Advanced Science
·
2019
·Vol. 6
·期 20
·1901461
·
IF 15.804
Xiaojuan Huang,Guoying Deng,Yong Han,Guizhu Yang,Rujia Zou,Zhiyuan Zhang,Shuyang Sun,Junqing Hu
Stimuli-responsive nanomedicines have become a recent research focus as a candidate for cancer treatment because of their effectiveness, sensibility, and minimal invasiveness. In this work, a novel nanosystem is developed based on Cu 2− x S@MnS core–shell nanoparticles (CSNPs) in which the Cu 2− x S core serves as a photosensitizer to generate hyperthermia and reactive oxygen species (ROS), and the MnS shell is used in H 2 O 2 -responsive O 2 production. Cu 2 −x S@MnS CSNPs with an independent core and shell ratio are synthesized by a controllable hot-injection method, resulting in an optimal photothermal (PT) effect with a PT conversion efficiency of up to 47.9%. An enhanced photodynamic (PD) effect also occurs in an H 2 O 2 environment. More significantly, in vivo experiments demonstrate that Cu 2 −x S@MnS CSNPs can mediate tumor shrinkage in both HeLa tumor cell line-derived xenograft (CDX) and head and neck squamous cell carcinoma (HNSCC) patient-derived xenograft (PDX) models, with the capability of being used as a T1-enhanced magnetic resonance (MR) contrast agent. These results suggest the great potential of as-prepared Cu 2 −x S@MnS CSNPs as photo/H 2 O 2 -responsive therapeutic-agents against tumors, even in a complicated and heterogeneous environment, thus promoting the clinical translation of nanomedicine.
研究领域:
生物医学工程
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纳米医学
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2014
·Vol. 16
·期 37
·8684-8690
·
IF 3.858
Haihang Ye,Aiwei Tang,Chunhe Yang,Kai Li,Yanbing Hou,Feng Teng
High-quality rhombohedral digenite (Cu1.8S) nanocrystals (NCs) were synthesized using a facile one-pot approach, in which foreign metal ions (Zn2+ and Cd2+) were added to drive a transformation in the phase and morphology of the as-obtained Cu2−xS NCs. During this process, the as-obtained products could transform from monoclinic djurleite (Cu1.94S) NCs to rhombohedral Cu1.8S NCs in the presence of Zn2+ and Cd2+ ions by extending the reaction time and increasing the reaction temperature, which could provide sufficient energy to overcome activation energy barriers. Moreover, we further studied the evolution of the plasmonic properties of the as-obtained Cu2−xS NCs, and the near-infrared (NIR) localized surface plasmon resonance (LSPR) absorption wavelength could be tuned by varying the amount of Zn2+ and Cd2+ ions added into the reaction system, which was in close association with the change in copper deficiencies and free hole densities induced by foreign metal ions.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Le Luo,Zhenghua Wang
Cu 2−x S nanochains network (NCNW) with tunable diameter in the range of 5–9 nm is prepared by a self-assembly strategy. Control experiments reveal that poly (sodium 4-styrenesulfonate) plays a key role in guiding the assembly of the nanochains. The Cu 2−x S NCNW demonstrates a broad localized surface plasmon resonance (LSPR) band in the near-infrared-Ⅱ region, which matches the optical window of biological tissues. The LSPR band of the Cu 2−x S NCNW red-shifts and intensifies with the increase of diameter. The Cu 2−x S NCNW with an average diameter of 8.7 nm exhibits a high photothermal conversion efficiency of 80.7% under 808 nm laser (0.75 W cm −2 ). Furthermore, the thermal effect stability of the Cu 2−x S NCNW is also good. In vitro experiments demonstrate that all the nanochains possess low cell cytotoxicity. The 8.7 nm Cu 2−x S NCNW own the maximum cellular uptake, and can cause> 90% apoptosis rate of Hela cells under low power density laser (808 nm, 0.75 W cm −2 ), demonstrating its promising application in photothermal therapy.
研究领域:
纳米技术
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材料科学
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生物医学工程
·
光学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2025
·
IF 4.1
Yu Rao,Penghua Liang,Chenxiao Guo,Xize Chen,Minglei Cao,Chuankun Zhang,Rui Tong,Kongjun Zhu
Metal sulfide is a promising anode material for lithium-ion batteries due to their unique layered structure and high theoretical specific capacity. However, the challenge lies in enhancing electronic conductivity and cycling stability. An effective method to enhance the rate capability and cycle performance of metal sulfide materials is to construct the hybrid structure. In this paper, the interfacial engineering of multiple sulfides is explored to develop ideal lithium-ion storage anode materials. Hence, the one-step mixed hydrothermal method was used to synthesize the Cu 2-x S/ZnS hybrid structure. The synthesized Cu 2-x S/ZnS hybrid structure exhibits better lithium storage performance and higher electronic conductivity compared with the single Cu 2-x S, which has resulted from the existence of the phase interface generating the built-in electric field and boosting Li + storage properties at the phase interfaces. In comparison with the single Cu 2-x S, the results display that the Cu 2-x S/ZnS hybrid structure shows enhanced rate capability and prominent long-term cycling performance (416.9 mAh g −1 at 1 A g −1 after 1300 cycles). This strategy demonstrates that the construction of hybrid structure can improve the electronic conductivity and structure stability for other advanced anode materials.
研究领域:
材料科学
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电化学
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纳米技术
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储能
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 8
·期 6
·1202-1211
·
IF 5.047
Kecan Lin,Yanbing Cao,Dongye Zheng,Qin Li,Hui Liu,Peiwen Yu,Jiong Li,Yanan Xue,Ming Wu
The development of nanotheranostic agents integrating diagnosis and therapy has gained tremendous attention in the past few decades, but many of them are inherently hydrophobic and need complicated phase-transfer and tedious surface modifications. This work proposed a facile method of transferring hydrophobic Fe3O4@Cu2−xS nanoparticles from oil to water by using red blood cell membrane to create theranostic nanobeads for T2-weighted MRI and second near-infrared photothermal ablation. The obtained nanoplatform, namely SCS@RBCM, showed a core–shell structure with the inner core densely packed with Fe3O4@Cu2−xS nanoclusters and the surface coated with a layer of RBCM. SCS@RBCM displayed a stable nanostructure, high NIR II light absorption and photothermal conversion ability, T2-weighted MR imaging and magnetic field targeting ability. Meanwhile, the RBCM cloaking endowed SCS with reduced elimination by macrophages. With the navigation of an external magnetic field (MF), the tumor accumulation of SCS@RBCM was dramatically increased, thus achieving good performance of MR imaging and antitumor efficacy through the PTT effect under NIR II irradiation. Therefore, our strategy presents a new and desirable paradigm in the phase-transfer of hydrophobic nanotheranostics for optimizing their biomedical performance.
研究领域:
生物医学工程
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材料科学
·
纳米技术
·
癌症治疗
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医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2019
·Vol. 22
·期 4
·678-685
·
IF 3.382
Xiao Shao,Tianyong Zhang,Bin Li,Yue Wu,Xiaoyuan Ma,Jingchao Wang,Shuang Jiang
Copper sulfide (Cu2−xS) is a kind of cation deficient transition metal sulfide, which has attracted great interest due to its unique properties that arise from degenerate vacancy-doping, particularly its tunable localized surface plasmon resonance (LSPR) properties. In this work, a range of vacancy-doped Cu2−xS nanocrystals (NCs) (Cu1.2S, Cu1.4S, Cu1.75S, and Cu1.94S NCs) with a size of around 10 nm was prepared with tunable LSPR through a hot injection method. The doping level was manipulated effectively by varying the injection volume of sulfur powder–oleic acid (S–OA) to finely tune the LSPR wavelength. Cu2−xS NCs with four different doping levels were investigated as photocatalysts for degradation of dyes. The Cu1.94S NCs with the highest LSPR energy exhibited the best photocatalytic activity due to the highest free carrier density, presumably influenced by Cu vacancies and the volume of the S–OA solution. Theoretical calculations of the free carrier density of Cu2−xS NCs are consistent with the order of the photocatalytic activity. The results demonstrate that the correlation of the photocatalytic activity with the corresponding concentration of free holes and the LSPR wavelength is of interest, which will provide inspiration for the design of non-noble metal catalysts by regulating the free hole concentration in degenerate p-doped Cu2−xS caused by cation vacancies.
研究领域:
材料科学
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纳米技术
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化学
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2026
·Vol. 16
·期 10
·636
·
IF 4.8
Hui Zhu,Mengzhe Zhao,Yang Chao,Jun Yao,Qin Yu,Na Sun
Non-stoichiometric copper sulfide (Cu2-xS) nanomaterials are promising antibacterial agents, but the role of morphology in regulating their bactericidal performance remains poorly understood. Herein, we rationally design two types of Cu2-xS nanostructures, namely nanoplates (NPs) and superparticles (SPs). Both materials were prepared via a ligand-directed synthesis method with the comparable sizes, surface ligands, and crystal phase. The antibacterial behaviors of Cu2-xS NPs and Cu2-xS SPs againstEscherichia coli(E. coli) andStaphylococcus aureus(S. aureus) were investigated under dark and 808 nm near-infrared (NIR) light irradiation. The results showed that under NIR light irradiation, Cu2-xS SPs exhibit a markedly higher bactericidal efficiency against bothE. coliandS. aureusthan Cu2-xS NPs, leading to almost complete eradication of bacterial colonies. Notably,S. aureusshows more sensitive thanE. coli, and significant growth inhibition is observed even in the absence of laser irradiation. Mechanistic investigations reveal that hierarchical assembly of primary nanoparticles in SPs can promote multiple internal light scatterings, thereby significantly enhancing light harvesting efficiency and further improving the photothermal conversion efficiency. In addition, the SPs exhibited higher peroxidase-like activity, resulting in enhanced reactive oxygen species (ROS) generation and aggravated oxidative damage, and the accelerated Cu2+release kinetics strengthens ionic toxicity.
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Meiling Yang,Xiaofang Liu,Bin Zhang,Yao Chen,Hengyang Wang,Jian Yu,Guoyu Wang,Jingtao Xu,Xiaoyuan Zhou,Guang Han
Cu2S, consisting of Earth-abundant and eco-friendly elements, is a promising candidate for thermoelectric energy conversion. The stoichiometric Cu2S has intrinsically low thermal conductivity together with meagre electrical conductivity. Herein, in order to improve the electrical properties, we develop a facile solvothermal method for synthesizing a series of Cu2–xS with tunable phase compositions. With reduction in the CuCl/Na2S molar ratio in the solution precursors from 2:1 to 1.75:1, the solvothermal products transform from single-phase Cu2S into Cu2S–Cu1.96S composites, which are preserved in the hot-pressed pellets. The decreased CuCl/Na2S molar ratio results in increased room-temperature Hall carrier concentration, leading to enhanced electrical conductivity. Specifically, the pellet corresponding to the 1.75:1 CuCl/Na2S precursor ratio obtains a power factor of 8.04 μW cm–1 K–2 at 815 K, which is ∼735% of the value obtained by stoichiometric Cu2S. Along with the moderate thermal conductivity, this sample achieves an enhanced zT value of 0.87 at 815 K, representing a ∼250% increase when compared to stoichiometric Cu2S. This study demonstrates an effective strategy in enhancing the thermoelectric performance of solution-synthesized Cu2S-based materials by phase tuning.
研究领域:
材料科学
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能源材料
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纳米技术
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Yongli Cao,Song Li,Xiaodi Yu,Wenhua Li,Zhishan Bo
Hybrid nanocrystals (NCs) with multiple components and junctions have attracted considerable attention due to their promising synergistic properties. In particular, great attention has been paid to the manipulation of buried multijunction heterointerfaces because they are closely related to the surface energy and carrier transfer of NCs. However, heterointerfaced NCs are usually constructed by sequential step-by-step pathways, and buried interfaces can only be formed along a given direction, resulting in the one and only spatial orientation of multiple interfaces. In this work, we demonstrate two types of Au-Ag 2 S-Cu 2-x S NCs with disparate interfacial features. Specifically, the first type (Type I) is prepared through a routine two-step method and shows that Au domain close to the Ag 2 S-Cu 2-x S interface; another type (Type II) is achieved by a facile one-pot synthesis procedure and contains Au domain with an interphase only with the Ag 2 S domain, far from the Cu 2-x S domain. More importantly, type II NCs could not be formed through other traditional strategies and an underlying mechanism of formation is developed by monitoring the evolution process. Au@Ag core–shell NCs, metastable Au@Ag 2 S NCs and Janus Au-Ag 2 S NCs are formed successively before the Cu 2-x S domain appears. We speculate that the Au@Ag 2 S intermediate plays an essential role in building the final complex nanostructure . We expect that such a simple and facile one-pot method will be used to fabricate additional asymmetric multicomponent NCs with distinctive interfacial features and promising potential applications.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2026
·
IF 9.2
Sen Yang,Yuhang Wang,Fenghuan Zhao,Xiaobin Xie,Yue Liu,Hongyu Zhao,Ziwei Liu,Chun-Chao Hou,Junjie Qin,Bohua Dong,Lixin Cao,Chenghui Xia
The atomic coherence of heterojunction interfaces critically governs charge transport but remains difficult to control in cation-mobile copper chalcogenides. Here, we identify the crystal phase of Cu2-xS seeds as a decisive and previously underappreciated parameter that governs interfacial coherence and strain in Janus Cu2-xS/CdS heteronanorods. By selectively employing hexagonal (covellite) and cubic (digenite) Cu2-xS seeds, heteronanorods with distinctly different interfacial structures are obtained. Atomic-resolution transmission electron microscopy combined with geometric phase analysis quantitatively reveals that the digenite seed forms a highly coherent interface with CdS, featuring a reduced lattice mismatch (~5.1% versus ~7.4%) and a markedly localized strain field with a halved maximum lattice strain (~4% versus ~8%). First-principles calculations further show that this coherent interface possesses a more negative formation energy and enhanced electronic coupling, giving rise to a stronger built-in electric field across the heterojunction. As a consequence of the improved interfacial coherence, the digenite-seeded heteronanorods exhibit more efficient charge separation and reduced interfacial resistance, which is reflected in their superior visible-light-driven photocatalytic hydrogen evolution performance. This work establishes seed crystal phase as a fundamental design parameter for regulating interfacial nanostructure and strain in heterostructures, providing a general physical guideline for minimizing interfacial losses in heteronanojunctions.
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Ning Li,Wenwen Zhao,Linping Li,Yangqin Gao,Lei Ge
Photocatalysts with hollow structures have drawn great interest owing to their high specific surface area, which can enhance the photocatalytic performance. Herein, we designed the hollow cubic Cu2–xS@Ni–Mo–S nanocomposites by vulcanizing from the Cu2O template and loading the Ni–Mo–S lamellas. The Cu2–xS@Ni–Mo–S composites greatly improved the photocatalytic hydrogen performance. Among them, Cu2–xS–NiMo-5 achieved the optimal photocatalytic rate of 1326.07 μmol/g h, which is approximately 3.85 times higher than that of hollow Cu2–xS (344 μmol/g h) and had good stability for 16 h. The enhanced photocatalytic property was attributed to the metallic behavior of bimetallic Ni–Mo–S lamellas and the LSPR (localized surface plasmon resonance) effect of Cu2–xS. The bimetallic Ni–Mo–S can effectively capture the photogenerated electrons and quickly transfer-diffuse to produce H2. Meanwhile, the hollow Cu2–xS not only provided many more active sites to take part in the reaction but also introduced the LSPR effect to increase the solar utilization. This work provides valuable insights into the synergistic effect of using non-precious metal co-catalysts and the LSPR materials to assist in the photocatalytic hydrogen evolution.
研究领域:
材料化学
·
光催化
·
能源科学
·
纳米材料
·
半导体物理
·
可再生能源
·
表面科学
✓ 已验证
DOI
高影响因子
Catalysts
·
2022
·Vol. 12
·期 2
·147
·
IF 4.501
Li Cheng,Yu-Ting Zhong,Qu-Quan Wang,Li Zhou
Herein, we report an approach to prepare Cu/Cu2−xS core/shell nanorods by in situ sulfidation of copper nanorods. Firstly, copper nanorods with tunable longitudinal surface plasmon resonances were synthesized by a seed-mediated method using Au nanoparticles as seeds. A convenient in situ sulfidation method was then applied to convert the outermost layer of Cu nanorods into Cu2−xS, to increase their stability and surface activity in photocatalytic applications. The thickness of Cu2−xS layer can be adjusted by controlling the amount of S source. The Cu/Cu2−xS core/shell nanorods exhibits two characteristic surface plasmon resonances located in visible and near-infrared regions, respectively. The photocatalytic performances of Cu nanorods and their derivatives were evaluated by measuring the degradation rate of methyl orange dyes. Compared with Cu nanorods, the Cu/Cu2−xS core/shell nanorods demonstrate more than a 13.6-fold enhancement in the degradation rate at 40 min. This work suggests a new direction for constructing derivative nanostructures of copper nanorods and exploring their applications.Keywords:Cu nanorods;sulfidation;degradation
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）