Materials
·
2022
·Vol. 15
·期 5
·1846
·
IF 3.748
Haiyao Cao,Zaiji Zhan,Xiangzhe Lv
Ti3AlC2presents a hexagonal layered crystal structure and bridges the gap between metallic and ceramic properties, and Gadolinia (Gd2O3) has excellent thermodynamic stability, which make them potentially attractive as dispersive phases for Cu matrix composites. In this paper, Cu@Ti3AlC2-Gd2O3/Cu composites, Ti3AlC2-Gd2O3/Cu composites, and Gd2O3/Cu composites were prepared by electroless Cu plating, internal oxidation, and vacuum hot press sintering. The microstructure and the effect of the Cu plating on the properties of the Cu@Ti3AlC2-Gd2O3/Cu composites were discussed. The results showed that a Cu plating with a thickness of about 0.67 μm was successfully plated onto the surface of Ti3AlC2particles. The ex situ Ti3AlC2particles were distributed at the Cu grain boundary, while the in situ Gd2O3particles with a grain size of 20 nm were dispersed in the Cu grains. The electroless Cu plating onto the surface of the Ti3AlC2particles effectively reduces their surfactivity and improves the surface contacting state between the Cu@Ti3AlC2particles and the Cu matrix, and reduces electron scattering, so that the tensile strength reached 378.9 MPa, meanwhile, the electrical conductivity and elongation of the Cu matrix composites was maintained at 93.6 IACS% and 17.6%.Keywords:Cu@Ti3AlC2-Gd2O3/Cu composites;electroless Cu plating;microstructure;electrical conductivity;mechanical properties
研究领域:
材料科学
·
冶金工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chemistry-An Asian Journal
·
2016
·Vol. 11
·期 17
·2458-2469
·
IF 4.592
Huai-Xin Zhao,Hong Wang,Quan Zou,Shao-Kai Sun,Chunshui Yu,Xuejun Zhang,Yan-Yan Fu
Graphical Versatile nanoparticle : A facile one-pot approach for the preparation of a versatile CuS/Gd 2 O 3 hybrid nanoparticle, which is used as a theranostic agent for magnetic resonance imaging and synergistic cancer therapy, has been developed. The versatile application of nanoparticles in integrating imaging and therapy has aroused extensive research interest in precision medicine. Of the various nanoparticles that have been studied, CuS has shown great potential in the construction of multifunctional agents, owing to its excellent photothermal heating properties. Herein, we report a facile one-pot biomineralization approach for the preparation of versatile bovine-serum-albumin-conjugated CuS/Gd 2 O 3 hybrid nanoparticles (BSA−CuS/Gd 2 O 3 HNPs), which simultaneously possessed strong longitudinal relaxivity, an outstanding photothermal effect, high drug-loading capacity, and pH/temperature-responsive drug release. The versatile nanoparticles were used for magnetic resonance imaging (MRI) and antitumor photothermal chemotherapy, both in vitro and in vivo. In vivo MRI showed that the BSA−CuS/Gd 2 O 3 HNPs had a long circulation time and effective passive tumor-uptake ability. More importantly, combined in vitro and in vivo therapy demonstrated that drug-loaded BSA−CuS/Gd 2 O 3 HNPs offered outstanding synergistic therapeutic efficacy for tumor inhibition.
研究领域:
医学影像学
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2014
·
IF 4.384
Jun Liu,Xiumei Tian,Ningqi Luo,Chuan Yang,Jun Xiao,Yuanzhi Shao,Xiaoming Chen,Guowei Yang,Dihu Chen,Li Li
Monoclinic Gd2O3:Eu3+ nanoparticles (NPs) possess favorable magnetic and optical properties for biomedical application. However, how to obtain small enough NPs still remains a challenge. Here we combined the standard solid-state reaction with the laser ablation in liquids (LAL) technique to fabricate sub-10 nm monoclinic Gd2O3:Eu3+ NPs and explained their formation mechanism. The obtained Gd2O3:Eu3+ NPs exhibit bright red fluorescence emission and can be successfully used as fluorescence probe for cells imaging. In vitro and in vivo magnetic resonance imaging (MRI) studies show that the product can also serve as MRI good contrast agent. Then, we systematically investigated the nanotoxicity including cell viability, apoptosis in vitro, as well as the immunotoxicity and pharmacokinetics assays in vivo. This investigation provides a platform for the fabrication of ultrafine monoclinic Gd2O3:Eu3+ NPs and evaluation of their efficiency and safety in preclinical application.
研究领域:
生物医学工程
·
材料科学
·
医学影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chinese Physics B
·
2022
·Vol. 31
·期 7
·078701
·
IF 1.652
Hua-Wei Deng,Di-Hu Chen
Multifunctional luminescent materials are attracting attention nowadays. In this work, monoclinic Gd2O3:Er3+ nanoparticles, which possess up-conversion luminescence and down-conversion luminescence properties, were successfully synthesized by laser ablation in liquid (LAL) technique. Up-conversion luminescence and down-conversion luminescence of monoclinic Gd2O3:Er3+ nanoparticles were got under the excitation of 980 nm and 379 nm, respectively. In addition, tunable luminescence was got. Furthermore, the cytotoxicity of the nanoparticles is low and the fluorescence of the nanoparticles in cell is also strong enough. The results indicate that the Gd2O3:Er3+ nanoparticles synthesized by LAL technique are promising candidates for bio-imaging or other fields that require controllable fluorescence.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 113
·93041-93047
·
IF 3.84
Haoyu Wang,Yan-Yan Fu,Xuejun Zhang,Chunshui Yu,Shao-Kai Sun
MR contrast agents play a crucial role in the early diagnosis of various diseases, and many nanoprobes with versatile properties have been developed. However, in order to seek high sensitivity, the biocompatibility and systemic toxicity assessment of the nanoprobes have attracted much less attention. To meet clinical requirements, it is highly desirable to develop a highly sensitive and biocompatible nanoprobe using a facile procedure. Herein, we report a sensitive and biocompatible Gd2O3 nanoprobe using hyaluronic acid (HA) via a one-pot facile synthesis. HA not only endows the nanoprobe with excellent biocompatibility, but also gives a synergistic effect for improving the sensitivity of the nanoprobe in the aspects of increasing rotational correlation time, water exchange rate and the ratio of surface Gd3+ to the inner ones. What’s more, the nanoprobe has specific ability for adrenal gland MR imaging. These results suggest that the HA–Gd2O3 nanoprobe has a potentially promising application in MR imaging in vivo.
研究领域:
医学影像学
·
纳米医学
·
生物材料
✓ 已验证
DOI
高影响因子
Results in Physics
·
2019
·
IF 3.042
Biao Zheng,Cheng Zhang,Chunlei Huang,Jinquan Hong,Yuliang Li,Jun Wang,Lin Lin,Zhiqiang Zheng
Multifunctional NiO@Gd 2 O 3 :Er 3+ ,Yb 3+ hollow nanocomposites (NCs) with mesoporous, upconversion (UC) luminescent and magnetic properties are synthesized by a facile hydrothermal process. Transmission electron microscope (TEM) and scanning electron microscope (SEM) images reveal that the samples have hollow structures with double shells of UC layer and magnetic layer. N 2 adsorption/desorption isotherm analysis shows the samples have large surface area of 29.052 m 2 /g and typical mesoporous structure. Multicolored UC luminescence at 521 nm, 541 nm and 654 nm are obtained under 980 nm laser excitation. In addition, the measured magnetic hysteresis loops indicate the samples exhibit high superparamagnetic behavior (15.8 emu/g). These multifunctional NCs have potential applications in the field of fluorescence probe, targeted therapy, magnetic separation, etc.
研究领域:
材料科学
·
纳米技术
·
光学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 11
·期 4
·1393-1400
·
IF 8.067
Donghao Sun,Meigui Ou
A one-step hydrothermal method was used to successfully synthesize the nanocomposites with an average size of 3.15 nm of graphene quantum dots (GQDs) and gadolinium oxide (Gd2O3), and a high-density ultrasonic vibration was applied to increase the concentration of oxygen vacancies in the obtained Gd2O3/GQD nanocomposites. The structure and properties of the nanocomposites were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, transmission electron microscopy and photoluminescence spectroscopy. It was found that after high-density ultrasonic dispersion for 2 h and 4 h, the fluorescence intensity of the nanocomposites was enhanced by about 42.7% and 54.6%, respectively, due to the formation of more activation sites induced by oxygen vacancies. The results of density functional theory (DFT) calculations confirmed the successful synthesis of the Gd2O3/GQD nanocomposites by Gd–O–C covalent bonds, and showed that the band gap narrowed (from 0.019 eV to 0.010 eV and 0.008 ev, respectively) for Gd2O3/GQD with more oxygen vacancies, offering an explanation to the enhancement of fluorescence intensity. Moreover, the magnetization increased (from 0.27 emu g−1 to 0.83 emu g−1) with the increasing concentration of oxygen vacancies. These results provide a favorable approach for realizing the application of the Gd2O3/GQD nanocomposites in the field of multimodal imaging.
研究领域:
材料科学
·
物理学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF INORGANIC BIOCHEMISTRY
·
2015
·
IF 3.444
Yi Jin,Shizhu Chen,Jianlei Duan,Guang Jia,Jinchao Zhang
With the wide applications of europium-doped Gd 2 O 3 nanoparticles (Gd 2 O 3 :Eu 3 + NPs) in biomedical fields, it will inevitably increase the chance of human exposure. It was reported that Gd 2 O 3 :Eu 3 + NPs could accumulate in bone. However, there have been few reports about the potential effect of Gd 2 O 3 :Eu 3 + NPs on bone marrow stromal cells (BMSCs). In this study, the Gd 2 O 3 :Eu 3 + nanotubes were prepared and characterized by powder X-ray diffraction (XRD), photoluminescence (PL) excitation and emission spectra, scanning electron microscope (SEM), and transmission electron microscopy (TEM). The cytotoxicity of Gd 2 O 3 :Eu 3 + nanotubes on BMSCs and the associated mechanisms were further studied. The results indicated that they could be uptaken into BMSCs by an energy-dependent and macropinocytosis-mediated endocytosis process, and primarily localized in lysosome . Gd 2 O 3 :Eu 3 + nanotubes effectively inhibited the viability of BMSCs in concentration and time-dependent manners. A significant increase in the percentage of late apoptotic/necrotic cells, lactate dehydrogenase (LDH) leakage and the number of PI-stained cells was found after BMSCs were treated by 10, 20, and 40 μg/mL of Gd 2 O 3 :Eu 3 + nanotubes for 12 h. No obvious DNA ladders were detected, but a dispersed band was observed. The above results revealed that Gd 2 O 3 :Eu 3 + nanotubes could trigger cell death by necrosis instead of apoptosis. Two mechanisms were involved in Gd 2 O 3 :Eu 3 + nanotube-induced BMSCs necrosis: lysosomal rupture and release of cathepsins B ; and the overproduction of reactive oxygen species (ROS) injury to the mitochondria and DNA. The study provides novel evidence to elucidate the toxicity mechanisms and may be beneficial to more rational applications of these nanomaterials in the future.
研究领域:
生物医学
·
毒理学
·
纳米材料科学
✓ 已验证
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2020
·Vol. 49
·期 22
·7397-7405
·
IF 4.174
Jie Chen,Yixin Gao,Haifeng Jiang,Yan Liu,Zhaohui Jin
Optimizing structure and varying doped ions are two main strategies to obtain excellent luminescence performance. Spherical morphology is considered to be the most ideal phosphor structure due to the least surface defects. Herein, a series of spherical and monodispersed Dy3+/Eu3+ co-activated SiO2@Gd2O3 core–shell phosphors with multicolor tunable luminescence were successfully prepared via a facile urea assisted precipitation method. Related chemical reactions and the possible growth mechanism of Gd2O3:Ln3+ directional deposition on the surface of SiO2 microspheres were put forward. Upon 273 nm UV radiation excitation, SiO2@Gd2O3:Dy3+ and SiO2@Gd2O3:Eu3+ samples exhibited characteristic yellow (4F9/2–6H13/2) and blue (4F9/2–6H15/2) emissions of Dy3+ and red (5D0–7F2) emission of Eu3+, respectively. Meanwhile, multicolor emissions (warm white, yellow and orange) could be easily obtained by modulating the relative content of Dy3+ and Eu3+ in SiO2@Gd2O3:Ln3+ samples under a single excitation wavelength. Moreover, it was confirmed that Dy3+ could transfer energy to Eu3+ in the form of quadrupole–quadrupole interaction and further improved the luminescence intensity of Eu3+ by comparing experimental data with theoretical calculations. These results imply that tunable luminescence Dy3+,Eu3+ co-doped SiO2@Gd2O3 microspheres have great potential applications in multicolor displays and biolabeling fields.
研究领域:
材料科学
·
光学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 94
·77204-77210
·
IF 3.84
Yue Dai,Aiping Zhang,Jia You,Jingjing Li,Huiting Xu,Kai Xu
Magnetic resonance imaging (MRI) as a noninvasive diagnostic technology with high spatial resolution has been widely used in clinics. However, the relatively low sensitivity is the main shortcoming of this technology. To address this issue, we would like to develop a molecular MRI nanoprobe for the sensitive and specific MRI of renal carcinoma cells with BSA-Gd2O3 nanoparticles as MRI contrast agents, mesoporous silica nanoparticles (mSiO2 NPs) as nanocarriers and the AS1411 aptamer as a targeting molecule. To achieve this aim, BSA-Gd2O3 NPs were assembled onto mSiO2 NPs with the help of anionic polyelectrolyte, sodium polystyrene sulfonate (PSS), and cationic polyelectrolyte, poly dimethyl diallyl ammonium chloride (PDDA) layer by layer. Such successful assembly was confirmed by transmission electron microscopy (TEM), FT-IR spectroscopy, zeta-potential analysis, hydrodynamic diameter determination and gel electrophoresis. After assembly, the mSiO2/PSS/PDDA/BSA-Gd2O3 nanoprobe presented a larger longitudinal relaxivity (r1) (26.1 s−1 mM−1 Gd) than BSA-Gd2O3 NPs (11.8 s−1 mM−1 Gd) and commercially used Gd–DTPA (3.87 s−1 mM−1 Gd). Additionally, with the AS1411 aptamer as a targeting molecule, our fabricated mSiO2/PSS/PDDA/BSA-Gd2O3-AS1411 nanoprobes could recognize clear cell renal carcinoma cells (ccRCC) specifically by MRI in vitro.
研究领域:
医学影像
·
纳米技术
·
癌症研究
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2015
·Vol. 8
·期 2
·303-310
·
IF 1.821
Xiao Sun,Chuanjie Cai,Tao Liu,Guilong Zhang,Dongqing Cai,Shiquan Xiong,Zhengyan Wu
A Fe3O4/Gd2O3 nanocomposite grafted with polyethyleneimine (PEI) molecules was prepared using a one-pot synthesis method. Through this amino functionalized nanocomposite, a selective and ultra-trace electrochemical sensor for Cu2+ was constructed. The electrochemical performances of the sensor were demonstrated by square wave anodic stripping voltammetry (SWASV). Parameters such as the supporting electrolyte, pH of solution, deposition time, and deposition potential for the sensor were optimized. The sensor linearly responded to Cu2+ concentration in the wide range from 6 to 1680 nM with a detection limit of 0.4 nM (3δ method), indicating that this amino functionalized Fe3O4/Gd2O3 composite could be a promising candidate material for the detection of Cu2+.
研究领域:
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 84
·44575-44582
·
IF 3.708
Peng Jing,Qin Wang,Baocang Liu,Guangran Xu,Yanbing Zhang,Jun Zhang,Gejihu De
We develop a facile layer-by-layer deposition process to create bi-functional Fe3O4@SiO2@Gd2O3:Yb,Er nanostructures composed of magnetic Fe3O4 cores, variable SiO2 mid-layers, and up-converting Gd2O3 shells. The synthetic process is well-controlled and the obtained Fe3O4@SiO2@Gd2O3:Yb,Er nanoparticles show relative monodispersity and exhibit tunable magnetic and up-conversion luminescence depending on the thickness of SiO2 mid-layers. The influences of SiO2 mid-buffer-layers on morphology, magnetism, and up-conversion luminescence are well addressed. The obtained bi-functional Fe3O4@SiO2@Gd2O3:Yb,Er nanoparticles may be potentially applicable in magnetic, fluorescent, and biological applications. The synthetic route may be employed for fabricating other multifunctional nanostructures.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）