CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Yi Wang,Aiping Tu,Xinwen Zhang,Mengyao Li,Laicheng Liu,Yongfei Li,Jiangling Wu,Pu Zhang
Nanomaterials have been widely used in the detection of biomarkers, but only a few of them can be really applied in clinical disease diagnosis in hospital. Herein, we fabricate a kind of defect-rich CoOOH nanorings (NRs) and employ them as probes to improve the clinical diagnosis performance for children heart failure (HF). This diagnosis platform is dependent on ultrasensitive and specific detection of the “gold standard biomarker” of HF, B-type natriuretic peptide (BNP), which is realized based on the prevention of fluorescence resonance energy transfer. The detection range for BNP is 30–800 fg/mL with a limit of detection as low as 30 fg/mL. For diagnosis of a large number of clinical cases of children who behave sign or symptom of HF (respiratory distress, edema, or tachycardia), a very close correlation ( r = 0.990) is obtained between this method and commercially available chemiluminescence immunoassay (CLIA, Siemens) that commonly adopted by hospital. It is worth noting that the present method has better diagnostic performance for children HF than CLIA including specificity (84.6% vs 61.5%), accuracy (82.2% vs 66.7%) and positive predictive value (40.0% vs 20.0%). Moreover, this method is more cost-effective than CLIA for BNP detection. The defect-rich, biocompatible, and low-cost CoOOH nanomaterial is promising to be applied in early clinical diagnosis of HF in hospital.
研究领域:
材料科学
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医学
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生物化学
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2018
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IF 6.14
Ming Zhu,Jie Miao,Xiaoguang Duan,Daqin Guan,Yijun Zhong,Shaobin Wang,Wei Zhou,Zongping Shao
The deployment of an efficient catalyst is critical for successful application of peroxymonosulfate-based advanced oxidation processes to the rapid degradation of retardant organics in wastewater. Considering the rich properties of perovskite oxides and their drawbacks of low specific area and easy cation leaching, we reported a facile postsynthesis hydrothermal treatment method for preparing SrCo0.6Ti0.4O3−δ@CoOOH (SCT@CoOOH) nanocomposite as an efficient catalyst for PMS activation here. Surprisingly, CoOOH nanosheets were grown in situ over the surface of SCT substrate, resulting in a significantly increased surface area (22.1 m2 g–1), enhanced charge transfer capability, more generated surface oxygen defects and a strongly synergistic effect created between the bulk SCT and CoOOH surface layer. Remarkably, SCT@CoOOH exhibited higher (1.7 times) catalytic activity (0.84 mg L–1 min–1) for phenol degradation than SCT. Additionally, suppressed cobalt leaching was demonstrated in the SCT@CoOOH/PMS system. Notably, singlet oxygen as additional oxidative species were formed to accelerate phenol degradation in the radical-based SCT@CoOOH/PMS system due to the surface oxygen defects. The beneficial effect of higher pH value and different influence of foreign anions on the reation rate were also investigated. As a universal method, it may be also useful for the development of innovative functional materials for other various applications.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
LUMINESCENCE
·
2021
·Vol. 36
·期 5
·1317-1326
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IF 2.464
Lu Ning Zhu,Ru Cheng,Kai Wen Kang,Ming Yun Chen,Tianrong Zhan,Jian Wang
As a natural enzyme, alkaline phosphatase (ALP) plays an essential role in clinicopathological examinations and biomedical research, and is capable of hydrolyzing the phosphate group of l -ascorbic acid-2-phosphate (AAP) to yield l -ascorbic acid (L-AA). L-AA reduced cobalt oxyhydroxide (CoOOH) nanoflakes to Co 2+ , leading to a smaller size and weaker light scattering, which could be monitored by electron microscopic images and optical spectra. The indirect detection of ALP was achieved by the reduced light scattering signal of CoOOH nanoflakes. Under optimal conditions, the decrease in scattering intensity was proportional to the ALP concentration over the range 0.1–160 U/L and the detection limit was 0.034 U/L (3σ/ k ). Compared with other assays, this proposed light scattering method was more convenient and economic for ALP sensing. The method was successfully applied to ALP analysis in human serum samples, and was similar to the results obtained by commercial kits.
研究领域:
生物医学工程
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临床检验
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Dilong Zhang,Chengting Wang,Mingzhu Xiao,Lu Gan,Xiujie Yang,Yong Xie,Qi Sun
In this study, a novel CoOOH/AuNPs nanozyme was synthesized through a two-step process by integrating gold nanoparticles (AuNPs) with cobalt oxyhydroxide (CoOOH) nanosheets. The CoOOH/AuNPs nanozyme exhibits significant oxidase and peroxidase (POD)-like activities, with a marked enhancement in POD-like activity attributed to the presence of AuNPs. This advancement facilitates the catalytic decomposition of hydrogen peroxide (H 2 O 2 ) into hydroxyl radicals (·OH), which subsequently oxidizes 3,3′,5,5′-tetramethylbenzidine (TMB) to form blue oxidized TMB (ox-TMB) with an absorbance peak at 652 nm. The CoOOH/AuNPs nanozyme's stability was evaluated and was found to be superior to that of natural horseradish peroxidase (HRP), maintaining over 90 % activity after a 30-day period at room temperature. Steady-state kinetic studies confirmed the nanozyme's higher affinity and quicker reaction rate for the TMB substrate compared to HRP. The POD-like catalytic mechanism was investigated, highlighting the essential role of ·OH in the catalytic reaction. A colorimetric sensing platform was then fabricated for H 2 O 2 detection in chicken feet with pickled peppers, demonstrating high sensitivity and selectivity. This study presents a significant advancement in the field of nanozyme-based sensors for food safety applications.
研究领域:
生物化学
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纳米生物学
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食品安全检测
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产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Qi Sun,Miaomiao Ma,Zhijuan Li,Xiang Chen,Jian Zeng,Meiqi Huang,Yuting Yin,Xueyan Ran,Jianmei Li,Tao Le
Zearalenone (ZEN) poses significant threats to food safety and human health due to its widespread contamination in cereals. Current detection methods face limitations in cost, complexity, and field applicability. To address this, we developed a novel colorimetric aptasensor leveraging the peroxidase-like activity of Au/CoOOH nanozymes for rapid and sensitive ZEN detection. Systematic characterization of cobalt-based nanomaterials (β-Co(OH) 2 , Co 3 O 4 , CoOOH, and Au/CoOOH) revealed that Au/CoOOH exhibited the highest catalytic efficiency, achieving a 3.5-fold enhancement over CoOOH due to synergistic interactions with Au nanoparticles. The aptasensor employed a competitive displacement strategy: ZEN binding to aptamer-functionalized magnetic beads released cDNA-conjugated Au/CoOOH, reducing 3,3′,5,5′-tetramethylbenzidine oxidation signals. Optimized parameters enabled a linear detection range of 0.3–500 ng/mL with a detection limit of 0.23 ng/mL. Specificity tests confirmed minimal cross-reactivity with other mycotoxins. The sensor demonstrated exceptional sensitivity, specificity, and practicality, validated by recovery rates of 90.65–105.63 % in spiked matrices, positioning it as a reliable tool for safeguarding food safety through rapid, precise mycotoxin monitoring.
研究领域:
食品安全
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分析化学
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纳米技术
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2023
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IF 9.9
Minghui Xiong,Bo Chai,Guozhi Fan,Xiaohu Zhang,Chunlei Wang,Guangsen Song
The strong electron interaction between metal oxide–carbon-based catalyst components plays a vital role in the peroxymonosulfate (PMS) activation for pollutant degradation. Herein, a novel CoOOH nanosheets anchored on rape straw-derived biochar (BC) surface (labeled as CoOOH/BC) as an efficient PMS activator toward degrading sulfamethoxazole (SMX) was synthesized. Experimental results indicated that integrating CoOOH nanosheets on the BC surface could inhibit CoOOH aggregation to increase the specific surface areas, exert a component synergistic effect to enhance activation degradation activity, and improve the catalyst stability. As a result, a 96 % degradation efficiency of SMX was achieved within 20 min over 20 wt% CoOOH/BC composite catalyst under the optimal conditions. Density functional theory (DFT) calculations disclosed that a built-in electric field (BIEF) pointing from BC to CoOOH was constructed at their interface, which could mediate PMS activation for reactive oxygen species (ROS) generation and induce direct electron transfer from SMX to PMS, resulting in efficient SMX degradation via both radical and non-radical pathways. Moreover, quenching experiments and electron paramagnetic resonance (EPR) measurements confirmed that single oxide ( 1 O 2 ) and superoxide radical ( O 2 · - ) are the dominant active species in the current system. Additionally, the possible SMX degradation routes were reasonably proposed based on liquid chromatography-mass spectrometry (LC-MS) results. This work provides an in-depth understanding of the role of BIEF in PMS activation, and expands the application of biochar-based materials in the field of environmental remediation.
研究领域:
环境科学
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材料化学
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污染修复
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2020
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IF 9.038
Jingyu Ren,Jie Li,Lei Lv,Jian Wang
Herein, Ce doped CoOOH was used as the catalyst for caffeic acid (CA) degradation by dielectric barrier discharge (DBD) plasma. The treatment performance and catalytic mechanism were studied by a series of experiments and density functional theory (DFT) simulations. The results show that the doping amounts of Ce significantly influenced the catalytic performance of CoOOH in DBD plasma, and the catalytic effect reached maximum when the molar ratio of Ce to Co was 1:9. CA was 100 % degraded by Ce 1 /Co 9 OOH/DBD with 10 min treatment, while only 75.6 % of CA was degraded by 10 min DBD treatment. Transformation of O 3 and H 2 O 2 to ⋅OH was mainly responsible for the catalytic effect. The content of oxygen vacancies and unsaturated Co (Lewis acid sites) of CoOOH was increased by doping Ce according to the results of experiments and simulations, and the change was conducive to the catalytic reactions. DFT simulations also indicated that DBD generated O 3 and H 2 O 2 were decomposed to O atoms, OH groups and free OH by Ce/CoOOH. The presence of reductive species in DBD plasma was confirmed, and ⋅H was a kind of important reactive specie for CA degradation. CA degradation pathway was proposed based on the detected degradation products.
研究领域:
环境科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
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IF 4.4
Jiaqi Li,Yarong Wang,Xiaoling Zheng,Lingling Chen,Qi Sun,Dapeng Peng,Tao Le
Sulfamethazine (SMZ) has been widely used in animal husbandry and exposed to water and soil environments, posing potential threat to human health and ecological environment. Hence, we designed a CoOOH-based aptasensor, the fluorescence resonance energy transfer between FAM-labeled aptamer and CoOOH was used to sensitively and selectively detect SMZ in water and soil environments. Molecular docking and molecular dynamics simulations were used to predict binding mechanisms of SMZ and aptamer. Under optimized conditions, the aptasensor exhibited high sensitivity and selectivity with a linear range of 5–40 ng/mL and a limit of detection of 2.43 ng/mL. The recoveries of the aptasensor were 84.6–115.8% in water and soil samples with relative standard deviations below 9%, and the detection results were highly consistent with high-performance liquid chromatography. Therefore, this developed aptasensor was a reliable tool and could be applied to monitoring of SMZ in environmental samples.
研究领域:
环境科学
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分析化学
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生物传感技术
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 35
·52995-53008
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IF 5.19
Xia Xinjing,Deng Lin,Yang Lingfang,Shi Zhou
Using MXene as substrate, CoOOH@MXene with different mass content of CoOOH were prepared and used to active peroxymonosulfate (PMS) for the sulfamethoxazole (SMX) degradation. The sample characterizations demonstrated the successful preparation of CoOOH@MXene. CoOOH@MXene possessed much higher BET surface area (183.82 m 2 /g) than CoOOH (85.36 m 2 /g) and MXene (6.89 m 2 /g) due to the good dispersibility of CoOOH particles on MXene. Due to its large surface area, 1.3CoOOH@MXene displayed the best catalytic performance for the degradation of SMX. With 0.2 g/L of 1.3CoOOH@MXene and 0.5 mM of PMS, 20 μM of SMX was completely eliminated in 10 min. The degradation followed pseudo-first-order kinetic model well, with rate constants of 0.33 min −1 for 1.3CoOOH@MXene and 0.054 min −1 for CoOOH. Influencing factors of initial pH, catalyst dosage, PMS concentration, SMX concentration, and co-existing anions on SMX degradation were assessed systematically. Recycling tests verified the excellent reusability and stability of the catalyst. Quenching experiments and electron paramagnetic resonance analysis substantiated that 1 O 2 played a leading role. Moreover, the intermediates were identified, and degradation pathways and activation mechanism of CoOOH@MXene for PMS were proposed. This work may highlight the application of MXene with transition metals in PMS activation.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
Journal of Materials Chemistry A
·
2017
·Vol. 5
·期 38
·20439-20447
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IF 8.867
Lang Pei,Zhe Xu,Zhan Shi,Heng Zhu,Shicheng Yan,Zhigang Zou
Charge separation/transfer and photocorrosion are two major factors limiting the photoelectrochemical (PEC) applications of the Ta3N5 photocatalyst. Herein, we have fabricated Ta3N5 single-crystal nanorods with Mg doping by flux-assisted crystal growth, aiming to shorten the charge transport distance and increase the electrical conductivity. The optimized Mg-doped Ta3N5 photoanodes exhibit an unprecedented PEC water splitting activity with an AM 1.5G photocurrent of 1.5 mA cm−2 at 1.23 VRHE. The high performance is attributed to the fact that the bulk modification, Mg doping, can induce oxygen-impurity surface states as effective electron trap centers, thus increasing the electrical conductivity of Ta3N5 and charge separation efficiency. After a conformal surface modification with CoOOH by a simple electrodeposition method as a water oxidation electrocatalyst to improve the hole extraction and reaction kinetics, the Mg-doped Ta3N5 photoanodes afford an over 4-fold increase in photocurrent (ca. 6.5 mA cm−2 at 1.23 VRHE) and about 70% retention of the initial photocurrent after 70 min irradiation at 1.0 VRHE. Our results testify that the bulk and surface co-modification is an effective route to develop high-performance PEC water splitting devices.
研究领域:
材料科学
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能源科学
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表面化学
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DOI
高影响因子
FOOD CONTROL
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2025
·
IF 6.3
Yanping He,Peixuan Li,Xin Zhao,Dongmei Wang,Fuqiang Zhang
The abuse or misuse of fleroxacin (FLE) in aquaculture and livestock may elevate FLE residues in foods, posing a serious threat to human health. Consequently, FLE detection has garnered extensive attention in food science. This study developed a magnetic separation-assisted colorimetric aptasensor for ultrasensitive FLE detection, leveraging the enhanced nanozyme activity of CoOOH nanoflakes with hairpins and dual cascade amplification (CHA-HCR). Under optimal experimental conditions, the proposed aptasensor exhibited high specificity for FLE with a wide linear range (1–100 nM) and a detection limit as low as 758 pM. Furthermore, the colorimetric aptasensor demonstrated robust performance in FLE-spiked honey analysis, achieving 96.70–101.06 % recoveries with 2.42–5.45 % RSDs, which showed strong agreement with commercial ELISA results. This study establishes a simple and effective platform for sensitive FLE detection in honey samples, demonstrating significant potential for practical food safety monitoring.
研究领域:
食品科学
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分析化学
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纳米技术
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环境卫生
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生物传感器
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产品关联
DOI
高影响因子
Journal of Energy Chemistry
·
2024
·
IF 14
Peiyun Zhou,Haokun Pan,Guangtong Hai,Xiang Liu,Xiubing Huang,Ge Wang
In this work, nickel foam supported CeO 2 -modified CoBDC (BDC stands for terephthalic acid linker) metal-organic frameworks (NF/CoBDC@CeO 2 ) are prepared by hydrothermal and subsequent impregnation methods, which can be further transformed to NF/CoOOH@CeO 2 by reconstruction during the electrocatalytic test. The obtained NF/CoOOH@CeO 2 exhibits excellent performance in electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) because the introduction of CeO 2 can optimize the electronic structure of the heterointerface and accelerate the accumulation of *OH. It requires only a potential of 1.290 V RHE to provide a current density of 50 mA cm −2 in 1.0 M KOH + 50 mM HMF, which is 222 mV lower than that required in 1.0 M KOH (1.512 V RHE ). In addition, density-functional theory calculation results demonstrate that CeO 2 biases the electrons to the CoOOH side at the heterointerface and promotes the adsorption of *OH and *HMF on the catalyst surface, which lower the reaction energy barrier and facilitate the electrocatalytic oxidation process.
研究领域:
材料科学
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电化学
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理论计算
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）