ACS Applied Nano Materials
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2023
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IF 5.9
Weiling Song,Huan Yang,Yujie Sun,Yuanming Yang,Qi Dong,Peng He,Gengjun Liu,Zhen Zhao,Lifeng Qin,Shunxiang Gao,Jing Liu,Hong Zhou,Haiyan Wang
Multifunctional nanomaterials have become a promising nanoplatform for anticancer treatment with tumor specific activation. Here, a cancer cell-activated nanocomposite Cu/ZIF-8@MPN@DOX@F127 (CZMDF) was constructed with a metal phenolic network (MPN)-modified Cu/ZIF-8 and loaded with doxorubicin (DOX). CZMDF was degraded to release tannic acid (TA), Fe3+, Cu2+, and DOX in cancer cells. Benefiting from the reducibility of TA, Fe3+ was converted to Fe2+, which could react with endogenous H2O2 to produce a highly toxic hydroxyl radical (•OH) by the Fenton reaction. The Fenton reaction-mediated chemodynamic therapy (CDT) was promoted by the accelerated Fe3+/Fe2+ conversion, which was also enhanced with a Cu2+-based Fenton-like reaction. In addition, endogenous glutathione (GSH) could reduce Fe3+ and Cu2+ to Fe2+ and Cu+, which led to further enhancement of CDT performance. DOX acted as a traditional drug to realize chemotherapy. Furthermore, the heat from MPN after near-infrared irradiation (NIR) could be applied to realize photothermal therapy (PTT). The multifunctional nanocomposite was designed to achieve synergistic tumor treatment with CDT/chemotherapy/PTT. In vitro experiments showed that the CZMDF caused about 70% of cell apoptosis, and the tumor growth in mice was also inhibited in vivo study. This multifunctional nanomaterial enriches the nanocatalyst types for synergistic tumor therapy, providing a nanoplatform for potential clinical transitions.
研究领域:
纳米技术
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癌症研究
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材料科学
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诊疗学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jiansen Li,Chen Cao,Xinlu Zhang,Huan Li,Qin Fan,Shutong Chen,Xu Zhang,Sheng Wang
Immune checkpoint blockade therapy has made great strides in cancer treatment, but conventional immune checkpoint blockade antibodies often lead to overactivation of the immune system and severe immune-related adverse effects. Herein, we report the design of a nanomedicine (denoted as CPD@M−TDN) based on multifunctional tetrahedral DNA nanostructures (M−TDN). In this system, a bimetallic metal–organic framework (Cu/ZIF-8) is synthesized as the core; doxorubicin-loaded polydopamine acts as a shell to reduce the immunogenicity of the nanomaterials in peripheral blood. Finally, the CpG oligodeoxynucleotides and PD-L1 aptamer-based M−TDN are coupled to the core–shell structure nanomedicine through the biotin-avidin-system. Under the acidic tumor microenvironment, the decomposition of Cu/ZIF-8 and the release of copper ions and doxorubicin can lead to immunogenic death of tumor cells through chemodynamic/chemotherapy. Furthermore, the M−TDN has the dual effects of weakening the immunosuppressive microenvironment with PD-L1 aptamer and promoting dendritic cell activation with the immunostimulant CpG. Overall, the developed CPD@M−TDN can effectively enhance the response rate to immunotherapy and has excellent potential in the field of integrated tumor treatment.
研究领域:
纳米技术
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癌症治疗
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免疫治疗
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药物递送系统
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Wenting Li,Xinglu Zhou,Shikai Liu,Jialing Zhou,He Ding,Shili Gai,Rumin Li,Lei Zhong,Huijie Jiang,Piaoping Yang
Therapeutic nanosystems triggered by a specific tumor microenvironment (TME) offer excellent safety and selectivity in the treatment of cancer by in situ conversion of a less toxic substance into effective anticarcinogens. However, the inherent antioxidant systems, hypoxic environment, and insufficient hydrogen peroxide (H2O2) in tumor cells severely limit their efficacy. Herein, a new strategy has been developed by loading the chemotherapy prodrug disulfiram (DSF) and coating glucose oxidase (GOD) on the surface of Cu/ZIF-8 nanospheres and finally encapsulating manganese dioxide (MnO2) nanoshells to achieve efficient DSF-based cancer chemotherapy and dual-enhanced chemodynamic therapy (CDT). In an acidic TME, the nanocatalyst can biodegrade rapidly and accelerate the release of internal active substances. The outer layer of MnO2 depletes glutathione (GSH) to destroy the reactive oxygen defensive mechanisms and achieves continuous oxygen generation, thus enhancing the catalytic efficiency of GOD to burst H2O2. Benefiting from the chelation reaction between the released Cu2+ and DSF, a large amount of cytotoxic CuET products is generated, and the Cu+ are concurrently released, thereby achieving efficient chemotherapy and satisfactory CDT efficacy. Furthermore, the release of Mn2+ can initiate magnetic resonance imaging signals for the tracking of the nanocatalyst.
研究领域:
纳米技术
·
癌症治疗
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）