ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Liang Yi-Zhong,Bao Lina,Xu Li,Yu Xu
Accurate and convenient detection of epinephrine (Ep) is critical for diagnosing neurological disorders and monitoring emergency medications. In this study, a ratiometric fluorescent platform was developed for Ep detection by integrating cysteine-functionalized carbon dots with gold ions (Cys-CDs/Au 3+ ). The platform relied on Au 3+ -mediated oxidation of epinephrine to generate a fluorescence response, which is further enhanced by boric acid. Two detection modes were established: fluorescence assay and smartphone-assisted RGB analysis, demonstrating limits of detection (LOD) of 0.12 μM and 0.85 μM, respectively. The platform enabled accurate quantification of Ep in injections and artificial cerebrospinal fluid (aCSF). Furthermore, principal component analysis (PCA) facilitated discrimination among multiple catecholamines by reducing the dimensionality of fluorescence spectral data. This work provides a versatile platform for Ep detection and catecholamine discrimination.
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PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 130
·107340-107347
·
IF 3.84
Tingting Yang,Fei Cai,Xiaodan Zhang,Yuming Huang
Nitrogen and sulfur codoped graphene quantum dots (N,S-GQDs) were facilely fabricated by a one-step hydrothermal treatment of citric acid as the carbon source in the presence of cysteine as the doping agent. The resulting N,S-GQDs were characterized by TEM, AFM, Raman, FT-IR, UV-vis, XPS and fluorescence spectroscopy. The N,S-GQDs display a luminescence quantum yield of 35.4%, which was about 14 times greater than that of the undoped graphene quantum dots (GQDs). The AFM image showed a typical topographic height of 0.5 to 1.5 nm with 1–4 graphene layers. The fluorescent emission spectra of N,S-GQDs display an excitation-dependent behavior, and the emission peaks shift from 413 to 440 nm on increasing the excitation wavelength from 310 to 380 nm. The N,S-GQDs possess a storage stability of at least 2 months and are stable in the presence of high concentrations of salt. Due to the strong specific reactivity between Au3+ and amine groups on the N,S-GQDs, the addition of Au3+ ions to the N,S-GQDs suspension results in the formation of gold nanoparticles, which strongly quench the fluorescence of N,S-GQDs. While, other common cations and anions result in negligible changes in the fluorescence of N,S-GQDs. On this basis, a sensitive fluorometric method for the detection of Au3+ was developed that has a 50 nM detection limit and a linear range that extends from 0.1 μM to 50 μM. The method has been successfully used for the determination of Au3+ in real aqueous samples and for gold content in auranofin.
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高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2020
·
IF 5.278
Lu-Shuang Li,Li Xu
Sensitive detection and efficient removal of Au 3+ are important for environmental monitoring and remediation. In this study, silicon quantum dots (SiQDs) were prepared with 3-aminopropyl trimethoxysilane as the silicon source and boric acid as the doping substance to enhance fluorescence quantum yield. The obtained SiQDs possessed fluorescence sensing ability of Au 3+ and were successfully decorated on the mesoporous silica microspheres (SiO 2 ), giving SiO 2 -SiQDs. Owing to the high affinity for Au 3+ and the relatively large surface area, the SiO 2 -SiQDs exhibited not only selective fluorescence detection of Au 3+ in water matrix with a relatively low limit of detection (13.67 μg L −1 ), but also efficient adsorption of Au 3+ with a maximal adsorption capacity of 530.7 mg g −1 . Besides, the Au 3+ adsorbed on the SiO 2 -SiQDs could be in-situ reduced into evenly dispersed small-size gold nanoparticles, showing high catalytic efficiency for the reduction of 4-nitrophenol. The remarkable performance of SiO 2 -SiQDs on detection, adsorption and reusability demonstrated its multi-purposed applicabilities.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 20
·9066-9072
·
IF 3.591
Shaoguang Li,Huilin Liu,Xiaoying Zhang,Jiasong Cai,Kunlong Huang,Bing Chen,Liying Huang,Zhen Lin,Xinhua Lin,Hong Yao
A label-free, rapid, and highly sensitive colorimetric assay for the detection of glutathione (GSH) was developed. o-Phenylenediamine (OPD) can be selectively oxidized by Au3+ in phosphate buffer to produce light yellow 2,3-diaminophenazine. After the addition of GSH, the autocatalytic redox reaction between OPD and Au3+ can be effectively inhibited, resulting in a significant decrease in chroma and absorbance intensity. Reduced absorbance intensity can be used for the quantification of GSH. In addition, this method can achieve the discriminative detection of biothiols, such as cysteine and homocysteine. Based on these findings, a simple colorimetric assay was developed for the detection of GSH in the range of 1 nM to 1 mM with a low detection limit of 0.08 nM. More importantly, this procedure is simple, and the whole assay can be accomplished quickly within 15 min. Additionally, the proposed method was successfully used for the determination of GSH in biological fluids, such as serum samples.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2016
·
IF 5.267
Jie Liao,Zehong Cheng,Li Zhou
Fluorescent carbon dots (CDs) hold great promise for a myriad applications due to their fascinating attributes. However, the development of CDs with high fluorescence quantum yield (QY) and unique surface property is still in its infancy. Herein, we report a simple and green strategy to produce water-soluble nitrogen-doped CDs (N-CDs) via the one-pot hydrothermal carbonization of the mixture of natural peach gum polysaccharide (PGP) and ethylenediamine. The resulting N-CDs exhibit a remarkably enhanced QY (28.46%) as compared with that of undoped CDs (5.31%). In addition, the N-CDs show stable fluorescence against ionic strength variation and pH change. Preliminary biological studies reveal that N-CDs possess low cytotoxicity and high fluorescent contrast in cells. Moreover, we present here for the first time that the obtained N-CDs can exhibit a fast and highly sensitive and selective fluorescence quenching effect toward Au3+ ions. The detection limit can reach 6.4 × 10–8 M, which compares favorably to other reported fluorescent probes. We have also demonstrated that the N-CDs can be employed to sense Au3+ ions in real river water. Considering the easy synthetic process and excellent performance of the N-CDs, this investigation opens up new opportunities for preparing high-quality fluorescent CDs to meet the requirement of many applications.
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高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Wenli Gao,Haohan Song,Xiao Wang,Xiaoqiang Liu,Xiaobin Pang,Yanmei Zhou,Bin Gao,Xiaojun Peng
Red emissive carbon dots (CDs) have drawn more and more attention due to their good organ penetration depth and slight biological tissue photodamage. Herein, the fluorescent CDs with red emission were synthesized by the facile one-pot hydrothermal treatment of citric acid and neutral red and they show red fluorescence both in aqueous solution and solid state. The solution of CDs exhibits the quantum yield of 12.1%, good stability against photobleaching, and low cytotoxicity. As-prepared CDs can be used as a fluorescent probe for peculiar detection of Pt2+, Au3+, and Pd2+. Furthermore, the CDs show excellent biocompatibility, which were successfully used as hopeful bioimaging and biosensing of noble metal ions in PC12 cells and zebrafish.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Jianing Li,Dongkui Zhang,Jiangbin Xia
Herein, hydrothermal method was used to prepare a series of multi-color polythiophene modified carbon quantum dots. Under UV excitation, fluorescence their maximum emission wavelengths appear at 612 nm, 570 nm, and 540 nm respectively. The prepared CD-BTH and CD-BN can have specific detection of Au 3+ and Hg 2+ through fluorescence quenching effect. The detection limits for Au 3+ are 3 nM and 5.4 nM respectively, and for Hg 2+ are 23 nM and 90 nM respectively. CD-KN detects Au 3+ specifically through fluorescence resonance, with a detection limit of 33 nM. Under the interference of other metal ions, three types of polythiophene modified quantum carbon dots exhibit excellent selectivity for the responsive ions. Meanwhile, this article also elucidates the law that as the electron withdrawing ability of the side chains of polythiophene derivatives increasing, the fluorescence emission peaks of the prepared polythiophene modified carbon dots shifts red and the fluorescence quantum yield is higher.
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高影响因子
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