Biomaterials Advances
·
2024
·
IF 5.5
Wenying Wei,Haifei Kang,Chenxi Lian,Jiawei Liu,Jinwei Lin,Junwei Yang,Zhangmancang Xu,Ziqi Wang,Meizhen Yin,Honglian Dai
Chemodynamic therapy (CDT) guided by Fenton chemistry and iron-containing materials can induce ferroptosis as a prospective cancer treatment method, but the inefficient Fe 3+ /Fe 2+ conversion restricts the monotherapeutic performances. Here, an iron-based nanoplatform (Fe 3 O 4 -SRF@FeTA) including a magnetic core and a reductive film is developed for combined CDT and photothermal therapy (PTT) through ferroptosis augmentation. The inner iron oxide core serves as a photothermal transducer, a magnet-responsive module, and an iron reservoir for CDT. The coated Fe 3+ -tannic acid film (FeTA) provides extra iron and reductants for Fe 3+ /Fe 2+ conversion acceleration, and functions as a door keeper for the pH- and light-responsive release of the embedded ferroptosis inducer sorafenib (SRF). The in vitro results demonstrate that the iron-based nanocomplexes promote the production of lipid peroxide through the amplified Fenton activity, and downregulate glutathione involved in lipid peroxide repair system through the responsively released SRF. Upon accumulation in tumor by magnetic targeting and sequential laser irradiation locoregionally, Fe 3 O 4 -SRF@FeTA nanocomplexes present prominent in vivo anticancer efficacy by leveraging PTT and CDT-enhanced ferroptosis.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Chao Xu,Shui Guan,Jianqiang Xu,Weitao Gong,Tianqing Liu,Xuehu Ma,Changkai Sun
In this study, protocatechuic acid (PCA) was grafted onto carboxymethyl chitosan (CMCS) via EDC/NHS to improve the antioxidant effect. The grafting ratio of PCA-g-CMCS conjugates could be controlled by adjusting the pH value and feed ratio of raw materials. The conjugates exhibited similar pH sensitivity to CMCS and showed dramatic enhancements of DPPH and ABTS radicals scavenging activities, total antioxidant capacity, reducing power, and Fe 2+ -chelating activity. Three-dimensional porous PCA-g-CMCS hydrogel was prepared by lyophilization and secondary cross-linking. The shaped hydrogel preserved its antioxidant activity, and the sustained release of PCA-containing degraded fragment from biodegradable hydrogel could be achieved with the aid of lysozyme in vitro (15 days). PCA-g-CMCS hydrogel also showed excellent biocompatibility and protective effect on H 2 O 2 -induced oxidative damage in SH-SY5Y cells. These results suggested that PCA-g-CMCS conjugates and its hydrogel would appear to be a promising oxidation-resistant material for applications such as drug release and tissue engineering.
研究领域:
材料科学
·
药学
·
生物技术
·
生物材料
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Zihua Wang,Chijia Wang,Weihao Fan,Shuyi Liu,Kaka Li,Hongxin Luo,Shupei Liu,Huaiyuan Wang
A robust bifunctional platform (FA-PANI-Fe-F) with both shielding performance and corrosion inhibition activity was prepared and observed for its structure and morphology. During the corrosion test , Fe 2+ /Fe 3+ and perfluorinated groups effectively strengthened the shielding performance and corrosion inhibition activity of the coating. The results show that the perfluorinated group not only improved the hydrophobic performance of the functional filler but also provided effective inhibition against corrosion for the anode area. In addition, Fe 2+ /Fe 3+ resulted in the functional filler exhibiting anodic protection and cathodic inhibition properties, thereby forming a dense metal passivation film between the coating and the substrate interface. After the EIS test, the |Z| 0.01 Hz value of FPF-Fe 10% C still reached 7.91 × 10 8 Ω·cm 2 . Additionally, the FPF-Fe 10% C showed a lower cathodic corrosion trend in the SVET test, which indicated that Fe 2+ /Fe 3+ effectively inhibited the corrosion process in the cathode region. This study is expected to open new insights into the anti-corrosion inhibition process between the interior of the coating and the metal substrate, and prepare a robust bifunctional filler platform with long-term corrosion resistance .
研究领域:
材料科学
·
腐蚀工程
·
表面化学
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产品关联
DOI
高影响因子
Nano Research
·
2021
·Vol. 15
·期 2
·1509-1516
·
IF 8.897
Ye Xinhui,Li Yu,Luo Peipei,He Bingcai,Cao Xinxing,Lu Tongbu
Sunlight-driven activation of molecular oxygen (O 2 ) for organic oxidation reactions offers an appealing strategy to cut down the reliance on fossil fuels in chemical industry, yet it remains a great challenge to simultaneously tailor the charge kinetics and promote reactant chemisorption on semiconductor catalysts for enhanced photocatalytic performance. Herein, we report iron sites immobilized on defective BiOBr nanosheets as an efficient and selective photocatalyst for activation of O 2 to singlet oxygen ( 1 O 2 ). These Fe 3+ species anchored by oxygen vacancies can not only facilitate the separation and migration of photogenerated charge carrier, but also serve as active sites for effective adsorption of O 2 . Moreover, low-temperature phosphorescence spectra combined with X-ray photoelectron spectroscopy (XPS) and electronic paramagnetic resonance (EPR) spectra under illumination reveal that the Fe species can boost the quantum yield of excited triplet state and accelerate the energy transfer from excited triplet state to adsorbed O 2 via a chemical loop of Fe 3+ /Fe 2+ , thereby achieving highly efficient and selective generation of 1 O 2 . As a result, the versatile iron sites on defective BiOBr nanosheets contributes to near-unity conversion rate and selectivity in both aerobic oxidative coupling of amines to imines and sulfoxidation of organic sulfides. This work highlights the significant role of metal sites anchored on semiconductors in regulating the charge/energy transfer during the heterogeneous photocatalytic process, and provides a new angle for designing high-performance photocatalysts.
研究领域:
材料科学
·
催化
·
光化学
·
有机合成
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产品关联
DOI
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-13
·
IF 16.6
Chen Na,Du Na,Shen Ruichen,He Tianpei,Xi Jing,Tan Jie,Bian Guangkai,Yang Yanbing,Liu Tiangang,Tan Weihong,Yu Lilei,Yuan Quan
Microbial communication can drive coordinated functions through sensing, analyzing and processing signal information, playing critical roles in biomanufacturing and life evolution. However, it is still a great challenge to develop effective methods to construct a microbial communication system with coordinated behaviors. Here, we report an electron transfer triggered redox communication network consisting of three building blocks including signal router, optical verifier and bio-actuator for microbial metabolism regulation and coordination. In the redox communication network, the Fe 3+ /Fe 2+ redox signal can be dynamically and reversibly transduced, channeling electrons directly and specifically into bio-actuator cells through iron oxidation pathway. The redox communication network drives gene expression of electron transfer proteins and simultaneously facilitates the critical reducing power regeneration in the bio-actuator, thus enabling regulation of microbial metabolism. In this way, the redox communication system efficiently promotes the biomanufacturing yield and CO 2 fixation rate of bio-actuator. Furthermore, the results demonstrate that this redox communication strategy is applicable both in co-culture and microbial consortia. The proposed electron transfer triggered redox communication strategy in this work could provide an approach for reducing power regeneration and metabolic optimization and could offer insights into improving biomanufacturing efficiency.
研究领域:
生物技术
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微生物学
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生物工程
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合成生物学
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代谢工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Xuesong Ye,Jun Nan,Zhencheng Ge,Qiliang Xiao,Bohan Liu,Meng Chen,Fangmin Wu
A novel mechanism for the effect of ferrous iron (Fe 2+ ) on low-pressure ultrafiltration membrane (LPM) flux is discovered in this study. In previous studies, the Fe 2+ concentrations of removing excessive Fe 2+ and manganese (Mn 2+ ) by LPM are low (0.4−1.5 mg L −1 ), and the presence of Fe 2+ would reduce the flux, thus not suitable for treating water with high Fe 2+ concentrations. In this study, we systematically investigated the performance of down-flow LPM (D-LPM) and opposite-flow LPM (O-LPM) under different Fe 2+ concentrations (0−5 mg L −1 ) with Mn 2+ and ammonia (NH 4 + ). The results demonstrate that the flux did decrease at low Fe 2+ concentration, while significantly increasing by 95.9% with Fe concentration at 3−5 mg L −1 . Furthermore, high Fe 2+ enhanced Fe, Mn 2+ , and NH 4 + removal by iron autocatalytic oxidation , enriching the relative abundance of manganese-oxidizing bacteria, and facilitating anammox activities, respectively. A series of characteristic analyses suggest that thin biofilm layer structures in D-LPM and O-LPM, along with the low soluble microbial products-polysaccharide concentrations, resulted in the high steady flux under high Fe 2+ concentrations. These findings widen the applicability of LPM in practical applications and provide novel strategies to increase the flux of LPM systems.
研究领域:
环境工程
·
水处理
·
膜技术
·
生物过程
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产品关联
DOI
高影响因子
Advanced Science
·
2024
·
IF 14.3
Rui Qiao,Zhongwen Yuan,Meijin Yang,Zhiying Tang,Lizhen He,Tianfeng Chen
Exploring efficient and low-toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression and poor prognosis remains one of the critical developmental challenges in radiotherapy. Nanoheterojunctions, due to their unique physicochemical properties, have demonstrated excellent radiosensitization effects in radiation energy deposition and in lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) to construct a nano-heterojunction (Se@PB), which could promote the increase of Fe 2+ /Fe 3+ ratio and conversion of Se to a high valence state with Se introduction. The Fe 2+ -Se-Fe 3+ electron transfer chain accelerates the rate of electron transfer on the surface of the nanoparticles, which in turn endows it with efficient X-ray energy transfer and electron transport capability, and enhances radiotherapy physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion and Fe 2+ accumulation through pro-Fenton reaction, thereby disturbs the redox balance in tumor cells and enhances biochemical sensitivity of radiotherapy. As an excellent radiosensitizer, Se@PB effectively enhances X-ray induced mitochondrial dysfunction and DNA damage, thereby promotes cell apoptosis and synergistic cervical cancer radiotherapy. This study elucidates the radiosensitization mechanism of Se-doped nanoheterojunction from the perspective of the electron transfer chain and biochemistry reaction, which provides an efficient and low-toxic strategy in radiotherapy.
研究领域:
纳米技术
·
肿瘤学
·
放射治疗
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材料科学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·
IF 10.6
Shaojie Dong,Yuwei Zhang,Yifei Zhang,Yukun Mei,Ahmadi Sina,Rui Zou,Lin Niu
Considering the high recrudescence and the long-lasting unhealed large-sized wound that affect the aesthetics and cause dysfunction after resection of maxillofacial malignant skin tumors, a groundbreaking strategy is urgently needed. Photothermal therapy (PTT), which has become a complementary treatment of tumors, however, is powerless in tissue defect regeneration. Therefore, a novel multifunctional sodium nitroprusside and Fe 2+ ions loaded microneedles (SNP-Fe@MNs) platform was fabricated by accomplishing desirable NIR-responsive photothermal effect while burst releasing nitric oxide (NO) after the ultraviolet radiation for the ablation of melanoma. Moreover, the steady releasing of NO in the long term by the platform can exert its angiogenic effects via upregulating multiple related pathways to promote tissue regeneration. Thus, the therapeutic dilemma caused by postoperative maxillofacial skin malignancies could be conquered through promoting tumor cell apoptosis via synergistic PTT—gas therapy and subsequent regeneration process in one step. The bio-application of SNP-Fe@MNs could be further popularized based on its ideal bioactivity and appealing features as a strategy for synergistic therapy of other tumors occurred in skin. Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1186/s12951-024-02409-4.
研究领域:
生物医学工程
·
癌症治疗
·
组织工程
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2024
·
IF 7.6
Jie Chen,Yan Liu,Yanting You,Ruisi Zhou,Yanchun Li,Xinghong Zhou,Xiaohu Chen,Ying Yang,Jinxiang Chen,Hiu Yee Kwan,Xiaoshan Zhao,Yuyao Wu
Celastrol (CEL) has garnered significant interest for its anti-tumour properties and potential for colorectal cancer (CRC) treatment. However, its clinical use is constrained by its limited bioavailability and potential toxicity. Herein, a biotin-decorated CEL nano-drug delivery system using a zeolitic imidazolate framework (ZIF-8) as a carrier was synthesized, named CEL@ZIF-8@BIO. It exhibits excellent water solubility, efficient loading of CEL, and a high release rate in acidic environments. In vitro experiments demonstrated that CEL@ZIF-8@BIO inhibited proliferation, induced cell cycle arrest in G0/G1 phase, increased ROS production and reduced mitochondrial membrane potential in CRC cells. RNA-Seq analysis indicated that the anticancer mechanism of CEL@ZIF-8@BIO may be linked to ferroptosis as indicated by a significant increase in Fe 2 + levels, oxidative stress, lipid peroxidation, and mitochondrial dysfunction in CRC cells. Furthermore, these effects could be reversed by ferroptosis inhibitor. In vivo research revealed that CEL@ZIF-8@BIO significantly inhibited the growth of CRC tumours and reduced the toxicity associated with CEL treatment. Taken together, the CEL@ZIF-8@BIO nano-drug delivery system shows great promise for CRC therapy due to its improved efficacy and reduced toxicity.
研究领域:
癌症研究
·
纳米技术
·
药学
·
分子生物学
·
细胞生物学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Chongqing Wang,Ruirui Sun,Rong Huang,Yijun Cao
Hydrogen peroxide activation by pyrite for degradation of recalcitrant contaminants receives increasing attention. The improvement of catalytic efficiency of natural pyrite is still a challenging issue. This work provides a novel strategy of enhancing catalytic efficiency via pre-reaction between pyrite and hydrogen peroxide. Effects of process factors including pre-reaction time, hydrogen peroxide, solution pH and initial dye concentration were examined. Natural pyrite with low purity was characterized by Raman, scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. Reaction kinetic verifies tremendous improvement of the reaction rate through pre-reaction. Enhanced dye degradation is ascribed to hydroxyl radical production promoted by self-regulation of pH, Fe 2+ releasing and Fe 2+ /Fe 3+ cycle. The plausible mechanism was proposed based on multiple determinations. Dye degradation in different water matrix was efficiently obtained, as well as multicomponent dyes. Additionally, broad operation pH and good reusing performance make the developed process highly attractive for application. This work provides a solid step-forward of pyrite/hydrogen peroxide Fenton process for treatment of recalcitrant contaminants in wastewater.
研究领域:
环境科学
·
化学工程
·
废水处理
·
催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-14
·
IF 16.6
Fang Fang,Wang Sa,Song Yueyue,Sun Meng,Chen Wen-Cheng,Zhao Dongxu,Zhang Jinfeng
Nanomedicine holds great promise to enhance cancer therapy. However, low active pharmaceutical ingredient (API) loading content, unpredictable drug release, and potential toxicity from excipients limit their translational capability. We herein report a full-API nanodrug composed of FDA-approved 5-aminolevulinic acid (ALA), human essential element Fe 3+ , and natural bioactive compound curcumin with an ideal API content and pH-responsive release profile for continuous spatiotemporal cancer therapy achieved by multi-step tandem endogenous biosynthesis. First, ALA enzymatically converts into photosensitizer protoporphyrin IX (PpIX). Afterward, multiple downstream products including carbon monoxide (CO), Fe 2+ , biliverdin (BV), and bilirubin (BR) are individually biosynthesized through the PpIX-heme-CO/Fe 2+ /BV-BR metabolic pathway, further cooperating with released Fe 3+ and curcumin, ultimately eliciting mitochondria damage, membrane disruption, and intracytoplasmic injury. This work not only provides a paradigm for exploiting diversified metabolites for tumor suppression, but also presents a safe and efficient full-API nanodrug, facilitating the practical translation of nanodrugs.
研究领域:
纳米医学
·
癌症研究
·
药学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
FEBS Journal
·
2021
·Vol. 289
·期 7
·1968-1983
·
IF 5.542
Ting-Ting Wei,Meng-Yuan Zhang,Xin-Hua Zheng,Tian-Hua Xie,Wenjuan Wang,Jian Zou,Yan Li,Hong-Ying Li,Jiping Cai,Xiaolu Wang,Jianxin Tan,Xusheng Yang,Yong Yao,Lingpeng Zhu
Retinal pigment epithelium (RPE) cell damage is implicated in the pathogenesis of age-related macular degeneration (AMD). An increase of interferon-γ (IFN-γ) levels was observed in patients with AMD, but whether inflammatory factors are causally related to AMD progression is unclear. Here, we demonstrate a direct causal relationship between IFN-γ and RPE cell death. IFN-γ induced human retinal pigment epithelial cell (ARPE-19) death accompanied by increases in Fe 2+ , reactive oxygen species, lipid peroxidation, and glutathione (GSH) depletion, which are main characteristics of ferroptosis. Mechanistically, IFN-γ upregulates the level of intracellular Fe 2+ through inhibiting Fe 2+ efflux protein SLC40A1 and induces GSH depletion by blocking cystine/glutamate antiporter, System xc-. At the same time, treatment with IFN-γ decreases the level of glutathione peroxidase 4 (GPx4), rendering the cells more sensitive to ferroptosis. JAK1/2 and STAT1 inhibitors could reverse the reduction of SLC7A11, GPx4 and GSH expression induced by IFN-γ, indicating IFN-γ induces ARPE-19 cell ferroptosis via activation of the JAK1-2/STAT1/SLC7A11 signaling pathway. The above results were largely confirmed in IFN-γ-treated mice in vivo . Finally, we used sodium iodate (NaIO 3 )-induced retinal degeneration to further explore the role of ferroptosis in AMD in vivo . Consistent with the role of IFN-γ, treatment with NaIO 3 decreased SLC7A11, GPx4 and SLC40A1 expressions. NaIO 3 -induced RPE damage was accompanied by increased iron, lipid peroxidation products (4-hydroxynonenal, malondialdehyde), and GSH depletion, and ferroptosis inhibitors could reverse the above phenomenon. Taken together, our findings suggest that inhibiting ferroptosis or reducing IFN-γ may serve as a promising target for AMD.
研究领域:
眼科学
·
细胞生物学
·
分子生物学
·
病理学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）