PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
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2022
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IF 7.926
Hailin Yu,Huili Zhang,Xin Wei,Yong Chen,Bo Yu,Yingjun Wang,Hongsheng Liu
Efficient purification of oily sewage, recycling, and standard discharge have become key issues for the sustainable development of oil fields. In this study, the surface of PPFS was organically modified by a silane coupling agent . Then, covalently bonded cationic block inorganic-organic composite coagulant was prepared by chosen sodium polyacrylate as the template. This unique structure significantly enhances the positive charge and molecular chain length of the coagulant, thus improving its ability to perform charge neutralisation, adsorption bridging, and sweep coagulation. The characteristic functional groups and thermophysical properties of the composite coagulant were analysed by FTIR and thermogravimetric analysis . The transformation of random copolymers to block copolymers was determined by 1 H NMR, thus confirming the successful synthesis of the cationic block structures. The turbidity removal and oil removal properties of oily sewage were investigated by coagulation experiment. The Zeta potential , dynamic and static light scattering, and field emission scanning electron microscopy (SEM) were used to study the effect of composite coagulants on the microscopic morphology and coagulation of flocs. Finally, the coagulation mechanism of the compound coagulant was analyzed with the dynamic change of the particle size of the flocs. The cationic block structure in TP(AM-DAC-PPFS) can effectively neutralise the negative charges on the surface of impurity particles and emulsified oil. The optimal dosage of TP(AM-DAC-PPFS) was 30 mg·L −1 , at which the turbidity and oil removal rates can reach 98.3% and 93.8%, respectively.
研究领域:
环境工程
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水处理
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高分子科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Jifan Zhang,Yuxi Li,Yuqing Dai,Tao Lin,Haojian Shao,Yi Liu,Xunyong Liu
The efficient reuse of agricultural wastes such as apple pomace has always been a research focus because it increases the economic added value of apple pomace and reduces environmental pollution . Using cellulose, the main component of apple pomace, is an important way to reuse apple pomace resources. Cellulose is widely used as a good adsorption material to remove dyes from water. However, the effective adsorption sites of cellulose are few, and the binding force between adsorption functional groups and dyes is weak, resulting in the unsatisfactory adsorption performance of cellulose. To solve these problems, first, cellulose from apple pomace was oxidized to easily modified dialdehyde cellulose (DAC), and a series of factors was optimized to obtain DAC with high aldehyde content. Second, an HPEI-DAC hydrogel with a three-dimensional porous structure characterized by FTIR, XPS and SEM was prepared by crosslinking hyperbranched polyethyleneimine (HPEI) containing many amine groups with DAC. Because of its special topological structure and increasingly stronger adsorption sites, the HPEI-DAC hydrogel exhibited good adsorption performance for methyl orange (MO). The effects of the DAC/HPEI ratio, synthesis temperature, pH value and HPEI-DAC dosage on the adsorption property of HPEI-DAC for MO were studied. The HPEI-DAC hydrogel exhibited an adsorption capacity as high as 416.72 mg/g for MO. For the MO adsorption process , the adsorption kinetics and equilibrium data were consistent with the pseudo-second-order and Langmuir isotherm models, respectively. Moreover, the HPEI-DAC hydrogel could be easily regenerated and showed good reusability. After six cycles of adsorption/desorption, the adsorption capacity of the HPEI-DAC hydrogel remained at the initial value of 70 %. Therefore, the HPEI-DAC hydrogel can be considered a good adsorption material for treating azo dye wastewater.
研究领域:
环境科学
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材料科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
Theranostics
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2020
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IF 8.579
Lu Chen,Zeyang Wang,Qingwen Xu,Yuxi Liu,Le Chen,Suhang Guo,Hua Wang,Kui Zeng,Junqing Liu,Su Zeng,Lushan Yu
Background: Human organic cation transporter 2 (OCT2) is the most abundant and important uptake transporter involved in the renal excretion of cationic drugs. Abnormal hypermethylation- mediated silencing of OCT2 results in oxaliplatin resistance in renal cell carcinoma (RCC). The epigenetic activation of OCT2 by decitabine (DAC) reversed this resistance in normoxic conditions. Given the hypoxic characteristic of RCC, it is still unclear whether hypoxia promotes DAC resistance and is involved in the regulation of OCT2. Methods: The mRNA and protein expression of OCT2 was determined by qRT-PCR and Western blotting. MSRE-qPCR and BSP were used to examine methylation modifications at the OCT2 promoter. The ChIP-qPCR analysis was performed to detect the abundance of histone modification and HIF-1α. The accumulation of DAC and 5-mC were detected using LC-MS, and the amount of 5-hmC was determined by dot blot analysis. To understand the role of hypoxia in the regulation of equilibrative nucleoside transporter 1 (ENT1) expression, the HIF-1α KO cell model was constructed. The re-emulsion method was used for the construction of H-NPs, an oxygen nanocarrier based on hemoglobin, to alleviate the drug resistance of DAC under hypoxia. Results: DAC was unable to upregulate OCT2 expression in hypoxic conditions because of the hypermethylation and low H3K4me3 modification in its promoter region. Hypoxia-mediated repression of human ENT1, which was markedly suppressed in RCC, resulted in a decrease in the cellular accumulation of DAC. Besides, hypoxia-induced upregulation of histone deacetylase HDAC9, which impaired the enrichment of H3K27ac modification in the OCT2 promoter, led to the transcriptional repression of OCT2. H-NPs could attenuate the hypoxia-induced loss of DAC activity and sensitize RCC cells to the sequential combination therapy of DAC and oxaliplatin. Conclusions: Hypoxia-mediated repression of ENT1 led to the inability of DAC to upregulate the expression of OCT2 under hypoxia. H-NPs could alleviate resistance to oxaliplatin and DAC in RCC cells under hypoxia and may have potential clinical applications.
研究领域:
肿瘤学
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分子生物学
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药理学
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纳米技术
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表观遗传学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Boqi Li,Yufeng Gao,Xiaohu Luo,Chuanzhi Hu,Mingyu Deng,Jinghua Chen,Gao Min
Natural extracellular matrices (ECM) provide a more accurate simulation of the cellular growth environment, making them excellent substrate materials for in vitro cell culture. The porcine small intestinal submucosa (SIS) is one of the most widely used natural ECM that display superior bioactivity. However, decellularization operations often result in fiber breakage and failure to recover mechanical strength in the SIS. In the current study, 2,3-dialdehyde cellulose (DAC) was synthesized and cross-linked with SIS gel to form hydrogels. The introduction of DAC into the SIS matrix resulted in a tunable increase in stiffness, which was instrumental in promoting stem cell adhesion and spreading, crucial factors for osteogenic differentiation. The cytotoxicity assessment confirmed the biocompatibility of the SIS-DAC hydrogels indicating their suitability for prolonged cell culture. Moreover, the degradation rate of the hydrogel could be effectively controlled by adjusting the DAC content, addressing the rapid degradation issue associated with SIS gels. This work confirmed the feasibility of using cellulose derivatives to modulate the mechanical properties of matrix gels and influence cell differentiation which offers a valuable experimental foundation for the development of advanced matrix gels tailored for cell culture and regenerative medicine applications.
研究领域:
生物材料
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组织工程
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干细胞研究
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再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Niu Liu,Dongfang Guo,Shiwang Gao,Hanming Liu,Hongwei Niu,Lianbo Liu,Shiqing Wang,Qi Wang,Huanjun Wang,Wei Xu,Hongjun Zhang
To elucidate the direct air capture (DAC) performance and CO 2 selective sieving mechanisms of distinct porous materials under trace CO 2 conditions, three types of materials, anion-pillared materials, open site MOFs, and amine-modified materials, were synthesized, with their DAC performance systematically characterized. DFT-D3 calculations revealed that in NbOFFiVE-1-Ni, the C···F distances (3.04 Å) between CO 2 and the pillared NbOF₅ 2− anions, as well as the O···H distances (2.89 Å) between CO 2 and pyrazine linker hydrogens, are shorter than those in SIFSIX-3-Ni and GEFSIX-3-Ni. These synergistic C···F van der Waals (vdW) and O···H hydrogen-bonding interactions afford NbOFFiVE-1-Ni the highest CO 2 binding energy (62.74 kJ/mol), exceeding that of SIFSIX-3-Ni (57.79 kJ/mol), GEFSIX-3-Ni (60.47 kJ/mol), and MIL-101(Cr) (22.86 kJ/mol). Consistently, NbOFFiVE-1-Ni exhibits the highest atmospheric CO 2 uptake (1.15 mmol/g) among these materials. Given the low atmospheric CO 2 uptake of pristine MIL-101(Cr), two amines (PEI and TEPA) were used to modify it, leveraging its abundant unsaturated metal sites to enhance CO 2 adsorption capacity. DAC performance of amine-modified MIL-101(Cr) first increased then decreased with amine loading, with optimal values of 2.07 mmol/g (50 wt% TEPA) and 1.52 mmol/g (70 wt% PEI). DFT-D3 calculations demonstrated that TEPA molecules and PEI chains bind directly to the unsaturated metal sites of MIL-101(Cr), forming tadpole-like amine-modified MOF structures with binding energies of 210.01 kJ/mol and 178.30 kJ/mol, respectively. Positron annihilation lifetime spectroscopy (PALS) confirmed that TEPA incorporation generates new cavities, microporous structures, and abundant active amine sites in MIL-101(Cr) crystals, synergistically enhancing its DAC performance.
研究领域:
材料科学
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环境化学
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物理化学
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多孔材料
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碳捕集
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2023
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IF 6.6
Weichu Zhu,Jian Xu,Xianxian Yao,Shuting Mai,Dan Shu,Wuli Yang
Pyroptosis is a proinflammatory form of cell death mediated by members of the gasdermin family, and is a powerful tool against cancer. Herein, a pH-responsive doxorubicin (DOX)-encapsulating zeolitic imidazolate framework-8 (ZIF-8) nanoparticle coated with a carboxybetaine-based zwitterionic polymer (DOX@ZIF-8@PCBMA) was prepared. Furthermore, decitabine (DAC) was loaded to obtain a pyroptosis nanotuner (DOX@ZIF-8@PCBMA-DAC). This nanotuner displayed extended blood circulation and enhanced tumor accumulation. In addition, the ZIF-8 structure and disulfide-crosslinked PCBMA coating endowed DOX@ZIF-8@PCBMA-DAC with acidic-pH- and glutathione-responsive degradation. The nanotuner could robustly activate caspase-3 to induce gasdermin E (GSDME)-dependent pyroptosis via the sustained release of DAC and DOX, contributing to excellent tumor suppression with negligible side effects, which may provide novel insights into traditional chemotherapy.
研究领域:
纳米技术
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药学
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癌症治疗
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2022
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IF 10.383
Jiulong Zhang,Xiaoyan Sun,Xiufeng Zhao,Lin Liu,Xin Cheng,Chunrong Yang,Haiyang Hu,Mingxi Qiao,Dawei Chen,Xiuli Zhao
The tumor immunosuppressive microenvironment (TIM) greatly hindered the efficacy of cancer immunotherapy. Overexpressed indoleamine 2,3-dioxygenase-1 (IDO1) in tumor tissues plays a vital role in TIM generation, and downregulation of IDO1 expression may reverse TIM. Inspired by the Watson–Crick base-pairing rule, a versatile noncationic miRNA vector (miDAC@PDA) is developed for cancer immunotherapy. Doxorubicin (DOX), adenosine triphosphate (ATP), and copper ions (Cu2+) are coassembled into coordination polymer nanoparticles (DAC) and bind miRNA via the hydrogen bond interaction (miDAC) between adenine residues (ATP) and uracil residues (miRNA). Polydopamine (PDA) is deposited onto the surface of miDAC for photothermal therapy. miDAC@PDA can efficiently accumulate into tumor tissues for cellular uptake. Under laser irradiation and high intracellular GSH levels, the PDA shell of miDAC@PDA can dissociate from miDAC for miRNA release due to local hyperthermia. Cu2+-mediated GSH consumption and intracellular ATP release can amplify the DOX-based immunogenic cell death (ICD) cascade, together with miR-448-mediated IDO1 inhibition, and these versatile nanoplexes will not only restrain primary tumor growth but also display a remarkable abscopal effect on distant tumors. Collectively, our study provides a unique strategy for intracellular gene delivery and an inspirational approach for multimechanism cancer management.
研究领域:
癌症研究
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纳米技术
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治疗学
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生物医学工程
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）