SCIENCE OF THE TOTAL ENVIRONMENT
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2019
·
IF 5.589
Ting-Kai Zhu,Pei-Pei Du,Li-Juan Zeng,Huixiong Lü,Hai-Ming Zhao,Yan-Wen Li,Ce-Hui Mo,Quan-Ying Cai
Crops can take up and accumulate di- n -butyl phthalate (DBP), an extensively used plasticizer with endocrine disrupting effect, which poses potential risk to human health. Our previous study found the genotype variation in accumulation of DBP by different cultivars of rice ( Oryza sativa L.). Nevertheless, the effect of DBP metabolism in vivo on the accumulation variation among different plant cultivars remains unknown. In this study, metabolism variation of DBP by low ( Fengyousimiao ) and high ( Peizataifeng ) DBP-accumulating cultivars of rice and the key enzymes involving in DBP metabolism in rice plants were investigated using in vivo exposure of rice plants and in vitro exposure of root crude enzyme extracts. Both mono- n -butyl phthalate (MBP) and phthalic acid (PA) were detected as DBP metabolites in all rice tissues ( i.e. , roots, stems, leaves) and crude enzyme extracts with MBP predominance. DBP metabolism occurred simultaneously when DBP uptake with the highest metabolism in roots in vivo . Degradation of DBP in root crude enzyme extracts fitted well with the first order kinetics ( R 2 = 0.49–0.76, P < 0.05). The activity of carboxylesterase (CXE) in root crude enzyme extracts was significantly positively correlated with DBP degradation rates. CXE played an important role in DBP metabolism of rice plants, confirming by the fact that triphenyl phosphate of CXE inhibitor could inhibit DBP metabolism of in vivo and in vitro exposure. This result was further confirmed by in vitro degradation of DBP with the commercial pure CXE. The crude enzyme solution from roots of Fengyousimiao with higher CXE activity had significantly higher DBP degradation rates than that of Peizataifeng . However, Fengyousimiao with lower tolerance to DBP stress and higher inhibition by triphenyl phosphate displayed lower DBP metabolism ability in vivo than Peizataifeng .
研究领域:
植物学
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环境科学
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分子生物学
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高影响因子
CHEMICAL ENGINEERING & TECHNOLOGY
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2013
·Vol. 36
·期 5
·851-862
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IF 1.366
L.-J. Chen,H.-B. Dong,Q. Li,C.-C. Niu,A.-W. Zeng
To simulate the centrifugal short-path distillation process, both two phases and interfacial transport are taken into account simultaneously for the first time. A new computational fluid dynamics model based on the volume-of-fluid and species transport methods is built up to analyze the detailed flow and transfer characteristics. A binary system with dibutyl phthalate-dibutyl sebacate (DBP-DBS) is used as an example for the investigation with both numerical and experimental methods. The residence time and the effects of operating parameters such as evaporator temperature and feed flow rate are explored comparatively. The simulation result for the liquid-film thickness shows a satisfactory agreement with literature data. On the basis of the simulation results, we may also obtain detailed characteristics of the heat and mass transfer such as gradients in temperature and concentration and the liquid overall mass transfer coefficient.
研究领域:
化学工程
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传热传质学
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高影响因子
Environmental Science-Water Research & Technology
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2025
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IF 3.1
Qiaojiao Mu,Hongtao Zhao,Yuan Zhuang,Yili Wang,Baoyou Shi
Corrosive iron pipes in drinking water distribution systems favor biofilm growth. A high protein-to-polysaccharide ratio could reduce the adhesion of biofilm on the pipe wall; however, the effects of the protein-to-polysaccharide ratio on disinfection by-product (DBP) formation are unclear. To investigate this issue, this study used bovine serum albumin (BSA) and sodium alginate (SA) to simulate proteins and polysaccharides in extracellular polymeric substances (EPSs), respectively, and systematically examined the effects of different protein-to-polysaccharide ratios on the generation of DBPs during chlorination disinfection. BSA promoted the formation of regulated DBPs, including trihalomethanes (THMs) and haloacetic acids (HAAs), as well as emerging DBPs such as haloacetonitriles (HANs), but SA did not obviously affect DBP formation. BSA also increased turbidity, enhanced particle dispersion, and led to the formation of a greater number of smaller iron particles. In contrast, SA promoted particle aggregation and sedimentation, resulting in reduced turbidity. Particle characterization further demonstrated that BSA exhibited stronger binding with iron particles than SA. Notably, from a toxicological perspective, BSA led to higher levels of cytotoxicity and genotoxicity due to the increased formation of DBPs. Thus, this study identified a new risk that a high protein-to-polysaccharide ratio increases the formation of DBPs promoted by the iron particle interface, besides the risk of microorganism release from pipe wall into bulk water.
研究领域:
环境科学
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公共卫生
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NUCLEAR ENGINEERING AND DESIGN
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2023
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IF 1.7
Guanghui Wang,Yulong Du,Meng Zhang,Caishan Jiao,Hui He
In the nuclear spent fuel reprocessing, zirconium dibutyl phosphate (Zr-DBP) is deposited on the surface of stainless steel equipment, making spent fuel reprocessing difficult. Therefore, in this study, hydrazine carbonate ((N 2 H 5 ) 2 CO 3 ) was used to dissolve Zr-DBP. The effects of solid–liquid ratio, different mass fractions of (N 2 H 5 ) 2 CO 3 solutions, and (N 2 H 5 ) 2 CO 3 solutions containing different concentrations of hydrogen peroxide (H 2 O 2 ) on the dissolution of Zr-DBP were investigated. The corrosion rates of different dissolution solutions on stainless steel were also investigated. When the mass fraction of (N 2 H 5 ) 2 CO 3 in solution was increased from 1 % to 20 %, the concentration of Zr(IV) at dissolution equilibrium increased from 1.05 g/L to 1.61 g/L, respectively. When the dissolution temperature was kept in the range of 25 °C to 65 °C, the increasing temperature promoted the dissolution of Zr-DBP. The presence of H 2 O 2 induced the production of the white precipitates zirconium hydroxide (Zr(OH) 4 ). In addition, the corrosion rate of stainless steel gradually increased from 0.00153 mm/a to 0.0138 mm/a when the concentration of H 2 O 2 in the (N 2 H 5 ) 2 CO 3 solution was increased from 0 M to 1.5 M. The dissolution ability of Zr-DBP in different carbonate solutions was (N 2 H 5 ) 2 CO 3 ≥ ammonium carbonate ((NH 4 ) 2 CO 3 ) > sodium carbonate (Na 2 CO 3 ) ≥ potassium carbonate (K 2 CO 3 ).
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Communications Biology
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2019
·Vol. 2
·期 1
·1-11
·
IF 0
Lin Yanke,Wang Shuai,Zhou Ziyue,Guo Lianxia,Yu Fangjun,Wu Baojian
Metabolism is a major defense mechanism of the body against xenobiotic threats. Here we unravel a critical role of Bmal1 for circadian clock-controlled Cyp3a11 expression and xenobiotic metabolism. Bmal1 deficiency decreases the mRNA, protein and microsomal activity of Cyp3a11, and blunts their circadian rhythms in mice. A screen for Cyp3a11 regulators identifies two circadian genes Dbp and Hnf4α as potential regulatory mediators. Cell-based experiments confirm that Dbp and Hnf4α activate Cyp3a11 transcription by their binding to a D-box and a DR1 element in the Cyp3a11 promoter, respectively. Bmal1 binds to the P1 distal promoter to regulate Hnf4α transcriptionally. Cellular regulation of Cyp3a11 by Bmal1 is Dbp- and Hnf4α-dependent. Bmal1 deficiency sensitizes mice to toxicities of drugs such as aconitine and triptolide (and blunts circadian toxicity rhythmicities) due to elevated drug exposure. In summary, Bmal1 connects circadian clock and Cyp3a11 metabolism, thereby impacting drug detoxification as a function of daily time.
研究领域:
药理学
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分子生物学
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时间生物学
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PubMed
RSC Advances
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2023
·Vol. 13
·期 31
·21537-21544
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IF 3.9
Xingya Wei,Bangjun Han,Renzheng Gu,Weimin Geng,Naiyun Gao
Disinfection by-products (DBPs) formed in chlorination and chloramination are proved to be cytotoxic and genotoxic and arouse increasing attention. However, previous studies of DBP precursors mainly focused on free amino acids (AAs) and few papers evaluated DBPs' formation potential of combined AAs. This study demonstrated that typical carbonaceous (C-) DBPs, trihalomethanes (THMs) and typical nitrogenous (N-) DBPs, dichloroacetonitrile (DCAN), trichloroacetonitrile (TCAN) and trichloronitromethane (TCNM) could be formed during chlorination and chloramination of polymyxin B sulfate (PBS), a common polypeptide antibiotic working against Gram-negative bacterial infections. The effects of major parameters, including disinfectant dose, contact time, solution pH, temperature, bromide concentration and chloramination mode were evaluated in batch experiments. Different kinds of DBPs exhibited different characteristics as disinfectant dose or contact time increased. Solution pH and temperature affected the formation of DBPs greatly. The formation pathways of different DBPs from chlor(am)ination of PBS were also proposed. Combined AAs, such as PBS, were proved to be important precursors of DBPs during disinfections.
研究领域:
环境科学
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公共卫生
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
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2026
·
IF 7.5
Yunhe Cui,Yue Tao,Hudong Fan,Ting Liu,Ying Zhang
SiO 2 @PDA-Lac achieved BPA-dominant removal with synchronous DBP reduction. • PDA-coated mesopores enhanced pollutant enrichment and laccase anchoring. • SiO 2 @PDA-Lac retained BPA/DBP removal after 5 cycles and 50 d storage. • Docking and GC-MS revealed competitive binding and divergent pathways. • ECOSAR predicted overall toxicity reduction after enzymatic transformation. The potential co-occurrence of bisphenol A (BPA) and dibutyl phthalate (DBP) in contaminated water motivates the development of treatment strategies for binary pollutant systems. Herein, a polydopamine-functionalized mesoporous silica immobilized laccase system (SiO 2 @PDA-Lac) was developed for BPA-dominant removal and synchronous DBP reduction. Immobilization time was first selected by balancing initial activity and cycling stability. With the time fixed at 6 h, immobilization pH, temperature, and laccase concentration were further optimized by RSM using relative enzyme activity as the response, yielding pH 4.0, 25 °C, and 80 mg/mL laccase. In the binary system at an initial pollutant concentration of 100 mg/L, SiO 2 @PDA-Lac removed approximately 81% of BPA and 20% of DBP. Control experiments with free laccase and inactivated SiO 2 @PDA-Lac indicated that BPA removal was driven by coupled interfacial adsorption and enzymatic catalysis, whereas DBP reduction was lower but still measurably assisted by immobilized laccase. SiO 2 @PDA-Lac retained detectable performance after five cycles, with BPA and DBP removal remaining at 57% and 14%, respectively, and maintained removal activity after 50 d of storage. Molecular docking and molecular dynamics simulations suggested that BPA and DBP may occupy partially overlapping binding microenvironments. GC-MS and ECOSAR analyses indicated possible transformation pathways with an overall tendency toward lower predicted ecological risk. These results demonstrate the feasibility of SiO₂@PDA-Lac for BPA-dominant removal and concurrent DBP reduction in a model BPA/DBP binary system. Download: Download high-res image (314KB) Download: Download full-size image
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Qiuyuan Huang,Ke Wang
Large-scale water treatment facilities in both coastal and inland regions worldwide face significant challenges posed by disinfection byproducts (DBPs) arising from excessive iodide (I⁻) and bromide (Br⁻) concentrations. Herein, we report the development of a magnetic composite with tailored side chains (AQBP) for the precise recognition of I⁻ and Br⁻ in complex aquatic environments. Comparative evaluation of AQBP against the control composite (PSMP) and two commercially available resins (MIEX and D201) highlights the precise sequestration of I⁻ and Br⁻ by AQBP across various complex aquatic matrices. Notably, AQBP maintains a removal efficiency exceeding 80% for trace precursors even when competing anion concentrations are 10 3 -fold higher, and continues to demonstrate excellent capture performance in real coastal estuarine water samples. The elongated alkyl chains and densely packed aromatic architecture within the AQBP synergistically enhance hydrophobicity, conferring superior selectivity for the highly hydrophobic I⁻ and Br⁻. The abundant quaternary ammonium groups on AQBP significantly enhance electrostatic attraction toward target halides. Theoretical calculations further substantiate the strong non-covalent interactions between AQBP and I⁻ and Br⁻. Collectively, these findings confirm that AQBP represents an innovative and cost-effective solution for the precise capture of I⁻ and Br⁻ in large-scale water treatment applications, offering considerable promise for improving drinking water safety.
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高影响因子
WATER RESEARCH
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2019
·
IF 7.913
Jijie He,Feifei Wang,Tiantao Zhao,Shaogang Liu,Wenhai Chu
Disinfection by-products (DBPs) precursors can be regarded mainly from the drinking water sources and the water treatment processes. A recent study showed that dissolved organic matter (DOM) in atmosphere is an important precursor source of DBPs through atmospheric wet deposition . However, little information is available on the characteristics of DOM derived from dry deposition particulate matter (PM) and the impact of dry deposition on CX 3 R-type DBP formation. This study determined whether dry deposition directly contributed the production of DBPs during chlor (am)ination and investigated the mechanism behind the contribution based on the combination of the resin and membrane for fractionating DOM fractions. The results showed that the hydrophilic fraction (HPI) contributed the most DOM and low molecular weight DOM (<10 kDa) was the main component of HPI. In addition, aromatic proteins and soluble microbial products-like compounds were the dominant fluorescent species in DOM derived from PM, and <10 kDa transphilic was the most abundant. The concentrations of C-DBPs and N-DBPs in disinfected PM solution were trihalomethanes (THMs) > haloacetic acids (HAAs) > haloaldehydes and haloacetamides > haloacetonitriles > halonitromethanes for both chlorination and chloramination. The main contributors of calculated toxicity are transphilic and hydrophobic in chlorination and chloramination respectively. Dry deposition PM was deduced to contribute DOM and DBP formation after chlorination in surface water, especially THMs and HAAs. These results presented herein provide key information for controlling DBPs from the perspectives of atmospheric dry deposition, especially in the case of heavy air pollution.
研究领域:
环境科学
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水处理工程
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高影响因子
Materials
·
2019
·Vol. 12
·期 17
·2813
·
IF 2.972
Haijuan Li,Ling Li,Shuaizhi Zheng,Xinming Wang,Zengsheng Ma
To improve the thermal shrinkage and ionic conductivity of the separator for lithium-ion batteries, adding carboxylic titanium dioxide nanofiber materials into the matrix is proposed as an effective strategy. In this regard, a poly(vinylidene fluoride-hexafluoro propylene)/dibutyl phthalate/carboxylic titanium dioxide (PVDF-HFP/DBP/C-TiO2) composite separator is prepared with the phase inversion method. When the content of TiO2nanofibers reaches 5%, the electrochemical performance of the battery and ion conductivity of the separator are optimal. The PVDF-HFP/DBP/C-TiO2(5%) composite separator shows about 55.5% of porosity and 277.9% of electrolyte uptake. The PVDF-HFP/DBP/C-TiO2(5%) composite separator has a superior ionic conductivity of 1.26 × 10−3S cm−1and lower interface impedance at room temperature, which brings about better cycle and rate performance. In addition, the cell assembled with a PVDF-HFP/DBP/C-TiO2separator can be charged or discharged normally and has an outstanding discharge capacity of about 150 mAh g−1at 110 °C. The battery assembled with the PVDF-HFP/DBP/C-TiO2composite separator exhibits excellent electrochemical performance under high and room temperature environments.Keywords:TiO2nanofiber;PVDF-HFP;composite separator;phase inversion;thermal shrinkage;ionic conductivity
研究领域:
材料科学
·
电化学
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2017
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IF 3.359
Ziying Wang,Yisheng Shao,Naiyun Gao,Na An
The ultraviolet/persulfate (UV/PS) process was used to degrade dibutyl phthalate (DBP) at different reaction conditions and a steady-state kinetic model was established based on the elementary reactions involved as well. UV/PS process, which can generate both sulfate radical (SO 4 − ) and hydroxyl radical (HO ) proved by the evidence that methanol had a larger inhibition impact on the degradation than tert -butyl, could effectively degrade DBP. The second-order rate constant of (1.2 ± 0.1) × 10 8 M −1 s −1 between DBP and SO 4 − and the second-order rate constant of (6.3 ± 0.1) × 10 9 M −1 s −1 between DBP and HO were determined by competition kinetics. The degradation efficiency of DBP was affected by PS dosage, initial DBP concentration, solution pH value, natural organic matter (NOM) and inorganic anions. Increasing PS dosage could enhance the degradation of DBP before PS dosage reaching 1.6 mM. However, the pseudo-first-order rate constants (k o ) decreased as initial DBP concentration increased probably owing to the radical scavenging effect of DBP. Generally, the k o value decreased slightly at pH values ranged from 4.0 to 6.0 while decreased significantly as pH increased from 6.0 to 8.0, which might be due to the scavenging effect on SO 4 − and HO by OH − and increasing concentration of HPO 4 2 - (with higher scavenging capacity than H 2 PO 4 - ) from the phosphate buffer with rising pH value. NOM and HCO 3 - showed an inhibition effect on the degradation of DBP through quenching SO 4 − and HO . However, Cl − had a dual role on the degradation of DBP in the UV/PS system, which enhanced the degradation at lower concentration (0–1 mM) and suppressed as Cl − concentration further increased to 2 mM. Additionally, a simple steady-state kinetic model involving SO 4 − and HO was developed to simulate the k o values and the radical contributions in this reaction system. Generally, HO had a higher contribution to DBP degradation than SO 4 − . The total cost including the electrical energy per order and oxidant cost was increased with increasing PS dosage and the oxidant cost was the major one. The results in this study can serve as a guide and indicate that UV/PS process is feasible for the treatment of water contaminated with DBP.
研究领域:
环境工程
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水处理
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化学动力学
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高影响因子
Expert Opinion on Drug Metabolism & Toxicology
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2025
·
IF 3.4
Yongbin Tong,Qi Zhang,Yutong Chen,Zhiqiang Zhao,Jingqi Li,Jinyi Wang,Haishan Xia,Danyi Lu,Yuyu Liu
Introduction Coumarin exhibit various biological activities, including anti-inflammatory, antioxidant and anxiolytic effects. However, its clinical application is restricted due to significant hepatotoxicity observed in multiple animal models. CYP2A5 is the primary enzyme responsible for metabolizing coumarin in the mouse liver, homologous to human CYP2A6.Methods Acute toxicity and pharmacokinetic investigations were conducted on Rev-erbα−/− and wild-type mice following coumarin administration. The regulatory effects of REV-ERBα on CYP2A5 expression were assessed both in vivo and in vitro. Western blotting and qPCR were used to measure the protein and mRNA levels, respectively.Results Firstly, coumarin-induced hepatotoxicity was mitigated in Rev-erbα−/− mice. Secondly, the systemic exposure of coumarin was lowered in Rev-erbα−/− mice compared with wild-type mice. Thirdly, deletion of Rev-erbα resulted in significant upregulation of CYP2A5 mRNA and protein expression in mice. REV-ERBα negatively regulated CYP2A5/2A6 expression in Hepa-1c1c7 and HepG2 cells. Furthermore, luciferase reporter and chromatin immunoprecipitation (ChIP) assays indicated that REV-ERBα modulated Cyp2a5 transcription and expression through the repression of DBP.Conclusions The knockout of Rev-erbα significantly reduces the hepatotoxicity of coumarin by modulating CYP2A5. This research underscores the potential of targeting the REV-ERBα/CYP2A5 axis as a novel strategy for reducing coumarin-induced hepatotoxicity.
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