RSC Advances
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2015
·Vol. 5
·期 98
·80728-80738
·
IF 3.84
Chunyu Yang,Wei Guo,Na An,Liru Cui,Ting Zhang,Ruihan Tong,Yuhua Chen,Huiming Lin,Fengyu Qu
Fe3O4@mSiO2 (magnetic Fe3O4 core coated by a mesoporous silica shell) nanoparticles were successfully synthesized as a carrier. The anti-cancer drug doxorubicin (DOX) and chlorambucil (Chl) were used as the model cargo. After the drug-loading, a sodium hyaluronic acid (HA) cross-linked gel was adopted to coat the outside of the Fe3O4@mSiO2 nanoparticles as a layer (named as drug–Fe3O4@mSiO2–HA) to prevent drug pervasion. The detailed release kinetics were investigated, revealing the sensitive release triggered by hyaluronidase (HAase), a major enzyme which is rich in the tumor microenvironment, which can degrade the HA shell to induce the enzyme sensitive drug release. Moreover, there are some HA receptors in many tumor areas, associating with magnetic targets to further ensure the specific targeted drug delivery. With these improved performances, these smart multifunctional nanocomposites are expected to possess potential applications in the biopharmaceutical for cancer therapy.
研究领域:
生物医学工程
·
药学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Xiang-long Tang,Feng Jing,Ben-lan Lin,Sheng Cui,Ru-tong Yu,Xiao-dong Shen,Ting-wei Wang
By overcoming drug resistance and subsequently enhancing the treatment, the combination therapy of photodynamic therapy (PDT) and chemotherapy has promising potential for cancer treatment. However, the major challenge is how to establish an advanced nanoplatform that can be efficiently guided to tumor sites and can then stably release both chemotherapy drugs and a photosensitizer simultaneously and precisely. In this study, which considered the possibility and targeting efficiency of a magnetic targeting strategy, a novel Fe3O4@mSiO2(DOX)@HSA(Ce6) nanoplatform was successfully built; this platform could be employed as an efficient synergistic antitumor nanoplatform with magnetic guidance for highly specific targeting and retention. Doxorubicin (DOX) molecules were loaded into mesoporous silica with high loading capability, and the mesoporous channels were blocked by a polydopamine coating. Human serum albumin (HSA) was conjugated to the outer surface to increase the biocompatibility and blood circulation time, as well as to provide a vehicle for loading photosensitizer chlorin e6 (Ce6). The sustained release of DOX under acidic conditions and the PDT induced by red light exerted a synergistic inhibitory effect on glioma cells. Our experiments demonstrated that the pH-responsive Fe3O4@mSiO2(DOX)@HSA(Ce6) nanoplatform was guided to the tumor region by magnetic targeting and that the nanoplatform suppressed glioma tumor growth efficiently, implying that the system is a highly promising photodynamic therapy/chemotherapy combination nanoplatform with synergistic effects for cancer treatment.
研究领域:
纳米技术
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癌症研究
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生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2014
·
IF 4.384
Chunyu Yang,Wei Guo,Liru Cui,Na An,Ting Zhang,Huiming Lin,Fengyu Qu
Polymer-modified nanoparticles, which can load anticancer drugs such as doxorubicin (DOX), showing the release in response to a specific trigger, have been paid much attention in cancer therapy. In our study, a pH-sensitive drug-delivery system consisting of Fe3O4@mSiO2 core–shell nanocomposite (about 65 nm) and a β-thiopropionate-poly(ethylene glycol) “gatekeeper” (P2) has been successfully synthesized as a drug carrier (Fe3O4@mSiO2@P2). Because of the hydrolysis of the β-thiopropionate linker under mildly acidic conditions, Fe3O4@mSiO2@P2 shows a pH-sensitive release performance based on the slight difference between a tumor (weakly acid) and normal tissue (weakly alkaline). And before reaching the tumor site, the drug-delivery system shows good drug retention. Notably, the nanocomposites are quickly taken up by HeLa cells due to their small particle size and the poly(ethylene glycol) modification, which is significant for increasing the drug efficiency as well as the cancer therapy of the drug vehicles. The excellent biocompatibility and selective release performance of the nanocomposites combined with the magnetic targeted ability are expected to be promising in the potential application of cancer treatment.
研究领域:
生物医学工程
·
纳米医学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DRUG DELIVERY
·
2019
·
IF 3.829
Minchao Liu,Xiangyu Sun,Zhihui Liao,Yahui Li,Xiaoliang Qi,Yuna Qian,Hicham Fenniri,Ping Zhao,Jianliang Shen
Multifunctional core-shell nanocarriers based on zinc oxide (ZnO)-gated magnetic mesoporous silica nanoparticles (MMSN) were prepared for cancer treatment through magnetic targeting and pH-triggered controlled drug release. Under an external magnetic field, the MMSN could actively deliver chemotherapeutic agent, daunomycin (DNM), to the targeted sites. At neutral aqueous, the functionalized MMSN could stably accommodate the DNM molecules since the mesopores were capped by the ZnO gatekeepers. In contrast, at the acid intercellular environment, the gatekeepers would be removed to control the release of drugs due to the dissolution of ZnO. Meanwhile, ZnO quantum dots not only rapidly dissolve in an acidic condition of cancer cells but also enhance the anti-cancer effect of Zn2+. An in vitro controlled release proliferation indicated that the acid sensitive ZnO gatekeepers showed well response by the ‘on-off’ switch of the pores. Cellular experiments against cervical cancer cell (HeLa cells) further showed that functionalized MMSN significantly suppressed cancer cells growth through synergistic effects between the chemotherapy and Zn2+ ions with monitoring the treatment process. These results suggested that the ZnO-gated MMSN platform is a promising approach to serve as a pH-sensitive system for chemotherapies delivery and Zn2+ controlled release for further application in the treatment of various cancers by synergistic effects.
研究领域:
纳米医学
·
肿瘤学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
ChenDi Ding,JianHua Xu,Ling Tong,GuangCai Gong,Wei Jiang,Jiajun Fu
Corrosion potential stimulus-responsive smart nanocontainers (CP-SNCs) are designed and synthesized based on the installation of the supramolecular assemblies (bipyridinium ⊂ water-soluble pillar[5]arenes) onto the exterior surface of magnetic nanovehicles (Fe3O4@mSiO2), linked by disulfide linkers. The supramolecular assemblies with high binding affinity as gatekeepers effectively block the encapsulated organic corrosion inhibitor, 8-hydroxyquinoline (8-HQ), within the mesopores of Fe3O4@mSiO2. When the corrosion potential of the magnesium alloy (−1.5 V vs SHE) is exerted, 8-HQ is released instantly because of the cleavage of disulfide linkers and the removal of the supramolecular assemblies. CP-SNCs were incorporated into the hybrid organic–inorganic sol–gel coating to construct a corrosion potential stimulus-feedback anticorrosion coating (CP-SFAC) that was then deposited on the magnesium alloy, AZ31B. With the aid of a magnetic field, CP-SNCs were gathered in the proximity of the surface of AZ31B. CP-SFAC showed a satisfactory anticorrosion performance, more importantly, through the evaluation of microzone electrochemical techniques. CP-SFAC presented the rapid self-healing functionality when the localized corrosion occurred. Shortening the distance between CP-SNCs and the surface of AZ31B enhances the availability of the incorporated CP-SNCs and makes most of the CP-SNCs to timely respond to the corrosion potential stimulus and facilitates the formation of a compact molecular protective film before the corrosion products pile up. The characteristics of fast response time and quick self-healing rate meet the requirements of the magnesium alloy for self-healing in local regions.
研究领域:
材料科学
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腐蚀工程
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纳米技术
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表面化学
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电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）