MICROCHIMICA ACTA
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2025
·Vol. 192
·期 3
·1-13
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IF 5.3
Xu Yuying,Chen Lijuan,Guo Xiaohui,Zhang Jian,Guo Xiaobing,He Ziqian,Zhang Jiani,Han Dongxue
A label-free photoelectrochemical (PEC) biosensing strategy was constructed based on a Cu 2 MoS 4 @Ti 3 C 2 T x MXene heterojunction for the sensitive detection of tetracycline (TC) in milk. The Cu 2 MoS 4 @Ti 3 C 2 T x MXene heterojunction substantially facilitates the separation of photogenerated electron–hole pairs, a key element in enhancing the photocurrent response. Cu 2 MoS 4 , renowned for its visible-light absorption and photocatalytic properties, is combined synergistically with Ti 3 C 2 T x MXene, contributing a large surface area and outstanding electrical conductivity. The heterojunction not only elevates photocatalytic efficiency but also provides abundant π–π stacking sites on the surface of Ti 3 C 2 T x MXene. These sites enable the direct immobilization of the TC aptamer without chemical modification, thereby minimizing marker interference and improving the detection accuracy. Furthermore, the heterojunction structure broadens the light-absorption spectrum and enhances charge-transfer efficiency, resulting in a higher photocurrent response. The proposed PEC aptasensor demonstrates a favorable linear response to TC within the concentration range 5 to 300 nM, with a detection limit of 1.24 nM. These results are comparable to those achieved by high-performance liquid chromatography. This study is expected to pioneer a novel approach for the design of a label-free PEC aptasensor applicable to the bioanalysis of food samples. Graphical abstract
研究领域:
食品科学
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分析化学
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生物传感技术
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2025
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IF 2.5
Dongling Meng,Zhiyan Chen,Zhibin Chen,Junrao Cen,Jitao Li,Yaling Yang
Herein, a two-dimensional ternary chalcogenide nanozyme (Cu2MoS4) was synthesized via a hydrothermal method. Generally, Cu2MoS4 exhibits peroxidase (POD)-like activity under acidic conditions. Interestingly, in this work, proline (Pro) improved the POD-like activity of Cu2MoS4, attributing to increasing its substrate affinity and thereby generating more ˙OH radicals. In the presence of H2O2, Cu2MoS4-Pro effectively catalyzed the conversion of colorless 2,2′-azino-bis-3-ethylbenzothiazoline-6 sulfonic acid (ABTS) to green oxidized-ABTS (oxABTS). Accordingly, a sensitive method for the colorimetric detection of Pro using Cu2MoS4 was established, with Pro solutions in a linear concentration range of 3–780 μg L−1. The developed colorimetric probe demonstrated excellent performance in real tobacco sample analysis, showing satisfactory recovery rates ranging from 87.50% to 113.94% while maintaining a low detection limit of 1.37 μg L−1 (calculated as 3.3σ/k). Thus, this nanozymatic colorimetry-based method provides a visual strategy for the detection of Pro in tobacco.
研究领域:
纳米酶
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生物传感器
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分析化学
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纳米技术
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生物化学
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DOI
高影响因子
TALANTA
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2024
·
IF 5.6
Jing Li,Shenglan Hu,Lingling Zheng,Lixin Xu,Yusheng Wu,Biyang Deng
In this study, we used meso-tetra (4-carboxyphenyl) porphyrin (TCPP) as an organic ligand to modify a lanthanide-based metal-organic framework as an electrochemiluminescence (ECL) platform to sensitively detect anti-Müllerian hormone (AMH). La-MOF amplified the ECL signal by suppressing the aggregation-caused quenching created by TCPP self-aggregation. Utilizing the reversible cycling of the mixed-valence transition metal ion (Cu + /Cu 2+ and Mo 4+ /Mo 6+ ) and the electrical conductivity of Cu 2 MoS 4 and silver nanoparticle (AgNP), Cu 2 MoS 4 –AgNP as a dual co-reaction promoter constantly generated sulfate radical anions (SO 4 •– ) and thus amplified the ECL signal. Based on this strategy, we built a sandwich-type ECL immunosensor for the sensitive detection of AMH with a linear range of 1 × 10 −4 to 50 ng/mL and a limit of detection of 24 fg/mL. This study provides a novel approach for the sensitive and selective detection of AMH, demonstrating its high potential and practical value for the sensitive detection of AMH.
研究领域:
生物医学工程
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分析化学
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免疫学
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Jiahui Yu,Ping Su,Dong Zhang,Huaihao Zhao,Nan Yang,Tengteng Liang,Dafeng Zhang,Xipeng Pu
Rationally designing a Step-scheme (S-scheme) hetero-structured photocatalyst with high redox capability and separation efficiency of photoinduced carriers is considered as an attractive approach to address the shortcomings of single component and traditional hetero-structured photocatalyst. Herein, enlightened by the predictions of density functional theory (DFT), a unique S-scheme heterojunction photocatalyst was successfully fabricated by incorporating zero-dimensional (0D) Cd 0.5 Zn 0.5 S (CZS) on two-dimensional (2D) lamellar Cu 2 MoS 4 (CMS) plates via a facile coprecipitation method, which substantially enhances the photocatalytic activity for hydrogen (H 2 ) generation. CZS nanoparticles deposited on the surface of CMS nanoplates play a crucial role in creating highly intimate heterojunction interfaces and abundant exposed reaction sites, laying the foundation for improved photocatalytic performance. Furthermore, the significant difference in Fermi levels and band structures between CZS and CMS result in the formation of the internal electric field (IEF) and energy band bending at the interface of the heterojunction. This S-scheme charge transfer path enables 0D/2D CZS/CMS heterojunction possesses an exceptional capacity to maintain the robust redox potential and boosts the separation efficiency of light-induced carriers, as verified by DFT calculations and energy band structure analyses. As expected, the optimal heterojunction exhibits a satisfactory H 2 generation rate of 13.1 mmol·g -1 ·h −1 , which is nearly 7.7-fold higher than that of individual CZS. This study is expected to inspire the design of morphology-controlled hetero-structured photocatalyst with S-scheme charge transfer route for photocatalytic H 2 generation.
研究领域:
材料科学
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光催化
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纳米技术
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能源材料
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DOI
高影响因子
Advanced Healthcare Materials
·
2024
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IF 10
Haonan Xiu,Kaili Yang,Li Dong,Haohua Lai,Zhangyu Zhu,Dongdong Jiang,Junwei Yan,Chen Shi,Shaowei Pan,Zhaowei Yin,Lihui Yuwen,Bin Liang
Managing fracture infections is a significant challenge in trauma orthopedics, given the limited self-healing capacity of fractures and the difficulty in eradicating infections. In this study, Cu 2 MoS 4 nanoparticles (CMSs) with are prepared enzyme-like activity and both pH and near-infrared (NIR) light responsiveness. These CMSs are combined with methacrylated gelatin (GelMA) to synthesize CMSs hydrogels (CMSs@Gel) with antimicrobial and bone tissue repair-promoting capabilities. In vitro and in vivo experiments, the CMSs@Gel demonstrated good biocompatibility; peroxidase-like (POD), oxidase-like (OXD), and catalase-like (CAT) activities; excellent photothermal conversion efficiency; and immunomodulatory capacity. Furthermore, the CMSs@Gel exhibited slow degradation, enabling it to exert different pH-responsive enzyme activities and modulate the production of reactive oxygen species (ROS) and the polarization of macrophages throughout the treatment process. Notably, these effects are significantly enhanced under near-infrared (NIR) light. Additionally, under NIR irradiation, the CMSs@Gel maintained the fracture environment at a mild temperature (40–42 °C), promoting osteogenesis and angiogenesis. In summary, the CMSs@Gel enhances bactericidal activity during fracture infection and effectively promotes fracture healing after infection control, providing long-term therapeutic effects. This study offers a robust theoretical basis for the staged and long-term treatment of fracture infections in the future.
研究领域:
生物医学工程
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材料科学
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骨科
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组织工程
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光热治疗
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抗菌技术
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骨再生
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产品关联
DOI
PubMed
高影响因子
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