydrogel with abundant anchoring sites, which facilitates Au NPs loading and accelerates electron transfer. • The Au NPs further improve conductivity, achieve dual signal amplification of the sensor. • The TC aptamer form a stable recognition interface with high affinity and specificity toward TC. • The proposed aptasensor exhibited an extra low detection limit of 2.7 pM toward TC. • the proposed aptasensor provides a robust and effective strategy for monitoring TC residues in real samples. Herein, a sensitive and reliable electrochemical aptasensor (BSA/Apt/PDA-PPY@Au NPs/GCE) was developed for the determination of tetracycline (TC). The sensing platform was built upon a green-synthesized PDA–PPY polymer hydrogel, which provides a three-dimensional porous architecture with abundant anchoring sites and favorable conductivity, enabling efficient loading of Au nanoparticles (Au NPs) and rapid interfacial electron transfer. The TC aptamer was then robustly immobilized onto the PDA–PPY@ Au NPs nanocomposite via directional Au–S bonding, forming a stable recognition interface with high affinity and specificity toward TC. Benefiting from the dual effects of the conductive PDA–PPY hydrogel and Au NPs, the proposed aptasensor exhibited high sensitivity with an extra low detection limit of 2.7 pM and a wide linear response range of 5 pM–1 μM. Moreover, it demonstrated excellent reproducibility, selectivity and good stability. Importantly, accurate determination of TC in real samples (milk and river water) was achieved with satisfactory recoveries and accuracy, highlighting the potential of this strategy for monitoring TC residues in food matrices and environmental waters. Download: Download high-res image (273KB) Download: Download full-size image
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2023
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IF 4.3
Baihui Wang,Huan Jiang,Ruyi Tang,Yaoyu Tan,Xuemin Xia,Xia Zhang
The activity of nanozymes is dependent on their surface for catalysis, and bioconjugation or adsorption of DNA aptamers will promote their activity. This paper aims to develop a novel aptamer sensor, for rapid, sensitive and specific detection of histamine. The design of the aptamer biosensor is based on the adsorption of histamine aptamers onto the surface of Au NPs by bioconjugation, which promotes the peroxidase activity of the nanozymes. Since histamine is strongly selective and specific for histamine aptamers, the histamine aptamer can be detached from the surface of Au NPs and bound to histamine, during which the catalytic activity of the nanozymes falls back due to the detachment of the histamine aptamer, which can be quantitative analysis by the TMB-H 2 O 2 system. The decrease in enzyme catalytic activity became larger with increasing histamine concentration, with a good linear correlation. Finally, the histamine aptamer biosensor was constructed, which has the advantages of ultrasensitive, high-accuracy, and wide linear range. The linear range and detection limit are 10 −11 ∼10 −3 M and 1.22 × 10 −12 M, respectively. With reference to this aptamer sensor design, this approach can also be extended to other schemes where the aptamer is combined with Au NPs as a way to detect the corresponding molecules.
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RSC Advances
·
2021
·Vol. 11
·期 63
·39797-39803
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IF 3.361
Rong Wang,Hongyan cao
In this paper, a simple and cost-efficient strategy was used to construct a uniform Au NPs distribution on the surface of flexible filter paper for the detection of benzidine. Taking full advantage of the adsorption properties of filter paper, small gold nanoparticles were adsorbed onto its surface as gold seeds, and subsequently grown by electroless plating to form a highly uniform distribution of Au NPs substrates. By changing the electroless plating time, an optimal substrate was obtained. The as-prepared substrate exhibited satisfactory sensitivity with a low detection limit of 10−13 M for 4-ATP, and good reproducibility and homogeneity. Furthermore, the as-prepared substrates were successfully used for the detection of benzidine in environmental water, with a minimum detection concentration as low as 0.1 ppm and recoveries in the range of 92.4 to ∼108.5%. This study indicated that filter paper-based SERS substrates have great potential value in the detection of environmental organic pollutants.
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SENSORS AND ACTUATORS A-PHYSICAL
·
2023
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IF 4.6
Ruizhen Li,Wanzhen Yuan,Yu Hu,Yonggang Zeng
Propranolol , a widely used β-adrenergic receptor antagonist drug with potential toxic effects to organisms and human beings, was not completely removed from environment through traditional wastewater treatments . It is necessary to sensitively and selectively monitor the trace content propranolol in various samples. In this work, a novel photoelectrochemical (PEC) aptasensor based on Au nanoparticles (NPs) modified g-C 3 N 4 /BiPO 4 heterojunction was successfully fabricated for detecting (S)-propranolol (S-Pro), an important racemic enantiomer of propranolol. Herein, g-C 3 N 4 was employed as visible light-active semiconductor. The photocatalytic activity of g-C 3 N 4 was enhanced via forming heterojunction with BiPO 4 to facilitate the separation and migration of photogenerated carriers . In addition, Au NPs with perfect conductivity and surface plasmon resonance (SPR) effect are not only beneficial to the electron transfer and visible light harvest of g-C 3 N 4 /BiPO 4 heterojunction, but also the crucial factor on assembling S-Pro-binding DNA aptamer via Au-S bonding. At the same time, as a π-π conjugated material, g-C 3 N 4 with large surface area also provides an excellent platform for loading Au NPs. Under the visible light illumination, the PEC aptasensor displayed high PEC performance. On such a sensor, specific captured S-Pro by the aptamer was quickly oxidized by the photogenerated holes to inhibit the recombination of the photogenerated carriers, enhanced the PEC response, and realized the detection of S-Pro. Under optimal conditions, the designed PEC aptasensor exhibited a wide linear range of 10 nM to 1000 nM with a low detection limit (defined as S/N = 3) of 2.55 nM. Moreover, the proposed sensor displayed high selectivity , good reproducibility, and general long-term stability. And the S-Pro in real sample was accurately detected using this proposed sensor.
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APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Xiao-Hong Wen,Xue-Feng Zhao,Bo-Fang Peng,Kai-Ping Yuan,Xiao-Xi Li,Li-Yuan Zhu,Hong-Liang Lu
The increase of homocysteine (Hcy) is closely related with the development of many diseases. Nevertheless, the effective detection of Hcy remains challenging due to the lack of a simple, specific, and cost-efficient method. Herein, an electrochemical biosensor based on Hcy aptamer/Au nano-particles/graphene sponge (Aptamer/Au NPs/GS) was designed for the detection of homocysteine. The biosensor employed methylene blue (MB) as a redox indicator. Due to the change of aptamer conformation, the adsorbed MB was released from aptamer, resulting in the decrease of electrochemical response. In the range of 1–100 μM, the concentration of Hcy had a good linear relationship with the relative redox peak current (Δ I ) of MB and the lowest detection limit was 1 μM. The experimental results demonstrated the aptasensor had good selectivity and reproducibility. In real serum sample, the aptasensor showed an acceptable recovery rate indicating its potential applications in the preliminary detection of various diseases associated with Hcy.
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APPLIED CATALYSIS A-GENERAL
·
2020
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IF 5.006
Jiyang Liu,Haojie Yu,Li Wang
The catalysis performance of noble metal nanoparticles always suffered from harsh aggregation during reaction hence promising supports that were able to restrict as well disperse the NPs were in great demand. Herein we reported a bottom-up synthesis of ultrathin two dimensional ferrocene based metal-organic framework (FMOF) nanosheets employing ZrCl 4 and 1,1′-ferrocene-dicarboxylic acid as metal nodes and organic ligands respectively. Employed as a stable and easy-contacted support, Au NPs were reduced and attached on the surface of FMOF nanosheets with average diameter of ca. 5 nm. The obtained Au/MOF composite was used in the reduction of 4-nitrophenol to 4-aminophenol, and rapid conversion of almost 100% could be achieved in 5 min with a maximum TOF of 10.9 × 10 −4 mol min −1 m 2 . Moreover, after 10 cycles of the reusability test, there was no obvious decline in catalytic performance with conversion of almost 100%, confirming the unprecedented stability of this Au-MOF composite.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Fang Li,Pengying Zhang,Jiayi Chen,Jiahui Xi,Shuai Gao,Yunhong Liu
Mercury ion (Hg 2+ ), a highly toxic and bioaccumulative pollutant, can contaminate medicinal herbs and pose significant risks to human health via the food chain. With the growing global demand for traditional Chinese medicine (TCM), there is an urgent need to develop reliable and sensitive Hg 2+ detection methods. In this paper, a novel electrochemical sensor based on magnetic nanoparticles and thymine-Hg 2+ -thymine (T-Hg 2+ -T) coordination chemistry was developed for detecting Hg 2+ in TCM. The magnetic Fe 3 O 4 /Au nanoparticles (Fe 3 O 4 /Au NPs) were synthesized and employed as carriers to conjugate with T-rich thiol-modified DNA probes. In the absence of Hg 2+ , the DNA probes hybridized with ferrocene (Fc)-labeled complementary DNA (cDNA), bringing the Fc signal molecules close to the Fe 3 O 4 /Au NPs surface. In the presence of Hg 2+ , these probes preferentially formed stable T-Hg 2+ -T complexes, effectively inhibiting cDNA hybridization. The Hg 2+ concentration was determined by measuring the corresponding changes in the Fc current. The sensor exhibited a good linear response to Hg 2+ in the range of 0.1–100 ng/mL, with a low detection limit of 0.08 ng/mL. Furthermore, the method was successfully applied to determine Hg 2+ in representative TCM matrices (Lotus leaf, Lonicera japonica , Angelica dahurica , and Houttuynia cordata Thunb.) with satisfactory recoveries (96.73 %−104.84 %). This indicates that the proposed method is particularly suitable for Hg 2+ determination in complex TCM samples, providing a practical solution for quality control and safety monitoring in TCM.
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BIOELECTROCHEMISTRY
·
2021
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IF 5.373
Jintao Liang,Xiaohang Shi,Huafu Feng,Min Chen,Wenzhan Li,Junxiang Lai,Weipeng Hu,Guiyin Li
In this paper, a novel silicon-based light-addressable potentiometric sensor (LAPS) has been designed for the detection of 1,5-anhydroglucitol (1,5-AG) in human serum. Reduced graphene oxide-chitosan-ferrocene (RGO-CS-Fc)/AuNPs nanohybrids and pyranose oxidase (PROD) enzyme is used to fabricate biological sensitive membrane unit by layer-by-layer assembly technology. When a bias voltage is provided to the LAPS system, the catalytic oxidation reaction between 1,5-AG and PROD to produce H 2 O 2 . The by-product H 2 O 2 can oxidize Fc(Fe 2+ ) ions in RGO-CS-Fc nanohybrids into Fc(Fe 3+ ) ions, which cause the potential of the sensitive membrane surface to change and the potential shift of I-V curve will generate a corresponding offset response. Under the optimal conditions, the potential shift of the LAPS is linearly related to the concentration of 1,5-AG at 10 µg·mL −1 –350 µg·mL −1 with the correlation coefficient of 0.97414. The sensitivity is 0.44273 mV/µg·mL −1 and the lowest detection limit is 10 µg·mL −1 . In addition, the biosensor showed good specificity, acceptable stability and satisfactory recovery rates (91.28%-107.66%), which would be a potential testing methods in actual clinical samples.
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NANO
·
2024
·
IF 1
Ying Zhou,Jinai Bian,Min Tian,Tingting Wang,Guomei Zhang,Yan Zhang,Caihong Zhang
Chronic ingestion of food containing clenbuterol (CLB) in the human body can cause acute poisoning. Thus, it is essential to develop a sensitive CLB detection way. Here, a novel electrochemical aptamer sensor based on aptamer/gold nanoparticles/amino magnetic ferric oxide/graphene nanosheets (aptamer/Au NPs/Fe 3 O 4 –NH 2 /GN) nanocomposite has been developed. The Fe 3 O 4 –NH 2 nanoparticles were self-assembled on GN, and then Fe 3 O 4 –NH 2 /GN nanocomposite was coated on the glassy carbon electrode (GCE) surface. Afterward, Au NPs were electrodeposited on Fe 3 O 4 –NH 2 /GN nanocomposite to fix the aptamer by the Au–S bonds. When CLB was added to the solution, the aptamer will specifically recognize CLB, causing current changes. Under the optimized conditions, the sensor shows better electrochemical performance (linear range is 1 × 1 0 − 1 3 M to 1 × 1 0 − 7 M, the detection limit is 1 . 1 6 × 1 0 − 1 4 M ( S / N = 3 )). It has been successfully applied to the detection of CLB in actual samples. The results show that the aptamer sensor has good selectivity, stability and repeatability, which will provide a novel idea for more sensitive and quicker CLB detection.
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ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Zhou Yang,Lingling Dai,Fangfei Liu,Kun Jia,Zhiyuan Ren,Yanmei Yang,Qingmeng Zhang,Weifeng Li,Ming Chen
Background Folate is an essential nutrient, but its bioavailability varies greatly depending on the molecular form present in food. The intake of forms that are not readily absorbed by the human body may lead to insufficient folate levels, particularly during pregnancy, thereby increasing the risk of birth defects. As a result, it is essential to develop a highly sensitive and accurate method capable of distinguishing between the two most common natural folates, 5-methyltetrahydrofolate (5-MTHF) and 5-formyltetrahydrofolate (5-FTHF), to ensure proper folate intake and health outcomes. Results In this study, a photochemical method was employed to load gold nanoparticles (Au NPs) onto carbon nanotubes (CNTs), successfully synthesizing CNTs@Au NPs nanocomposites that exhibit excellent thermal stability and robust surface-enhanced Raman scattering (SERS) activity. These nanocomposites, capable of maintaining structural integrity at temperatures as high as 400 °C, serve as highly effective substrates for in situ high-temperature SERS detection. Using this reliable high-temperature-assisted SERS approach, the structural changes of both folates at elevated temperatures were effectively monitored, enabling clear molecular fingerprinting and distinct differentiation between the two natural folates. Moreover, the CNTs@Au NPs demonstrate exceptional sensitivity, achieving a detection limit as low as 10 -8 M for both 5-MTHF and 5-FTHF, enabling accurate quantification of mixed folate samples and demonstrating reliable performance in real sample analysis. Significance The CNTs@Au NPs with in situ high-temperature SERS capabilities show great potential for various analytical applications. In particular, they provide an effective method for monitoring the quality of folate in dietary supplements and fortified foods, thus contributing significantly to the safety and quality assurance of folate products in the market.
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