CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Zhao Zhao,Mei Ji,Qianqing Wang,Nannan He,Yue Li
Off-target drug delivery, together with multidrug resistance (MDR), are two keys obstacles that account for the disappointing outcome in clinical chemotherapy of cancer. To solve these dilemmas, Herein, we constructed cancer cell membrane (CCM) modified silica (CS) nanoparticles (CCM/CS) to co-deliver Ca 2+ channel siRNA with doxorubicin (DOX) to construct a platform (CCM/CS/R-D) for the efficient therapy of cervical cancer. It was demonstrated that the optimal CCM/CS/R-D was spherical nanoparticles with size at 122.39 ± 4.69 nm and the surface charge of -27.76 ± 3.12 mV. In addition, the CCM/CS/R-D showed acid responsive drug release while high stability under physiological conditions with negligible hemolysis. The CCM/CS/R-D showed CCM mediated cellular uptake and efficient endosomal escape as well as siRNA transfection potential (comparable to that of PEI 25 K) on MDR cervical cancer cells (HeLa/DOX). Most importantly, the MDR of cancer cells was conquered through modulation of T-type Ca 2+ (Cav) channels. It was observed that the Cav channel siRNA could negatively regulate the level of cytosolic Ca 2+ concentration which triggered G0/G1 phase cell cycle arrest and elevated intracellular drug retention in HeLa/DOX cells without significantly affect the expression of P-glycolprotein (P-gp). The in vitro and in vivo experiments revealed that CCM/CS/R-D exerted greatly enhanced tumor targetability and therapeutic effect on HeLa/DOX, which was superior than CS/R-D or mono delivery system (CCM/CS/R or CCM/CS/D).
研究领域:
癌症研究
·
纳米医学
·
药理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Haike Li,Zhiyun Kong,Huan Zhang,Xiaolei Wang,Yaohua Xie,Xingqing Zhao,Yidan Hong
It is necessary to prepare a nanofiltration membrane with high permeation flux that can be used in the field of organic solvents. Gel membranes have a high solvent permeation flux, but their chained macromolecular structure is often unstable. In this study, tannic acid-bridged sodium alginate (TA x -Ca/FeSA) organic solvent nanofiltration (OSN) membranes were prepared by the phase transition method using aqueous Ca 2+ and Fe 3+ solutions as cross-linking agents. TA can interact with SA through hydrogen bonding hydrophobic bonding and other interactions to form an interpenetrating three-dimensional network structure. Compared with Ca/FeSA membrane, the average pore size of TA 0.125 -Ca/FeSA membrane was reduced from 1.03 nm to 0.74 nm, and the porosity was increased from 47.62 to 59.2 %. In addition, the TA 0.125 -Ca/FeSA membrane has the characteristics of a negative charge, super hydrophilicity, and high mechanical properties, exhibits a high permeation flux of 48.97 L·m −2 ·h −1 ·bar −1 with a rejection of 96.25 % for Congo red ethanol solution, has excellent solvent resistance, stain resistance, and self-cleaning ability. The TA 0.125 -Ca/FeSA membrane was demonstrated to have great potential for application in the fields of purification and solvent recovery.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2021
·
IF 4.952
Bing Cui,Wenxin Chen,Hongshan Liang,Jing Li,Di Wu,Shuxin Ye,Bin Li
The thermal stability of the κ-carrageenan/konjac gum (KC/KGM) mixed gel during heating treatment (at 85 °C for 30 min) does not satisfy the demand of the practical application. To solve this problem, gellan gum (GG) or/and Ca 2+ were introduced in the κ-carrageenan/konjac gum (KC/KGM) mixed system to enhance mechanical and thermal properties. The effect of GG and Ca 2+ on the gel matrix properties was studied by two deformation test (TDT), rheological measurement, scanning electron microscopy (SEM), combined with visual observation. The results showed that neither GG nor Ca 2+ alone could reduce the deterioration of the mechanical properties of the KC/KGM gel after heat treatment (at 85 °C for 30 min). Only the participation of GG and Ca 2+ could ensure the consistent mechanical properties of the mixed gel before and after heating. The rheological and micro-rheological analysis confirmed that the KC/KGM gel with GG and Ca 2+ could always remain solid-state without gel-sol transition under heat treatment. In addition, the thermo-irreversible gels with different texture properties were prepared by adjusting the mass ratio of KC and KGM. Hence, this study may enrich the design of novel gel-based food ingredients.
研究领域:
食品科学
·
生物材料
✓ 已验证
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2023
·
IF 5.7
Guangjin Chen,Cuiwei Li,Huaiming Jia,Hao Li,Siyuan Li,Bo Gong,Linan An,Kepi Chen
Five equimolar multicomponent oxides were synthesized by replacing one of five cations in (Ce 0.2 Zr 0.2 Ti 0.2 Sn 0.2 Hf 0.2 )O 2 with Ca 2+ . The results reveal that except for the one in which Ce 4+ replaced by Ca 2+ , the other four components can form single-phase high-entropy fluorite oxides (HEFOs) at different temperatures, which indicates that Ce 4+ is very important for the formation of single-phase HEFOs. The sintering behavior, lattice parameter and properties containing density, porosity, flexural strength and thermal conductivity of the four single-phase HEFOs were investigated. With the change of substituted ions, grain size, relative density, flexural strength and thermal conductivity of the materials vary greatly, which are correlated to the size disorder and mass disorder of these materials. The results of this paper provide a reference for the composition designing and performance tailoring of equimolar HEFOs.
研究领域:
材料科学
·
无机化学
✓ 已验证
DOI
高影响因子
Journal of Environmental Sciences
·
2021
·
IF 5.565
Biran Zhu,Ziniu Wang,Lei Lei,Yongyong Guo,Jian Han,Bingsheng Zhou
Cadmium (Cd), a ubiquitous environmental hazardous heavy metal, poses a significant threat to the health of aquatic organisms, including teleosts. Although the toxic profile of Cd is well recognized, little is known regarding the overall view of toxic responses to varying aquatic environmental parameters (e.g., water hardness) at an individual level. Herein, differences in water hardness were partially mimicked by adjusting Ca 2+ levels in E3 medium. As an in vivo model, zebrafish embryos were exposed to variable Ca 2+ levels (NV, normal Ca 2+ ; LV, low Ca 2+ ; HV, high Ca 2+ ) alone or combined with 30.7 µg/L Cd 2+ (NC, LC, and HC, respectively) until 144 hr post-fertilization. The genome-wide transcriptome revealed differentially expressed genes between groups. Functional enrichment analysis found that biological processes related to metabolism, particularly lipid metabolism, were significantly disrupted in NC and LC treatments, while a remission was observed in the HC group. Biochemical assays confirmed that the decrease in Ca 2+ enhanced synthesis, inhibited mobilization and increased the storage of lipids in Cd 2+ treatments. This study suggests that the toxic effect of Cd on biological pathways will be influenced by Ca 2+ , which will improve the toxicological understanding and facilitate accurate assessment of Cd.
研究领域:
毒理学
·
环境科学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2023
·
IF 5.2
Jun-qi Zhan,Yue-wen Chen,Gao-shang Li,Ya-qin Hu
The viscosity and plasticity of surimi is remarkable, which is a suitable 3D printing material. But low printing accuracy limit its wide application. Adding xylo-oligosaccharide (XOS) can enhance printing accuracy of surimi printing ink and improve the self-supporting ability and anti-deformation ability of the printed object. At the same time, XOS can impart antioxidant properties to 3D printed surimi. Additionally, adding 20 mM kg −1 of Ca 2+ to the surimi can significantly improve the printing accuracy. With the addition of Ca 2+ , the gel strength and texture of surimi are enhanced, as well as the surimi protein became denser. Moreover, the Ca 2+ in the “ink” can activate the activity of digestive enzymes which increase the contact of enzymes and surimi. The process of enzymatic hydrolysis is promoted, which improving the release rate and antioxidant properties of XOS. Functional surimi with Ca 2+ can be used to deliver functional components and enhance the printing effects.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Kui Liu,Huaiwu Zhang,Cheng Liu,Jie Li,Liang Shi,Xueying Wang,Yulong Liao,Lichuan Jin,Dainan Zhang
Herein, Zn 1- x Ca x ZrTa 2 O 8 (0 ≤ x ≤ 0.1) ceramics with wolframite structure were prepared via the solid-state reaction method. Zn 0.94 Ca 0.06 ZrTa 2 O 8 exhibited the best dielectric properties with ε r = 23.14, Q × f = 140,915 GHz (@7.79 GHz), and τ f = −26.42 ppm/°C. ε r increases gradually with the Ca 2+ content. The change in ε r is related to the Ca 2+ ion polarizability and the redshift of Raman vibrational modes. Appropriate Ca 2+ substitution makes the dominant Ta-O have higher lattice energy, resulting in a lower dielectric loss. In addition, the reduction of FWHM of Raman characteristic peaks also had a positive effect on reducing the dielectric loss. First-principles calculations illustrate that the trace substitution of Ca 2+ leads to an increase in the electron cloud density of the [Zn/Ca/ZrO 6 ] octahedra, resulting in lower dielectric losses. Suitable Ca 2+ substitution resulted in higher bond energy and smaller [Zn/Ca/ZrO 6 ] octahedral distortion, implying that τ f is closer to 0 ppm/°C.
研究领域:
材料科学
·
物理学
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Xuefei Zhang,Fanfei Min,Lingyun Liu,Lujun Wang,Qi Liu
Ca 2+ is an important ion in industrial wastewater such as coal slurry water. The concentration of Ca 2+ directly affects the water quality of recycled water, the physicochemical properties of particle surfaces, and the effectiveness of coal beneficiation. However, the determination of Ca 2+ in coal slurry water is influenced by other coexisting metal ions (M: K + , Na + , Mg 2+ , and Al 3+ ) in the system. The complexation color development – visible spectrophotometry (CCDVS) has been proven to be a rapid and accurate way to determine Ca 2+ . This study investigates the impact and mechanism analysis of factors such as the concentrations of coexisting ions (K + : 0–15 mg/L, Na + : 0–2000 mg/L, Mg 2+ : 0–20 mg/L, Al 3+ : 0–0.05 mg/L) and valence states (monovalent, divalent, trivalent) on the accurate determination of Ca 2+ using the CCDVS method. All ions are interested in the indicator, with the light absorption intensity order of Al 3+ (Abs = −1.783) > Mg 2+ (Abs = −1.723) > Ca 2+ (Abs = −1.248) > K + (Abs = −0.268) > Na + (Abs = −0.075) under the same ions concentration (e.g. 16 mg/L). Interestingly, the absorbance of Ca–M mixed solutions shows different trends. For example, adding Na + decreases the absorbance value of Ca 2+ , with a decrease in Abs of 0.065 when the Na + concentration is 2000 mg/L. This indicates a competitive relationship between the complexation color development reaction of Ca and Na due to the same reaction mechanism. However, for Ca–Mg mixed solutions, when the Mg 2+ concentration increases to 15 mg/L, the increase in Abs is 0.078, attributed to the stronger absorption of Mg 2+ occupying the adsorption sites of Ca 2+ . On the contrary, at industrial concentrations, the influence of K + (0–20 mg/L) and Al 3+ (0–0.05 mg/L) on Ca 2+ detection can be ignored. Complementary characterization (XRD, XPS) and DFT theoretical calculations indicate that complexation color development reaction depends on the adsorption of metal ions on the sulfonic acid sites on the indicator. Other metal cations compete with Ca 2+ for the same adsorption sites, and the reactivity of metal ions with the indicator is as follows Al 3+ > Mg 2+ > Ca 2+ > K + > Na + . Therefore, this study provides technical and theoretical support for the development of highly selective Ca 2+ detection methods, aiding in the rational control of chemical agent dosages.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
MINERALS ENGINEERING
·
2025
·
IF 5
Yijiang Li,Xiaoxia Yang,Zhaohua Wang,Wencheng Xia,Feng Wu,Yujin Sun,Xiangyun Sun,Shiqi Liu
This study researched into the underlying influence mechanism of Ca 2+ and Mg 2+ on the rheological properties of kaolinite slurry through rheological technique, turbidity analysis and DLVO theory calculation. The rheological results showed that both the viscosity and yield stress of kaolinite slurry were reduced under high Ca 2+ /Mg 2+ concentration. The apparent viscosity of slurry containing Mg 2+ was lower than that of slurry containing Ca 2+ , but the yield stress of slurry containing Mg 2+ was higher than that of slurry containing Ca 2+ . Turbidity results showed that Ca 2+ have a stronger turbidity removal effect on kaolinite suspension than Mg 2+ . The agglomeration of kaolinite in the presence of Ca 2+ was greater than that in the presence of Mg 2+ . The DLVO theoretical calculation results indicated that there was strong attractive energy between silica face-alumina face, silica face-edge face and edge face-edge face under 1 mmol/L Ca 2+ /Mg 2+ . There were repulsive energy barriers between the silica face-silica face, as well as between the alumina face-alumina face and alumina face-edge face. However, there was an attractive energy between the alumina face-edge face under 1 mmol/L Mg 2+ . The kaolinite agglomeration was a basal face-basal face (F-F) structure with tight and large under 1 mmol/L Ca 2+ , but the kaolinite agglomeration was F-F and edge face-basal face (E-F) structure with loose and large under 1 mmol/L Mg 2+ . The E-F structure in the presence of Mg 2+ caused high yield stress of kaolinite slurry. Under high ions concentration, there was a weak attraction or repulsion between basal faces of kaolinite, but there was an attractive effect between the edge faces. The kaolinite agglomerates were edge face-edge face (E-E) structure with small and even dispersed, resulting in a low viscosity of the slurry. The conclusion of this study provides a basis for regulating the rheological properties of rich-clay slurry during mineral processing.
研究领域:
矿物加工工程
·
胶体化学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
Yayu Su,Xiaolei Li,Huiming Ji,Zhihao Zhao,Peng Zhang
The Ca 2+ -Mn 2+ doped LaAlO 3 was prepared by solid state reaction method, and the effects of different doping content of Ca 2+ and Mn 2+ ions on the infrared radiation properties of LaAlO 3 were investigated. The result showed that after doping Ca 2+ and Mn 2+ ions, the infrared radiation properties of LaAlO 3 significantly increased. When 40 mol% Ca 2+ and 50 mol% Mn 2+ ions were doped into LaAlO 3 , the average emissivity in the wavelength range of 1–22 µm was up to 0.90, which was higher than pure LaAlO 3 (0.71). The enhancement of infrared radiation properties of LaAlO 3 was mainly due to the decrease of band gap of LaAlO 3 , the increase of hole carriers absorption of energy, and the increase of lattice vibration absorption after doping Ca 2+ and Mn 2+ ions. Ca 2+ -Mn 2+ doped LaAlO 3 with high infrared radiation properties shows application prospect in the high temperature oxidation environment.
研究领域:
材料科学
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Songfeng E,Yuan Wang,Yuanming Wang,Jiaming Yang,Junli Ma,Kaiyue Huang,Zhangzi Li,Zhaoqing Lu,Lejia Wang
We discovered that incorporating the Ca 2+ into sodium alginate (SA) solution as ball-milling medium of hexagonal boron nitride ( h -BN) could increase the lateral size of the exfoliated h -BN nanosheets (BNNSs) at least twice those of pure SA solution obtained, which can be owing to the Ca 2+ −induced crosslinking of SA and enhancement of interfacial adhesion forces between SA and h -BN that not only boost the impacting resistance to milling balls but also the exfoliation energy to h -BN. Based on the crucial role of Ca 2+ in h -BN exfoliation, the large-area and small-thickness BNNSs are produced simultaneously with the increased milling speed and Ca 2+ concentration, which can be assembled into highly compact and horizontal oriented structures with aramid nanofibers (ANFs) due to the favorable compatibility, dispersity, and interfacial binding force. This kind of compact and ordered structure enables ANF/BNNS film with high thermal conductivity (TC) since the connective and high-efficiency heat conduction paths, of which the highest TC is 27.57 W⋅m −1 ⋅K -1 . Compared with soft and molecular SA chains, the ANFs show an incredible ability to guide the horizontal orientation of BNNSs for the superior TCs of their composites.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
·
2020
·Vol. 52
·期 5
·563-569
·
IF 2.836
Wang Lianqing,Lan Yongting,Du Yanqin,Xiang Xinxin,Tian Wenxiu,Yang Baoye,Li Tao,Zhai Qiaoli
Osteoblast differentiation is a key process in bone homeostasis. Mutations in plastin 3 have been reported to be responsible for X-linked osteoporosis. Plastin 3 and plastin 2 act synergistically to regulate osteoblast differentiation. However, the bone-related function of plastin 1, another family member of plastins, has not been assessed. In this study, we addressed the functional importance of plastin 1 in osteoblasts. We characterized the expression patterns of plastin 1 during osteoblast differentiation and revealed its important role in this process. In both HEK 293T and hFOB1.19 cells, plastin 1 was demonstrated to regulate intracellular Ca2+. Accordingly, we revealed that higher Ca2+ concentration promotes osteoblast differentiation. Finally, we found that plastin 1 may play a compensatory role in osteoporosis patients with plastin 3 deficiency. Together, our results indicate that plastin 1 promotes osteoblast differentiation by regulating intracellular Ca2+. Our work sheds new light on the role played by plastins in bone homeostasis.
研究领域:
骨骼生物学
·
细胞生理学
·
分子生物学
·
医学遗传学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）