Systems
·
2022
·Vol. 10
·期 1
·16
·
IF 2.895
Chunmei Zhang,Ziwen Feng,Qilong Ren,Wei-Lng Hsu
Ecological land has two definitions: the broad category and the narrow category. This paper studied the narrow category, which refers to the land whose main purpose is to provide ecological services, such as environmental regulation and biological conservation. Ecological land areas are likely to decrease with the development of urbanisation all over the world, which poses potential risks to the environment, society, and public health, and low utilisation efficiency of ecological land will exacerbate this risk. Based on the actual input–output situation of ecological land utilisation, we constructed an index system in the Yangtze Delta to measure the ecological land utilisation efficiency with a Slack-Based Model (SBM) in the data envelopment analysis (DEA). The results revealed that the comprehensive efficiency exhibited an increasing trend from 2012 to 2020, and more high-efficiency cities appeared in the areas closer to Shanghai. Both the technical efficiency and scale efficiency increased over the research period. The technical efficiencies in most cities were efficient and equal to the scale efficiencies. Among the remaining cities, the technical efficiencies and scale efficiencies were inefficient and not synchronous. In addition, we found that the that poor efficiencies of some cities can mainly be attributed to low-technology, an unsuited-scale, or a combination of these. In the future, improvement should be focused on the economical and intensive use of ecological land, technical innovations, and the optimal scale. The present results can provide references for making scientific decisions regarding the efficient utilisation of ecological land in the Yangtze Delta and other similar rapid-urbanization areas.
研究领域:
环境科学
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城市规划
·
系统建模
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可持续发展
·
土地利用管理
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高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2026
·
IF 4
Hongmei Wang,Bo Lei,Xinyu Bao,Xiaobin Gu,Jing Xia,Yong Huang,Huaqiao Tang,Fei Shi,Xing Huang,Bo liang,Jing Xu
Scabies (or Sarcoptic mange) is a highly contagious skin disease caused by the ectoparasite Sarcoptes scabiei. The resistance of S. scabiei to common acaricides like permethrin has been reported, yet their precise mechanisms remain elusive. Glutathione S-Transferase (GSTs) constitute an important class of detoxification enzymes. In this study, we found that the expression levels of SsGSTd3 and SsGSTd5 in S. scabiei were significantly up-regulated after exposure to LC 30 of permethrin, amitraz, and selamectin, suggesting that SsGSTd3 and SsGSTd5 are involved in the detoxification of these acaricides. Therefore, we used in vitro metabolic assay and bacterial survival assays to further investigate their specific detoxification mechanisms. Co-incubation with the acaricides reduced the 1-Chloro-2,4-dinitrobenzene (CDNB) activities of both recombinant proteins to varying degrees. HPLC analysis revealed that SsGSTd3 and SsGSTd5 metabolized 35.24% and 53.28% of permethrin, respectively, but did not metabolize amitraz. SsGSTd3 metabolized a small fraction of selamectin (3.25%). In addition, bacterial survival assays demonstrated that under oxidative stress induced by CHP and H 2 O 2 , the OD 600 values of E. coli overexpressing SsGSTd3 or SsGSTd5 were significantly higher than those of control group, indicating robust antioxidant activity for both proteins. In conclusion, our findings demonstrate that SsGSTd3 and SsGSTd5 facilitate permethrin detoxification via a dual mechanism—metabolic and alleviation of oxidative stress, and may represent an early warning sign of decreased susceptibility to amitraz and selamectin through their antioxidant functions.
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Remote Sensing
·
2021
·Vol. 13
·期 7
·1235
·
IF 4.848
Min Yu,Shan Guo,Yanning Guan,Danlu Cai,Chunyan Zhang,Klaus Fraedrich,Zhouwei Liao,Xiaoxin Zhang,Zhuangzhuang Tian
The long-term changes of the relationship between nighttime light and urbanization related built-up areas are explored using nighttime light data obtained from the Defense Meteorological Satellite Program/Operational Linescan System (DMSP/OLS, data before 2013) and the Suomi National Polar-orbiting Partnership Visible Infrared Imaging Radiometer Suite (NPP/VIIRS, data after 2012) and information of the spatiotemporal heterogeneity of urban evolution. This study assimilates two datasets and diagnoses the spatial heterogeneity in administrative city scale based on built-up area tendencies, temporal heterogeneity in pixel scale based on nighttime light intensity tendencies, and GDP associated spatiotemporal variability over the Yangtze River Delta comparing the first two decades of this century (2001–2010 versus 2011–2019). The analysis reveals the following main results: (1) The built-up areas have generally increased in the second period with the center of fast expansion moving southward, including Suzhou-Wuxi-Changzhou, Hangzhou, Ningbo, Nanjing, and Hefei. (2) Urban development in the original city core has saturated and is spilling over to the suburbs and countryside, leading to nighttime light intensity tendency shift from a “rapid to moderate” and a “moderate to rapid” development (a “hot to cold” and a “cold to hot” spatial clustering distribution). (3) The tendency shifts of built-up area and nighttime light intensity occur most frequently in 2010, after which the urban development is transforming from light intensity growth to built-up area growth, particularly in the developed city cores. The urban agglomeration process with nighttime light intensity reaching saturation prior to the urban development spreading into the surrounding suburbs and countryside, appears to be a suitable model, which provides insights in addressing related environmental problems and contribute to regional sustainable urban planning and management.
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高影响因子
Journal of Energy Storage
·
2026
·
IF 10.7
Qingyun Ma,Wenjing Cui,Jiamei Liu,Junshe Zhang
As promising electrode materials for pseudocapacitors, perovskite-typed oxides have been widely investigated because of their excellent electrochemical stability, high energy storage capacity, and fast charge/discharge rate. Herein, we investigated the intercalation/deintercalation behaviors of oxygen anions in porous polyhedral SrFeO 3- δ particles that were prepared by a hard-templating method. The hydrothermally synthesized Sr 3 Fe 2 (OH) 12 transformed into a solid dispersion in which SrCO 3 is embedded in the perovskite matrix after thermal treatment in air. By removing carbonate by acid leaching, porous polyhedral particles were obtained. The porous perovskite ( δ = 0.04) has a specific surface area of 35.8 m 2 /g and the average particle size is around 2.6 μm. The electrochemical energy storage was evaluated in a three-electrode system. In 1 M aqueous KOH solution, the fresh sample exhibits a specific capacitance of 438 F/g at a scan rate of 2 mV/s. After subtracting the contribution of the electric double-layer contribution, the specific capacity is 581C/g that approximately corresponds to a change of one in the average valence state of bulk iron (Fe 4+ ↔Fe 3+ ). The intercalation/deintercalation processes are governed by the diffusion of oxygen ions (O 2− ) in solids, which most likely evolve from/into free hydroxide ions (OH − ) via ⁎ OH − ↔ ⁎ OOH − ↔ ⁎ O − ↔O int 2− at the electrode-electrolyte interface. In the cycling stability test, the specific capacitance first decreased and then quickly stabilized, which was also observed for a non-porous SrFeO 3- δ in 1 M aqueous KOH solution and the porous one in 1 M K 2 CO 3 aqueous solution. The porous one in 1 mol/L K 2 CO 3 aqueous solution, likely arising from a gradual increase in the average oxidation state of iron at the end of deintercalation during initial charge/discharge cycles.
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高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Jian Li,Fei Pan,Yurou Yun,Jun Tian,Linyan Zhou
In this study, the physicochemical properties of pectin from Nicandra physalodes (Linn.) Gaertn. seeds (NPGSP) were analysed firstly, and the rheological behavior, microstructure and gelation mechanism of NPGSP gels induced by Glucono–delta–lactone (GDL) were investigated. The hardness of NPGSP gels was increased from 26.27 g to 226.77 g when increasing GDL concentration from 0 % (pH = 4.0) to 1.35 % (pH = 3.0), and the thermal stability was improved. The peak around 1617 cm −1 was decreased as the adsorption peak of the free carboxyl groups was attenuated with addition of GDL. GDL increased the crystalline degree of NPGSP gels, and its microstructure exhibited more smaller spores . Molecular dynamics was performed on systems of pectin and gluconic acid (GDL hydrolysis product), indicating that inter–molecular hydrogen bonds and van der Waals forces were the main interactions to promote gels formation. Overall, NPGSP has the potential commercial value for developing as a thickener in food processing.
研究领域:
食品科学
·
生物化学
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PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 16
·48248-48259
·
IF 5.8
Pan Zewen,Tang Changyuan,Cao Yingjie,Xuan Yingxue,Zhou Qianyi
The sources and distribution characteristics of three phenolic endocrine-disrupting compounds (EDCs), e.g., alkylphenols (APs) (including nonylphenols (NPs) and 4-t-octylphenol (OP)) and Bisphenol A (BPA), were investigated in the rivers of the Pearl River Delta Region (PRDR) with complex land-use types. The mean concentrations of NPs, OP, and BPA in river water including wet and dry seasons were 87, 6, and 74 ng/L in the agricultural regions ( n = 10), 135, 7, and 61 ng/L in the transitional regions ( n = 8), and 249, 15, and 152 ng/L in the urban regions ( n = 28). Contents of NPs and BPA were high in the river sediments (ranged from 7 to 3048 ng/g and 2 to 271 ng/g, respectively). Equilibrium analysis results suggested that sediment release was not the main source of the river EDCs. Principal component analysis (PCA) showed that sewage was the major source of EDCs in the dry season, while the leaching effect of rainfall on the agricultural soils, urban roads, and commercial products was an important source in the wet season. Furthermore, the ratio of APs and total concentration of phenolic EDCs (ΣEDCs) was used to characterize the agricultural regions and urban regions in the PRDR. The ratio was less than 0.6 in the agricultural regions while the ratio was large than 0.6 in the dry season and less than 0.6 in the wet season in urban regions. BPA and NPs in transitional region and urban region had small/medium potential risk to aquatic organisms.
研究领域:
环境科学
·
化学工程
·
水资源管理
·
生态毒理学
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PubMed
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-14
·
IF 3.8
He Keting,Wei Dongfan,Liu Qiuhong,Liu Xiaoli,Zhou Diwenxin,Chen Shangci,Zhu Danhua,Xu Xiaowei
Acute liver injury (ALI) presents a challenging problem worldwide, prompting extensive research efforts. Cellular senescence has been found to be induced following ALI, and targeting cellular senescence has shown therapeutic potential. Therefore, understanding the expression of senescence-related genes in ALI can help to explore pathogenesis and treatment of this common disease. Carbon tetrachloride (CCl 4 ) is commonly used to study ALI. Although polymerase chain reaction (PCR) is a convenient and economical molecular biology technique widely used in basic medicine, research on selecting suitable reference genes to obtain objective and reproducible PCR data is scarce. Moreover, evidence supporting the choice of reference genes for experimental studies of CCl4-induced ALI and hepatic senescence in mice is limited. In this study, we obtained murine livers at four time points (0, 12, 24, and 48 h) following CCl4 treatment. We used five algorithms (geNorm, BestKeeper, NormFinder, delta Ct, and RefFinder) to rank 12 candidate genes in real-time reverse-transcription quantitative PCR (RT-qPCR) experiments. Focusing on cellular senescence in this model, we adopted four senescence-associated secretory phenotype (SASP) genes ( Il6 , Il1b , Ccl2 , and Ccl5 ) as target genes. Our results confirmed Gapdh and Tbp as suitable reference genes in murine CCl 4 -induced ALI models. Furthermore, we provide a table of published studies recommending reference genes for various liver disease models. This study provides a valuable reference for enhancing the reliability and reproducibility of ALI molecular findings.
研究领域:
分子生物学
·
肝病学
·
病理学
·
基因组学
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PubMed
高影响因子
Water
·
2019
·Vol. 11
·期 10
·2036
·
IF 2.524
Steven G. Pueppke,Wangshou Zhang,Hengpeng Li,Dongqiang Chen,Weixin Ou
Rapid economic development and population growth in China’s Yangtze River Delta (YRD) are exerting significant environmental pressure on the region’s land and water, especially in hilly areas where many drinking water reservoirs have been constructed. These areas, which are characterized by steep slopes and thin soils, provide critical services, including flood control, water resource supply, food production, and recreational opportunities for nearby highly developed and heavily populated areas of the delta. We contrast two of these areas—the well-studied Tianmu Lake watershed and the much larger Qiandao Lake watershed. Both face similar challenges from nitrogen and phosphorus pollution due to rapid socio-economic development, but differences in watershed size and distinctions related to political boundaries influence the range of approaches available to maintain water quality. We review experiences of controlling nutrient pollution in these watersheds as case studies, and based on that information, propose an integrated framework to minimize nitrogen and phosphorus pollution in similarly challenged watersheds. The framework, which is designed to be generalizable rather than prescriptive, emphasizes source control, delivery interception, and fate management of nutrients.
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高影响因子
NEUROPHARMACOLOGY
·
2022
·
IF 5.273
Ji Chuan Zhou,Jian Bo Jiang,Han Guo,Su Rong Yang,Chun Feng Liu,Wei Min Qu,Zhi Li Huang,Feng Fei Ding
Both human and rodent studies suggest the link between non-rapid eye movement (NREM) sleep and cognition. Recent study indicated that selective activation of cholinergic neurons in basal forebrain inhibits electroencephalogram (EEG) delta power and shortens NREM sleep. In the current study, we aimed to test the pharmacological effect of trihexyphenidyl (THP), a selective muscarinic M1 receptor antagonist, on EEG power spectra and sleep with or without the selective activation of basal forebrain cholinergic neurons. THP (1, 2, and 3 mg/kg) was administrated intraperitoneally in natural sleep phase. Basal forebrain cholinergic neurons expressing modified G protein-coupled muscarinic receptors (hM3Dq) were activated by intraperitoneal injection of clozapine- N -oxide in ChAT-IRES-Cre mice. EEG and electromyogram (EMG) signals were recorded in freely moving mice to analyze EEG power spectrum and sleep hypnogram. Y-maze and novel object recognition tests were used for testing cognition. THP 1 mg/kg significantly increased EEG delta power and facilitated NREM sleep in wildtype mice, while THP 3 mg/kg was required in ChAT-IRES-Cre mice treated with clozapine- N -oxide. THP with dosage up to 8 mg/kg did not induce cognitive impairments in wildtype mice. EEG delta power of NREM sleep is often used as an indicator of sleep depth or sleep quality, which tightly link with sleep-dependent cognition. Taken together, the data collected from rodents hinted that, THP could possibly be used as the NREM sleep facilitator in humans.
研究领域:
神经科学
·
药理学
·
睡眠研究
·
认知科学
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DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2018
·
IF 3.974
Yuandan Ma,Yuqiong Tang,Hao Xu,Xiuying Zhang,Hongling Liu,Shanqian Wang,Wuting Zhang
The bulk depositions of trace metals to three land uses in the Yangtze River Delta are investigated based on the collected 154 precipitation samples from August 2015 to May 2017. The volume-weighted mean (VWM) concentrations of Ni, Cu, Zn, Cd, and Pb were 13.28, 5.32, 13.02, 0.33, and 10.53 μg L −1 , and 12%, 16%, 3%, 11%, and 26% of precipitation events exceeded the limits in the Central Drinking-Water Source Area (GB3838-2002), respectively. Furthermore, the five metals varied significantly under urban, industrial, and rural land use conditions, indicating that these metal concentrations were greatly determined by local sources; lower concentrations were found in sea and local air masses than in air masses from inland trajectories. Combining the precipitation amounts, the bulk deposition fluxes of the five metals were 25.99, 25.47, 20.60, 10.40, 0.64 mg m −2 yr −1 . By comparing the metal deposition fluxes in 98 studies across China, Ni and Pb deposition in the Yangtze River Delta was higher, while that of Cd and Zn was lower than their respective averages across China, indicating that Ni and Pb pollution should receive more attention in the study area. Capsule Bulk/wet deposition fluxes of trace metals varied greatly among rural, industrial, and urban areas, and Pb and Ni showed severe pollution levels in the Yangtze River Delta.
研究领域:
环境科学
·
大气化学
·
污染研究
·
环境监测
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DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Chengjie Huang,Xiao Zhi,Tianbao Ye,Xiuyuan Wang,Ke Li,Yiyang Li,Qiang Zhang,Lai Jiang,Xianting Ding
Vaccination is essential for preventing and controlling infectious diseases, along with reducing mortality. Developing safe and versatile adjuvants to enhance humoral and cellular immune responses to vaccines remains a key challenge in vaccine development. Here, we designed hierarchical mesoporous MOF-801 (HM801) using a Cocamidopropyl betaine (CAPB) and a Pluronics F127 in an aqueous phase system. Meanwhile, we synthesized a novel SARS-CoV-2 nanovaccine (R@M@HM801) with a high loading capacity for both the STING agonist (MSA-2) and the Delta receptor binding domain (Delta-RBD) antigen. R@M@HM801 enhanced MSA-2 and RBD utilization and effectively co-delivered MSA-2 and RBD antigens to antigen-presenting cells in the draining lymph nodes, thereby promoting the activation of both T and B cells. Lymphocyte single-cell analysis showed that R@M@HM801 stimulated robust CD11b + CD4 + T cells, CXCR5 + CD4 + T follicular helper (T fh ), and durable CD4 + CD44 + CD62L − , CD8 + CD44 + CD62L − effector memory T cell (T EM ) immune responses, and promoted the proliferative activation of CD26 + B cells in vivo. Meanwhile, R@M@HM801 induced stronger specific antibodies and neutralization of pseudovirus against Delta compared to the RBD + MAS-2 and RBD + MAS-2 + Alum vaccines. Our study demonstrated the efficacy of a hierarchical mesoporous HM801 and its potential immune activation mechanism in enhancing adaptive immune responses against viruses and other diseases.
研究领域:
免疫学
·
病毒学
·
药学
·
纳米技术
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PubMed
高影响因子
MARINE POLLUTION BULLETIN
·
2025
·
IF 4.9
Hao-jie Zheng,Xu-feng Wang,Ye-ni Zhang,Chao-ping Hou,Ke Huang
Diazepam (DIAZ), a widely prescribed benzodiazepine for insomnia and anxiety, has been frequently detected in aquatic ecosystems, raising concerns about potential impacts on human and animal health. To investigate its environmental presence, water and sediment samples were collected from 187 aquaculture ponds across the Pearl River Delta, China. The concentrations of DIAZ and its metabolites—nordazepam (NDZ), oxazepam (OXZ), and temazepam (TEM)—were determined using ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS). Detection frequencies in water ranged from 0.535 % to 58.8 %, with concentrations from below detection (nd) to 392 ng·L −1 , whereas in sediments, frequencies ranged from 1.07 % to 35.8 %, with levels from nd to 1.66 μg·kg −1 . Marked spatial variability was evident, with aquaculture ponds in Foshan (FS) exhibiting the highest DIAZ concentration (392 ng·L −1 ), while Zhongshan (ZS) displayed higher detection frequencies but lower concentrations. Fish ponds contained significantly greater cumulative concentrations of DIAZ and its metabolites compared with shrimp ponds. Strong positive correlations were identified between DIAZ in water and DIAZ and NDZ in sediments. Similarly, NDZ in water was strongly correlated with NDZ and DIAZ in sediments, and TEM in water showed significant correlations with DIAZ and NDZ in sediments. Environmental risk assessment revealed that NDZ and OXZ presented low ecological risks in both matrices at all sites, whereas DIAZ and TEM posed medium to high risks at certain water sites, with DIAZ also showing medium risks in some sediments. The study provides an integrated evaluation of occurrence, spatial distribution, and ecological risks of DIAZ and its metabolites in aquaculture systems, offering critical evidence to support food safety measures and strategies for pharmaceutical pollution control in the Pearl River Delta.
研究领域:
环境科学
·
药物代谢
·
生态毒理学
·
水生生态系统
·
环境污染
·
食品安全
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）