SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Ningning Dong,Lifa Ge,Pei Chen,Wei Wang,Fatang Tan,Xinyun Wang,Xueliang Qiao,Po Keung Wong
Stable, cheap and environmentally friendly CaO 2 was widely used to remediate environmental pollution, especially in advanced oxidation process (AOP) systems. However, its non-radical activation was still a huge challenge. In this study, the non-radical activation of CaO 2 nanoparticles was realized by MgNCN/MgO composites for efficient remediation of organic and heavy metal-contaminated wastewater. The presented CaO 2 -based AOP system exhibited excellent degradation performance towards tetracycline (TC) and methylene blue (MB) over a broad pH range, accompanied with the weak influences of common coexisting anions and natural water sources. Singlet oxygen ( 1 O 2 ) was verified as the dominant active species for organics degradation, and the coordination between MgNCN and MgO in MgNCN/MgO composites played a crucial role in the non-radical activation of CaO 2 nanoparticles. More importantly, the AOP system could not only degraded effectively organic pollutants, but also remove simultaneously heavy metal ions in wastewater. 100 mg/L CaO 2 and MgNCN/MgO could successfully remediate the complex pollution consisting of 10 mg/L MB and 100 mg/L Cd 2+ . Furthermore, the degradation intermediates of MB and the solid residues after treating pollutants were analyzed in detail to reveal the degradation process and conversion products.
研究领域:
环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 3
·1214-1228
·
IF 4.5
Qian Guowen,Wang Junzhe,Yang Liuyimei,Zeng Zhikui,Zhao Zhenyu,Peng Shuping,Shuai Cijun
The insufficient of H 2 O 2 restricts the efficacy of chemodynamic therapy in tumor microenvironment. Calcium peroxide (CaO 2 ) is expected to solve this problem due to its H 2 O 2 -evolving ability. However, it prematurely decomposes in the moist air or water before reaching tumor site. In this study, zeolitic imidazolate framework-67 (ZIF-67) was in-situ grown on the surface of CaO 2 to construct a pH-responsive CaO 2 @ZIF-67 system and then incorporated into poly-L-lactic acid (PLLA) to prepare PLLA/CaO 2 @ZIF-67 scaffold by selective laser sintering technology. On the one hand, ZIF-67 is used as a chemodynamic therapy agent due to the release of cobalt ions after degradation. On the other hand, ZIF-67 can serve as protective layers to prevent premature decomposition of CaO 2 due to its hydrophobic properties, and then CaO 2 is exposed and reacts with water to form H 2 O 2 after the pH-responsive degradation of ZIF-67 under tumor acidic microenvironment. Results showed that the PLLA/CaO 2 @ZIF-67 scaffold could sustainedly produce H 2 O 2 under acidic pH and achieve 84.64% antitumor ratio against MG-63 cells. In addition, the scaffold also promoted proliferation and osteogenic differentiation of mouse bone marrow mesenchymal stem cells due to the release of calcium ions. The prepared PLLA/CaO 2 @ZIF-67 scaffold with chemodynamic antitumor and osteogenic effects has great potential to treat tumorous bone defect.
研究领域:
生物材料
·
组织工程
·
癌症治疗
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2022
·Vol. 36
·期 12
·e6888
·
IF 4.072
Tiedong Sun,Zhengya Yue,Yan Song,Jiatong Ni,Wenxin Wang,Junge Zhao,Jialun Li,Yuan Sun,Bin Li
Chemodynamic therapy (CDT) is a highly effective clinical treatment strategy based on the Fenton or Fenton-like responses. However, its efficacy has been greatly limited by the complex tumor microenvironment, TME, such as the low levels of H 2 O 2 and the overexpression of the glutathione (GSH). Polyoxometalates (POMs) are compounds that consist of anionic transition metal oxide clusters, such as tungsten (W) and molybdenum (Mo), and notably, these compounds have excellent redox properties in biological systems that can be utilized therapeutically. Therefore, POM-CaO 2 @ZIF-8 nanoparticles (NPs) have been synthesized and used as a mediator to develop an electrically enhanced CDT strategy. It is hoped that the simultaneous modulation of endogenous (the H 2 O 2 generated by CaO 2 NPs and GSH depletion by POM) and exogenous (Electric, E) stimulation enhanced Fenton-like responses will lead to better therapeutic results. Such a treatment strategy has shown excellent tumor cell killing effects in both in vitro and in vivo studies.
研究领域:
纳米医学
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Dongdong Ge,Weixiang Wu,Guangming Li,Yuhui Wang,Guobiao Li,Yanting Dong,Haiping Yuan,Nanwen Zhu
Sludge dewaterability is commonly poor due to the hydrophilic biopolymeric substances. The highly efficient oxidation process is of great significance for extracellular biopolymers disintegration and bound water discharge. This work investigated the novel CaO 2 -enhanced peroxone (CaO 2 /O 3 ) process to adjust sludge characteristics for dewaterability enhancement and focused on the molecular composition and transformation of dissolved organic matters (DOM). CaO 2 /O 3 (60/40 mg/gTS (total solid)) treatment showed more powerful sludge solubilization of 57.8% and cell death proportion of 46.1% over single CaO 2 or O 3 treatment. Hydrophilic extracellular polymeric substances, especially protein-like substances, were substantially degraded, and their conformation turned to be more hydrophobic, and carbohydrate-like, aminosugars-like, and lignins-like substances increased in CaO 2 /O 3 process. Meanwhile, CaO 2 /O 3 handling resulted in more decomposition of CHO-containing compounds than N-containing or S-containing compounds. Subsequently, 60 mg/gTS PFS (polyferric sulfate) reflocculation exerted a strengthened role in eliminating proteins & lipids-like, lignins-like, and unsaturated hydrocarbons-like substances, and especially S-containing compounds, which compensated for the unsatisfactory removal effects of these substances in the CaO 2 /O 3 oxidation process. Therefore, the CaO 2 /O 3 -PFS treated sludge with less hydrated DOM easily harvested deep-dewatering in pressure filtration. Furthermore, it was noteworthy that the presence of CaO 2 created an alkaline environment and served as the source of sustained-release H 2 O 2 , which accelerated O 3 decomposition and greatly improved • OH generation. These findings provided molecular insight into a novel sludge conditioning approach for ideal dewaterability based on the CaO 2 -enhanced peroxone process in sludge treatment.
研究领域:
环境工程
·
污水处理
·
化学工程
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Chaoqun Tan,Wangqi Yu,Hong Mei,Kaiyang Chen,Tianhui Xu,Huiming Xiang,Yiming Feng,Lin Deng
In this study, Fe(III) catalyzed calcium peroxide (CaO 2 , CP) Fenton-like process assisted by crystal boron (C-boron) was applied for in situ chemical oxidation. Flunixin meglumine (FMME), aspirin (ASA), nitrobenzene (NB) and benzoic acid (BA) were selected as target contaminants. Pollutants decomposition by the CP/Fe(III) and C-boron/CP/Fe(III) systems was proposed in terms of diverse parameters, including C-boron dosage, pH, and temperature, with regard to the pseudo-first-order kinetic model (R 2 > 0.95). About 26.8% of 20 μM FMME was removed by 0.5 mM CP and 0.5 mM Fe(III) after 20 min at pH 4.0, whereas 90.4% of FMME was decomposed in the C-boron/CP/Fe(III) system with 100 mg/L C-boron. The removal rates of the other three pollutants were also improved to varying degrees. The k obs of the C-boron/CP/Fe(III) system for these four pollutants degradation at pH 4.0 was approximately 4.1 ∼ 5.3 times higher compared to the CP/Fe(III) system. Electron paramagnetic resonance and quenching experiments indicated that OH, O 2 − and 1 O 2 were present in both systems and contribution of OH was 71.3% at initial pH 4.0 in C-boron/CP/Fe(III) system, suggesting that it was the main reactive oxygen species for the contaminants elimination. Furthermore, experiments on the characterization of C-boron showed great reactivity and stability. This work manifested the promotion mechanism of pollutant degradation in the C-boron/CP/Fe(III) system.
研究领域:
环境科学
·
化学工程
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2021
·Vol. 9
·期 20
·6830-6841
·
IF 6.843
Liming Ruan,Gao Song,Xueya Zhang,Tianqi Liu,Yanfang Sun,Junlan Zhu,Zhiyong Zeng,Guohua Jiang
The development of multifunctional nanoformulations (NFs) include several features in a single nanosystem for these devices to overcome the disadvantages of inefficiency and undesirable toxicity of traditional therapies and provide new opportunities in the management of tumors. Herein, multifunctional CaO2@Mn-PDA NFs with a core–shell structure, integrating the photothermal conversion properties of Mn-PDA, the chemodynamic properties of doped Mn ions, and relieving hypoxia in the tumor microenvironment (TME) were developed. The as-fabricated CaO2@Mn-PDA NFs were embedded in microneedles (MNs) for transdermal delivery into tumor sites, leading to the generation of a new minimally invasive and synergistic therapeutic strategy against skin melanoma. Under near-infrared (NIR) light irradiation, the CaO2@Mn-PDA NFs exhibited a synergistic therapeutic effect, including photothermal therapy (PTT), chemodynamic therapy (CDT), and modulating hypoxia due to their high photothermal conversion efficiency, boosted intracellular production of reactive oxygen species, excellent chemodynamic reactions, etc. Therefore, the developed MN platform, which can build implanted multifunctional characteristics for on-demand NIR-induced synergistic therapy, have a bright future in tumor suppression.
研究领域:
生物医学工程
·
纳米技术
·
癌症治疗
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
·
2024
·
IF 4.7
Zhiqiang Zhang,Qinglong Wang,Haibo Zhang,Shengchao Wang,Xia Ma,Hui Wang
Mitophagy is a distinct physiological process that can have beneficial or deleterious effects in particular tissues. Prior research suggests that mitophagic activity can be triggered by CaO2-PM-CsPbBr3 QDs, yet the specific role that mitophagy plays in hepatic injury induced by CaO2-PM-CsPbBr3 QDs has yet to be established. Accordingly, in this study a series of mouse model- and cell-based experiments were performed that revealed the ability of CaO2-PM-CsPbBr3 QDs to activate mitophagic activity. Golm1 was upregulated in response to CaO2-PM-CsPbBr3 QDs treatment, and overexpressing Golm1 induced autophagic flux in the murine liver and hepatocytes, whereas knocking down Golm1 had the opposite effect. CaO2-PM-CsPbBr3 QDs were also able to Golm1 expression, in turn promoting the degradation of P53 and decreasing the half-life of this protein. Overexpressing Golm1 was sufficient to suppress the apoptotic death of hepatocytes in vitro and in vivo, whereas the knockdown of Golm1 had the opposite effect. The ability of Golm1 to promote p53-mediated autophagy was found to be associated with the disruption of Beclin-1 binding to Bcl-2, and the Golm1 N-terminal domain was determined to be required for p53 interactions, inducing autophagic activity in a manner independent of helicase activity or RNA binding. Together, these results indicate that inhibiting Golm1 can promote p53-dependent autophagy via disrupting Beclin-1 binding to Bcl-2, highlighting a novel approach to mitigating liver injury induced by CaO2-PM-CsPbBr3 QDs.
研究领域:
细胞生物学
·
分子生物学
·
药理学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2024
·
IF 9.4
Cong Tang,Kairui Liu,Xiaoning Gao,Hanmeixuan Kang,Weijie Xie,Jin Chang,Linling Yin,Jun Kang
Cuproptosis is an emerging form of programmed cell death and shows enormous prospect in cancer treatment. Excessive generation of reactive oxygen species (ROS), metal ion accumulation, and the tricarboxylic acid (TCA) cycle collapse are pivotal elements in the triggering of cell death via mitochondrial pathways. Herein, a cascade nanoreactor CaCuZC has been constructed by incorporating nanosonosensitizer IR780 carbon dots (IR780 CD) and calcium peroxide (CaO 2 ) into metal-organic frameworks (MOF) for synergistic cuproptosis–ferroptosis and Ca 2+ overload mediated immunotherapy. Within tumor cells, CaCuZC dissociates into CaO 2 , Cu 2+ and sonosensitizer IR780 CD. The decomposition of CaO 2 could generate H 2 O 2 to strengthen the Cu 2+ -based chemodynamic therapy and Ca 2+ overload induces amplified intracellular oxidative stress, thus leading to mitochondrial dysfunction. As a result, the combination of Cu 2+ and Ca 2+ overload together induce cascade mitochondrial damage. Moreover, the sonosensitizer IR780 CD generates ROS under ultrasound irradiation to amplify intracellular oxidative stress. In addition, the overloaded Cu 2+ released from CaCuZC leads to the aggregation of lipoylated protein dihydrolipoamide S-acetyltransferase, thus resulting in cuproptosis. Furthermore, ferroptosis could been concomitantly induced by CaCuZC with intracellular glutathione (GSH) consumption and lipid peroxidation (LPO) accumulation. The cuproptosis–ferroptosis and Ca 2+ overload-enhanced synergistic therapy also activates robust immunogenic cell death. CaCuZC enhances the infiltration and activation of tumor-specific cytotoxic T cells to transform a “cold” tumor into a “hot” tumor, activating the anti-tumor immune response. This study provides a cascade of mitochondrial damage strategy for triggering cuproptosis–ferroptosis and Ca 2+ overload-enhanced immunotherapy and achieving improved therapeutic effects. Statement of significance To improve the efficacy of tumor immunotherapy, a cascade nanoreactor CaCuZC was successfully constructed based on a self-assembly strategy for cuproptosis–ferroptosis and Ca 2+ overload mediated immunotherapy. Upon decomposition within the acidic and GSH-overexpressing tumor microenvironment, CaCuZC released CaO 2 and Cu 2+ and sonosensitizer IR780 CD. The CaO 2 further produced H 2 O 2 /O 2 and Ca 2+ in a weakly acidic environment to strengthen the Cu 2+ -based CDT and IR780 CD-mediated SDT, respectively. The overload copper ions not only led to cuproptosis, but also efficiently induced ferroptosis. The cuproptosis–ferroptosis and Ca 2+ overload-enhanced synergistic therapy also activates robust immunogenic cell death. This study presents a cascade of mitochondrial damage strategy for cuproptosis–ferroptosis and Ca 2+ overload-enhanced immunotherapy.
研究领域:
癌症研究
·
纳米技术
·
治疗学
·
免疫学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xinlin Li,Mengfei Xu,Zhaoli Geng,Xinyi Xu,Xu Han,Lin Chen,Ping Ji,Yi Liu
Titanium-based implants often lead to premature implant failure due to the lack of antimicrobial, osteogenic, and angiogenic properties. To this end, a new strategy was developed to fabricate CaO2@ZIF-67-HA-ADH coating on titanium surfaces by combining calcium peroxide (CaO2) nanoparticles, zeolite imidazolate framework-67 (ZIF-67), and the chemical coupling hyaluronic acid–adipic acid dihydrazide (HA-ADH). We characterized CaO2@ZIF-67-HA-ADH with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and inductively coupled plasma–atomic emission spectrometry (ICP–AES). The results demonstrated that CaO2@ZIF-67-HA-ADH was pH-sensitive and decomposed rapidly under acidic conditions, and it released inclusions slowly under neutral conditions. Antibacterial experiments showed that the CaO2@ZIF-67-HA-ADH coating had excellent antibacterial properties and effectively killed methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PAO-1). Cell experiments revealed that the CaO2@ZIF-67-HA-ADH coating promoted pro-osteoblast adhesion, proliferation, and differentiation and also promoted the migration and angiogenesis of human umbilical vein endothelial cells (HUVECs), exhibiting excellent osteogenic and angiogenic properties. In in vivo animal implantation experiments, the CaO2@ZIF-67-HA-ADH coating exhibited strong antimicrobial activity early after implantation and excellent osseointegration later after implantation. In conclusion, the pH-responsive CaO2@ZIF-67-HA-ADH coating conferred excellent antibacterial, osteogenic, and angiogenic properties to titanium implants, which effectively enhanced osseointegration of the implants and prevented bacterial infection; the coating shows promise for use in the treatment of bone defects.
研究领域:
生物材料
·
生物医学工程
·
组织工程
·
材料科学
·
骨科
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIORESOURCE TECHNOLOGY
·
2024
·
IF 9.7
Yongli Liu,Linyan He,Miao Liu,Yi Wang,Lin Li,Li Gu,Jinze Li,Shaowu Liu,Qiang He
This study examined the combination of activated carbon and magnetite with calcium peroxide in enhancing the anaerobic digestion (AD) performance of food waste (FW). The individual mechanisms of these two approaches were also clarified. The results indicated that AC/CaO 2 achieved the highest specific methane yield of 434.4 mL/g VS, followed by Fe 3 O 4 /CaO 2 (416.9 mL/g VS). Both were significantly higher than other groups (control, AC, Fe 3 O 4 , and CaO 2 were 330.1, 341.4, 342.8, and 373.2 mL/g VS, respectively). Additionally, compared to Fe 3 O 4 /CaO 2 , AC/CaO 2 further increased reactive oxygen species (ROS), thereby enhancing the hydrolytic acidification process. Simultaneously, the higher ROS levels of Fe 3 O 4 /CaO 2 and AC/CaO 2 promoted the formation of microbial aggregates and established a more robust enzymatic defense system and unique damage repair strategy. The research comparatively analyzed the synergistic mechanism of iron-based and carbon-based conductive materials with CaO 2 , providing new perspectives for optimizing the AD of FW.
研究领域:
环境工程
·
生物技术
·
废物管理
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Yao Xu,Fei-er Han,Da-peng Li,Jing Zhou,Yong Huang
The transformation of sedimentary phosphorus (P) fractions by point injection of CaO 2 was investigated in this study. The results showed that the addition of CaO 2 increased the dissolved oxygen (DO) in the overlying water as well as its pH. Simultaneously, the concentrations of total organic carbon (TOC), ammonia nitrogen (NH 4 + -N), total phosphorus (TP) and dissolved inorganic P (DIP) in the overlying water were sharply reduced by the point injection of CaO 2 , indicating that this accelerated the mineralisation rate of organic matter. It also favoured the formation and maintenance of the micro-oxidation environment in the deep sediments. NH 4 Cl-P, Fe/Al-P and Ca-P increased significantly, while the Res-P decreased sharply, especially close to the injection point of CaO 2 , accelerating the transformation of P. These results can all be attributed to the oxidation of organic P and the adsorption of dissolved P from the overlying water. Additionally, the NaHCO 3 -extractable phosphorus (Olsen-P) and algal available phosphorus (AAP) were reduced, and their percentages in Ca-P and Fe/Al-P also decreased, especially close to the injection point of CaO 2 . The bioavailable P decreased from 25.6% (the initial) to 17.2% (the mean for the different distances) after the point injection of CaO 2 , when the sum of the Olsen-P and AAP was used to calculate the bioavailable P. This indicates that point injection of CaO 2 favours not only the transformation of P species but also inhibition of the bioavailable P. This is attributable to acceleration of the transformation from bioavailable to inert P.
研究领域:
环境科学
·
生态学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-14
·
IF 9.429
Ruan Shuangrong,Yin Weimin,Chang Jiao,Yang Yan,Sun Jiuyuan,Ma Xiaoyi,Liu Ying,Zang Jie,Liu Yiqiong,Li Yongyong,Ren Tianbin,Dong Haiqing
Hypoxia and high accumulation of lactic acid in the tumor microenvironment provide fertile soil for tumor development, maintenance and metastasis. Herein, we developed a calcium peroxide (CaO2)-loaded nanostructure that can play a role of “one stone kill two birds”, i.e., acidic and hypoxic tumor microenvironment can be simultaneously regulated by CaO2 loaded nanostructure. Specifically, CaO2-loaded mesoporous polydopamine nanoparticles modified with sodium hyaluronate (denoted as CaO2@mPDA-SH) can gradually accumulate in a tumor site. CaO2 exposed in acidic microenvironment can succeed in consuming the lactic acid with oxygen generation simultaneously, which could remodel the acid and hypoxia tumor microenvironment. More importantly, the relief of hypoxia could further reduce lactate production from the source by down-regulating the hypoxia inducible factor-1α (HIF-1α), which further down-regulated the glycolysis associated enzymes including glycolysis-related glucose transporter 1 (GLUT1) and lactate dehydrogenase A (LDHA). As a result, CaO2@mPDA-SH alone without the employment of other therapeutics can dually regulate the tumor hypoxia and lactic acid metabolism, which efficiently represses tumor progression in promoting immune activation, antitumor metastasis, and anti-angiogenesis.
研究领域:
纳米技术
·
肿瘤学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）