ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Chang Liu,Dingkun Lu,Xinrui You,Guoyue Shi,Jingjing Deng,Tianshu Zhou
Herein, a novel ratiometric fluorescent probe based on [email protected] /GMP ICP nanoparticles was developed for the detection of Aβ monomer in rat as a biomarker for Alzheimer’s disease (AD) by fully exploring the competitive coordination interaction and by taking advantage of excellent optical property of carbon dots sensitized lanthanide infinite coordination polymer (ICP) nanoparticles. The carbon dots (CDs) with abundant functional groups were encapsulated into Eu/GMP ICPs through self-adaptive chemistry , which could not only sensitize the red fluorescence of Eu/GMP ICPs effectively, but also act as an internal reference for self-correction. In the absence of Cu 2+ , the as-formed [email protected] /GMP ICPs exhibited the characteristic emission of CDs at 400 nm and strong emission of Eu 3+ at 592 nm, 615 nm, 650 nm and 694 nm. With the addition of Cu 2+ , the red fluorescence of Eu 3+ decreased due to the coordination interaction between CDs and Cu 2+ , thus destroyed the antenna effect. After the subsequent addition of Aβ monomer, the specific binding occurred between Cu 2+ and Aβ monomer, and then the red fluorescence of Eu 3+ restored again. During this process, the fluorescence of CDs remained unchanged, thus could be used as an internal reference to cancel out the environmental fluctuation and was more adaptive for the detection of Aβ monomer in biological fluids. The method demonstrated here was highly sensitive, free from the interference of other species in rat brain, the in vivo analysis of Aβ monomer in CSF and different brain regions from normal rats and Alzheimer’s rats could be realized, which was of great significance for better understanding the mechanism of AD and paving the way to understand the chemical essence involved in AD.
研究领域:
纳米技术
·
荧光光谱
·
生物标志物检测
·
神经退行性疾病
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产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2023
·
IF 8.4
Daiwang Shi,Siyi Li,Wenhan Liu,Liang Song,Ran Xu
Lung cancer is a serious disease and the leading cause of cancer-related death. Metal-phenolic network nanoparticles have been proposed as a promising strategy for cancer therapy. In this work, eight-arm PEG succinimidyl glutarate, copper ions and doxorubicin (DOX) were integrated into one nanoparticle via hydrophobic interactions and coordination interactions to achieve chemotherapy (CT) and chemodynamic therapy (CDT). [email protected] accumulated in tumour tissue and released DOX and Cu 2+ into the tumour microenvironment. Cu 2+ reacted with GSH to form Cu + . Cu + continued to react with H 2 O 2 to form •OH. DOX killed lung cancer cells and activated NOX4, up-regulating the endogenous H 2 O 2 level and further enhancing the efficiency of CDT. In vitro and in vivo experiments demonstrated that [email protected] has superior biological safety and can inhibit the growth of lung cancer tumours via synergistic CT/CDT. This research offers a new strategy for the construction of metal-phenolic network nanoparticles for the synergistic treatment of lung cancer by CT/CDT.
研究领域:
肿瘤学
·
纳米技术
·
癌症治疗
·
生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2020
·Vol. 24
·期 3
·583-590
·
IF 2.646
Yu Zhipeng,Kong Chuncai,Lv Jian,Ma Bo,Zhang Xiaojing,Yang Zhimao
Designing highly active material to fabricate high-performance glucose sensor was great importance for diabetes treatment. In this work, we develop a novel nanocomposite composed of multilevel nanostructure with ultrathin Cu x O nanoflakes anchored on Cu 2 O nanowires, directly on Cu foil and its application as non-enzymatic glucose sensor. Due to more active sites endowed by the ultrathin Cu x O nanoflakes, the as-prepared Cu x O nanoflakes/Cu 2 O nanowires@Cu nanoarray exhibit high sensitivity (3.59 mA mM −1 cm −2 ), low detection limit (0.69 μM), high selectivity, fast amperometric response (~ 2 s) and excellent reliability in human serum. And the sensitivity of ultrathin Cu x O nanoflakes/Cu 2 O nanowires@Cu nanoarray was 1.9-fold than that of Cu 2 O nanowires@Cu nanoarray. Such novel multilevel nanoarray synthesized by convenient method provides a facile way to design metal oxide nanomaterial for promising non-enzymatic glucose sensor.
研究领域:
材料科学
·
纳米技术
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Pengfei Han,Zhiming Li,Xin Wei,Liwen Tang,Mengting Li,Zhenyi Liang,Xueqiong Yin,Suying Wei
Ion-imprinted thermosensitive chitosan derivative (ITC) was successfully synthesized through a novel gradient heating process towards applications in heavy metal remediation, using Cu 2+ template paired with N -isopropylacrylamide (NIPAM) monomer. SEM, DSC, FTIR and Raman spectroscopy were used to characterize the structure and properties of ITC. The phase change temperature (PCT) of ITC was 35.31 °C in the heating cycle, whereas in the cooling cycle the PCT for ITC was 26.27 °C. The adsorption capacity of ITC for Cu 2+ at 45 °C (> PCT) was 88.94 mg/g. Desorption rate of 98.90 % was achieved after washing with ultra-pure water at 20 °C (< PCT). An adsorption capacity of 85 mg/g and a desorption rate of 97 % sustained after five cycles reuse. The adsorption capacity for Cu 2+ was measured at 80.23 mg/g under other seven interfering metal ions. The adsorption kinetics and adsorption isotherm fitted pseudo-second-order and Langmuir equation, respectively.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Liang Yao,Jiang Xu,Liwei Zhang,Tao Zheng,Lei Liu,Lei Zhang
To enhance the stability of anthocyanin, an amphiphilic peptide C6 with tryptophan amino acid was used to co-assemble with anthocyanin C3G. The characterization, stabilities, and antioxidant activity of peptide-anthocyanin (C6-C3G) nanocomposites (70.82 ± 12.41 nm) were investigated. To illustrate the interaction between peptide and anthocyanin, circular dichroism spectroscopy and fluorescence quenching method were used. Here, the peptide C6 switches from random coil structure to β-sheet structure and the fluorescence of tryptophan amino acid in peptide quenched during the intermolecular interaction between them, which was further confirmed a static quenching. The nanocomposites significantly enhance the stabilities of anthocyanin to different alkaline conditions, high temperature of 80 °C, long time storage, and various concentration of Cu 2+ ion. In addition, it maintained the excellent intrinsic capacity of anthocyanin to scavenge free radicals. The approach of using an amphiphilic peptide to enhance the stabilities of anthocyanin presents a high potential to expand its application.
研究领域:
化学
·
材料科学
·
食品科学
·
生物技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2023
·Vol. 46
·期 13
·2300092
·
IF 3.1
Kunlin He,Yu Cao,Qian Chen,Shuling Yang,Min Chen,Lianhai Shan
Therapeutic drug monitoring of captopril, which is a commonly used antihypertensive agent in clinical practice, is necessary. However, matrix effect-induced pretreatment is the bottleneck for determination. Metal-mediated molecularly imprinted polymers, an essential branch of molecularly imprinted polymers with better specificity and selectivity, have been used to separate/enrich analytes from complex matrices. In this work, Cu 2+ was introduced to dynamically establish the binding sites of metal-mediated molecularly imprinted polymer towards captopril. All evidence demonstrated that the metal-mediated molecularly imprinted polymer based on Cu 2+ coordination obtained a higher adsorption capacity (81.23 mg/g), faster adsorption rate (adsorption equilibrium within 50 min), and better selectivity (with the unrecognized analog). Subsequently, the Cu 2+ -mediated molecularly imprinted polymer was used as dispersive molecularly imprinted solid-phase extraction to successfully establish an analytical platform for the determination of trace captopril in rat plasma. The enrichment factor was up to 20, the detection limit was as low as 0.16 μg/ml, and the average recovery was in the range of 87.51%–98.28% with a relative standard deviation of less than 3.29%. This study provides a promising reference for the preparation of selective adsorbents to improve pretreatment.
研究领域:
药物分析
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分析化学
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Xiaoyu Su,Kaiyi Zheng,Xiaoyu Tian,Xuan Zhou,Xiaobo Zou,Xuechao Xu,Zongbao Sun,Wen Zhang
An indirect and ultrasensitive ratiometric molecularly imprinted (MIP) sensor, based on metal ion reoxidation, is introduced for glyphosate (GLY) determination in fruit. As high-performance signal amplification substrates, carbon nanotubes (MWCNTs) and gold nanoparticles (AuNPs) are conveniently modified on GCE. The artificial antibody-MIP membrane, presents typical three-dimensional structure to GLY template. Built-in reference methylene blue (MB) is directly electropolymerized on MWCNTs-Au/GCE. Particularly, Cu 2+ and GLY interestingly form chelate complex, and the Cu 2+ ( I Cu ) in Cu(Ⅱ)-GLY-complex can be reoxidized, and indirectly quantizes GLY. The reference signal ( I MB ) presents noteworthy stability with different GLY levels, and the ratiometric readout ( I Cu / I MB ) is recognized as a more trustworthy indicator to quantize GLY. Proposed sensor presents broad range as 1.73 ∼ 400 ng/mL, and limit of detection is well found as 0.24 ng/mL (S/N = 3). Finally, as-fabricated method is verified with standard HPLC in real-fruit-sample, and the errors and recovery rates are calculated as 3.4% ∼ 6.7% and 94.4% ∼ 104.6%, respectively.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2021
·
IF 4.598
Minhui Wang,Jiahui Zhou,Xiaolin Jiang,Yeming Sheng,Min Xu,Xun Lu
Self-healing materials have attracted considerable attention because of their sustainable property of prolonging service life and reducing resource consumption. However, as plenty of room-temperature self-healable materials have been studied, it still remains a great challenge to equip these materials with admirable mechanical strength since there is a compromise between intermolecular interactions and chain mobility. Herein, a novel strategy of integrating self-healing ability with robustness in polymeric elastomer at ambient condition was developed. The synthesized polyurethane was equipped with multiple reversible interactions including disulfide bonds, oxime urethane bonds, H-bonds and coordination interactions, and formed triple cross-linking network. What’s important is that Cu 2+ could not only act as the coordination center, but also serve as the catalyst to accelerate disulfide exchange and oxime urethane exchange reaction. XPS and stress relaxation tests revealed that the introduction of CuCl 2 reduced the relaxation activation energy of both the disulfide metathesis and oxime urethane exchange reaction. Thanks to the multiple interactions design and the effects of Cu 2+ , the elastomer was endowed with excellent mechanical strength of 19.5 MPa and self-healing efficiency of 83% at room temperature.
研究领域:
材料科学
·
聚合物化学
·
机械工程
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yanqiao Ren,Yusheng Guo,Bo Sun,Licheng Zhu,Wenlong Wu,Bin Liang,Xiangjun Dong,Chuansheng Zheng
Transarterial chemoembolization (TACE) requires the complete embolization of tumor vessels. However, after embolization, tumor hypoxia and angiogenesis increase, and copper ions (Cu 2+ ) play a key role in the regulation of angiogenesis. Decreasing the undesirable release of Cu 2+ into serum and tumor tissues is a major challenge in the use of TACE. In this study, we constructed an adhesive injectable thermosensitive hydrogel (poly(N-isopropylacrylamide-codopamine methacrylamide), PND) loaded with a small Cu chelator (SO-N) for use in synergistic tumor embolization; this agent is called PNDS. SO-N chelates Cu 2+ in a highly selective manner and can effectively consume the biocopper that is involved in angiogenesis. In addition, the adhesive thermosensitive hydrogel rapidly formed a gel in situ , which further inhibited the local blood ny to the tumor and accelerated ischemic necrosis. Moreover, the ability of PNDS to efficiently chelate Cu 2+ and inhibit angiogenesis was investigated in vitro . Our in vivo experiments demonstrated that PNDS can promote tumor necrosis, reduce tumor Cu 2+ levels, inhibit angiogenesis and tumor metastasis, and greatly prolong rabbit survival. This study is the first to show elevated serum Cu 2+ levels in liver cancer patients with TACE failure/refractoriness; PNDS provides a promising approach for improving the efficacy of TACE for liver cancer by regulating Cu homeostasis.
研究领域:
肿瘤学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 9
·1-9
·
IF 5.3
Liu Shendong,Chen Xinlian,Zhao Hong,Lin Tianran,Hou Li,Zhao Shulin
An ultrasensitive photothermal assay was designed for point-of-care testing (POCT) of tumor markers based on a filter membrane. Firstly, Cu 2-x Se was successfully encapsulated in liposome spheres with biotin on the surface and connected to carcinoembryonic antigen (CEA) aptamer with 3'end modified biotin by streptavidin. Secondly, the CEA antibody was successfully modified on the surface of the nitrocellulose membrane through simple incubation. Finally, the assay process was completed using a disposable syringe, and the temperature was recorded using a handheld infrared temperature detector. In the range 0–50 ng mL −1 , the temperature change of the nitrocellulose membrane has a strong linear relationship with CEA concentration, and the detection limit is 0.097 ng mL −1 . It is worth noting that the entire testing process can be easily performed in 10 min, much shorter than traditional clinical methods. In addition, this method was successfully applied to the quantitative determination of CEA levels in human serum samples with a recovery of 96.2–103.3%. This rapid assay can be performed by “one suction and one push” through a disposable syringe, which is simple to operate, and the excellent sensitivity reveals the great potential of the proposed strategy in the POCT of tumor biomarkers. Graphical Abstract
研究领域:
生物医学工程
·
分析化学
·
即时诊断
·
癌症生物标志物
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Qian Li,Xin Shen,Chenguang Liu,Dongming Xing
Dissolvable hydrogels have shown great potentials in removing the exudes and alleviating pain during wound dressing replacement. Herein, a series of carbon dots (CDs) composing high complexation ability with Cu 2+ were prepared for capturing Cu 2+ from Cu 2+ -alginate hydrogels. CDs were prepared using biocompatible lysine as the main starting material, while ethylenediamine was chosen as the other starting material for its extremely high complexation ability with Cu 2+ . The complexation ability increased with the increasing amount of ethylenediamine, while the cell viability decreased. When the mass ratio of ethylenediamine to lysine in CDs was above 1/4, six-coordinate copper centers could be formed. CD 1/4 at the concentration of 90 mg/mL could dissolve Cu 2+ -alginate hydrogels within 16 min, which was about twice faster than lysine. In vivo results showed the replaced hydrogels could ameliorate hypoxic conditions, alleviate local inflammatory reactions and promote the healing speed of burn wounds. Thus, the above results suggested the competitive complexation of CDs with Cu 2+ could effectively dissolve Cu 2+ -alginate hydrogels, which have much potential in realizing facile wound dressing replacement.
研究领域:
材料科学
·
生物医学工程
·
伤口愈合
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Qionghao Wang,Yaqi Peng,Min Chen,Mengxia Xu,Jiamin Ding,Qi Yao,Shengyong Lu
The process of urbanization has resulted in a continuous growth of the production of municipal solid waste , consequently leading to the increase of municipal solid waste incineration fly ash (MSWI FA) over time. This has prompted the need for effective disposal and value-added utilization strategies for MSWI FA. In this study, a hydrothermal method was employed to synthesize Ca Al layered double hydroxides (LDHs) using MSWI FA as the raw material. The main objective was to investigate how different synthesis parameters affect the crystallinity of the layered bimetallic hydroxides. Subsequently, the synthesized LDHs were characterized using various techniques such as BET, SEM , XRD, FT-IR, and XPS. The results revealed the presence of calcium and aluminum cations in the interlayer region of the synthesized material, with chloride ions, sulfate ions, and acetate ions being the predominant anions. Moreover, the formation of LDHs presents an effective approach for the self-purification of leachates derived from MSWI FA. The LDHs exhibited excellent adsorption capacity for Cd 2+ and Cu 2+ in wastewater, with maximum values of 730 mg·g −1 and 446 mg·g −1 , respectively. The adsorption mechanisms involved isomorphous substitution, complexation, as well as the precipitation of hydroxides or interlayer anions. This method presents a novel approach for effectively utilizing MSWI FA to produce environmentally friendly value-added adsorbents.
研究领域:
环境科学
·
废物管理
·
材料科学
·
化学工程
✓ 已验证
DOI
PubMed
高影响因子
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