FITOTERAPIA
·
2016
·
IF 2.408
Heng-Yi Yu,Juan Li,Ye Liu,Wen-Ming Wu,Han-Li Ruan
Five new triterpenoids , named schiglausins P-T ( 1 – 5 ), together with twelve known analogues ( 6 – 17 ), were isolated from the fruit of Schisandra glaucescens Diels. Their structures were determined by various spectroscopic methods, including HRESIMS, 1D and 2D NMR spectra and CD experiment. Additionally, all these compounds were tested for their cytotoxicities against B16 mouse melanoma cell line. Compounds 8 , 11 , 14 , and 15 exhibited moderate anti-proliferative effects against B16 cells with IC 50 values ranging from 3.64 to 27.00 μM.
研究领域:
植物化学
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药理学
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肿瘤学
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DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-17
·
IF 15.7
Feng Na,Zhang Jiaxing,Tian Juanhua,Zhang Yirui,Li Mengjie,Guo Xin,Han Qian,Wang Yuefei,Gao Aiting,Wang Yingbo,Yan Luke,Kong Jia,Yang Peng
Addressing critical challenges in perishable fruit preservation, including hydrophobic surface treatment, protective layer adhesion on complex cuticles, and synergistic integration of preservation components, here we present an eco-friendly amyloid-like protein coating strategy developed through computer-aided molecular simulation. This system employs phase-transitioned lysozyme as an adhesive layer bonded to fruit epicuticular wax, synergized with sodium alginate and cellulose nanocrystals to form a proteinaceous barrier. Validated across 17 fruit varieties, the coating extends shelf-life by 2-5-fold through microbial inhibition, moisture loss reduction, and rot delay, while maintaining 60–98% nutrient retention, surpassing chemical preservation efficacy without toxicity risks. With edible properties, easy washability, and low cost, the coating demonstrates universal applicability for post-harvest and fresh-cut fruits. Notably, it reduces carbon dioxide emissions by 90% versus refrigeration while achieving 2.5-fold longer shelf-life. These positions the amyloid-like protein coating as a practical and sustainable approach to mitigating global food waste issues.
研究领域:
食品科学
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材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
Journal of Functional Foods
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2017
·
IF 3.144
Xuchao Jia,Dan Yang,Haihui Xie,Yueming Jiang,Xiaoyi Wei
The fruit of Averrhoa carambola L. (Oxalidaceae) is a commercially important fruit. Our study on the chemical constituents present in the fresh sweet fruit led to the isolation of eleven non-flavonoid phenolic compounds. Their structures were identified by analyses of spectroscopic data. They were two new alkyl phenol diglucosides, carambolasides K ( 1 ) and L ( 2 ), four phenylpropanoids, (+)-isolariciresinol 9- O -β- d -glucoside ( 3 ), (+)-lyoniresinol 9- O -β- d -glucoside ( 4 ), (−)-lyoniresinol 9- O -β- d -glucoside ( 5 ), and 1- O -feruloyl-β- d -glucose ( 6 ), three benzoic acids, protocatechuic acid ( 7 ), 1- O -vanilloyl-β- d -glucose ( 8 ), and tecomin ( 9 ), a simple phenol, koaburaside ( 10 ), and a naphthoquinone, (+)-cryptosporin ( 11 ). All of them were reported from A. carambola fruit for the first time. Compounds 1 – 8 and 10 showed 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation scavenging activity comparable to l -ascorbic acid, while compounds 3 , 5 , and 7 exhibited potent ferric reducing antioxidant power (FRAP). In addition, compounds 6 and 11 demonstrated weak porcine pancreatic lipase inhibitory activity.
研究领域:
植物化学
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药理学
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食品科学
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DOI
高影响因子
Nutrients
·
2023
·Vol. 15
·期 8
·1889
·
IF 5.9
Tae Sik Sung,Seung-Bum Ryoo,Chang-Hyun Lee,Seon-Min Choi,Joo-Won Nam,Hyun-Bok Kim,Ji young Lee,Jung-Dae Lim,Kyu Joo Park,Hyun-Tai Lee
The fruit ofMorus albaL. (MAF) has been consumed as a food worldwide. MAF has also been widely used in traditional medicine for thousands of years in East Asia, and its diverse bioactivities have been reported in numerous publications. However, no prokinetic activity has been reported for MAF or its components. In the present study, therefore, we investigated the effects of MAF on gastrointestinal motor function by measuring the intestinal transit rate (ITR) of Evans blue in mice in vivo. The ITR values accelerated by MAF were significantly higher than those accelerated by cisapride or metoclopramide, suggesting that MAF has potential as a new prokinetic agent to replace cisapride and metoclopramide. We also investigated the effects of MAF on myogenic and neurogenic contractions in human intestinal smooth muscles by measuring spontaneous contractions of smooth muscle strips, smooth muscle contractions induced by neural stimulation, and migrating motor complexes from intestinal segments in the human ileum and sigmoid colon in situ. MAF increased both myogenic and neurogenic contractions to enhance ileal and colonic motility in the human intestine. Taken together, these results indicate that MAF enhanced intestinal motility by increasing both myogenic and neurogenic contractions, thereby accelerating the ITR.Keywords:intestinal transit;Morus alba;mulberry fruit;myogenic contraction;neurogenic contraction;prokinetic;smooth muscle
研究领域:
药理学
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胃肠病学
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DOI
PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Xiaohua Nie,Mengqing Chen,Chengyu Jin,Xiaoyu Zhou,Ningxiang Yu,Yuanchao Lu,Xianghe Meng
Defatted seed, pulp and whole fruit of Idesia Polycarpa Maxin. ( I. Polycarpa ) are the by-products of the oil extraction process, but have attracted little attention as natural sources of bioactive phenolics. This study aimed to clarify the profiles of phenolic compounds in the extracts from these by-products and their contribution to the anti-inflammatory activity. Twenty-one phenolic compounds were identified, belonging mainly to salicinoid analogues and p -coumaroyl derivatives. Idescarpin was the predominant phenolics in all extracts, especially in seed extract. Nearly half the p -coumaroyl derivatives presented relatively high content in the extracts of pulp and whole fruit. All extracts inhibited the production of nitric oxide (NO) and the mRNA expressions of inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF-α), and interleukin (IL)-6; and suppressed the accumulation of reactive oxygen species (ROS) along with the restoration of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities. Seed extract exerted better potential than the pulp and whole fruit extracts. Furthermore, correlation analysis demonstrated that idescarpin and idesin were the crucial phenolics against inflammation, whereas some p -coumaroyl derivatives contributed to regulating oxidative stress. These findings suggested that phenolic extracts from defatted I. Polycarpa fruit and its parts, especially seed, could be utilized as inflammation inhibitors in the functional food and cosmetics industries.
研究领域:
植物化学
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药理学
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食品科学
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产品关联
DOI
高影响因子
POSTHARVEST BIOLOGY AND TECHNOLOGY
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2016
·
IF 2.618
Xiaoya Tao,Linchun Mao,Jiayin Li,Jingxin Chen,Wenjing Lu,Si Huang
The development of wound periderm is vital to prevent water vapor loss and pathogen invasion in wounded fruit. The effect of abscisic acid (ABA) on wound-healing in harvested tomato fruit was evaluated in this study. Wounded tomato fruit were treated with ABA or fluridone (FLD, an inhibitor of ABA biosynthesis), respectively, and allowed to wound-heal at 20 °C in darkness for 4 days. Weight loss of tomato fruit reflected the intuitionistic effects of different treatments during wound-healing. Autofluorescence and histochemical staining demonstrated the development of suberized wound periderm in harvested tomato fruit at 3–4 day after wounding. Alkanoic acids, n -alkanes, unsaturated fatty acids and pentacosane represented the major components in the suberin. ABA-treated fruit showed enhanced autofluorescence, histochemical intensity and suberin deposition along with increased activities of phenylalanine ammonia-lyase (PAL) and peroxidase (POD). FLD treatment, however, alleviated the features of suberization and enzyme activities during wound-healing. The results suggest that ABA is involved in the stimulation of wound-induced suberization in harvested tomato fruit.
研究领域:
植物学
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园艺学
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DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Wei Xu,Xiyu Jia,Mingchuan Yang,Ziyi Peng,Hongping Chen,Xiangchun Zhang,Bing Wei
Fruit spoilage has led to significant food waste and economic losses and poses risks to human health. Currently, widely used plastic bag preservation techniques exhibit limited effectiveness, often leading to environmental pollution and potential health hazards. Moreover, many emerging nanopreservation materials lack comprehensive safety evaluations, raising concerns regarding their biological safety and stability. In this study, we developed a nanocomposite coating that utilizes plant-derived polyphenols as a structural framework for food preservation. This coating is synthesized through a one-step self-assembly process involving tea polyphenols and zinc ions (TPZn). The TPZn nanocomposite coating exhibits exceptional antibacterial, antioxidant, adhesion, and water retention properties. By inhibiting the formation of bacterial biofilms, it effectively prevents bacteria from colonizing the surfaces of fruits, resulting in long-lasting antibacterial effects and significantly extending the shelf life. Additionally, the application of TPZn on strawberries and bananas has led to a doubling of their shelf life while maintaining the freshness and nutrient content of the fruits. This polyphenol-based preservation material not only provides a shield coating against spoilage but also demonstrates excellent biological safety across various models including cells, zebrafish, nematodes, mice, and bean sprouts. This study presents insights into the rational design of biosafe preservation materials utilizing natural plant-derived components.
研究领域:
食品科学
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纳米技术
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材料科学
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食品保鲜
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微生物学
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农业科学
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产品关联
DOI
PubMed
高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2025
·
IF 4
Bing Bai,Huan-Juan Zhao,Bo-Kun Wang,Yu-Ting Li,Ping Gao,Yun-Tong Lv,Xue-Qing Yang
During long-term plant-insect interactions, plants have evolved diverse plant secondary metabolites (PSMs) as defenses against herbivory, while insects have developed sophisticated detoxification mechanisms to neutralize these compounds. Invasive and native herbivorous species may employ distinct metabolic strategies to cope with PSMs, a phenomenon that remains incompletely characterized. Here, we report the differential detoxification strategies of two closely related fruit borers, the invasive Cydia pomonella and the native Grapholita molesta , which exhibit interspecific competition, in response to quercetin stress—a flavonoid present in their host fruits. C. pomonella requires more generations to adapt 70 μg/g quercetin, indicating differential tolerance to flavonoid toxicity. Metabolic profiling shows G. molesta primarily detoxifies quercetin mainly via synergistic cytochrome P450 (P450) and transmembrane transport, whereas C. pomonella shifts from transport to a predominant role of oxidation over time. Given that C. pomonella was not pre-adapted to high quercetin stress in its native habitat, its constitutive defense system was likely suppressed under quercetin exposure. This species compensated by upregulating ATP-binding cassette (ABC) transporter-mediated excretion, as evidenced by HPLC quantification which indicated that the fecal quercetin content exceeded 50 % of the administered dose. Correlation analysis suggests that C. pomonella employs a biphasic detoxification: initial short-term dominated by ABC transporter activity, followed by a long-term reliance on P450-mediated metabolism. Conversely, G.molesta primarily utilizes a synergistic enzymatic detoxification system involving multiple enzymes. These findings elucidate divergent adaptive mechanisms to quercetin stress in the two fruit borers and enhance understanding of herbivorous insect-plant co-evolution and the interspecific interactions between invasive and native pest species.
研究领域:
昆虫学
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植物-昆虫互作
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生态适应
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生化毒理学
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入侵物种生物学
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产品关联
DOI
PubMed
高影响因子
FITOTERAPIA
·
2016
·
IF 2.408
Ye Liu,Yan-Mei Wang,Wen-Ming Wu,Jian Song,Han-Li Ruan
Three new ( 1–3 ) and seven known ( 4–10 ) triterpenoids , together with one new ( 11 ) and fifteen known ( 12–26 ) dibenzocyclooctadiene lignans , were isolated from the fruit of Schisandra sphenanthera Rehd. et Wils. Their structures were elucidated by extensive analysis of spectroscopic methods, including HRESIMS, 1D and 2D NMR spectra and CD experiments. All of the isolated triterpenoids ( 1 − 10) were evaluated for their in vitro cytotoxicities against HepG2 human hepatocellular carcinoma cell line, and compounds 1 , 3–7 and 10 exhibited moderate antiproliferative effects against HepG2 cell line with IC 50 ranging from 18.12 to 49.52 μM. The lignans ( 11–26 ) were tested for their neuroprotective activities against CoCl 2 , H 2 O 2 and A β 25–35 -induced SH-SY5Y cell injuries and showed considerable neuroprotective effects of different degrees. And at the low concentration of 3.2 nM, compounds 14 , 17–19 , 23 in CoCl 2 -induced, compounds 11 , 13–15 , 17 , 19–20 , 22–24 in H 2 O 2 -induced, and compounds 12–14 , 19 , 25–26 in A β 25–35 -induced SH-SY5Y cell injury models, showed statistically significant neuroprotective activities compared with the negative control group, respectively.
研究领域:
药理学
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植物化学
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神经科学
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 2
·256
·
IF 3.06
Xuchao Jia,Dan Yang,Yue Yang,Haihui Xie
The fruit ofAverrhoa carambolaL. (Oxalidaceae), commonly known as star fruit or carambola, is popular in tropical and subtropical regions. Carotenoid-derived components, mainly C13- and C15-norisoprenoids, contribute greatly to the flavor of star fruit. Previously reported norisoprenoids were tentatively identified by GC-MS analysis after enzymatic hydrolysis. To gain accurate information about glycosidically bound flavor precursors in star fruit, a phytochemical study was conducted, which led to the isolation of 16 carotenoid derivatives—One new C13-norisoprenoid glucoside, (5R,6S,7E,9R)-5,6,9-trihydroxy-7-megastigmene 9-O-β-d-glucoside (1); one new C15-norisoprenoid, (6S,7E,10S)-Δ9,15-10-hydroxyabscisic alcohol (11); and 14 known ones, of which 12 were in glucoside form. The structures of the two new compounds were elucidated on the basis of extensive spectroscopic data analysis and chemical reaction. Compound11was a rare C15-norisoprenoid with a double bond between C-9 and C-15, and its possible biogenetic pathway was proposed. The known compounds were identified by comparison of their mass and nuclear magnetic resonance (NMR) data with those reported in the literature. The structure identification of one new (1) and seven known (3–7,9, and10) C13-norisoprenoid glucosides from the genusAverrhoafor the first time enriches the knowledge of carotenoid-derived flavor precursors in star fruit.Keywords:Averrhoa carambola;star fruit;flavor precursor;C13-norisoprenoid glucoside;C15norisoprenoid
研究领域:
植物化学
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风味化学
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食品科学
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产品关联
DOI
PubMed
高影响因子
SCIENTIA HORTICULTURAE
·
2022
·
IF 4.342
Sun Yingjie,Zhang Xinyue,Jiang Yaping,Wang Jihan,Li Bingru,Zhang Xinhua,Li Xiaoan,Li Fujun
Ethylene response factors 2 (ERF2) belongs to the AP2/ERF transcription factor family and plays key roles in ethylene signal transduction . The roles of MdERF2 in apple ( Malus × domestica ) cuticular wax synthesis regulated by ethylene were studied in this work. Result shows that MdERF2 overexpression (ERF2-OE) up-regulated the expression levels of wax-related synthetic genes long-chain acyl-CoA synthetase 2 ( MdLACS2), Wax synthase1 ( MdWSD1), Eceriferum 4 ( MdCER4) and Eceriferum 6 ( MdCER6) , while has no effect on the transcription of Eceriferum 1 ( MdCER1) , and shows different regulation effects on the expression levels of mid-chain alkane hydroxylase 1 ( MdMAH1) between calli and fruit. Furthermore, different MdERF2 expression levels changed the apparent structure of the apple cuticular wax and positively regulated the total wax accumulation. ERF2-OE also increased alkane and alcohol production but decreased acid and ester contents. Thus, ethylene regulated the synthesis of apple cuticular wax at the transcriptional level through MdERF2, thereby altering the wax structure and composition.
研究领域:
植物学
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分子生物学
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产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2023
·
IF 5.9
Yuzhen Du,Baoying Shi,Xiayu Luan,Yufeng Wang,Haiyan Song
Storage and transportation of fresh fruits and vegetables result in significant wastage, making their preservation post-harvest a global issue. Although petroleum-based synthetic wax is commonly used in fruit post-harvest preservation due to its effectiveness, its adverse effects on ecological environment and human health cannot be ignored. Hence, it is imperative to explore natural and sustainable coatings that can serve as an eco-friendly and healthy alternative to petroleum-based synthetic waxes for fruit preservation. In this study, we developed a biocomposite coating based on chitosan (CS) as the bio-based film forming material, cellulose nanocrystals (CNC) as the reinforcement and sodium tripolyphosphate (TPP) as the crosslinking agent. By employing the dip coating process, it becomes feasible to apply micron-sized films onto the surfaces of diverse perishable fruits. The results revealed that the CNC and TPP significantly enhanced mechanical strength, oxygen barrier performance, thermal stability, antibacterial activity, and hydrophobicity of the coating. As a proof-of concept, bananas were utilized as experimental samples to investigate the impact of the coating. The findings demonstrate the efficacy of this coating in preserving the fruit's visual appeal and prolonging its storage duration. The coating can be used in various scenarios and on different products, having excellent potential in preservation technology, transportation and storage of postharvest agricultural products. The utilization of a multifunctional coating based on chitosan represents a promising and sustainable approach to address the pressing issue of global food waste. This innovative coating offers a cost-effective solution to effectively reduce postharvest losses of perishable foods, contributing to a more sustainable food system.
研究领域:
食品科学
·
材料科学
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农业工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）