MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 12
·1-9
·
IF 6.232
Zhao Yunfei,Chen Jun,Zhong Hangtian,Zhang Chengli,Zhou Yuan,Mao Weiran,Yu Chao
The development of a novel signal amplification system is described for sensitive determination of α2,6-sialylated glycans (α2,6-sial-Gs), an important prognostic tumor biomarker. First, Fe-based metal-organic frameworks (Fe-MOFs) with silver nanoparticles (AgNPs) decorated onto the outer surface were designed and synthesized with controlled octahedron structures. The new Ag/Fe-MOFs nanocomposite possessed strong conductivity and a large surface area to carry more nanoprobes. To connect the Ag/Fe-MOFs nanocomposite with more groups, the nanocomposite was functionalized by -COOH with SH-PEG-COOH to bind with an α2,6-sial-Gs catcher, M-APBA, via -CONH- bonds. More importantly, the Ag/Fe-MOFs also exhibited an excellent endogenous redox mediator property to produce electrons, which is the fundamental mechanism underlying amplification of an electronic signal. A gold electrode was used to accelerate electron transfer and immobilize the α2,6-sial-Gs lectin (SNA). After the sandwich-type catcher recognition (SNA/α2,6-sial-Gs/M-APBA), the current peak response was provoked in the process of oxidizing AgNPs to Ag + in the forward anodic potential sweep, while Cl − in a PBS solution was transferred into Ag + to maintain charge neutrality. Optimized particles were employed for direct fabrication of the sandwich-type affinity biosensor, which was found to show a linear detection range from 1 fg mL −1 to 1 ng mL −1 with a detection limit of 0.09 fg mL −1 . Furthermore, the biosensor exhibited excellent specificity and stability, indicating that such a novel nanobiotechnology platform can be used to initiate potential utility for monitoring biomarkers in serum. Graphical abstract
(A)Schematic presentation of synthesis and surface modification of Ag/Fe-MOFs. The new Ag/Fe-MOFs nanocomposite possessed commendable conductivity and large surface area to carry more nanoprobe; after functionalizing the Ag/MOFs with SH-PEG-COOH, the functionalized endogenous redox mediator (c-Ag/MOFs) realized the possibility that can connect with the biological catcher. (B) Schematic diagram of electrode construction for detecting α2,6-sialylated glycans (α2,6-sial-Gs). By using the c-Ag/Fe-MOFs functional endogenous redox mediator, we successfully implemented the electrochemical detection of α2,6-sial-Gs.
研究领域:
分析化学
·
生物材料
·
生物技术
·
电化学
·
癌症诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Fa-Ting Xie,Xiao-Lan Zhao,Kuan-Neng Chi,Tong Yang,Rong Hu,Yun-Hui Yang
A ratiometric electrochemical aptasensor is proposed for the detection of thrombin. In the sensor, the iron metal-organic frameworks (Fe MOFs)-labeled aptamer as signal tags was used as signal probe (SP), and the electrolyte solution [Fe(CN) 6 ] 3-/4- was utilized as an inner reference probe (IR). In the presence of thrombin, the signal of Fe-MOFs can be detected. Meanwhile, the signal of [Fe(CN) 6 ] 3-/4 -IR almost remains stable. Accordingly, thrombin concentration can be monitored with the ratio response of I Fe-MOFs-SP /I [Fe(CN)6] 3-/4- -IR . The proposed ratiometric biosensor owns a strong ability to eliminate the disturbance that arises from different DNA loading densities, environmental impact and instrumental efficiency. DNA nanotetrahedron (NTH) with three-dimensional (3D) scaffold can effectively eliminate nonspecific adsorption of DNA and protein. The accessibility of target molecules and loading amounts of signal substances could be increased because of the enhanced mechanical rigidity of well-designed 3D NTH. Thus, detection reproducibility and sensitivity can be further improved. Moreover, the biosensor only requires conjugation with one electroactive substance. The modification procedure can be greatly simplified. The biosensor owns high sensitivity with the detection limit of 59.6 fM. We expect that it will emerge as a generalized ratiometric sensor that may be useful for detecting target analytes .
研究领域:
分析化学
·
生物化学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2022
·
IF 4.331
Rutong Song,Jun Yao,Mei Yang,Zhongbin Ye
Metal–organic frameworks (MOFs), especially Fe-MOFs, have shown prospective application in eliminating organic dyes from wastewater due to their well-developed pores, water stability, easy preparation, and economy. Herein, we synthesized four types of Fe-MOFs (such as MIL-88A, MIL-88B, MIL-100, and MIL-101) using the hydrothermal method. The products were analyzed with several methods. By comparing the adsorption effect of those four types of Fe-MOFs on three kinds of dyes, it has been shown that MIL-100 owns the best adsorption efficiency on cationic organic dyes methylene blue (MB) and Rhodamine B (RhB) in 180 min, while all MOFs have slight removal capacity on methyl orange (MO). MIL-100, as an adsorbent, was studied under various research conditions, and the maximum removal efficiencies to MB, RhB, and MO were found to be up to 97.36%, 88.75%, and 13.00%, respectively. Furthermore, cationic dye MB’s removal by MIL-100 was fitted with a pseudo-second-order model and Langmuir isotherm model (Qm = 411.041 mg/g) by adsorption kinetics and isotherms research, and MIL-100 could rapidly and selectively divide MB from a binary complex aqueous solution of MB and MO. The as-fabricated MIL-100 also exhibited excellent recyclability after four adsorption–desorption recycles and can be treated as a potential substance with high removal efficiency of cationic organic dye-containing industrial effluents.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Saudi Chemical Society
·
2022
·
IF 4.712
Fuhua Wei,Liang Xiao,Qinhui Ren,Kui Wang,Lan Qin,Hongliang Chen,Yufu Ma,Zhao Liang
Fe/Zr-base metal–organic frameworks(Fe/Zr-MOFs) were prepared using a solvothermal method from 1,3,5-phthalic acid (H 3 BTC, 98 %) as the organic chain and ferrous heptahydrate (FeSO 4 ·7H 2 O) and zirconium acetate Zr(CH 3 COO) 4 ] as the metal ions. The resulting material was used to remove Doxycycline hydrochloride (DC). The experimental results showed that when the concentration of DC was 10 ppm and the mass of Zr/Fe-MOFs was 100 mg, the maximum removal rate after 5 h was 87.5 %. The results showed that the correlation coefficients ( R 2 ) of the pseudo-second-order kinetics model and Freundlich isotherm model of Zr/Fe-MOFs adsorption of DC were greater than 0.99, indicating good consistency. The results showed that the adsorption process of DC by Zr/Fe-MOFs was endothermic and spontaneous. Fe/Zr-MOFs had a high adsorption capacity for DC removal and good application prospects.
研究领域:
材料科学
·
环境科学
·
医药化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Gangya Cheng,Chen Yuan,Wansheng Ruan,Ben Ma,Xinyu Zhang,Xinjing Yuan,Zhihui Li,Dan Wang,Fei Teng
In this work, Fe-based metal-organic frameworks (Fe-MOFs) are prepared by a simple solvothermal method, in which acetic acid/N, N-dimethylformamide (HAc/DMF) mixture solvents are employed to regulate the particle morphology, exposed facets and ligand defects. At HAc/DMF = 0/50, 5/45 and 8/42 (volume ratio), the irregular particles (MIL-53(Fe)), elongated icosahedrons (5H-MIL-101(Fe)) and icosahedrons (8H-MIL-101(Fe)) are obtained, respectively. Under visible light irradiation (λ > 420 nm) and the addition of sodium persulfate (PS), 5H-MIL-101(Fe) shows the highest degradation activity for tetracycline (TC). Specifically, 80% of TC has been removed by 5H-MIL-101(Fe) within 25 min, and the degradation kinetics rate is 3.03 times higher than that over MIL-53(Fe). The improvement of catalytic activity is mainly attributed to the active facets exposed and ligand defects of 5H-MIL-101(Fe). Density functional theory (DFT) calculation further confirms that the active facets exposed and ligand defects of 5H-MIL-101(Fe) favor the adsorption and activation of PS, benefiting the generation of •SO 4 − . Besides, a probable degradation pathway of TC is proposed based on trapping experiments and liquid chromatography-mass spectrometry (LC-MS) test. Furthermore, the toxicities of intermediates are predicted by the quantitative structure-activity relationship (QSAR) mathematical model. This work demonstrates that visible light enhanced PS activation (Vis-PSA) can more effectively degrade organic pollutants, and this work also provides a simple strategy to precisely regulate ligand defects and actively exposed facets of Fe-MOFs to enhance the adsorption and activation of PS.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Yu Gao,Siyu Liu,Xu Huang,Weiwen Lu,Jian Huang,Hua Zhang,Yong Zhang,Jinhua Wang,Shanshan Xi,Jun Liu,Tao Luo
Considering the difficulty in recovering powder materials and the low photocatalytic efficiency, we have developed a series of Fe-MOFs (MIL-53(Fe), NH2-MIL-53(Fe), MIL-101(Fe), NH2-MIL-101(Fe) and MIL-100(Fe)) on pure iron mesh. In this study, the growth of Fe@MILs on the iron mesh was confirmed through SEM, XRD, and FT-IR characterizations. Among the photocatalytic experiments, Fe@NH2-MIL-53(Fe) and Fe@NH2-MIL-101(Fe), which are amine-functionalized, showed improved photocatalytic activity. This improvement is believed to be due to the combination of NH2 functionality and electron transfer to the Fe-O cluster centre, resulting in dual excitation pathways. Furthermore, Fe@MIL-100(Fe) showed the highest performance for the removal of Cr(VI), with over 92% of Cr(VI) being removed in the fifth photocatalytic cycle. Mechanism indicated that the close connection between the compact structure of Fe-MOFs and effective electron migration. Additionally, sacrificial reagent experiments identified two important species for Cr(VI) reduction: electrons (e-) and superoxide radicals (O2-). The photocatalytic recovery tests showed a 97% recovery rate of Cr(VI). This work offers a novel solution for the treatment of water sources contaminated with Cr(VI).
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 17
·9977-9984
·
IF 3.361
Fuhua Wei,Qinhui Ren,Huan Zhang,Lili Yang,Hongliang Chen,Zhao Liang,Ding Chen
Zirconium-iron metal–organic frameworks (Zr/Fe-MOFs) and Zr/Fe-MOF/graphene oxide (GO) composites were prepared via solvothermal synthesis using ferrous sulfate heptahydrate, zirconium acetate, and 1,3,5-benzenetricarboxylic acid. The MOFs and composites were measured using scanning electron microscopy (SEM), infrared spectrometry (IR), and thermogravimetric analysis (TGA). In this study, we explored the ability of Zr/Fe-MOFs and Zr/Fe-MOF/GO composites to adsorb tetracycline hydrochloride from an aqueous solution. Additionally, we optimized the adsorption performance by varying the ratio of MOFs and MOF composites to tetracycline hydrochloride solution, the concentration of tetracycline hydrochloride solution, and the pH of the solution. The results were investigated and fit to both pseudo-first-order and pseudo-second-order kinetic models. The results of the Freundlich and Langmuir isotherm models indicate that Zr/Fe-MOFs and Zr/Fe-MOF/GO composites have heterogeneous adsorption surfaces and that tetracycline hydrochloride is adsorbed over Zr/Fe-MOFs and Zr/Fe-MOF/GO by multilayer adsorption. Overall, our findings indicate that Zr/Fe-MOFs and Zr/Fe-MOF/GO composites can effectively treat wastewater, providing an inexpensive alternative to other methods.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2024
·Vol. 20
·期 34
·2401024
·
IF 13
Yuquan Wu,Da Lei,Jiawen Li,Ying Luo,Yuwan Du,Shi Zhang,Baiyi Zu,Yuhong Su,Xincun Dou
Exposing different facets on metal-organic frameworks (MOFs) is highly desirable to enhance the performance for various applications, however, exploiting a concise and effective approach to achieve facet-controlled synthesis of MOFs remains challenging. Here, by modulating the ratio of metal precursors to ligands, the facet-engineered iron-based MOFs (Fe-MOFs) exhibits enhanced catalytic activity for Fenton reaction are explored, and the mechanism of facet-dependent performance is revealed in detail. Fully exposed (101) and (100) facets on spindle-shaped Fe-MOFs enable rapid oxidation of colorless o -phenylenediamine (OPD) to colored products, thereby establishing a dual-mode platform for the detection of hydrogen peroxide (H 2 O 2 ) and triacetone triperoxide (TATP). Thus, a detection limit as low as 2.06 n m is achieved, and robust selectivity against a wide range of common substances (>16 types) is obtained, which is further improved by incorporating a deep learning architecture with an SE-VGG16 network model, enabling precise differentiation of oxidizing agents from captured images. The present strategy is expected will shine light on both the rational synthesis of nanomaterials with modulated morphologies and the exploitation of high-performance trace chemical sensors.
研究领域:
材料科学
·
化学传感
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Lili Zhang,Yiming Chen,Haowei Wang,Junyi Wang,Jun Shi,Qijian Niu,Xiuxiu Dong
Accurate detection of phthalic acid esters (PAEs) in food samples is critically important for food safety monitoring due to their endocrine-disrupting effects. A colorimetric (CL) sensing platform was developed, which shows universal response to all PAEs analytes. In the sensing system, Fe-MOFs with peroxidase-like (POD-like) activity catalyze H 2 O 2 to generate reactive oxygen species (ROS), which oxidize colorless 3,3′,5,5′-tetramethylbenzidine (TMB) into blue oxidation product (oxTMB). However, after the addition of PAEs, it will compete with TMB for active substances, resulting in a decrease in the generated oxTMB. Therefore, with the increase of PAEs concentration, the intensity of UV absorption peak attributed to oxTMB decreased. Taking dibutyl phthalate (DBP) as an example, the linear equation between absorption intensity ( A 652 ) and target concentration (1.0 × 10 −9 –5.0 × 10 −5 mol/L) was established. The correlation coefficient ( R 2 ) was 0.996, and the limit of detection (LOD) was 2.7 × 10 −10 mol/L. The signal response evaluation of multiple target PAEs was carried out separately. The CL sensing platform constructed using Fe-MOFs has been proved to be a reliable sensing system for the detection of DBP in real samples and yielded satisfactory recovery results. The successful application of this method for the detection of DBP in pakchoi, cherry tomato and fruit cucumber samples showed that it has the potential to detect PAEs in complex samples.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2026
·
IF 6.2
Xianfeng Wang,Genchang Chen,Gongle Shen,Zhenping Liu,Fengwu Lin,Lei Shen,Jianhua Su,Dapeng Zhou,Sen Yang
Salt-sensitive hypertension represents a significant global health burden, yet its underlying pathogenic mechanisms remain incompletely understood. Recent evidence indicates that the microbial metabolite α-lipomycin contributes to vascular dysfunction by selectively suppressing endothelial TRPV4 channels, thereby impairing vasodilation and promoting the development of salt-sensitive hypertension. Consequently, the highly sensitive and selective detection of α-lipomycin is of critical importance for early risk assessment and intervention. Herein, Fe-MOFs nanorods were prepared using TCPP as organic ligands and Fe(III) as metal centers via solvothermal method for α-lipomycin detection. Specific host-guest effects between α-lipomycin and Fe(III) centers in Fe-MOFs, and selectively disrupt the ligand-to-metal charge transfer within Fe-MOFs, triggering simultaneous fluorescence emission at 645 nm and brown chromogenic appearance. Consequently, Fe-MOFs nanorods serve as a fluorescent and colorimetric nanoprobe for dual-mode detection of α-lipomycin. The sensor demonstrated a broad linear response range of 0.05-10 µM and ultralow detection limits of 23.83 nM (fluorescence) and 409.80 nM (colorimetry), respectively. Furthermore, the dual-signal response of the Fe-MOFs nanoprobe toward α-lipomycin further confers exceptional selectivity against interferents and high repeatability (RSD < 5.64%). Notably, practical validation in tap water shows acceptable recoveries from 93.47 to109.35% recovery rates. Importantly, clinical serum analyses demonstrate a elevated α-lipomycin level in hypertensive patients, validating strong practicability of Fe-MOFs nanoprobe for early pathogenesis detection and therapeutic monitoring. These findings highlight the Fe-MOFs nanoprobe as a dual-mode optical platform for selective and reliable α-lipomycin detection. Its field-deployable design overcomes the clinical limitations in utility of conventional methods like mass spectrometry. It also offers a transformative approach for applications in pathogenesis research, typing, early warning, and prevention of salt-sensitive hypertension.
✓ 已验证
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2017
·Vol. 46
·期 47
·16525-16531
·
IF 4.029
Fu-hua Wei,Ding Chen,Zhao Liang,Shuai-qi Zhao,Yun Luo
Fe-Based metal–organic frameworks (Fe-MOFs) were prepared with trimesic acid and FeSO4·7H2O via a microwave-assisted ball milling approach. The structure and thermal stability of the as-prepared Fe-MOFs were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectrometry (FTIR), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). When used to degrade 20 mg L−1 hexavalent chromium in aqueous solution, the Fe-MOFs were found to completely reduce a 100 mL solution within 120 min under natural light and a 400 mL solution within 90 min under Xe lamp irradiation. Under natural sunlight, 98% of the Cr(VI) was removed from a 40 mL solution after 40 min.
研究领域:
环境化学
·
材料科学
·
纳米技术
·
污染控制
·
光催化
·
水处理
✓ 已验证
DOI
高影响因子
Nano-Micro Letters
·
2020
·Vol. 12
·期 1
·1-16
·
IF 12.264
Deng Baiwen,Xiang Zhen,Xiong Juan,Liu Zhicheng,Yu Lunzhou,Lu Wei
Sandwich-like laminated Fe&TiO 2 @C nanocomposites were successfully prepared from the MXene–MOFs hybrids.
A broad effective bandwidth of 6.5 GHz at a thickness of only 1.6 mm was achieved.
研究领域:
材料科学
·
电磁学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）