SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Mengyao Chen,Wenjing Qin,Yanli Wang,Yu Song,Fei Tian,Hanlin Zhai,Changshun Gu,Le Ge,Song Xue,Xinxin Li,Xiangchuan Zhao,Yixin Xu,Zeyu Ming,Shengrong Li,Shougen Yin
3D printing hydrogel shows a broad application prospect in soft actuator/robot and flexible electronics due to its adaptable structure and designable chemical composition. Herein, a Zr 4 + -deep eutectic solvent (DES)-PAAc hydrogel is developed via digital light processing (DLP) 3D printing technology. By synergistically integrating hydrogen bonding, Zr⁴⁺-carboxylate ionic coordination bonds, and electrostatic interactions between DES and PAAc chains, the hydrogel achieves a unique soft-hard phase-separated dual-network architecture. This design provides an internal energy dissipation-storage mechanism, endowing the hydrogel with exceptional mechanical robustness (maximum stress of 1.86 MPa), high conductivity (conductivity of 0.51 S/m), and cyclic compression stability (energy dissipation of 2.69 kJ m⁻³), thereby overcoming the trade-off between toughness and functionality in conventional hydrogels. Leveraging DLP 3D printing, the hydrogel is precisely tailored into complex architectures (e.g., bioelectrodes, impact-resistant structures). Remarkably, the hydrogel serves as a self-powered pressure-sensing electrolyte in Zn-Cu batteries and a weather-resistant bioelectrode for real-time monitoring of bio-signals. Furthermore, its tailored structures exhibit programmable impact resistance for delicate device protection. The combination of additive manufacturing and cross-domain functionality establishes a paradigm for hydrogels in wearable healthcare, soft robotics, and energy-autonomous sensing systems.
研究领域:
材料科学
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3D打印/增材制造
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柔性电子器件
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传感器
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能源存储
·
生物医学工程
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软体机器人
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高分子科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Bin Li,Xiaojuan Li,Shuying Li,Chen Chen,Ting Xiao,Yuehong Xu
Psoriasis is a chronic and incurable inflammatory skin disease usually requiring long-term disease management. Natural phytochemical resveratrol (RES) has been known for high efficiency and low toxicity, exhibiting good anti-psoriasis potential. However, its biological activity is limited by poor solubility, chemical instability, and insufficient skin retention. Herein, we developed an adhesive eutectogel loaded with RES constructed through electrostatic and hydrogen bonding cross-linking between cyclodextrin-levulinic acid supramolecular deep eutectic solvent (DES) and chitosan (CS). A series of characterizations combined with molecular dynamics simulations demonstrated that such DES not only significantly increased the solubility and stability of RES, but also acted as the cross-linker and plasticizer in eutectogel preparation. When applied to the skin surface, the eutectogel formed a soft film in situ that established tight contact with the skin, thereby enhancing RES sustained penetration into the skin. In an imiquimod-induced psoriasis-like mice model, the eutectogel effectively alleviated psoriasis symptoms, inhibited the excessive proliferation of keratinocytes, and regulated the expression of IL-23/IL-17 axis-related factors, whose therapeutic effect was better than that of commercially available calcipotriol ointment. Overall, The DES-strengthened eutectogel offers a promising topical drug delivery platform for psoriasis treatment and expands the applications of green polysaccharide medical materials.
研究领域:
药剂学
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皮肤科
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生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2023
·
IF 6.6
Ruiping Zhang,Zhuo Li,Qiang Ma,Puiki Leung,Zhizhong Guo,Yan Sun,Huaneng Su,Chunsheng Li,Qian Xu
In the past, non-aqueous redox flow batteries usually used organic solvents or ionic liquids as electrolytes. However, these two liquids are not suitable as electrolytes in terms of safety and production costs. Herein, we chose a deep eutectic solvent (DES) for non-aqueous redox flow battery. DES has been applied to play two functions in Fe/V non-aqueous redox flow battery: commercial graphite felt electrode is treated with DES and heat treatment for surface modification; DES also acts as a main electrolyte for the non-aqueous redox flow battery. While ensuring no external substances are introduced to produce side reactions, the electrode reaction kinetics are enhanced, and better cyclability is achieved. The modified treatment increases the number of oxygen-containing groups and defect sites on electrode surface. Electrode exhibits higher electrochemical activity and lower charge transfer resistance. In the full battery test, the maximum power density with modified electrode reaches 13.26 mW·cm −2 , which is 114% higher than commercial graphite felt electrode. The energy efficiency reaches 90.50% and battery life is extended by 70.58% compared with commercial graphite felt electrode. This study has successfully improved the electrochemical performance of Fe/V DES redox flow battery and provides a novel idea for electrode modification.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Separations
·
2023
·Vol. 10
·期 2
·111
·
IF 2.6
Zexing Xie,Meiying Xie,Tingting Tang,Fan Yang,Liyan Xue,Zhengming Jiang
6Li and7Li are strategic resources. Because Li+ions have no outermost electrons and the radii of6Li and7Li differ by only one neutron, the separation of the naturally stable isotopes of Li, especially by solvent extraction, is recognized as a difficult problem worldwide. Therefore, in this paper, an advancedβ-diketone-driven deep eutectic solvent (DES) extraction system containing 2-thenoyltrifluoroacetone (HTTA) and tri-n-octyl phosphine oxide (TOPO) is introduced to the extraction and separation of6Li+and7Li+ions. Compared with those of reported HTTA extraction systems and crown ether extraction systems, the separation coefficient (β7Li/6Li) of theβ-diketone-driven DES extraction system can reach the best value of 1.068, which is now the highest knownβ-value reported in the extraction system. From the intramolecular hydrogen bond of HTTA to the intermolecular hydrogen bond of DES, the bond energy increases by 47.8%. Because the active site of the proton in DES provides a higher energy barrier for the separation of7Li, theβ7Li/6Liis significantly increased. The extractions were characterized by spectrum, using1H nuclear magnetic resonance (NMR) spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, and X-ray photoelectron spectroscopy (XPS). The mechanism was determined on the basis of the reaction kinetics and density functional theory (DFT). The DES extractant shows excellent cycle performance with regard to stripping and reusability. In conclusion, the highly efficient, economical, and stableβ-diketone-driven DES extraction system can be used for the separation of naturally stable Li isotopes, which provides good industrial application prospects.Keywords:β-diketone;Lithium-7;separation of isotopes;deep eutectic solvent (DES);solvent extraction
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER TESTING
·
2023
·
IF 5.1
Wei Wu,Hailan Zeng,Yanan Li,Haiyun Jiang,Jinqi Wu,Ziyu Li,Weili Zhang,Xiang Wang,Qiong Xue
Deep eutectic solvents (DES) doping is an important method to realize the preparation and modification of PEDOT:PSS films in aqueous solution, but there is no systematic research focusing on its action mechanism in polymerization process. A series of in-situ characterizations were conducted to investigate the effect of DES doping on properties and structure. The UV–Vis spectra indicated the DES doping can strengthen the π−π* stacking interaction and conjugation stabilization of PEDOT:PSS, and then lead to stronger photovoltaic conversion ability. The in situ FTIR spectra revealed the hydrogen bonds were incorporated into the polymer chain during polymerization process. The CV and SEM analysis results suggested that DES doping delayed passivation nucleation stage of PEDOT:PSS film in the thickness direction and remained a stable polymerization rate. The XPS spectra of S 2p proved DES doping decrease the interaction between PEDOT and PSS. Comprehensive experiments demonstrate that the structure-induced effects of DES can trigger structural reorganization in line conformation of PEDOT:PSS/DESs. It is structure-induced effects of DES that delays passivation nucleation stage in polymerization and improves the optical absorption contrast, maximum current density and some other properties efficently.
✓ 已验证
产品关联
DOI
高影响因子
Wood Material Science & Engineering
·
2024
·
IF 2.2
Mengyao Chen,Haiqiao Zhang,Xingzhou Yao,Ke Tong,Yan Wu
Deep eutectic solvents (DES) offer advantages such as environmental friendliness, recyclability, and biocompatibility, demonstrating promising applications in functional materials, chemical reactions, and electrochemistry. This study investigated the softening effect of DES on beech with the assistance of FeCl3, considering different treatment durations (1, 2, 3, and 4 h) on varying thicknesses (1, 2.5, 3.5, and 5 mm). Results indicate that longer treatment time leads to better softening effects on beech wood at the same thickness. FeCl3 acts as an active site providing acidic protons, thereby enhancing the softening efficiency of DES. Wood treated with Fe3+-assisted DES removes 86% of the lignin and 48% of the hemicelluloses, resulting in enhanced flexibility. Scanning electron microscopy reveals that most of the vessel lumens, cell lumens, and intercellular spaces of beech wood treated with Fe3+-assisted DES are filled with DES, reducing the wood's porosity. Color difference analysis and energy-dispersive X-ray spectroscopy demonstrate that wood color darkens gradually with prolonged treatment time, correlating with the addition of FeCl3. Thermal analysis indicates an improvement in the flame retardancy of the treated wood. This research methodology significantly enhances wood utilization and diversifies the aesthetic possibilities of wood products, thereby may expanding their applications in architecture and furniture.
研究领域:
材料科学
·
林业科学
✓ 已验证
DOI
高影响因子
VETERINARNI MEDICINA
·
2023
·
IF 0.7
Weifeng Zhang,Hualong Deng,Yanfen Liu,Shaohong Chen,You Liu,Yuntao Zhao
Peste des petits ruminants virus (PPRV), a member of the family Paramyxoviridae, belongs to the genus Morbillivirus. It causes devastating viral diseases in small ruminants and has been rapidly spreading over various regions in Africa, the Middle East, and Asia. Although vaccination is thought to be an effective management strategy against PPR infections, the heat sensitivity of PPRV vaccines severely restricts their use in regions with hot climates. In this research, we studied the antiviral activities of ribavirin and aimed to understand the potential mechanisms of action of ribavirin in the African green monkey kidney cells (Vero cells). In brief, the adsorption, intrusion, replication, and release of PPRV, as well as the mRNA expression level of RNA-dependent RNA polymerase ( RdRp ), were significantly inhibited in the ribavirin-treated Vero cells compared to those in the PPRV-infected cells that were not treated with ribavirin. Additionally, ribavirin has potential as an antiviral drug against PPRV, and its antiviral activity is mediated by the Janus kinase signal transducer and activator of transcription (JAK/STAT) and PI3K/AKT pathways.
研究领域:
兽医学
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病毒学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Marine Drugs
·
2014
·Vol. 12
·期 4
·1815-1838
·
IF 3.512
Chang-Jing Wu,Chang-Wei Li,Cheng-Bin Cui
AD-2-1 is an antitumor fungal mutant obtained by diethyl sulfate mutagenesis of a marine-derivedPenicillium purpurogenumG59. The G59 strain originally did not produce any metabolites with antitumor activities in MTT assays using K562 cells. Tracing newly produced metabolites under guidance of MTT assay and TLC analysis by direct comparison with control G59 extract, seven new (1–7) and two known (8–9) lipopeptides were isolated together with five known polyketides10–14from the extract of mutant AD-2-1. Structures of the seven new compounds including their absolute configurations were determined by spectroscopic and chemical evidences and named as penicimutalides A–G (1–7). Seven known compounds were identified as fellutamide B (8), fellutamide C (9), 1′-O-methylaverantin (10), averantin (11), averufin (12), nidurufin (13), and sterigmatocystin (14). In the MTT assay,1–14inhibited several human cancer cell lines to varying extents. All the bioassays and HPLC-photodiode array detector (PDAD)-UV and HPLC-electron spray ionization (ESI)-MS analyses demonstrated that the production of1–14in the mutant AD-2-1 was caused by the activated production of silent metabolites in the original G59 fungal strain. Present results provided additional examples for effectiveness of the chemical mutagenesis strategy using diethyl sulphate mutagenesis to discover new compounds by activating silent metabolites in fungal isolates.Keywords:marine-derived fungus;lipopeptide;penicimutalide;Marfey analysis;polyketide;Penicillium purpurogenum;DES mutagenesis
研究领域:
微生物学
·
药物化学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2025
·
IF 4.3
Ling Cao,Xiuhua Zheng,Yuxiu An,Lei Zhang,Peizhi Yu
Drilling instability in oil and gas drilling has long challenged drilling safety and economics. Conventional oil-based drilling fluids offer high-temperature resistance and good inhibition. However, oil-based drilling fluids have significant problems in terms of environmental impact, cost, and waste fluid disposal. This has led to the widespread use of water-based drilling fluids. This study aims to investigate the synthesis of a new water-based drilling fluid inhibitor, a hybrid low eutectic solvent ChCl-Gly-Urea (CGU-DES), and its performance evaluation. While conventional eutectic solvents (DES) usually consist of a single type of hydrogen bond acceptor (HBA) and hydrogen bond donor (HBD), CGU-DES extends its performance characteristics by introducing a combination of one HBA and two HBDs. The study confirmed the successful synthesis of CGU-DES using FT-IR spectroscopy. The following advantages of CGU-DES over CU-DES and CU-DES consisting of a single type of HBA and HBD were verified. Below 175 °C, the temperature resistance of CGU-DES is better, and the mass loss rate is less than 5%. The first and second rolling recoveries of CGU-DES aqueous solution with low concentration (<0.5 wt %) were greater than 95% and 85%, respectively, higher than the rolling recoveries of CG-DES and CU-DES.CGU-DES has a good ability to reduce water activity. When the dosage is 10%, the activity of DES aqueous solution is less than 0.950, and the efficiency of reducing water activity is nearly twice that of CG-DES and CU-DES. CGU-DES is compatible with sodium slurry and drilling fluids with polymer-sulfonated materials because it has little influence on rheology and fluid loss. At 180 °C, 0.7% CGU-DES was added to the polysulfonate drilling fluid system, and the fluid loss reduction rate reached 30.59%. Experiments show that CGU-DES can inhibit the hydration and dispersion of shale by inserting into the crystal spacing of montmorillonite , adsorbing onto the surface, reducing the surface tension of drilling fluid, reducing the contact angle between drilling fluid and shale, and reducing the water activity of drilling fluid. In summary, CGU-DES, a new type of green solvent, has potential application prospects in water-based drilling fluids and provides new technical support for solving the borehole instability problem during drilling.
研究领域:
石油工程
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Kai Nie,Boya Li,Pixiang Wang,Yan Song,Haoxi Ben,Guangting Han,Wei Jiang,Arthur Ragauskas
Phloem biomass has gradually attracted attention for its conversion and utilization due to its fast growth rate and suitability for textile use. Currently, clean methods for separating the chemical components of biomass have attracted attention. In this study, the choline chloride-lactic acid (CLA) and choline chloride-glycolic acid (CGA) pretreatment were developed for kenaf chemical components separation, and the solid residue and regenerated lignin were characterized. The results demonstrated that two acidic deep eutectic solvents (DESs) pretreatment had good removal capacities for lignin and hemicellulose even when the kenaf was not crushed. Under optimal treatment conditions, the retention rates of cellulose were 82.4% and 81.1%, respectively. The cellulose content in the recovery solids residues reached 91.5% and 91.3%, which also resulted in good enzymatic hydrolysis conversion efficiency (85.4% and 84.9%). The regenerated lignin exhibited high purity (91.9% and 90.1%), and low molecular weight (1209 and 1086 g/mol), which was attributed to the amount of ether bonds cleavage in lignin. Meanwhile, the DES exhibited a good ability to recycle and reuse. Overall, acidic DES pretreatment holds promise for efficient fractionation and component utilization of kenaf phloem biomass.
研究领域:
生物质能
·
化工
✓ 已验证
产品关联
DOI
高影响因子
Advanced Optical Materials
·
2023
·Vol. 11
·期 22
·2300861
·
IF 9
Ping Qi,Shideng Yuan,Yihan Liu,Renhao Dong,Aixin Song,Jingcheng Hao
Here, a polymerizable type-IV deep eutectic solvent (DES) is synthesized via the coordination reaction between acrylamide and SbCl 3 , and for the first time it is demonstrated that the resultant type-IV DES-based polymers can exhibit luminescence after polymerization due to the efficient Sb-ligand and ligand–ligand charge transfer. Notably, the quantum yield of Sb-ligand charge transfer emission can be tuned with the controllable reversible addition-fragmentation chain transfer (raft) polymerization of acrylamide, reaching up to 15.32%. As a proof-of-concept application, the polymerizable DES is utilized as fluorescent anti-counterfeit ink, successfully realizing the fluorescence encryption.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Marine Drugs
·
2012
·Vol. 10
·期 6
·1266-1287
·
IF 3.854
Shi-Ming Fang,Cheng-Bin Cui,Chang-Wei Li,Chang-Jing Wu,Zhi-Jun Zhang,Li Li,Xiao-Jun Huang,Wen-Cai Ye
Two new drimenyl cyclohexenone derivatives, named purpurogemutantin (1) and purpurogemutantidin (2), and the known macrophorin A (3) were isolated from a bioactive mutant BD-1-6 obtained by random diethyl sulfate (DES) mutagenesis of a marine-derivedPenicillium purpurogenumG59. Structures and absolute configurations of1and2were determined by extensive spectroscopic methods, especially 2D NMR and electronic circular dichroism (ECD) analysis. Possible biosynthetic pathways for1–3were also proposed and discussed. Compounds1and2significantly inhibited human cancer K562, HL-60, HeLa, BGC-823 and MCF-7 cells, and compound3also inhibited the K562 and HL-60 cells. Both bioassay and chemical analysis (HPLC, LC-ESIMS) demonstrated that the parent strain G59 did not produce1–3, and that DES-induced mutation(s) in the mutant BD-1-6 activated some silent biosynthetic pathways in the parent strain G59, including one set for1–3production.Keywords:purpurogemutantin;purpurogemutantidin;sesquiterpene;meroterpenoid;structure determination;antitumor activity;Penicillium purpurogenum;marine-derived fungus;DES mutagenesis
研究领域:
药物化学
·
微生物学
·
有机化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）