JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2018
·Vol. 316
·期 2
·685-690
·
IF 1.181
Song Hu,Wang Yunhan,Wang Jing,Wang Guanquan,He Jiaheng,Wei Hongyuan,Luo Shunzhong
For the superiority of graphene quantum dots (GQDs) in bioimaging and drug delivery carrier, GQDs bring new opportunities for theranostics of diseases. In this study, GQDs were successfully prepared and labeled with 131 I. The in vitro properties, biodistribution and SPECT imaging of 131 I-GQDs were investigated. The uptake of 131 I-GQDs at tumor sites can be clearly observed via SPECT imaging and T/B and T/M ratios increase with increasing time, which can contribute to enhanced permeability and retention (EPR) effect.
研究领域:
核医学
·
放射学
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材料科学
·
生物医学工程
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高影响因子
DIAMOND AND RELATED MATERIALS
·
2025
·
IF 5.1
Qi Hu,Chenhao Xu,Yulong Hua,Cunkang Qi,Jing Zhang,Yuemin Wang,Chengchun Tang
To explore the improvement of microwave absorption performance of boron nitride nanosheets (BNNSs) after doping with graphene quantum dots (GQDs). Herein, a series of point-layer structure BNNSs supported by GQDs composite absorbing materials were designed and prepared. The influence of the substrate on the wave absorption intensity was investigated by loading the same GQDs with BNNSs of different scales. Among them, the BG-1400 with BNNSs-1400 as the substrate and GQDs as the load has the best microwave absorption performance. Its minimum reflection loss ( RL min ) reaches −60.3 dB and the effective absorption frequency band is 8.5 GHz. In order to further analyze the factors influencing the effective absorption frequency bands of BNNSs/GQDs composites, BNG-1400 and BFG-1400 were prepared by loading N-GQDs and F-GQDs respectively on the BNNSs-1400 substrate, and their RL min and effective absorption frequency bands were -57.3 dB, −57.7 dB and 11.3 GHz, 13.4 GHz, respectively. The effective absorption frequency bands of BNG-1400 and BFG-1400 have been significantly improved compared with BG-1400.This indicates that the substrate size of the BNNSs/GQDs composite material can control its absorption intensity, while different doped elements in GQDs can adjust its effective absorption frequency band. This discovery lays the foundation for the research on the controllable adjustment of the wave absorption performance of BNNSs/GQDs composite absorbing materials.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Jian Gao,Deyi Zhuang,Bing Yu,Yun Fa,Wansheng Zhang,Xingyong Han,Huimin Li,Maocai Feng
A composite gel microsphere with a three-dimensional porous network structure has been developed: AO/SA-GQDs. • Under the same adsorption conditions, the introduction of GQDs increased the uranium adsorption capacity of the material from 52.584 mg·g −1 to 186.996 mg·g −1 . • AO/SA-GQDs composite gel microspheres exhibited a rapid U(VI) adsorption rate, reaching adsorption equilibrium within 300 min. • The highest experimental U(VI) adsorption capacity reached 231.593 mg·g −1 at 298.15 K and pH 5. • After five cycles, AO/SA-GQDs retained 84.99% of its initial adsorption capacity, with desorption rate above 80%. • The material is easy to prepare, and its raw materials are readily available and inexpensive, suggesting its potential for practical application. Stable uranium supply is essential for the development of nuclear power, and uranium extraction from seawater is regarded as a promising strategy for the sustainable development of nuclear energy. In this study, amidoxime-functionalized sodium alginate/graphene quantum dot composite gel microspheres (AO/SA-GQDs) were prepared via an in situ composite droplet-ion cross-linking method. Sodium alginate served as the matrix, amidoxime groups were introduced as U(VI)-specific binding sites, and graphene quantum dots (GQDs) were incorporated to regulate the pore structure and hydrophilicity of the microspheres. The AO/SA-GQDs microspheres exhibited a porous network structure, with a BET specific surface area of 42.997 m 2 ∙g −1 . Batch adsorption experiments showed that the optimal adsorption pH was 5. Adsorption kinetic analysis demonstrated that the AO/SA-GQDs microspheres reached adsorption equilibrium within 300 min, indicating a rapid U(VI) adsorption rate. At 298.15 K and pH 5, the highest experimentally measured equilibrium adsorption capacity was 231.593 mg∙g −1 , whereas the Langmuir-fitted maximum monolayer adsorption capacity was 244.499 mg∙g −1 . In the presence of various coexisting ions, the microspheres still maintained a high adsorption capacity for U(VI), demonstrating good selectivity. After five adsorption-desorption cycles, the adsorption capacity remained at more than 84% of its initial value, and the desorption efficiency remained above 80%. These results indicate that AO/SA-GQDs composite gel microspheres possess favorable adsorption capacity, selectivity, and recyclability, suggesting their potential for uranium extraction from aqueous environments. Download: Download high-res image (243KB) Download: Download full-size image
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高影响因子
Analytical Methods
·
2016
·Vol. 8
·期 11
·2366-2374
·
IF 1.915
Zongen Liu,Xiaohui Cai,Xuefang Lin,Yanjie Zheng,Yangting Wu,Pingping Chen,Shaohuang Weng,Liqing Lin,Xinhua Lin
Graphene quantum dots (GQDs) exhibit strong photoluminescence, biocompatibility, and low toxicity and can easily functionalize surfaces to improve the detection of biomolecules. As-prepared MnO2 nanosheets were applied in the fabrication of GQDs–MnO2 composite to develop a signal-on fluorescent platform for sensing glutathione (GSH). The fluorescence of the GQDs was quenched by MnO2 in the GQDs–MnO2 composite as a result of fluorescence resonance energy transfer within the composite. The fluorescence of GQDs was restored when GSH was introduced because GSH reduced the MnO2 nanosheets into Mn2+ and released GQDs. Under the optimized conditions, the concentration of GSH can be accurately detected with high sensitivity and specificity in Tris–HCl buffer and simulated serum. The proposed sensing strategy was successfully used to measure GSH in the range of 1–1000 μM with a detection limit of 0.45 μM. In addition, GSH in reduced glutathione injection and reduced glutathione tablets can be determined accurately using the proposed method. GQDs–MnO2 composite is thus a promising GSH fluorescence sensor for the analysis of complex systems and for quality control in the pharmaceutical industry.
研究领域:
分析化学
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生物医学工程
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药物分析
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2019
·Vol. 21
·期 12
·1-9
·
IF 2.009
Yao Xinyue,Qian Chuntong,Zhong Yuanyuan,Sun Shian,Xu Huanghuang,Yang Dongzhi
Graphene quantum dots capped in hollow mesoporous silica nanoparticles (GQDs@hMSN) exhibited great potential in medical applications due to its good optical properties and high drug loading capacity. Compared with antibodies, peptide has a better affinity with target proteins. Herein, we demonstrated efficient targeting of triple-negative breast cancer with GQDs@hMSN, which was conjugated to a peptide ligand, F3 against nucleolin, to form GQDs@hMSN-F3. The core/shell GQDs@hMSN and GQDs@hMSN-F3 had diameters of 100 nm and 130 nm, respectively, based on transmission electron microscope (TEM) and dynamic laser scattering (DLS) measurement. Doxorubicin (DOX) was loaded onto GQDs@hMSN with a relatively high loading capacity. Systematic in vitro and in vivo studies were performed to investigate the targeting specificity and tissue distribution of GQDs@hMSN conjugates. Fluorescence microscopy examination and flow cytometry confirmed the targeting specificity of F3-attached GQDs@hMSN conjugates against cell nucleolin. A more potent uptake of GQDs@hMSN-F3 in MDA-MB-231 nodules was witnessed when compared with that of non-targeted GQDs@hMSN. Based on the findings from cellular targeting and in vivo fluorescence imaging, F3-attached GQDs@hMSN conjugates had the potential to serve as an image-guidable, tumor-selective cargo delivery nanoplatform.
研究领域:
纳米医学
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癌症研究
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药剂学
·
分子生物学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Weifeng Chen,Guo Lv,Jinrun Fu,Haiyan Ren,Jialu Shen,Jie Cao,Xiang Liu
Achieving the controlled release of H2 through an effective approach still faces many challenges. Herein, high-quality graphene quantum dots (GQDs) are synthesized from a new precursor, 1,2,4-trihydroxy benzene, and a multifunctional platform of Rh@GQDs is further developed for the controlled H2 evolution upon the hydrolysis of NH3BH3 (AB). More importantly, the designing concepts of multistep and stepless speed controls have been introduced in the domains of both H2 evolution for the first time. Through a novel designing protocol, the rate of H2 evolution can be freely regulated and constantly varied on demand by means of chelation between Zn2+ and ethylene diamine tetraacetic acid (EDTA). The density functional theory calculation indicates that Zn2+ has the priority to be adsorbed onto Rh(100) due to its larger adsorption energy (107.98 kcal·mol–1) than that of AB (36.36 kcal·mol–1). A controlling mechanism is presented such that Zn2+ will cover the active sites of the nanocatalyst to prevent the H2 evolution, and EDTA can chelate Zn2+ to reactivate the nanocatalyst for the production of H2, greatly facilitating use of this strategy in other catalytic reactions. Moreover, it is demonstrated that the protocol is equally valid for diverse hydrogen storage materials. Therefore, this work not only establishes whole new concepts for the controlled production of H2 but also explains their mechanism, thus remarkably advancing the utilization of H2 energy and significantly enlightening the controlled process of catalysis.
研究领域:
材料科学
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催化化学
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能源科学
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PubMed
高影响因子
Advanced Materials Interfaces
·
2022
·Vol. 10
·期 1
·2200738
·
IF 6.389
Bo Wu,Minzhang Li,Rajendran Ramachandran,Gaoqiang Niu,Mingxiang Zhang,Changhui Zhao,Zongxiang Xu,Fei Wang
Dopamine (DA) and uric acid (UA) are biomolecules of great consideration that coexist in human body. It is essential and challenging to detect them simultaneously with high sensitivity. This paper reports a novel electrochemical biosensor based on the nanocomposites of cobalt phthalocyanine (CoPc) anchored with graphene quantum dots (GQDs) for DA and UA detection. The GQDs incorporation on CoPc nanorods with partial end stretching significantly enhances the electrocatalytic activity and promotes the electron transfer rate. Low detection limits of 21 n m for DA and 145 n m for UA have been successfully achieved for the fabricated CoPc/GQDs biosensor. The density-functional theory proves the enhanced conductivity of CoPc/GQDs and the biomolecule's interaction with the electrode surface. Furthermore, the proposed sensor shows remarkable reproducibility, repeatability, and stability. The fabricated sensor is applied for the simultaneous detections of DA and UA in human urine samples. The excellent performance suggests that the CoPc/GQDs could be a promising and potential candidate for electrochemical sensors to detect DA and UA selectively.
研究领域:
生物传感器
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材料科学
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分析化学
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DOI
高影响因子
DIAMOND AND RELATED MATERIALS
·
2023
·
IF 4.1
Youliang Cheng,Yue Zhang,Jiaxian Li,Changqing Fang,Jing Chen,Jiarui Zhao,Tong Zhao,Jia Zhu
Volatile organic compounds (VOCs) in the field of printing and packaging, have caused great harm to the environment. Therefore, the removal of volatile organic compounds (VOCs) is a hot topic, and metal-organic frameworks (MOFs) and graphene quantum dots (GQDs) have been applied in this field. However, improving the removal efficiency of different VOCs by using the two kinds of materials is still a great challenge. Herein, ZIF-8 like materials of Zn-His-GQDs were prepared by assembling Zn 2+ and histidine functionalized GQDs (His-GQDs) in this work. The morphologies, structure and adsorption performances of Zn-His-GQDs were investigated. These results showed that mesoporous Zn-His-GQDs with a specific surface area of 63.3 m 2 ·g −1 had similar structure to ZIF-8. When the content of Zn-His-GQDs was 200 mg, the equilibrium adsorption capacity for toluene solution of 500 mg·L −1 and ethyl acetate solution of 1600 mg·L −1 was 350 mg·L −1 and 669.44 mg·L −1 , respectively. Due to channel filling, cation-π interaction, π-π interaction, hydrogen bond and high surface energy, Zn-His-GQDs exhibited a relative high removal efficiency for high concentration of toluene and ethyl acetate. The removal rate of Zn-His-GQDs on toluene and ethyl acetate after five cycles remained 59.80 % and 36.75 %, respectively. Moreover, this kind of MOFs like materials maintained stable structure during the adsorption in different pH solutions. Therefore, as-prepared Zn-His-GQDs with excellent adsorption performances for typical VOCs simulants in this work have potential application in the treatment of VOCs in the field of printing and packaging.
研究领域:
环境科学
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材料科学
·
化学工程
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高影响因子
ACS Sensors
·
2026
·Vol. 11
·期 7
·6157-6166
·
IF 10.9
Lu Jiaqi,Chen Xiangdong,Ding Xing,Liu Yanchang,Zhong Jialun,Liu Fang,Li Han,Li Guoping
Respiratory infectious diseases continue to pose a serious threat to public health. Their transmission relies on respiratory droplets that are small in size and evaporate rapidly, making real-time monitoring difficult. In this study, we propose a flying droplet sensor based on hydroxylated graphene quantum dots (H-GQDs) deposited on a cellulose nanofiber (CNF) film. Owing to the network water-locking structure of the film, the sensor is capable of detecting coughing droplets transmitting over long distances (≥2.4 m). By placing multiple such sensors at equal intervals along the cough airflow direction, the spatiotemporal transmission features of coughing droplets were obtained, including arrival time and signal intensity at different distances. On this basis, we investigated the transmission behavior of cough droplets from multiple individuals at various distances. The results show that regions close to the volunteer’s mouth exhibit a broader droplet size distribution, whereas at longer distances, the remaining droplets are mainly composed of small-size and low-intensity components. We further found that coughing droplets typically take 4−5 s to travel more than 2 m, indicating that a time window for timely protection still exists at this distance. In addition, the relationships between cough sound level and droplet signal intensity as well as transmission time were evaluated. No clear correlation was observed, suggesting that acoustic indicators alone cannot directly reflect the infection risk associated with cough droplet transmission. This study provides important insights for the real-time monitoring and protection against respiratory droplet transmission.
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PubMed
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Li Jiaxin,Guo Hui,Ji Weiwei,Chen Hanqi,Zhao Fengju,Yang Wei,Guo Lili,Qian Junqing
Tyrosinase inhibitors have the ability to resist melanin formation and can be used for clinical and cosmetic, so it is becoming extremely crucial to search a rapid and effective method for detecting t the activity of tyrosinase. In this study, a sensing probe based on Nitrogen-doped graphene quantum dots (N-GQDs) were prepared with carbamide and citric acid. Tyrosinase can oxidize dopamine to dopamine quinone, which can quench the fluorescence of N-GQDs based on the principle of fluorescence resonance energy transfer (FRET) process, and then the detection of tyrosinase activity can be achieved. The result demonstrated that the fluorescence intensity of N-GQDs was a linear correlation with the activity of tyrosinase. Wide detection linear ranges between 0.05 and 5 U/mL and high selectivity. The detection range of tyrosinase was 0.05 to 5 U/mL and LOD of 0.005 U/mL. According to the above, the fluorescence method established in this work could be successfully used for the trace analysis of tyrosinase and it was verified that KA is an inhibitor of tyrosinase.
研究领域:
生物化学
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医学检测
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材料科学
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DOI
PubMed
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 20
·11576-11584
·
IF 3.049
Jingjing Dong,Xinyue Yao,Shian Sun,Yuanyuan Zhong,Chuntong Qian,Dongzhi Yang
According to our previous experiment, graphene quantum dots capped in hollow mesoporous silica nanoparticles, denoted as GQDs@hMSN, and its conjugates exhibited great potential for medical applications due to their commendable biocompatibility. Due to the fluorescence and structural stability, and enormous porosity, polyethylene glycol (PEG) modified GQDs@hMSN (GQDs@hMSN-PEG) is a good candidate in a drug carrying and delivery system. However, the goal of targeted drug delivery couldn't be achieved simply by utilizing the enhanced permeability and retention (EPR) effect of tumors. In this study, GQDs@hMSN-PEG was further functionalized with vascular endothelial growth factor antibodies (VEGF Abs) for VEGF targeting of breast tumors. Doxorubicin (DOX) was loaded into GQDs@hMSN-VEGF Abs with a drug loading capacity of 0.80 mg DOX per mg GQDs@hMSN. With GQDs as the fluorescent source, GQDs@hMSN-VEGF Abs demonstrated strong fluorescence intensity in VEGF-positive cells. Results from in vitro and in vivo targeting experiments indicated that GQDs@hMSN-VEGF Abs had high specificity on tumor vasculature, and it could be used as an image-guidable, tumor-selective delivery nanoplatform for breast cancer.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
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DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 92
·75380-75385
·
IF 3.84
Han Wang,Xiaomin Wang
Graphene quantum dots surface passivated by polyethylenimine (GQDs-PEI) were prepared with a simple solvothermal method. Compared with the unfunctionalized graphene quantum dots (GQDs), the GQDs-PEI were well dispersed with an ultrasmall average diameter of ca. 1.66 nm, and have achieved better optical properties including high quantum yield (53.0%) and narrow emission spectral features which is probably because of the positively charged amines on PEI which facilitated the dispersion of GQDs. By being applied to the bioimaging of MG-63 cells, the GQDs-PEI showed brighter luminescence and minor cytotoxicity. Moreover, the GQDs-PEI are clearly rendered in the nucleus region, which offered a further application in the diagnosis of diseased phenotypes and the targeted therapy of tumour cells.
研究领域:
纳米技术
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材料科学
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生物医学工程
·
细胞生物学
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DOI
高影响因子
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