FOOD CHEMISTRY
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2022
·
IF 9.231
Yajuan Qin,Xiaoai Chen,Fei Xu,Chunhe Gu,Kexue Zhu,Yanjun Zhang,Gang Wu,Ping Wang,Lehe Tan
The structure–activity relationship and inhibitory mechanism of flavonols on α-glucosidase were studied by inhibition kinetics, multispectral study, and molecular docking. The flavonols of rutin, quercetin and kaempferol effectively inhibit the activity of α-glucosidase, among which quercetin and rutin showed the strongest and weakest inhibitory abilities, respectively. The inhibitory ability of flavonols was enhanced by hydroxylation at C3′ of B ring, while it was weakened by diglycosylation at C3 of C ring. Remarkably, the quenching affinity and inhibitory ability of flavonols were inconsistent, which was different from the conclusions reported by some previous studies. This may be ascribed to the hydroxyl groups of C3′ of B ring and C3 of C ring. Furthermore, three flavonols were spontaneously bound to α-glucosidase through hydrophobic interactions and hydrogen bonding, which caused the structure and hydrophobic microenvironment of α-glucosidase to change, resulting in significant inhibition of α-glucosidase by flavonols.
研究领域:
药理学
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生物化学
·
分子生物学
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高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2018
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IF 4.816
Xiao-san Li,Yi-chang Ren,Yu-zhou Bao,Jie Liu,Xiao-kun Zhang,You-wei Zhang,Xue-Long Sun,Xin-sheng Yao,Jin-Shan Tang
Cardiac glycosides exhibit significant anticancer effects and the glycosyl substitution at C 3 position of digoxigenin is pivotal for their biological activity . In order to study the structure-activity relationship (SAR) of cardiac glycosides toward cancers and explore more potent anticancer agents , a series of C 3 - O -neoglycosides and C 3 -MeO N -neoglycosides of digoxigenin were synthesized by the Koenigs-Knorr and neoglycosylation method, respectively. In addition, digoxigenin bisdigitoxoside and monodigitoxoside were prepared from digoxin by sodium periodate (NaIO 4 ) oxidation and 6-aminocaproic acid hydrolysis. The SAR analysis revealed that C 3 - O -neoglycosides of digoxigenin exhibited stronger cytotoxicity and induction of Nur77 expression of tumor cells than C 3 -MeO N -neoglycosides. Also, 3 β - O -glycosides exhibited stronger anticancer effects than 3 α - O -glycosides. Among them, 3 β - O -( β - l -fucopyranosyl)-digoxigenin ( 3i ) showed the highest activity on induction of Nur77 expression and translocation from the nucleus to cytoplasm, leading to cancer cell apoptosis.
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CHEMICAL ENGINEERING SCIENCE
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2024
·
IF 4.1
Yu Xie,Wangyang Wang,Jiale Cui,Hui Li,Kang Cheng,Qinghong Zhang,Ye Wang
The oxidative coupling of methane (OCM) into C 2−3 hydrocarbons is still limited to a few types of catalysts with low product yield. Herein, we reported our discovery that a K 2 SO 4 -promoted TiO 2 catalyst can effectively catalyze the OCM reactions with a C 2−3 yield of up to 26 %, which is comparable to the classical Mn-NaWO x /SiO 2 catalyst. Besides, this catalyst not only exhibits promising stability for at least 200 h without signs of deactivation under typical OCM conditions but also demonstrates high sulfur-resistance performance, outperforming most reported catalysts. We have evidenced that K + ions are responsible for increasing the surface basicity of rutile TiO 2 , thus benefiting C 2−3 selectivity. The presence of SO 4 2− can prevent the formation of potassium titanates, which catalyze the over-oxidation of CH 4 . The surface lattice oxygen species are confirmed to be the active sites for selective CH 4 activation, while the chemisorbed oxygen species catalyze the combustion of CH 4 to CO 2 .
研究领域:
化学工程
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催化化学
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高影响因子
GREEN CHEMISTRY
·
2020
·Vol. 22
·期 19
·6579-6587
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IF 9.48
Xiaohao Liu,Xiaodong Liu,Haiyong Wang,Tianci Xiao,Ying Zhang,Longlong Ma
Efficient conversion of renewable cellulose to high value-added C3 chemicals is a great challenge in the field of biomass valorization. In this work, we found that the combination of Co and Sn could significantly improve the efficiency of cellulose conversion to acetol. 54.4% yield of acetol and 66.6% total yield of C3 products were obtained when using 2%Sn–10%Co/SiO2 (2 wt% Sn content) as a catalyst. However, using the same Sn content of 2%Sn–10%Ni/SiO2, no acetol and only 7.1% yield of C3 products were produced. By studying the effects of different Sn and Co concentrations on cellulose conversion, it was found that the Sn species play an important role in catalyzing glucose conversion to C3 intermediates, while Co mainly played a role in hydrogenation, the same as Ni. The study demonstrated that Sn–Co/SiO2 with low Sn content can convert glucose to C3 intermediates more efficiently than the Sn–Ni/SiO2 catalyst. Moreover, Sn–Co/SiO2 could effectively convert C3 intermediates to acetol at a high temperature which is essential for acetol production from cellulose; but under the same conditions, the Sn–Ni/SiO2 catalyst tended to catalyze the polymerization of C3 intermediates. A series of characterization methods including AAS, TEM, HRTEM, EDS, XRD, ex situ XPS, in situ XPS, and CO2-TPD found that the combination of Sn and Co could significantly increase the noninteger valent SnOx species in the catalyst. These species increased the basicity of the catalyst and were beneficial in catalyzing the isomerization of glucose and the retro-aldol condensation of fructose.
研究领域:
生物质能
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催化化学
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NEURON
·
2025
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IF 15
Shuang Zhang,Mengqi Yuan,Jin Zhou,Yuan Zhao,Liuyongwei Wang,Changxiong Gong,Hui Lu,Xiaofeng Cheng,Xiaoman Wang,Qian He,Linlin Hu,Bingqiao Wang,Chengkang He,Yiliang Fang,Sen Lin,Wenjie Zi,Ying He,Chenhao Zhao,Hongting Zheng,Jianqin Niu,Feng Mei,Baoliang Sun,Qi Xie,Qingwu Yang
Following central nervous system injury, astrocytes form borders that were traditionally regarded as physical barriers. Emerging evidence demonstrates their capacity to regulate inflammation and repair; however, the specific characteristics of these border astrocytes and their interactions with immune cells remain insufficiently characterized. Using single-cell sequencing and spatial transcriptomics, we identified astrocytes expressing the interferon-inducible protein bone marrow stromal cell antigen 2 (BST2) enriched at injury boundaries that promote microglial recruitment via C3/C3aR signaling. Astrocyte-specific Bst2 knockout reduced astrocyte-microglia interactions and attenuated border formation, correlating with early neurological improvement after stroke. Mechanistically, BST2 enhanced C3 expression through protein kinase C-βII (PKCβII) phosphorylation. Moreover, treatment with a BST2 monoclonal antibody diminished astrocyte-microglia interactions and improved neurological function. Together, these findings highlight the pivotal role of astrocyte-microglia interactions in lesion border formation and suggest that BST2 may represent a therapeutic target to modulate these interactions and reduce early brain injury after stroke.
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高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
·
IF 14.7
Niu Wenzhe,Feng Jie,Chen Junfeng,Deng Lei,Guo Wen,Li Huajing,Zhang Liqiang,Li Youyong,Zhang Bo
The synthesis of multi-carbon (C 2+ ) fuels via electrocatalytic reduction of CO, H 2 O using renewable electricity, represents a significant stride in sustainable energy storage and carbon recycling. The foremost challenge in this field is the production of extended-chain carbon compounds (C n , n ≥ 3), wherein elevated * CO coverage (θ co ) and its subsequent multiple-step coupling are both critical. Notwithstanding, there exists a “seesaw” dynamic between intensifying * CO adsorption to augment θ co and surmounting the C-C coupling barrier, which have not been simultaneously realized within a singular catalyst yet. Here, we introduce a facilely synthesized lattice-strain-stabilized nitrogen-doped Cu (LSN-Cu) with abundant defect sites and robust nitrogen integration. The low-coordination sites enhance θ co and concurrently, the compressive strain substantially fortifies nitrogen dopants on the catalyst surface, promoting C-C coupling activity. The n-propanol formation on the LSN-Cu electrode exhibits a 54% faradaic efficiency and a 29% half-cell energy efficiency. Moreover, within a membrane electrode assembly setup, a stable n-propanol electrosynthesis over 180 h at a total current density of 300 mA cm −2 is obtained.
研究领域:
能源化学
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材料科学
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催化反应
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PubMed
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
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2020
·
IF 4.335
Zhiwei Chen,Xiang Bai,Jie Sun,Yicheng Xu
A facile Fe(III)-catalyzed oxidative decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with coumarins has been developed. This transformation, which provides a series of C-3 difluoroarylmethylated coumarins containing various functional groups in moderate-to-good yields, features easily accessible starting materials and operational simplicity.
研究领域:
有机化学
·
药物化学
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PubMed
高影响因子
CATALYSIS TODAY
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2022
·
IF 6.562
Jia-Min Lyu,Shen Yu,Zhao Peng,Jian Zhou,Zhan Liu,Xiao-Yun Li,Yu-Li,Li-Hua Chen,Bao-Lian Su
Bifunctional catalysts are widely applied for many important reactions as the synergetic effect of two types of active sites remarkably improves catalysis performance. However, their bifunctionality has not been fully exploited since the proximity of bifunctional catalysts is hard to control. Herein, we demonstrate a bifunctional ZSM-5@Al 2 O 3 catalyst with a core-shell structure and a nano-scale proximity by in-situ growth of γ-Al 2 O 3 nanosheets on the surface of ZSM-5 crystals for methanol conversion. The nano-scale proximity endows the catalyst with higher reaction activity and C 2 –C 3 olefins yield (53 %) in comparison to the catalysts with micro-scale proximity (20 %) and millimeter-scale proximity (27 %), which can be attributed to the fluent transport of the reaction intermediates between two types of active sites. This strategy for constructing bifunctional catalysts with nano-scale proximity is conducive to understanding the relationship between proximity and catalytic performance in methanol conversion.
研究领域:
催化化学
·
材料科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
·
IF 8.1
Yu Wang,Ailing Pan,Yuhua Ma,Hong Du
Single - atom catalysts (SACs) have attracted extensive attention because of their high atomic utilization and superior catalytic activity. Herein, single - atom Co has anchored on the β - ketoenamine - linked covalent organic framework (Tp-Tta COF) pores and used for remarkable photocatalytic hydrogen(H 2 ) production under Ultraviolet – Visible light (UV – Vis light) irradiation. The single - atom Co is visualized by the aberration - corrected high - angle annular dark - field scanning transmission electron microscopy (AC HAADF - STEM), and the C 3 – Co – N 1 coordination structure is demonstrated by X - ray absorption fine structure (XAFS) measurements. The modified Co 0.4 -SAC/Tp-Tta COF shows a high photocatalytic H 2 production of 1798.5 μmol g −1 h −1 and the Apparent quantum yield(AQY) is 3.02% at 420 nm. The improvement of the activity and stability of the photocatalyst is mainly attributed to the incorporation of Co single-atom that boosts the separation efficiency of photogenerated electron-hole pair and provides well - dispersed active sites. This study provides valuable insights into the development of UV–Vis light-responsive photocatalysts at the atomic level.
研究领域:
材料科学
·
催化化学
·
能源科学
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高影响因子
ACS Catalysis
·
2020
·
IF 12.35
Haiyong Wang,Haosheng Xin,Chiliu Cai,Changhui Zhu,Zhongxun Xiu,Qiying Liu,Yujing Weng,Chenguang Wang,Xinghua Zhang,Shijun Liu,Zifang Peng,Longlong Ma
Keto-alcohols, which are traditionally produced from fossil resources with multisteps, are considered as important intermediates for diversified high-value-added fine chemical synthesis due to their involved carbonyl and hydroxyl groups. Herein, direct cellulose hydrogenolysis to C3-C4 keto-alcohol products (hydroxyacetone and 1(3)-hydroxy-2-butanone) was achieved over Ni-WOx/C catalysts with an W/Ni atom ratio of 1.0–5.0. The keto-alcohol yield was proposed to strongly depend on the W/Ni ratio and the catalyst annealing temperature. The highest keto-alcohol yield of 63% was obtained at the optimal balance of basic/acidic WOx species and metallic Ni. The introduction of Ni facilitated the formation of the basic W5+ sites, which enhanced the formation of basic sites at the Ni-WOx interface. The synergistic effect between the basic W5+ and acidic oxygen vacancy (Vö) could activate the target C–O/C═O bonds, promoting the isomerization of glucose and C3-C4 aldehyde intermediates with the assistance of the interfacial Ni. The cooperative adsorption of the −OH and −C═O groups at the Ni-O-W-Vö interface stabilized the adjacent ketone and hydroxyl groups and kept the other hydroxyl groups for hydrogenolysis, obtaining the final C3-C4 keto-alcohols. This work expanded the application of cellulosic biomass, enabling the green and sustainable synthesis of the high-value C3-C4 keto-alcohol products using lignocellulosic biomass as a raw material.
研究领域:
化学工程
·
催化
·
绿色化学
·
可再生能源
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xiang Li,Ting Wu,Yawei Zhu,Qingwen Tian,Qiang Yang,Guigan Fang
Photocracking of lignin β–O–4 bonds is a green approach for the high-value modification of lignin. Graphitic carbon nitride (g-C 3 N 4 ) that can photocleave the β–O–4 bond is presently the only stable, metal-free photocatalyst owing to the residual metal ions generated due to photocorrosion of metal sulfides. Herein, g-C 3 N 4 with a N–C 3 vacancy structure is prepared by etching site–engineering strategy based on the protection of C–N=C structure by chlorine atom. The N–C 3 vacancy structure can reduce the transport path of the photogenerated electrons by tuning the conduction band (CB) region to the edge of the photocatalyst, which impedes the critical complexation of the photogenerated electron–hole pairs and enhances the photoelectric conversion efficiency five-fold. Combined with the unique chemisorption capacity (137.82 kJ/mol) of N–C 3 vacancies for oxygen, the g-C 3 N 4 photocatalysts with N–C 3 vacancy structure can generate 9.6-fold higher superoxide radicals and 13-fold higher lignin β–O–4 bond photocleavage efficiency lignin compared with untreated g-C 3 N 4 . Based on the reaction enthalpy changes and free energies investigated through simulations, a route of lignin C α –C β bonds being oxidized and dehydrogenated twice by photogenerated cavities is proposed for the first time. This work reveals the relation between the properties of g-C 3 N 4 and the photocleavage efficiency of lignin β–O–4 bonds.
研究领域:
化学
·
材料科学
·
可再生能源
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产品关联
DOI
高影响因子
EBioMedicine
·
2026
·
IF 11.2
Qiao Yin,Mengyang Ding,Yurui Tang,Yuwan Qi,Yuan Qin,Hong Jin,Yang Li,Jili Bao,Shuyang Ma,Ying Li,Haozhe Ding,Xinyu An,Enyou Qiao,Yan Tang,Qilin Zhang,Linna Wang,Jianfeng Shao,Jianfeng Feng,Li-Fang Hu,Jing Wang,Pan Fang,Weifeng Luo,Qifei Cong
Background Depression is a common and early non-motor symptom of Parkinson's disease (PD) with significant sexual dimorphism, yet its underlying molecular mechanisms remain poorly understood. This study aimed to elucidate the sex-specific plasma proteomic profiles of depression in patients with PD (DPD) and to investigate the role of complement-mediated synaptic pruning in its pathophysiology. Methods Plasma proteomic analysis was performed on data from the Parkinson's Progression Markers Initiative (PPMI) and an independent validation cohort, stratified by sex. Functional enrichment analyses identified dysregulated pathways. A chronic MPTP/probenecid-induced mouse model of PD was used to validate findings. Behavioural tests assessed motor and depressive-like phenotypes. Proteomic, biochemical, and imaging techniques were used to evaluate protein expression, synapse density, and microglial phagocytosis. The therapeutic mechanism of Botulinum Neurotoxin A (BoNT/A) on DPD was investigated in wild-type, C3 −/− and C3aR −/− mice and in microglial cultures. Findings Proteomic profiling revealed both conserved complement-driven immune dysfunction and profound sex-divergent molecular perturbations underlying PD and DPD. Complement and coagulation cascades were consistently upregulated in both sexes. In MPTP-treated male and female mice, hippocampal complement components (C1Q, C3, C3aR) and downstream signalling (p-STAT3, p-P65) were elevated, accompanied by microglial synapse phagocytosis and depressive-like behaviours. Genetic deletion of C3 rescued both MPTP-induced motor and depressive-like behavioural deficits and prevented hippocampal synaptic loss associated with microglial synaptic engulfment. BoNT/A treatment alleviated depressive-like behaviours and reduced microglial synaptic engulfment in an MPTP model; these therapeutic effects were abolished in C3 −/− and C3aR −/− mice. Single-cell RNA sequencing and in vitro phagocytosis assay confirmed that BoNT/A modulated phagocytosis-related microglial subclusters. Interpretation DPD exhibits distinct sex-specific immune signatures, with convergent complement pathway activation driving microglial synaptic pruning and depressive symptoms. The antidepressant effect of BoNT/A is mediated through inhibition of the C3–C3aR signalling axis. These findings highlight the potential for sex-stratified diagnostics and complement-targeted therapies for depression in patients with PD. A key limitation is that our clinical analyses were constrained by limited validation cohort sizes, and mechanistic studies were limited to male mice, which may restrict the generalisability of our findings to female populations. Funding National Natural Science Foundation of China, Key Project of the Natural Science Foundation of Jiangsu Provincial Higher Education Institutions, Project of Biomedical Basic Research Center (BBRC) of Jiangsu, Clinical Research Center of Neurological Disease in The Second Affiliated Hospital of Soochow University, Project of MOE Key Laboratory of Geriatric Diseases and Immunology, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases; The Lingang Laboratory fund; Shanghai Science and Technology Innovation Sailing Special Project, and Shanghai Municipal Science and Technology Major Project; Zhejiang Provincial Natural Science Foundation of China.
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