ACS Applied Nano Materials
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2023
·
IF 5.9
Shuoshuo Yang,Hailing Li,Zhonghong Gao
As a critical factor in bone regeneration, oxidative stress affects the effectiveness of implantation seriously. Construction of bioactive coatings with ideal antioxidative and osteogenic activities is essential for the repair of bone injury. Here, inorganic cerium oxide nanoparticles (CeO2NPs) and organic baicalein (BAI)-modified bovine serum albumin (BSA) were used as assembly units to fabricate (CeO2NPs/BAI-BSA)4 coating via the layer-by-layer self-assembly technique. The drug-loaded CeO2NP coating obviously promoted cell adhesion and spreading of MC3T3-E1 cells in the early stage. Moreover, the CeO2NPs/BAI-BSA coating could scavenge both ABTS+• and DPPH• free radicals, and exhibited good antioxidative effect at the cellular level against the negative effect of oxidative stress. In addition, CeO2NP-based coatings exhibited good blood compatibility with low platelet adhesion and almost no damage to erythrocytes. The composite coatings of CeO2NPs and BAI-BSA have antioxidative, osteogenic, and blood-biocompatible properties, serving as a promising strategy for bone repair under oxidative stress.
研究领域:
生物材料
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组织工程
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生物医学工程
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材料科学
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产品关联
DOI
高影响因子
BIOMATERIALS
·
2023
·
IF 14
Cai Feng,Zongling Xiong,Xianting Sun,Hao Zhou,Tianming Wang,Ying Wang,Harrison X. Bai,Peng Lei,Weihua Liao
It is a challenging task to develop a contrast agent that not only provides excellent image contrast but also protects impaired kidneys from oxidative-related stress during angiography. Clinically approved iodinated CT contrast media are associated with potential renal toxicity, making it necessary to develop a renoprotective contrast agent. Here, we develop a CeO 2 nanoparticles (NPs)-mediated three-in-one renoprotective imaging strategy, namely, i) renal clearable CeO 2 NPs serve as a one-stone-two-birds antioxidative contrast agent, ii) low contrast media dose, and iii) spectral CT, for in vivo CT angiography (CTA). Benefiting from the merits of advanced sensitivity of spectral CT and K-edge energy of Cerium (Ce, 40.4 keV), an improved image quality of in vivo CTA is successfully achieved with a 10 times reduction of contrast agent dosage. In parallel, the sizes of CeO 2 NPs and broad catalytic activities are suitable to be filtered via glomerulus thus directly alleviating the oxidative stress and the accompanying inflammatory injury of the kidney tubules. In addition, the low dosage of CeO 2 NPs reduces the hypoperfusion stress of renal tubules induced by concentrated contrast agents used in angiography. This three-in-one renoprotective imaging strategy helps prevent kidney injury from being worsened during the CTA examination.
研究领域:
医学影像
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纳米技术
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放射学
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肾病学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 44
·9204-9212
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IF 6.331
Xinyue Guo,Zongjia Li,Sitong Liu,Miaomiao Zhang,Yanxue Guan,Juan Qin,Xiaomeng Li,Bailin Zhang,Jilin Tang
Studying the influence of nanomaterials on the microstructure and mechanical properties of cells is essential to guide the biological applications of nanomaterials. In this article, the effects of the first synthesized PDA@CeO2 nanoparticles (NPs) with multiple ROS scavenging activities on cell ultra-morphology and mechanical properties were investigated by atomic force microscopy (AFM). After the cells were exposed to PDA@CeO2 NPs, there was no obvious change in cell morphology, but the Young's modulus of the cells was increased. On the contrary, after the cells were damaged by H2O2, the secreted molecules appeared on the cell surface, and the Young's modulus was decreased significantly. However, PDA@CeO2 NPs could effectively inhibit the reduction of the Young's modulus caused by oxidative stress damage. PDA@CeO2 NPs could also protect F-actin from oxidative stress damage and maintain the stability of the cytoskeleton. This work investigates the intracellular antioxidant mechanism of nanomaterials from the changes in the microstructure and biomechanics of living cells, providing a new analytical approach to explore the biological effects of nanomaterials.
研究领域:
纳米技术
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生物物理学
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细胞生物学
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材料科学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Shuhan Zhao,Junhong Ling,Nan Wang,Xiao–kun Ouyang
Diabetic wounds are among the most severe chronic complications in patients with diabetes. Owing to the detrimental effects of high glucose and high levels of reactive oxygen species (ROS) in the wound microenvironment, diabetic wound healing is significantly challenging. To address the issues of elevated ROS levels and infection susceptibility in diabetic wounds, we designed a composite hydrogel system loaded with cerium dioxide nanoparticles (CeO 2 NPs) and vancomycin. This hydrogel aimed to reshape the wound microenvironment by continuously consuming ROS and inhibiting infection. Experimental results demonstrated that the CeO 2 NPs-loaded hydrogel demonstrated an 85.40% clearance rate of hydroxyl radicals (·OH) and achieved over 90% inhibition against Staphylococcus aureus ( S. aureus ) and Pseudomonas aeruginosa ( P. aeruginosa ), and effectively promoted the healing of diabetic mouse wounds. This cerium dioxide nanozyme hybrid hydrogel system can exert antioxidative and antibacterial effects and serve as a wound dressing to promote the healing of infected diabetic wounds.
研究领域:
纳米技术
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材料科学
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生物医学工程
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药学
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伤口愈合
✓ 已验证
产品关联
DOI
高影响因子
AIP Advances
·
2024
·Vol. 14
·期 5
·
IF 1.4
Yang Changfeng,Zhang Bowen,Lin Xiaoqian,Han Qinglin,Bao Hongze,Liu Yan
Concentration plays an essential role in generating hydroxyl radicals in irradiated nanoenhancer suspensions. In this paper, we used coumarin-3-carboxylic acid as a hydroxyl radical-specific probe to investigate the hydroxyl radical production of different concentration nanodiamonds (NDs) and CeO 2 NPs in phosphate-buffered saline under x-ray irradiation. NDs significantly enhanced hydroxyl radical production, and the maximum enhancement of hydroxyl radical production was observed at a concentration of 10 µ g/ml, with an enhanced factor of 1.398 ± 0.262. CeO 2 NPs can increase and scavenge hydroxyl radicals at different concentration ranges, with the lowest and highest enhanced factors of 0.623 ± 0.069 and 1.738 ± 0.264, respectively. We tested the hydrodynamic diameter at various concentrations to explore the concentration effect further. We found that with increasing concentration, there might be factors, such as hydroxyl radical recombination and nanoparticle agglomeration, that lead to changes in the enhancement factor. Based on the data from previous and present studies, the experimental results indicate that the concentration factor is essential for hydroxyl radical generation in nanoenhancer suspensions under ionizing radiation. We also provide possible mechanisms for enhancing hydroxyl radical production by nanoenhancers in water under ionizing radiation and the decrease in enhancement factor at high concentrations of nanoenhancers.
研究领域:
辐射化学
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纳米技术
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物理化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2023
·
IF 6.2
Dongdong Xu,Zhigao Xue,Lei Han,Kai Tao
Bimetallic sulfides with superior electrochemical activity are extensively explored as electrode materials for electrochemical energy related applications. However, their utilizations are impeded due to unfavorable faradaic reaction kinetics and poor electrochemical stability. To overcome these defects, this study reports interface engineering of heterogeneous nanosheet arrays on Ni foam (NF) through surface modification of metal-organic framework (MOF)-derived zinc cobalt sulfide (Zn/Co-S) with CeO 2 nanoparticles (NPs). MOF-derived porous Zn/Co-S nanosheets have highly exposed electrochemical active sites and abundant channels for charge transport. The strong interfacial coupling between Zn/Co-S and defective CeO 2 leads to fast charge transfer, thereby improving electrochemical activity. The CeO 2 can also prevent Zn/Co-S from degrading in KOH solution. Moreover, the self-supported electrode shows high electronic conductivity and strong adhesion with the conductive substrate. Therefore, the specific capacity and electrochemical stability of resulting Zn/Co-S@CeO 2 /NF are significantly higher compared with Zn/Co-S/NF. Furthermore, an asymmetric supercapacitor (ASC) based on Zn/Co-S@CeO 2 /NF and activated carbon (AC) exhibits high energy storage capability (42.4 Wh kg −1 ) and outstanding operating durability (91.1 % after 8000 cycles). These results demonstrate that the as-prepared electrode is a superior candidate for electrochemical devices .
研究领域:
材料科学
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电化学
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能源存储
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 27
·13126-13138
·
IF 6.97
Yurui Zhou,Lu Li,Shenghui Li,Shufei Li,Miao Zhao,Qinghong Zhou,Xiaoqun Gong,Jin Yang,Jin Chang
Diabetic cataracts (DCs) are one of the most common ocular complications of diabetes, and easily causes blindness among diabetics. However, there are limited drugs to delay and prevent DCs. Research studies indicate that oxidative damage of the crystalline lens and nonenzymatic glycosylation of the lens protein play a key role in the pathogenesis of DCs. Hence, we developed a kind of autoregenerative redox nanoparticle, which was CeO2 NPs coated with PEG-PLGA (PCNPs). We first found that PCNPs could work not only as an antioxidant to protect lens epithelial cells from oxidative stress based on the repetitive elimination of reactive oxygen species (ROS), but also as a glycation inhibitor effectively restraining α-crystallin glycation and crosslinking, thereby keeping the lens transparent and alleviating DCs. Experimental results successfully validated the fact that the PCNPs were able to operate in eyes for a long time to attenuate lens opacity. We expect that this strategy will provide promising potential for the treatment of DCs.
研究领域:
药理学
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眼科学
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纳米技术
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糖尿病研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）