FOOD CONTROL
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2026
·
IF 7
Yunjia Yang,Yixing Feng,Xin Zhang,Wenjing Zhang,Qian Jiang,Jie Yin
Bisphenol S (BPS), considered a “regrettable substitute” for the well-known endocrine disruptor bisphenol A (BPA), has also been demonstrated to pose health risks. An underinvestigated exposure route is the placement of thermal price labels on fresh food packaging. Here, a structure-guided suspect screening strategy was employed to characterize BPS derivatives in 137 supermarket price labels. A total of 26 candidate features were identified by high resolution mass spectrometry, among which 9 BPS derivatives were confirmed by authentic standards, and 4 candidates were identified with a confidence of level 2. DBSP, BPS, BPS-MAE and D-90 were the major derivatives, with maximum concentrations ranging from 7.5 to 40 mg/g. A novel derivative, HDPS was first identified as a component coexisting with DBSP in thermal price labels. The concentrations of DBSP were higher than those of BPS and had a significant negative correlation (r = −0.53, P < 0.001), suggesting an ongoing substitute for BPS. Analysis of matched food samples revealed consistent contamination trends: BPS was detected in 89.0% of samples, followed by DBSP (86.1%), BPS-MAE (60.6%), and BPA (59.8%). High levels of BPS (129.4 ng/g), BPA (124.8 ng/g), DBSP (78.1 ng/g) and BPS-MAE (63.8 ng/g) could be observed in individual cling film-wrapped food items with attached price labels. Dietary intake assessments revealed a median ∑BPs exposure level of 5.6 ng/kg bw/day, but a level of 92 ng/kg bw/day in high-exposure scenarios. The estimated DBSP, BPS, and BPA exposure levels exceeded the stringent EFSA TDI for BPA. This study provides insight into the potential contamination of fresh food caused by thermal labels, informing policies for preventing “regrettable substitutions”.
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高影响因子
ANALYTICA CHIMICA ACTA
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2016
·
IF 4.712
Qiong Hu,Baojing Zhou,Pengyun Dang,Lianzhi Li,Jinming Kong,Xueji Zhang
We report a versatile approach for the colorimetric assay of alkaline phosphatase (ALP) activity based on the distinctive metal-to-ligand charge-transfer (MLCT) absorption properties of Fe(II)-phenanthroline reporter. In the presence of ALP, the applied substrate ascorbic acid 2-phosphate is enzymatically hydrolyzed to produce ascorbic acid, which then reduces Fe 3+ to Fe 2+ . The complexation of Fe 2+ with the bathophenanthroline disulfonate (BPS) ligand generates a blood-red Fe(BPS) 3 4− reporter, which is characterized by an intense MLCT absorption band at 535 nm in the visible range. Under optimal conditions, the spectral output exhibits a good quantitative relationship with ALP activity over the range of 0–220 mU mL −1 with a detection limit of 0.94 mU mL −1 . Moreover, the activity of ALP can also be conveniently judged through naked-eye observations. Results indicate that it is highly selective and can be applied to the screening of ALP inhibitors. In addition, it has been successfully employed to detect the endogenous ALP level of undiluted human serum samples, with a detection limit of 1.05 mU mL −1 being achieved. This approach avoids any elaborately designed substrates and holds considerable simplicity and flexibility for reporter design. This study broadens the horizon of the applications of phenanthroline-based transition metal complexes. Furthermore, an efficient and practical method like this has the potential to be widely used in clinical applications and in the point-of-care testing.
研究领域:
分析化学
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生物化学
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临床诊断
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PubMed
高影响因子
CHEMOSPHERE
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2018
·
IF 4.427
Zhiyuan Meng,Dezhen Wang,Sen Yan,Ruisheng Li,Jin Yan,Miaomiao Teng,Zhiqiang Zhou,Wentao Zhu
The widespread application of bisphenols (BPs) makes them ubiquitous in the natural environment and poses many potential risks. In this study, we examined the effects of perinatal exposure to BPA and its 3 alternatives (BPS, BPF, and BPAF) on lipid and glucose homeostasis in female mice adolescent offspring . Specifically, BPA exposure promoted the expression of hepatic lipid synthesis and fatty acid accumulation genes, resulting in a significant increase in 2 free fatty acids contents. BPS exposure caused an increase in 6 free fatty acids and triglyceride contents through promoting the expression of fatty acid synthesis, triglyceride synthesis and fatty acid accumulation genes and inhibiting the expression of fatty acid β-oxidation genes. Interestingly, BPAF exposure showed completely opposite effects on hepatic lipid metabolism compared to BPS exposure. 9 free fatty acids and triglycerides contents in the liver were significantly reduced. In particular, BPF exposure caused decreases in 2 free fatty acids contents, but no significant changes were found in the genes for lipid metabolism. In addition, unlike BPA and BPF exposure, BPS and BPAF exposure also resulted in significant increases in glucose and glycogen contents in the liver by activation of Fxr-Sh p pathway and glycolysis, and inhibition of gluconeogenesis. The results showed that compared to BPA and BPF exposure, BPS and BPAF exposure significantly regulated the expression of genes related to glucose and lipid metabolism and severely interfered with hepatic lipid and glucose homeostasis. This suggested that we should thoroughly evaluate the potential health risks of BPA and its alternatives.
研究领域:
环境科学
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分子生物学
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毒理学
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PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2019
·Vol. 26
·期 6
·5804-5813
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IF 2.914
Meng Zhiyuan,Zhu Wentao,Wang Dezhen,Li Ruisheng,Jia Ming,Yan Sen,Yan Jin,Zhou Zhiqiang
The widespread application of bisphenols (BPs) in the industry has made them ubiquitous in the environment, causing potential environmental risks. Its unknown impacts on human being have received more and more attention. In this study, we have assessed the metabolic effects of perinatal exposure to bisphenol A (BPA) and its substitutes (bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF)) in female mice adolescent offspring and female mice adulthood offspring. 1 H NMR-based serum metabolomics showed that metabolic profiles were disturbed with BPA and its three substitutes exposure in female mice adolescent offspring and female mice adulthood offspring. In addition, age-related metabolic effects were found based on changes in serum endogenous metabolites and metabolic pathways. Specifically, metabolic pathway analysis showed that major disturbed metabolic pathways in female mice adulthood offspring compare with female mice adolescent offspring also changed significantly. With the increase of age of the female mice offspring, changes in the metabolic pathways became more obvious in the BPA treatment group. Conversely, partially disturbed metabolic pathways were restored in the BPS, BPF, and BPAF treatment groups. In conclusion, perinatal exposure to BPA and its three substitutes significantly interferes with metabolic profiles and metabolic pathways, and this metabolic effects were age-related. These results offer more detailed information about the age-related metabolic effects of perinatal exposure to BPA, BPS, BPF, and BPAF in female mice offspring and provide data for systematic evaluation of the health risk assessment of BPA and its substitutes.
研究领域:
环境毒理学
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代谢组学
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发育生物学
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生殖毒理学
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分子毒理学
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环境健康
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生命早期暴露
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Lijun Chen,Chenguang Wang,Guozhao Liu,Guanwen Su,Leping Dang,Hongyuan Wei
Rational utilization of the surface charge property of components is an effective method to prepare heterojunction. The surface of g-C 3 N 4 nanosheets (CNs) and black phosphorous nanosheets (BPs) both exhibit negative charge, which would produce repulsive force to hinder them from approaching each other. Herein, non-noble and low-toxic Cu(II) was selected to harmonize the CNs and BPs together under the interaction of surface charges, and the Cu(II) was reduced in situ to Cu with good conductivity, obtaining the sandwich-like product BPs/Cu/CNs with tight interface and high separation efficiency of photogenerated carriers. The composites exhibited attractive degradation performance for various pollutants under visible light, especially, 95.3 % of ciprofloxacin (10 mg/L, 200 mL) was removed in 60 min with 50 mg of 6BPs/4Cu/CNs as photocatalyst, and the removal ratio can still reach 87.4 % after the fifth reuse with negligible leaching of Cu ions. An unconventional type-II band structure was built in the BPs/Cu/CNs under the drive of internal electric field and mutual attraction of opposite charges, in which the e - from CB of BPs transferred to Cu and then combined with the h + from VB of CNs, leaving the e - from CB of CNs and h + from VB of BPs still work. Despite the same result to that of typical type-II band structure of BPs/CNs, the flow of photogenerated carriers in the BPs/Cu/CNs was more favorable in thermodynamics.
研究领域:
材料科学
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环境科学
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高影响因子
Analytical Methods
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2017
·Vol. 9
·期 18
·2673-2681
·
IF 1.9
Lingling Wang,Qi Li,Lei Zhang
An elastic cylindrical three-dimensional porous spongy graphene rod (3D-PSGR) was synthesized by a facile one-step hydrothermal method and applied in a syringe system as a solid phase adsorbent for the extraction of nine trace bisphenol analogs (BPs) from environmental samples. In this study, a simple sample pretreatment procedure in-syringe-assisted solid phase microextraction (ISA-SPME) was developed for the detection of nine BPs with HPLC. The full protocols for the extraction and elution process were achieved in a syringe. After enrichment, the sample solution was expelled slowly from the syringe to leave the adsorbent with the analytes behind. The analyte-enriched adsorbent was then eluted by drawing MeOH into the syringe, and the elution solution was then injected in HPLC. The 3D-PSGR exhibits excellent cycling stability and can be reused for eight consecutive cycles without significant loss of extraction efficiencies. The 3D-PSGR-ISA-SPME was applied successfully to the analysis of nine BPs in river water and soil samples. The method detection limits (MDLs) were in the range of 0.39–3.97 ng mL−1, and the extraction recoveries of the spiked samples were in the range of 96.5–102.6% with relative standard deviations (RSDs) of 2.11–4.27%. A convenient method is proposed for the analysis of nine trace BPs in environmental samples.
研究领域:
分析化学
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环境科学
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高影响因子
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
·
2020
·Vol. 246
·期 9
·1857-1865
·
IF 2.366
Yang Fanfan,Xu Long,Liu Xiang,Chen Chen,Dias Alberto C. P.,Zhang Xiaoying
Abstract Bisphenol S (BPS) is a major alternative to Bisphenol A (BPA) newly applied in food packing material and disrupts reproductive and developmental endpoints through endocrine pathways. This study aimed to develop a rapid, sensitive, and accurate chemiluminescence immunoassay (CLIA) for the detection of BPS in canned beverage. Anti-BPS monoclonal antibody (mAb) was generated by immunizing Balb/c mice with immunogen (BPS–BSA conjugation). CLIA assay conditions, including 3-[9-(((3-( N -succinimidyloxycarboxypropyl) [4-methxylphenyl] sulfonyl) amine) carboxyl]-10-acridiniumyl)-1-propanesulfonate inner salt (NSP-SA-NHS) labeling ratio (1:40), antigen concentration (1 μg mL −1 ) and antibody titer (1:8000; 125 ng mL −1 in PBS (0.01 M, pH 7.4)) were determined, respectively. The half inhibition concentration (IC 50 ), detection limit (IC 10 ), and working range of the CLIA in canned beverage were 0.04, 1.48, and 0.32–5 ng mL −1 , respectively. Cross-reactivity with other bisphenols (4,4′-thiodiphenol, Bisphenol F, 4,4′- dihydroxy benzophenone, Bisphenol A and Bisphenol B) was less than 0.56%, and the recovery rates of BPS in canned beverage ranged from 80 to 109.2% (intra-assay) and from 82 to 108.4% (inter-assay). The results of CLIA were compared with high-performance liquid chromatography–UV (HPLC–UV) analysis, showing a good correlation of 0.956. After proper sample pre-treatment, this method allows relatively large amounts of sample analysis in a limited time period (30 min). Thus, it was deemed suitable and efficient for routine screening of BPS in canned beverage. Graphic abstract
研究领域:
分析化学
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环境科学
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食品安全
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免疫学
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毒理学
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Tingting Chai,Yinyin Jin,Feng Cui,Zongjie Li,Mingxiao Li,Shunlong Meng,Lilai Yuan,Jing Qiu,Jiandong Mu,Guohua Xiao,Xiyan Mu,Yongzhong Qian
Freshwater systems near highly urbanized areas are extremely susceptible to emerging contaminants (ECs), yet their stereoscopic persistence in aquatic ecosystems and related risks remain largely unknown. Herein, we characterized the multi-mediums distribution of 63 ECs in Baiyangdian Lake, the biggest urban lake in the North of China. We identified variations in the seasonal patterns of aquatic EC levels, which decreased in water and increased in sediment from wet to dry seasons. Surprisingly, higher concentrations and a greater variety of ECs were detected in reeds than in aquatic animals, indicating that plants may contribute to the transferring of ECs. Source analysis indicated that human activity considerably affected the distribution and risk of ECs. The dietary risk of ECs is most pronounced among children following the intake of aquatic products, especially with a relatively higher risk associated with fish consumption. Besides, a comprehensive scoring ranking method was proposed, and 9 ECs, including BPS and macrolide antibiotics, are identified as prioritized control pollutants. These findings highlight the risks associated with aquatic ECs and can facilitate the development of effective management strategies.
研究领域:
环境科学
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水资源管理
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毒理学
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公共卫生
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生态学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）