NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 42
·16478-16489
·
IF 3.069
Wenfang Liu,Bingqiang Wang,Haishuang Jia,Jun Wang,Youtao Song
Based on the esterification of 2-(2-hydroxyphenyl)benzothiazole (HBT) and a rare-earth metal ion complex EuIII-dtpa, a novel dual-excitation fluorescence probe, EuIII-dtpa-bis(HBT), was developed for the detection of hydrazine (N2H4). The structure of dtpa-bis(HBT) was characterized via FT-IR and NMR, and its optical properties were studied via UV-vis absorption and fluorescence spectroscopy. Influencing factors including solution acidity, interfering substances and N2H4 concentrations were considered for the detection of N2H4 using EuIII-dtpa-bis(HBT). EuIII-dtpa-bis(N2H4) and HBT emit significant fluorescence at 470 nm (λex = 270 nm) and 480 nm (λex = 325 nm), respectively. The detection limit of EuIII-dtpa-bis(HBT) with N2H4 was 0.283 μM (14 ppb) and 0.182 μM (9 ppb) upon excitation at 270 nm and 325 nm, which is close to and lower than the EPA standard (10 ppb), respectively. The mechanism for the detection of N2H4 by EuIII-dtpa-bis(HBT) was deduced from the experimental results and theoretical calculations. Also, cytotoxicity and cell imaging experiments of EuIII-dtpa-bis(HBT) were performed. The experimental results showed that the fluorescent probe EuIII-dtpa-bis(HBT) can be applied to detect N2H4 in aqueous solution and living cells.
研究领域:
分析化学
·
生物医学工程
·
环境科学
✓ 已验证
DOI
高影响因子
POLYHEDRON
·
2018
·
IF 2.067
Fuxian Wan,Lipeng Wang,Wenxin Xu,Changcheng Li,Ying Li,Chunbao Zhang,Lin Jiang
A novel dimeric gadolinium(III) complex, bis(4-Gd-DTPA-aminophenyl)adamantane ( 5 ), was successfully synthesized using bis(4-aminophenyl)adamantane to link two Gd-DTPA units. All the intermediates and bis(4-Gd-DTPA-aminophenyl)adamantane ( 5 ) have been characterized by 1 H NMR, 13 C NMR, ES-API-MS, HR-ESI-MS, FT-IR and elemental analysis (EA). The longitudinal relaxivity of bis(4-Gd-DTPA-aminophenyl)adamantane is 8.43 mM −1 Gd −1 s −1 at 0.43 T (32 °C, pH 7.0), and 4.89 mM −1 Gd −1 s −1 at 3.0 T (32 °C, pH 7.4). The T 1 -weighted imaging in vitro showed that bis(4-Gd-DTPA-acetylaminophenyl)adamantane can enhance the contrast of images distinctly. But most of all, the kinetic inertness of bis(4-Gd-DTPA-aminophenyl)adamantane ( 5 ) was comparable to that of [Gd(DTPA)(H 2 O)] 2− (Magnetvist®). Moreover, cytotoxicity tests indicated that the bis(4-Gd-DTPA-acetylaminophenyl)adamantane exhibited low toxicity to healthy liver cells (L-02 cells). These results demonstrate that the Gd(III) complex 5 may be a promising MRI contrast agent candidate.
研究领域:
医学影像学
·
化学
✓ 已验证
DOI
高影响因子
MAGNETIC RESONANCE IMAGING
·
2017
·
IF 2.225
Chuanling Wan,Youyang Zhan,Rong Xue,Yijie Wu,Xiaojing Li,Fengkui Pei
Objectives The purposes of this study were (1) to detect the dynamic metabonomic changes induced by gadopentetate dimeglumine (Gd-DTPA) and (2) to investigate the potential metabolic disturbances associated with the pathogenesis of nephrogenic systemic fibrosis (NSF) at the early stage. Methods A nuclear magnetic resonance (NMR)-based metabolomics approach was used to investigate the urinary and serum metabolic changes induced by a single tail vein injection of Gd-DTPA (dosed at 2 and 5 mmol/kg body weight) in rats. Urine and serum samples were collected on days 1, 2 and 7 after dosing. Results Metabolic responses of rats to Gd-DTPA administration were systematic involving changes in lipid metabolism , glucose metabolism , TCA cycle, amino acid metabolism and gut microbiota functions. Urinary and serum metabonomic recovery could be observed in both the 2 and 5 mmol/kg body weight group, but the metabolic effects of high-dosed (5 mmol/kg body weight) Gd-DTPA lasted longer. It is worth noting that hyperlipidemia was observed after Gd-DTPA injection, and nicotinate might play a role in the subsequent self-recovery of lipid metabolism. The disturbance of tyrosine , glutamate and gut microbiota metabolism might associate with the progression of NSF. Conclusion These findings offered essential information about the metabolic changes induced by Gd-DTPA, and could be potentially important for investigating the pathogenesis of NSF at the early stage. Moreover, the recovery of rats administrated with Gd-DTPA may have implications in the treatment of early stage NSF.
研究领域:
代谢组学
·
药理学
·
毒理学
·
肾病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Haijiao Jia,Xiao Zhang,Guirong Borjihan,Shengbo Yang,Youxin Li
Using ruthenium chloride as catalyst precursor, magnetic silicon spheres as support, 4-formylphenylboronic acid and ethylenediaminepentaacetic acid as functional ligands, a magnetic heterogeneous nano-ruthenium catalyst (Fe 3 O 4 @SiO 2 -FPBA-DTPA-Ru) was prepared for the first time. It was nano level with 20.17 emu/g saturation magnetic strength and thermal stability under 249.63 °C. Fe 3 O 4 @SiO 2 -FPBA-DTPA-Ru contained 0.38 mmol/g Ru and was successfully used to catalyze the oxidation reactions of 15 aromatic secondary alcohols. Results proved that Fe 3 O 4 @SiO 2 -FPBA-DTPA-Ru as catalyst had good catalytic activity for the oxidation of secondary aromatic alcohols with yields exceeding 90 % for 12 products and 95 % for 10 products. High TON and TOF values (6386 and 9158 h −1 ) in 1-phenylethanol oxidation were obtained. All the reactions of aromatic alcohols were carried out in a solvent-free system, so the prepared catalyst had the characteristics of green and pollution-free. It was’nt suitable for oxidation of aromatic primary alcohols. If there was steric hindrance around the hydroxyl group in substrate, the catalysis also may be limited. The Fe 3 O 4 @SiO 2 -FPBA-DTPA-Ru catalyst also exhibited the advantages of energy saving, satisfactory reusability and stability in 9 consecutive runs. It showed great potential for future large-scale industrial production.
研究领域:
化学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Yanjun Huang,Hailing Wu,Taikang Shao,Xia Zhao,Hong Peng,Yuefa Gong,Huihai Wan
A novel composite adsorbent of Ca-DTCS/ALG bead was prepared by immobilization of DTPA-modified chitosan micro-gels (DTCS) into the alginate matrix. The copper sorption properties of Ca-DTCS/ALG beads were tested and compared with the other two adsorbents of DTCS powder and plain alginate (ALG) beads. In addition, the mechanisms of copper sorption on the adsorbents were investigated by FTIR and XPS analysis. Similar to DTCS powder, Ca-DTCS/ALG beads exhibited high copper removal efficiency in strongly acidic solutions, whereas calcium, sodium and aluminum salts had little effect on its copper adsorption capacities. The maximum adsorption capacities of Ca-DTCS/ALG and DTCS were 107.5 and 106.0 mg g −1 at pH 3.0, respectively, which were close to the values predicted by the Sips model. However, the maximum adsorption capacity of ALG beads predicted by the Sips model was much higher than its experimental one (101.1 mg g −1 ). The copper adsorption equilibrium by DTCS powder was achieved within 1 min, nevertheless, ALG and Ca-DTCS/ALG gel beads reached the adsorption equilibrium within 500 min and 1440 min, respectively. Moreover, Ca-DTCS/ALG gel beads showed good reusability, but DTCS powder was not easily reused due to its notable swelling property. Furthermore, the efficiency of copper recovery by Ca-DTCS/ALG beads in the simulated electroplating wastewater at the copper concentration of 1–5 mg L −1 was much higher than that of DTCS and ALG beads. These results reveal that immobilization of DTCS into the alginate matrix greatly improves the adsorption and separation performance of the adsorbent.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 6
·5569-5576
·
IF 1.338
Li Qinqin,Li Chenglin,Tong Weijun
Here, a novel poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NPs) for magnetic resonance (MR) and fluorescence imaging was developed for cell imaging. PLGA NPs loaded with fluorescent dye Nile red (NR) and surface-coated with poly(ethyleneimine) (PEI) were produced in a single
step nanoprecipitation process. Diethylenetriamine pentaacetic dianhydride (DTPA) was conjugated to PLGA/NR@PEI NPs through amidation reaction between –COOH of DTPA and –NH2 of PEI, which can chelate gadolinium (Gd3+) as an MR imaging contrast agent. The PLGA/NR@PEI-DTPA-Gd
NPs exhibited a uniform particle size of ∼200 nm and were stable in culture medium. These NPs had a high T
1 relaxivity (R
1) of 28.36 mM−1S−1. They did not introduce serious cytotoxicity against A549 lung cancer cells.
Furthermore, fluorescence and MR imaging studies on A549 lung cancer cells in vitro revealed that PLGA/NR@PEI-DTPA-Gd NPs can serve as an efficient fluorescence/MR dual-modality imaging nanoprobe.
研究领域:
纳米技术
·
生物医学工程
·
材料科学
·
医学成像
·
癌症研究
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Yaoyao Huang,Huaili Zheng,Xuebin Hu,Yuyang Wu,Xiaohui Tang,Qiang He,Shangyu Peng
Simultaneously removing heavy metal and dye from complex wastewater is of great significance to industrial wastewater treatment . Herein, a novel magnetic adsorbent, DTPA-modified chitosan-coated magnetic silica nanoparticle (FFO@Sil@Chi-DTPA), was successfully prepared and used to enhance the Pb(II) selective adsorption from multi-metal wastewater based on anion-synergism. In the competitive experiment conducted in a multi-ion solution, the type of selective adsorption of metals was changed by the adsorbents before and after amidation, in which FFO@Sil@Chi-DTPA exhibited an excellent selectively for capturing Pb(II), while FFO@Sil@Chi demonstrated highly selective adsorption of silver. More importantly, the selective adsorption of Pb(II)S by FFO@Sil@Chi-DTPA was enhanced from 111.71 to 268.01 mg g −1 when the coexisting MB concentrations ranged from 0 to 100 mg L −1 at pH 6.0. In the Pb(II)-MB binary system, Pb(II) and MB exhibited a synergistic effect, in which the presence of MB strengthened the adsorption effect of Pb(II) due to the sulfonic acid groups in MB molecules that create new specific sites for Pb(II) adsorption, while MB adsorption was also enhanced by the presence of Pb(II). This work provides a new strategy for exploring novel adsorbents that can enhance the selective removal of heavy metal in complex wastewater based on anion-synergism.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 32
·18061-18077
·
IF 4.22
Xi Jufang,Zhang Liyun,Zheng Wenting,Zeng Qingle,He Yi,He Ze,Chen Jingyu
Highly efficient adsorbents, which can effectively remove both metal ions and dyes from wastewater with robust stability, are strongly required for the remediation of current polluted aqueous system, but still a challenge to be realized. Herein, a new adsorbent has been designed to solve this problem by anchoring diethylene triamine pentaacetic acid (DTPA) grafted polyethyleneimine (PEI) onto carboxylated GO (GOC-g-PD). Given the amino and carboxyl active groups from PEI and GOC/DTPA, our GOC-g-PD displays good adsorption capacity against not only inorganic metal ions (Cu 2+ and Pb 2+ ) but also organic dye (methylene blue: MB). The maximum adsorption capacity of GOC-g-PD for Cu 2+ , Pb 2+ and MB reached 309.60 mg·g −1 , 316.17 mg·g −1 and 262.10 mg·g −1 , respectively. Furthermore, our GOC-g-PD also exhibits good cycling stability and chemical stability against wide pH values. These outstanding properties revealed our GOC-g-PD held great potential in purifying the sewage discharged from industries. Graphical abstract
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2020
·
IF 3.333
Jiahong Wang,Min Mao,Saleem Atif,Yao Chen
The presence of widely used chelating agents such as ethylenediaminetetraacetic acid (EDTA) in aqueous solution increases the difficulty of heavy metal removal by the formation of heavy metal chelates. In this study, diethylenetriaminepentaacetic acid (DTPA)-chitosan functionalized magnetic silica (Fe 3 O 4 @SiO 2 /Cs-DTPA) was developed for the removal of Cr(III) and Cr(III)-EDTA. The obtained results from characterization confirmed that Fe 3 O 4 @SiO 2 /Cs-DTPA with the core-shell structure and superparamagnetic properties was synthesized. The maximum theoretical adsorption capacity of Cr(III) and Cr(III)-EDTA chelates on the adsorbents were 39.27 and 22.24 mg/g at 25 °C and pH 4.0, respectively. Adsorption equilibrium of Cr(III) and Cr(III)-EDTA on Fe 3 O 4 @SiO 2 /Cs-DTPA was achieved within 15 min, and the adsorption data fit the pseudo second-order model. The co-existing complex agents (EDTA) and cations (Na + , Ca 2+ , and Mg 2+ ) in the aqueous solution reduced Cr(III) adsorption by the competition with Cr(III) and Cr(III)-EDTA chelate for active groups of the adsorbent. The affinity of the Fe 3 O 4 @SiO 2 /Cs-DTPA for Cr(III) and Cr(III)-EDTA was excellent even at high salt and organic chelates concentration. The Cr(III) adsorption was attributed to surface complexation between Cr(III) and DTPA moieties of the adsorbent, while Cr(III)-EDTA as a whole was adsorbed on the adsorbent by the complexation and electrostatic interaction . Cr(III) saturated Fe 3 O 4 @SiO 2 /Cs-DTPA can be readily regenerated in acid solution and Cr(III) or Cr(III)-EDTA adsorption of regenerated adsorbent exhibits no obvious reduce.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Liang Zhang,Chao Nie,Yi Zhang,Chuan-Chuan Liu,Hui Jiang,Ling-Hu Cai,Yao Xiao,Rong Li,Ming-Hua Liu
After a nuclear accident, radioactive nuclides are rapidly absorbed through wounds into the body, causing serious internal radiation injury. In this study, we synthesized chitosan methacryloyl (CSMA) and graft-modified it with the broad-spectrum chelating agent diethylenetriamine pentaacetate (DTPA) to prepare a DTPA-modified chitosan hydrogel dressing (CSMA-g-DTPA). The compounds and hydrogels were examined for their physical and chemical properties and their biological safety was verified. The effectiveness of CSMA-g-DTPA dressings for early decontamination and promotion of wound healing was evaluated in vivo. The results indicated that CSMA-g-DTPA exhibits good mechanical properties and swelling behavior as well as excellent biocompatibility. In vitro experiments revealed that CSMA-g-DTPA is capable of removing uranium and strontium. In vivo experiments demonstrated that the CSMA-g-DTPA hydrogel can decontaminate radioactive Sr-89 and U-238 from rat skin wounds, prevent the absorption of Sr-89 and U-238 through the wounds and alleviate oxidative stress and inflammatory responses in the wounds, thereby promoting wound healing. Overall, the DTPA-modified chitosan hydrogel dressing has good mechanical performance, biosafety and decontamination effects on strontium and uranium. It has potential applications for emergency decontamination of wounds during the early stages of a nuclear disaster.
研究领域:
材料科学
·
生物医学工程
·
辐射防护
·
伤口愈合
·
核医学
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2013
·Vol. 20
·期 2
·849-860
·
IF 3.476
Duan Chunting,Zhao Ning,Yu Xiaolan,Zhang Xiaoyan,Xu Jian
Kapok fiber, a natural hollow fiber with thin shell and large cavity, has rarely been used as adsorbent for heavy metal ions. In this paper, kapok fibers were modified with diethylenetriamine pentaacetic acid (DTPA) after hydrophilicity treatment. The adsorption behavior of the resultant kapok-DTPA influenced by pH, adsorption time and initial concentration of metal ion was investigated. The results demonstrate that adsorption equilibrium was reached within 2 min for Pb 2+ and Cd 2+ . Adsorption kinetics showed that the adsorption rate was well fitted by pseudo-second-order rate model. The adsorption isotherms were studied, and the best fit was obtained in the Langmuir model. The maximum adsorption capacities of kapok-DTPA were 310.6 mg g −1 for Pb 2+ , 163.7 mg g −1 for Cd 2+ , 101.0 mg g −1 for Cu 2+ , respectively. After eight desorption and re-adsorption loops, the lost adsorption capacities for Pb 2+ and Cu 2+ were less than 10 %. Because of the large specific area derived from the hollow fiber structure, kapok-DTPA exhibited much better adsorption capacity compared with many other reported adsorbents based on natural materials.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
WATER AIR AND SOIL POLLUTION
·
2018
·Vol. 229
·期 4
·1-10
·
IF 1.769
Dai Ying,Lv Riwen,Huang Dejuan,Tao Qinqin
Humic acid (HA) plays an important role in the migration and transformation of uranium in natural waters. To effectively remove uranium in the presence of HA, a bifunctional polymer, diethylenetriaminepentaacetic acid cross-linked β -cyclodextrin (DTPA- β -CD), was synthesized by polycondensation reaction. The sorption performance of DTPA- β -CD in functions of pH, ionic strength, contact time, initial time, and temperature were explored batch wise. Experimental results showed that DTPA- β -CD could concurrently sorb uranium and HA around pH of 3.0. The sorption strongly depended on pH and on ionic strength, demonstrating outer-sphere surface complex in nature. Two sorption kinetics well followed pseudo-second-order model. Sorption isotherm accorded with Sips model. Increasing temperature facilitated uranium and restrained HA sorption. This work demonstrated that DTPA- β -CD was a promising material for sorbing uranium in the presence of HA.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）