BIOMACROMOLECULES
·
2023
·
IF 6.2
Tao Wang,Haowei Fang,Subate Yalikun,Jinyan Li,Yuqing Pan,Kunxi Zhang,Jingbo Yin,Haiyan Cui
Developing strong anti-inflammatory wound dressings is of great significance for protecting inflammatory cutaneous wounds and promoting wound healing. The present study develops a nanocomposite Pluronic F127 (F127)-based hydrogel dressing with injectable, tissue adhesive, and anti-inflammatory performance. Briefly, Ce3+/tannic acid/ulinastatin nanoparticles (Ce3+/TA/UTI NPs) are fabricated. Meanwhile, α-lipoic acid is bonded to the ends of F127 to prepare F127-lipoic acid (F127LA) and its nanomicelles. Due to the gradual viscosity change instead of mutation during phase transition, the mixed Ce3+/TA/UTI NPs and F127LA nanomicelles show well-performed injectability at 37 °C and can form a semisolid composite nanohydrogel that can tightly attach to the skin at 37 °C. Furthermore, ultraviolet (UV) irradiation without a photoinitiator transforms the semisolid hydrogel into a solid hydrogel with well-performed elasticity and toughness. The UV-cured composite nanohydrogel acts as a bioadhesive that can firmly adhere to tissues. Due to the limited swelling property, the hydrogel can firmly adhere to tissues in a wet environment, which can seal wounds and provide a reliable physical barrier for the wounds. Ce3+/TA/UTI NPs in the hydrogel exhibit lipopolysaccharide (LPS)-scavenging ability and reactive oxygen species (ROS)-scavenging ability and significantly reduce the expression of inflammatory factors in wounds at the early stage, accelerating LPS-induced wound healing.
研究领域:
材料科学
·
医学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2017
·
IF 4.3
Xiaoyan Wu,Weihong Ge,Tengfei Shao,Weijun Wu,Jian Hou,Li Cui,Jing Wang,Zhenghai Zhang
Biochanin A (BCA), a natural dietary isoflavone, has been reported to show anticancer activities. However, its low biological availability and poor aqueous solubility limit its usefulness as a chemotherapeutic agent. We developed BCA-loaded micelles with Pluronic F127 and Plasdone S630 (BCA-FS). The optimized, spherical-shaped BCA-FS was obtained at a ratio of 1:1 (F127:S630). The particle size was 25.17±1.2 nm, and the zeta potential was −10.9±0.24 mV. BCA solubility in water increased to 5.0 mg/mL after encapsulation, and the drug-loading efficiency was 5.88%±0.76%. In vitro release experiments showed a delayed release of BCA from the mixed micelles. Furthermore, the BCA absorption permeability across a Caco-2 cell monolayer from the apical side to the basolateral side increased by 54% in BCA-FS. A pharmacokinetics evaluation showed a 2.16-fold increase in the relative oral bioavailability of BCA-FS compared with raw BCA, indicating that the mixed micelles may promote absorption in the gastrointestinal tract. A gastrointestinal safety assay was used to assess the reliability and safety of BCA-FS. On the basis of these findings, we conclude that this simple nanomicelle system could be leveraged to deliver BCA and other hydrophobic drugs.
研究领域:
药剂学
·
肿瘤学
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2012
·
IF 1.289
Chun-Hui Du,Chun-Jin Wu,Li-Guang Wu
Amphiphilic copolymer Pluronic F127 was used as macromolecular additive to investigate the polymorphism and thermoresponsive properties of poly(vinylidene fluoride) (PVDF) membranes. Fourier transform infrared spectrometer (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were conducted to characterize the polymorphism and morphology of PVDF/F127 blend membranes. FTIR results indicated that F127 existed stably in the blend membranes, and lower F127 concentration in the cast solution was in favor of the formation of α-crystal phase, but higher F127 concentration could promote the formation of β- and γ-crystal phase in PVDF membranes. The results of XRD also confirmed these phenomena. With the increase of F127 in the cast solutions, a more sponge-like structure appeared at the bottom surface of the membranes as investigated by SEM. PVDF/F127 blend membranes also exhibited good thermoresponsive properties. The water flux of the membranes increased distinctly with the increase of the experimental temperature, decreased with the decrease of the temperature, and the increasing and decreasing curves were almost overlapped. Contact angle measurement and permeation experiment indicated that the blend membranes had good hydrophilicity and fouling resistance. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
研究领域:
材料科学
·
高分子化学
·
膜技术
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2013
·
IF 2.404
Yong-Yong Li,Lan Li,Hai-Qing Dong,Xiao-Jun Cai,Tian-Bin Ren
PKKKRKV (Pro-Lys-Lys-Lys-Arg-Lys-Val, PV7), a seven amino acid peptide, has emerged as one of the primary nuclear localization signals that can be targeted into cell nucleus via the nuclear import machinery. Taking advantage of chemical diversity and biological activities of this short peptide sequence, in this study, Pluronic F127 nanomicelles engineered with nuclear localized functionality were successfully developed for intracellular drug delivery. These nanomicelles with the size ~ 100 nm were self-assembled from F127 polymer that was flanked with two PV7 sequences at its both terminal ends. Hydrophobic anticancer drug doxorubicin (DOX) with inherent fluorescence was chosen as the model drug, which was found to be efficiently encapsulated into nanomicelles with the encapsulation efficiency at 72.68%. In comparison with the non-functionalized namomicelles, the microscopic observation reveals that PV7 functionalized nanomicelles display a higher cellular uptake, especially into the nucleus of HepG2 cells, due to the nuclear localization signal effects. Both cytotoxicity and apoptosis studies show that the DOX-loaded nanomicelles were more potent than drug nanomicelles without nuclear targeting functionality. It was thus concluded that PV7 functionalized nanomicelles could be a potentially alternative vehicle for nuclear targeting drug delivery.
研究领域:
药学
·
纳米技术
·
癌症研究
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2025
·
IF 5.7
Yingchong Chen,Wenhui Hu,Lizhen Huang,Yuling Liu,Fang Li,Haibin Zou,Pengfei Yue
In glioma treatment, the poor penetration of therapeutic drugs through the blood–brain barrier (BBB) to the tumor region, along with the intrinsic resistance of glioma cells via multiple survival mechanisms, remain major challenges. Liposomes are a popular choice for glioma therapy due to their ability to help drugs penetrate the BBB. However, unmodified liposomes have drawbacks, such as poor stability, low drug entrapment efficacy, and rapid removal from circulation, leading to reduced drug absorption at the lesion sites. To address these issues, a novel F127-grafted vitamin E succinate (F127–VES) was designed to prepare multifunctional modified liposomes for delivery of harmine (HAR). Compared to conventional liposomes (Ordinary-Lip), F127–VES-Lip shows greater potential in enhancing the anti-glioma effect of HAR. This is attributed to several key features: Firstly, Pluronic can enhance the transport across the blood–brain barrier. Secondly, the presence of F127 in the formulation extends the circulation time of the drug in the bloodstream. Finally, the combination of F127 and VES in F127–VES-Lip can induce tumor cell apoptosis. In vitro and in vivo results confirmed that the F127–VES-Lip could significantly elevate cellular uptake, promote apoptosis and increase the antitumor effect for C6 glioma cells. The F127–VES-Lip is a promising nanoformulation to enhance the effect of HAR for glioma treatment.
研究领域:
肿瘤学
·
药剂学
·
生物医学工程
·
神经科学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2018
·
IF 3.997
Qin Meng,Bin Peng,Chong Shen
Organic matters in wastewater dramatically impaired the removal capability of adsorbents to heavy metal ions , thus greatly limited their applications for real systems. Here we fabricated the F127/PAA hydrogels that could effectively remove Cu 2+ and Hg 2+ from organic wastewater due to their anti-fouling properties against organic matters. The F127/PAA hydrogels performed high swelling ratio and mechanical stress, showing maximum adsorption capacities of Cu 2+ and Hg 2+ at 283.4 and 222.1 mg/g, respectively. For the BSA containing water, the removal ratio of Cu 2+ and Hg 2+ by F127/PAA hydrogels could reach to 94.0% and 70.2%, respectively. For the humic acid containing water, the corresponding data were 89.5% and 72.1%. Besides, five cyclic adsorption–desorptions in humic acid solution and simulated cosmetic wastewater only slightly decreased the removal efficiencies of F127/PAA hydrogels to Cu 2+ and Hg 2+ . Our results suggested the potential application of the F127/PAA hydrogels in treatment of real organic wastewater.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2013
·
IF 2.108
Yi Yang,Xiao Chen,Dandan Huang,Wei Ye
Being considered as building blocks, the inorganic nanodimer particles such as Ag-Fe 3 O 4 , Cd-Se and Pt-Fe 3 O 4 , have attracted much attention because of their capability of dual surface functionalization and potential applications in field-emission, data storage and photovoltaic devices. For these motivations and as a continuation of our previous study, a gel with flower-like morphology based on Ag-Fe 3 O 4 nanodimers has been constructed with the carboxylated cyclodextrin (MAH-CD) and Pluronic F127 molecules in mixed solvent of cyclohexane and water. The morphology of Ag-Fe 3 O 4 nanodimers and structure of MAH-CD were characterized by transmission electron microscopy (TEM) and nuclear magnetic resonance (NMR) respectively. The mechanism of gel formation is discussed along with the data obtained from rheological measurement, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Fourier transformation infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Each Ag-Fe 3 O 4 particle was coated by lots of MAH-CD molecules, which were threaded by F127 chains. The gel fabrication is controlled by the inclusion of MAH-CD with F127, the interaction between the carboxyl group and the Fe 3 O 4 surface. The cyclohexane molecules in gel were trapped with F127 by cyclodextrin, which may be packed orderly through hydrogen bond. Meanwhile, the Fe 3 O 4 side of nanodimers provides the anchoring position for carboxyl group to induce the formation of gel. Such an Ag-Fe 3 O 4 nanodimer initiated gel can be used either based on Ag side for catalytic and sensing properties, or based on superparamagnetism from Fe 3 O 4 side.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Jing Xin,Sijia Wang,Bing Wang,Jiazhuang Wang,Jing Wang,Luwei Zhang,Bo Xin,Lijian Shen,Zhenxi Zhang,Cuiping Yao
Purpose As a promising photodynamic therapy (PDT) agent, Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) provides deep penetration into tissue, high quantum yields, good photostability, and low photobleaching. However, its low delivery efficiency and high binding affinity to serum albumin cause its low penetration into cancer cells, further limiting its PDT effect on gastric cancer. In order to improve AlPcS4/PDT effect, the AlPcS4 delivery sys tems with different drug carriers were synthesized and investigated.Materials and methods Gold nanorods, cationic liposomes, and Pluronic® F127 nanomicellars were used to formulate the AlPcS4 delivery systems. The anticancer effect was evaluated by CCK-8 assay and colony formation assay. The delivery efficiency of AlPcS4 and the binding affinity to serum proteins were determined by fluorescence intensity assay. The apoptosis and necrosis ability, reactive oxygen species and singlet oxygen generation, mitochondrial transmembrane potential and ([Ca2+]i) concentration were further measured to evaluate the mechanism of cell death.Results The series of synthesized AlPcS4 delivery systems with different drug carriers improve the limited PDT effect in varying degrees. In contrast, AlPcS4 complex with gold nanorods has significant anticancer effects because gold nanorods are not only suitable for AlPcS4 delivery, but also exhibit enhanced singlet oxygen generation effect and photothermal effect to induce cell death directly. Moreover, AlPcS4 complex with cationic liposomes shows the potent inhibition effect because of its optimal AlPcS4 delivery efficiency and ability to block serum albumin. In addition, AlPcS4 complex with Pluronic F127 exhibits inferior PDT effect but presents lower cytotoxicity, slower dissociation rate, and longer retention time of incorporated drugs; thus, F127–AlPcS4 is used for prolonged gastric cancer therapy.Conclusion The described AlPcS4 drug delivery systems provide promising agents for gastric cancer therapy.
研究领域:
药学
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2017
·Vol. 38
·期 4
·1600551
·
IF 4.265
Shi-Lei Dong,Lu Han,Cai-Xia Du,Xiao-Yu Wang,Lu-Hai Li,Yen Wei
Electroactive hydrogel scaffolds are fabricated by the 3D-printing technique using composites of 30% Pluronic F127 and aniline tetramer-grafted-polyethylenimine (AT-PEI) copolymers with various contents from 2.5% to 10%. The synthesized AT-PEI copolymers can self-assemble into nanoparticles with the diameter of ≈50 nm and display excellent electroactivity due to AT conjugation. The copolymers are then homogeneously distributed into 30% Pluronic F127 solution by virtue of the thermosensitivity of F127, denoted as F/AT-PEI composites. Macroscopic photographs of latticed scaffolds elucidate their excellent printability of F/AT-PEI hydrogels for the 3D-printing technique. The conductivities of the printed F/AT-PEI scaffolds are all higher than 2.0 × 10 −3 S cm −1 , which are significantly improved compared with that of F127 scaffold with only 0.94 × 10 −3 S cm −1 . Thus, the F/AT-PEI scaffolds can be considered as candidates for application in electrical stimulation of tissue regeneration such as repair of muscle and cardiac nerve tissue.
研究领域:
生物材料
·
组织工程
·
再生医学
·
高分子化学
·
生物医学工程
✓ 已验证
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 118
·97648-97657
·
IF 3.84
Cong Wu,Guangmei Xia,Jing Sun,Rui Song
With dopamine as a reducing and sticking agent, triblock copolymer poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (PEO–PPO–PEO), Pluronic F127, was employed to immobilize and stabilize silver nanoparticles (Ag NPs) by the chemical reduction of silver nitrate, AgNO3. Thus, a ternary system comprising Ag NPs, dopamine and F127, i.e. a Ag@DA@F127 system was constructed. In this ternary system, Ag NPs were anisotropically self-assembled and uniformly dispersed in network-like F127 micelles. As evidenced the dispersion stability of Ag NPs in this system was significantly enhanced compared to the Ag@DA and Ag@NaBH4@F127 system, which in turn resulted in a more sensitive and quantitative detection of H2O2. Further investigation demonstrated that the Ag@DA@F127 system exhibited a UV-vis absorption band at ∼405 nm and the intensity of this absorption band dramatically decreased linearly over the concentration range of 0.1–100 μM H2O2 (r2 = 0.99056), deriving a detection limit of 33 nM, which was superior to recent reports. Apart from its excellent performance in H2O2 detection, this Ag@DA@F127 system has other benefits including facile and simple, being environmentally friendly, and especially the formation of a specific network-like structure to fully disperse Ag NPs, which makes it practical in H2O2 detection.
研究领域:
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
POLYMER SCIENCE SERIES A
·
2018
·Vol. 60
·期 3
·381-390
·
IF 0.729
Yang Dongyu,Yuan Chaosheng,Yang Kun,Shao Chunguang,Wang Yongqiang,Cheng Xuerui,Su Lei
Isothermal crystallization behavior of Pluronic F127 blended with and without an ionic liquid (IL) was investigated by in situ polarized optical microscopy (POM) and Fourier transform infrared spectroscopy (FTIR). For the pure F127, the POM and FTIR results showed that the spherulite size and crystallinity of F127 increased with the melting temperature increasing to 60, 80, and 135°C. This could be explained by the flexibility of the polymer chain at high melting temperatures. For the F127 blended with IL, the POM results showed that the morphology of F127 evolved from spherulite to dendritic segregation and fibrous crystal with the increasing IL content. FTIR results indicated that hydrogen bonds were formed between F127 and IL, and the intensity of the hydrogen bonds became strengthened gradually with increasing IL content. The effect of hydrogen bonds on the morphology evolution of F127/IL is discussed.
研究领域:
高分子科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Yujuan Chen,Abdur Rauf Khan,Dexin Yu,Yujia Zhai,Jianbo Ji,Yikang Shi,Guangxi Zhai
Traditional cancer therapies carry a risk of serious side effects and toxicity. Developing an alternative treatment modality that is highly effective, has low toxicity and is noninvasive is urgently required. Here, we exploited molybdenum oxide (MoOx) nanosheets as a drug carrier and degradable photothermal agent to provide a chemo-photothermal combination cancer therapy. The MoOx nanosheets were synthesized by a one-pot hydrothermal method and then modified with pluronic F127 to improve physiological stability and biocompatibility. The F127-modified nanosheets (MoOX@F127) showed ultrahigh drug loading efficiency (DLE) of doxorubicin (DOX) (DLE%; 65%, W (load DOX) /[W (load DOX) + W MoOx@F127 ]), strong near-infrared (NIR) absorption and desirable pH-dependent degradability. After intravenous injection, MoOx@F127 nanosheets were degraded at physiological pH and were rapidly excreted from normal organs, while they were effectively accumulated and retained long-term in the more acidic tumor tissue. This simultaneously ensured effective tumor ablation after NIR irradiation and avoided long-term retention and toxicity in vivo . Compared to chemotherapy or photothermal therapy alone, in vitro and in vivo tumor ablation studies have shown a notably improved synergistic effect of the combination therapy. Our study presents a multifunctional nanosystem with a desirable degradability for chemo-photothermal combination cancer therapy that has great potential in biomedical applications.
研究领域:
肿瘤学
·
纳米医学
·
生物材料学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）