NANOTECHNOLOGY
·
2016
·Vol. 27
·期 16
·165101
·
IF 3.573
Sheng Wang,Weitao Yang,Hongli Du,Fangfang Guo,Hanjie Wang,Jin Chang,Xiaoqun Gong,Bingbo Zhang
Multifunctional superparamagnetic iron-oxide (SPIO)-based nanoparticles have been emerging as candidate nanosystems for cancer diagnosis and therapy. Here, we report the use of reduction- responsive SPIO/doxorubicin (DOX)-loaded poly(ethylene glycol) monomethyl ether (PEG)ylated polymeric lipid vesicles (SPIO&DOX-PPLVs) as a novel theranostic system for tumor magnetic resonance imaging (MRI) diagnosis and controlled drug delivery. These SPIO&DOX-PPLVs are composed of SPIOs that function as MR contrast agents for tumor enhancement and PPLVs as polymer matrices for encapsulating SPIO and antitumor drugs. The in vitro characterizations show that the SPIO&DOX-PPLVs have nanosized structures (∼80 nm), excellent colloidal stability, good biocompatibility, as well as T2-weighted MRI capability with a relatively high T2 relaxivity (r2 = 213.82 mM−1 s−1). In vitro drug release studies reveal that the release rate of DOX from the SPIO&DOX-PPLVs is accelerated in the reduction environment. An in vitro cellular uptake study and an antitumor study show that the SPIO&DOX-PPLVs have magnetic targeting properties and effective antitumor activity. In vivo studies show the SPIO&DOX-PPLVs have excellent T2-weighted tumor targeted MRI capability, image-guided drug delivery capability, and high antitumor effects. These results suggest that the SPIO&DOX-PPLVs are promising nanocarriers for MRI diagnosis and cancer therapy applications.
研究领域:
医学影像学
·
纳米医学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 39
·21975-21984
·
IF 2.936
Zideng Dai,Xue-Zhi Song,Junkai Cao,Yunping He,Wen Wen,Xinyu Xu,Zhenquan Tan
Biological applications of nanosheets are rapidly increasing currently, which introduces new possibilities to improve the efficacy of cancer chemotherapy and radiotherapy. Herein, we designed and synthesized a novel nano-drug system, doxorubicin (DOX) loaded titanium peroxide (TiOx) nanosheets, toward the synergistic treatment of lung cancer. The precursor of TiO2 nanosheets with high specific surface area was synthesized by a modified hydrothermal process using the polymer P123 as a soft template to control the shape. TiOx nanosheets were obtained by oxidizing TiO2 nanosheets with H2O2. The anti-cancer drug DOX was effectively loaded on the surface of TiOx nanosheets. Generation of reactive oxygen species, including H2O2, ·OH and ·O2−, was promoted from TiOx nanosheets under X-ray irradiation, which is effective for cancer radiotherapy and drug release in cancer cells. In this way, chemotherapy and radiotherapy were combined effectively for the synergistic therapy of cancers. Our results reinforce the DOX loaded TiOx nanosheets as a pH sensitive and X-ray controlled dual-stimuli-responsive drug release system. The cytotoxicity, cellular uptake, and intracellular location of the formulations were evaluated in the A549 human non-small cell lung cancer cell line. Our results showed that TiOx/DOX complexes exhibited a greater cytotoxicity toward A549 cells than free DOX. This work demonstrates that the therapeutic efficacy of DOX-loaded TiOx nanosheets is strongly dependent on their loading mode and the chemotherapeutic and radiotherapy effect is improved under X-ray illumination, which provides a significant breakthrough for future applications of TiOx as a light activated drug carrier in cancer chemotherapy and radiotherapy.
研究领域:
纳米技术
·
癌症治疗
·
药学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Zhaoxiang Zeng,Lihua Huang,Caiyan Xu,Siqi Rao,Yin Chen,Wenjin Xu,Hao Hong
Metal-organic frameworks (MOFs) are a unique type of coordination polymer characterized by their high porosity and enormous specific surface area, which enable their use as carriers. We have constructed a novel MOFs-based nanodelivery system designed for multimodal combination therapy to enhance the delivery efficiency and efficacy of chemotherapeutic drugs. The synthesis of MOF-199, which inherently possesses a drug-release response function, was used as a nanodrug carrier. Doxorubicin (DOX) was encapsulated through physical adsorption, and the carrier surface was modified with a biomimetic material, polydopamine (PDA). Both PDA and hyaluronic acid (HA) molecules contain carboxyl groups, which can be connected through Fe3+-mediated coordination interactions. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) were used to test the size, dispersity, and structural characteristics of the synthesized products, confirming their appropriate size and dispersity. BET(BET surface area) and TGA test results indicated that the nanocarrier exhibits good stability, a large specific surface area, and high porosity, making it suitable for use as a drug carrier. Ultraviolet spectrophotometry confirmed that the nanocarrier MOF-199-PDA-HA has the ability to consume GSH, with the drug loading rate and encapsulation efficiency of DOX in the system were measured as 39.58% and 73.26%, respectively. In cellular experiments, the DOX@MOF-199-PDA-HA group produced toxic hydroxyl radicals following H2O2 addition. After near-infrared light irradiation, both cellular toxicity and reactive oxygen species fluorescence intensity increased, indicating further enhanced anticancer efficacy. Using free HA as a control, it was confirmed that HA enhances tumor-specific accumulation of DOX@MOF-199-PDA-HA by binding to CD44 receptors on cancer cell surfaces.DOX@MOF-199-PDA-HA is a pH/GSH/NIR-responsive nanodelivery system with targeting functionality. This system ensures that drugs are released with higher efficiency in the tumor microenvironment through pH and glutathione (GSH) responsive drug-release mechanisms, thereby reducing toxicity to healthy tissues
研究领域:
药剂学
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF INORGANIC BIOCHEMISTRY
·
2020
·
IF 3.212
Han-Long Cheng,Hai-Ling Guo,An-Jian Xie,Yu-Hua Shen,Man-Zhou Zhu
At present, cancer has become a major disease threatening human health worldwide. Therefore, developing targeting guided multimode synergetic therapy has become one of the hot spots in current antitumor research and is also a great challenge. Herein, a new Fe 3 O 4 /g-C 3 N 4 @PPy-DOX nanocomposite containing magnetic iron oxide (Fe 3 O 4 ) nanoparticles (NPs), lamellar structure of graphite-like carbon nitride (g-C 3 N 4 ) and polypyrrole (PPy) shell with the loaded anti-tumor drug doxorubicin hydrochloride (DOX) was designed and prepared. The monodisperse Fe 3 O 4 nanoparticles (NPs) with the diameter of 20 nm endowed the nanocomposite with the magnetic targeting ability, reducing damage to normal tissues. It is very interesting that the Fe 3 O 4 NPs also possessed photosensitizer function for photodynamic therapy (PDT). The g-C 3 N 4 sheets as the photocatalysis towards the degradation of water for generating O 2 could effectively improve the hypoxia of solid tumors and increase the efficiency of PDT. In addition, PPy has high light-to-heat conversion efficiency, so was chosen for the cancer photothermal therapy (PTT). Finally, an anticancer drug (DOX) was loaded on the nanocomposite because the presence of mesoporous structure. Thus, the prepared Fe 3 O 4 /g-C 3 N 4 @PPy-DOX nanocomposites exhibit synergetic chemotherapy/PTT/enhanced PDT antitumor effect. This study provides an inspiration for combining targeting and multimodality to improve the anticancer efficiency.
研究领域:
肿瘤学
·
纳米医学
·
生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2017
·
IF 4.3
Juqun Xi,Lanyue Da,Changshui Yang,Rui Chen,Lizeng Gao,Lei Fan,Jie Han
Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn 2+ -coordinated doxorubicin (DOX)-loaded poly(lactic- co -glycolic acid) (PLGA) nanoparticles as a platform for synergistic chemo-photothermal tumor therapy. DOX-loaded PLGA (DOX/PLGA) nanoparticles were first synthesized through a double emulsion-solvent evaporation method, and then modified with polydopamine (PDA) through self-polymerization of dopamine, leading to the formation of PDA@DOX/PLGA nanoparticles. Mn 2+ ions were then coordinated on the surfaces of PDA@DOX/PLGA to obtain Mn 2+ -PDA@DOX/PLGA nanoparticles. In our system, Mn 2+ -PDA@DOX/PLGA nanoparticles could destroy tumors in a mouse model directly, by thermal energy deposition, and could also simulate the chemotherapy by thermal-responsive delivery of DOX to enhance tumor therapy. Furthermore, the coordination of Mn 2+ could afford the high magnetic resonance (MR) imaging capability with sensitivity to temperature and pH. The results demonstrated that Mn 2+ -PDA@ DOX/PLGA nanoparticles had a great potential as a smart theranostic agent due to their imaging and tumor-growth-inhibition properties.
研究领域:
纳米技术
·
癌症治疗
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 6
·2866-2875
·
IF 7.233
Yeying Wang,Xijian Liu,Guoying Deng,Jian Sun,Haikuan Yuan,Qi Li,Qiugeng Wang,Jie Lu
In this study, a versatile tumor-targeted and multi-stimuli-responsive drug delivery vehicle (Se particle@porous silica–folic acid–copper sulfide/doxorubicin (Se@SiO2–FA–CuS/DOX)) was fabricated for combined photothermal therapy with chemotherapy in cancer treatment. Due to excellent targeting ability, the Se@SiO2–FA–CuS/DOX nanocomposites actively accumulated in tumor tissues and thus provided photothermal therapy under NIR irradiation and chemotherapy through the release of DOX and Se. Owing to the synergistic effect of chemotherapy (Se and DOX) and photothermal therapy, the Se@SiO2–FA–CuS/DOX nanocomposites could efficiently inhibit cancer cells both in vitro and in vivo and even completely eliminate tumors. Moreover, as the toxicity of DOX could be reduced by Se, the treatment using Se@SiO2–FA–CuS/DOX nanocomposites exhibited no appreciable adverse reactions. Thus, the Se@SiO2–FA–CuS/DOX nanocomposites have great potential as a multifunctional nanoplatform in future clinical applications.
研究领域:
肿瘤学
·
纳米医学
·
药剂学
✓ 已验证
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2024
·
IF 4.5
Yan Wang,Jiaqi Lu,Menghui Wan,Yanbao Zhao
Asymmetric nanocarriers with different functions can achieve synergistic effect in cancer treatment. In this study, asymmetric carbon-silica (C-SiO 2 ) carriers were prepared for drug delivery and combining therapy. The C-SiO 2 carriers presented acorn-like structure with dendritic mesoporous silica hat and carbon body. The carbon body render the carriers photothermal effect. The prepared C-SiO 2 carriers with size around 130 nm have improving cell uptake efficiency, and excellent biocompatibility. After loading doxorubicin hydrochloride (DOX), menthol (LM) was used to seal the loaded drug (DOX@C-SiO 2 -LM). LM coating can melt above the phase transition temperature, leading to the release of loaded cargo. The DOX@C-SiO 2 -LM displayed temperature/NIR-triggered drug release.
研究领域:
纳米技术
·
药学
·
生物医学工程
·
癌症治疗
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Mengting Lin,Yuqing Li,Haiyue Long,Yueling Lin,Zhuo Zhang,Fengyun Zhan,Manmei Li,Chaoxi Wu,Zhong Liu
Biomimetics plays an important role in cancer treatment since it can prolong the circulation of nanoparticles, enhance their delivery and retention in target tissues, and reduce the systemic toxicity of drugs and their carriers. In this study, we developed a biomimetic nanosystem consisting of chemotherapeutic and immunotherapeutic agents wrapped in cell membranes. Specifically, the anti-tumor drug doxorubicin (DOX) was loaded into a bacterial-derived immunomodulatory agent (low molecular weight curdlan, lCUR), and the lCUR-DOX was further wrapped in the red blood cell membrane for camouflage and prolonged circulation. The successful preparation of the [email protected] nanosystem was supported by various optical and morphological characterizations. In vitro studies indicated that the nanosystem can escape uptake by macrophages, inhibit the invasion of tumor cells, and reprogram M2 macrophages with an immunosuppressive phenotype into M1 macrophages with an immunopromoting phenotype via the MAPK signaling pathway while promoting the phagocytosis of macrophages. In vivo studies showed that the nanosystem effectively inhibits tumor growth in the A-375 tumor-bearing mouse model. Taken together, the above results support further development of the [email protected] platform for cancer immunochemotherapy in clinical applications.
研究领域:
癌症治疗
·
纳米技术
·
免疫学
·
药理学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2020
·Vol. 49
·期 7
·2209-2217
·
IF 4.174
Wenyan Kong,Qi Wang,Guoying Deng,Hang Zhao,Linjing Zhao,Jie Lu,Xijian Liu
Photothermal therapy (PTT) is a promising treatment for tumors due to its efficiency and non-invasiveness. However, during the PTT treatment, reactive oxygen species (ROS) are produced in response to hyperthermia and thus harm the neighboring normal cells. In this work, a multifunctional theranostic agent (Se@SiO2@Au-PEG/DOX NCs) was exploited to solve this problem by introducing selenium, which can efficiently prevent normal cells from oxidative damage by scavenging reactive oxygen species during photothermal therapy. In addition, the Se@SiO2@Au-PEG/DOX nanocomposites (NCs) not only exhibited excellent properties of combined chemo-thermal synergistic therapy, but also showed no appreciable toxicity towards normal tissues due to the protective effect for continuous release of selenium. Thus, the fabricated Se@SiO2@Au-PEG/DOX NCs provide an integrated solution to overcome the limitations of selenium and PTT, and demonstrate great prospects as a safe and highly reliable theranostic agent.
研究领域:
癌症治疗
·
材料科学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2018
·Vol. 18
·期 12
·8070-8077
·
IF 1.354
Zhao Hongli,Sun Shanshan,Wang Zhaodong,Hong Yayun,Shi Lulu,Lan Minbo
In this work, a novel combination of drug therapy and cryotherapy for tumor treatment was developed. Pluronic F127 modified with poly(acrylic acid) at two terminals (denoted as PAA-PF127-PAA) was used as carriers for doxorubicin (DOX) delivery. Due to the pH-sensitive property endowed
by PAA, the DOX-loaded PAA-PF127-PAA micelles released DOX faster in the slightly acidic physiological environment of the tumor site than that in the neutral physiological environment. Three-group rats bearing Walker 256 carcinosarcoma were respectively treated with cryotherapy, combination
of DOX-loaded micelles and cryotherapy, and saline injection to investigate the effect of the combined therapy. The apoptosis rate of TdT-mediated dUTP nick-end labeling (TUNEL) slices indicated that compared with cryotherapy alone, the DOX-loaded PAA-PF127-PAA micelles combining with cryotherapy
showed increased apoptosis. Thus, the combination of drug therapy and cryotherapy can be used as an effective technique for tumor treatment.
研究领域:
肿瘤学
·
药学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2018
·
IF 3.997
Shujuan Xiong,Zhe Wang,Juan Liu,Xiangping Deng,Runde Xiong,Xuan Cao,Zhizhong Xie,Xiaoyong Lei,Yanming Chen,Guotao Tang
This work has presented a novel strategy for designing pH-sensitive TOS-H-DOX prodrug-loaded TPGS nanomicelles for co-delivery TOS and DOX to enhance tumor therapy and reduce the toxic side effects. DOX was covalently conjugated to the vitamin E succinate through hydrazone bond to produce an pH-sensitive prodrug TOS-H-DOX (amido bond as a control, TOS-A-DOX), which was responsive to the acidic environment in tumor cells, and the prodrugs were subsequently encapsulated in the core of TPGS nanomicelles via hydrophobic effects with a significant drug loading capacity. The pH-sensitive prodrug nanomicelles TOS-H-DOX/TPGS exhibited potent release of DOX in acidic media relative to the pH-insensitive prodrug nanomicelles TOS-A-DOX/TPGS, and further studies of their intracellular uptake and intracellular localization demonstrated that TOS-H-DOX/TPGS nanomicelles can be effectively taken up by cells and drugs can be released. In vitro results confirmed that TOS-H-DOX/TPGS nanomicelles exhibited significant antitumor cell proliferation activity compared to TOS-A-DOX/TPGS and free DOX, TPGS. Furthermore, in vivo studies further confirmed an excellent synergistic antitumor efficacy in MCF-7 tumor-bearing nude mice model. More importantly, the H&E staining of the heart, liver, kidney tissue sections of experimental nude mice showed that TOS-H-DOX/TPGS nanomicelles can reduce damage to them.
研究领域:
药学
·
纳米技术
·
癌症治疗
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Research
·
2020
·Vol. 14
·期 1
·222-231
·
IF 8.183
Zhu Huimin,Cao Guodong,Fu Yike,Fang Chao,Chu Qiang,Li Xiang,Wu Yulian,Han Gaorong
Multidrug resistance (MDR) restricts chemotherapy efficacy due to P-glycoprotein (P-gp) mediated drug efflux, whereas current approaches to suppressing P-gp expression suffer from intrinsic challenges, such as low transfection, high toxicity and poor specificity. Here, hollow ferric-tannic acid complex nanocapsules (HFe-TA), which can be effectively degraded by the reaction with adenosine triphosphate (ATP), are synthesized for the delivery of glucose oxidase (GOx) and doxorubicin (DOX) for tumor treatment. The findings indicate that the intracellular ATP is significantly decreased due to the combined effect of HFe-TA degradation and GOx-mediated glucose consumption. Along with this ATP down-regulation, P-gp expression of tumor cells is suppressed remarkably, which in turn promotes the intracellular accumulation and anticancer efficacy of DOX. In addition, the production of OH by Fe ions released from HFe-TA is promoted by the by-products of the oxidation of glucose process by GOx. In consequence, HFe-TA nanocapsules loaded with DOX and GOx enable significant inhibition effect to tumors both in vitro and in vivo due to the synergistic effect of cascade reactions. This study has therefore provided an alternative therapeutic platform for effective tumor inhibition with the potential in overcoming intrinsic MDR.
研究领域:
纳米技术
·
药学
·
癌症研究
·
生物医学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）