Journal of Building Engineering
·
2026
·
IF 8.1
Zhaoyang Sun,Cuiyi Chen,Bin Xu,Zixuan Yang,Binmeng Chen
Four HPMC samples are synthesized with molecular weight ranging from 35 to 450 kDa. • Long-chain HPMC causes τ s to peak then drop, while τ d rises monotonically. • Longer-chain HPMC enhances flocculation but deteriorates floc structure. • τ s is governed by competing polymer-bridging and steric-hindrance effects. • τ d increases with HPMC dosage and chain length via stronger polymer interactions. Hydroxypropyl methylcellulose (HPMC), one of the most commonly used viscosity-modifying admixtures (VMAs), is extensively employed in fresh cement-based materials. Indeed, the chain length of HPMC greatly influences the rheological behavior of cement pastes. Here, four HPMC samples with distinct molecular weights ( M w ) from 35 to 450 kDa were chemically synthesized to systematically elucidate how chain length governs the rheology of cement pastes and to reveal the underlying mechanisms. Results show that HPMC with shorter chains (H1, H2, and H3 with M w < 220 kDa) induces a monotonic increase in both τ s and τ d with increasing dosage. In contrast, long-chain HPMC (H4 with M w = 450 kDa) causes τ s to rise from 29 to 114 Pa and then decrease beyond 0.3%, reaching 59 Pa at 0.5%, while τ d continues to increase from 45 to 148 Pa. This divergence in τ s suggests a dual role of adsorbed HPMC: longer chains (H4) may simultaneously intensify interparticle attraction through polymer bridging and enlarge particle separation via steric hindrance, the latter eventually overriding the former at higher dosages. The continuous increase in τ d is attributed to the strengthened polymer-polymer interactions with increasing chain length and concentration, promoting the formation of a more rigid polymer network in the interstitial solution that resists applied shear stress. Overall, this work establishes a systematic mechanistic framework describing how HPMC chain length modulates the rheology of cement paste.
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ACS Applied Polymer Materials
·
2025
·
IF 4.7
Jingliu Wang,Yue Wu,Kewei Zhao,Gaozheng Liu,Rongyan Wang,Yanyan Zhao,Yong Liu,Yaqing Ge,Xubao Jiang,Xiangling Gu
Poly(N-isopropylacrylamide) (PNIPAM)-based hydrogels are widely used in the preparation of Janus actuators due to their remarkable temperature-responsive properties. However, preparing PNIPAM-based hydrogel actuators with excellent mechanical properties, mass transfer ability, and programmable deformation, as well as gaining a profound and systematic understanding of their driving mechanisms, remains a challenge to date. To address these challenges, an efficient PNIPAM-hydroxypropylmethyl cellulose/polyacrylamide-Graphene oxide (PNIPAM-HPMC/PAM-GO) Janus hydrogel actuator with strong interfacial stability was constructed based on the self-generation method; PNIPAM-HPMC was used as the active layer, and PAM-GO was used as the passive layer. The introduction of HPMC makes the active layer have excellent tensile strength (7.55–28.3 kPa) and mass transfer ability (39.07–73.03%), thereby improving the deformation ability of the actuator (239–360°). It can still achieve a 360° deformation after being actuated repeatedly 5 times. The deformation dynamics of the Janus hydrogel actuator under thermal response conditions were quantitatively analyzed by real-time tracking of the response behavior, and the important role of mechanical moduli in the deformation process of the Janus hydrogel actuator was revealed for the first time. Therein, the effect of the elastic modulus difference on the deformation of the actuator is 48 times that of the compression modulus difference. Finally, the Janus hydrogel actuator with high interface stability, mechanical robustness, time-programmable, and double-layer integration prepared in this work shows potential application in the fields of bionics, intelligent switches, and display systems.
研究领域:
材料科学
·
生物工程
·
智能材料
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高影响因子
Marine Drugs
·
2026
·Vol. 24
·期 5
·162
·
IF 5.7
Yuting Dong,Songlin Ye,Xiaojun Hong,Yafang Shi,Youcheng Liu,Xueqin Zhang,Jing Ye,Meitian Xiao
While hydroxypropyl methylcellulose (HPMC) is a promising plant-based alternative to gelatin, its industrial application is limited by poor mechanical properties and high production costs. In this study, high-performance HPMC-based hard capsules were developed using an HPMC/gellan gum/ι-carrageenan ternary system. The formulation and preparation process were optimized via single-factor experiments, response surface methodology, and low-field nuclear magnetic resonance analysis. Scanning electron microscopy was applied to characterize the microstructural evolution during disintegration. The optimized capsules exhibited rapid disintegration within 15 min across four pH media and satisfied the requirements of the Chinese Pharmacopoeia (2025). Drug dissolution profiles using cefradine and ranitidine hydrochloride showed over 85% cumulative release within 30 min, with similarity factors higher than 50 relative to commercial gelatin capsules under the tested conditions. This work provides a feasible and low-cost strategy for the industrial production of plant-based capsules and promotes the high-value utilization of polysaccharide-based capsule materials.
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PubMed
高影响因子
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
·
2020
·Vol. 10
·期 10
·1562-1567
·
IF 2.831
Yuan Hui,Guo Jixi,Jia Dianzeng,Guo Mingxi,Liu Lang,Wu Dongling,Li Feng
A novel photochromic compound, 1,3-diphenyl-4-(3-chloro-4-fluorobenzal)-5-hydoxypyrazole 4-phenylsemicarbazide ( 1a ), has been synthesized by introducing a phenylsemicarbazide unit. The material exhibits good fatigue resistance and reversible fluorescent switching properties with distinct fluorescence on/off ratio under alternating UV irradiation and heating at 120 °C. For the fabrication of actual application materials, 1a /hydroxypropylmethylcellulose (HPMC) composite film has been successfully fabricated using hydrogel casting method. The 1a /HPMC composite film obtained can also show reversible photochromic reaction under UV irradiation and rapid thermal bleaching properties by heating. The HPMC composite film shows similar good photochromic properties as those of 1 in the crystalline state.
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TALANTA
·
2021
·
IF 6.057
Ping Sun,Jing Wu,Shenghong Yang,Hongli Li,Lei Zhao,Yuanhang Wang,Xiayan Wang,Qiaosheng Pu
Microchip capillary electrophoresis (MCE) is a powerful technique for rapid separation; however, its acceptance in routine laboratories is still limited. Compromises caused by the efforts for solving different problems, such as reducing its cost of fabrication and ensuring high separation efficiency, undermine the competitiveness of this technology compared to other separation techniques. Contrary to the conventional pursuit of narrow microchannels, this study investigated the suitability of microchips with channels at the sub-millimeter level, targeting the simplification of the overall operation, cost reduction, and robustness improvement. To this effect, we considered the influence of pressurized flow and Joule heating on the separation. The suppression of pressurized flow with viscous solutions was confirmed through a combination of simulations and experimental results, indicating that the buffer viscosity was enough for successful separation. We fabricated channels of 200 μm × 230 μm using computer numerical controlled (CNC) machining and obtained theoretical plate numbers of 4.8 × 10 5 m −1 and 5.3 × 10 5 m −1 for fluorescein isothiocyanate (FITC) labeled small molecules and DNA fragments, respectively, with a buffer viscosity of 168 mPa s (0.5 % hydroxypropyl methylcellulose , HPMC). These values are comparable with that of narrow-bore microchips. Furthermore, we did not observe any deleterious effects with low-conductivity buffers. We investigated the rapid and highly sensitive detection of mycoplasma contamination and the real samples of circulating cell-free DNA (cfDNA), which gave a limit of detection (LOD) as low as 2.3 ng mL −1 . Owing to the significant reduction in cost, ease of operation, and fast separation capabilities demonstrated in this work, MCE can be a viable alternative to the usual slab gel electrophoresis running in most biological laboratories.
研究领域:
分析化学
·
生物技术
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Meixia Zheng,Meichun Chen,Rongfeng Xiao,Jianwen Feng,Hailan Su,Fengfang Lin,Jianfu Chen,Kok Bing Tan,Yujing Zhu
Colletotrichum gloeosporioides , the primary fungal pathogen responsible for mango anthracnose, causes significant economic losses. Hence, we developed a xanthan gum/hydroxypropyl methylcellulose (XG/HPMC) film incorporating Dictyophora echinovolvata carbon quantum dots (DE-CQDs). These green-synthesized DE-CQDs are 2 nm spherical nanoparticles with good crystallinity and thermal stability, featuring functional groups such as -OH, -COOH, -NH₄ + , and -SO₃H, which enhance hydrophilicity, solubility, and charge properties. The negative charge of DE-CQDs, as evidenced by zeta potential measurements, enhances their dispersibility and inhibits aggregation, thereby contributing to the film's augmented UV-blocking and water vapor transmission characteristics. DE-CQDs inhibit C. gloeosporioides growth through a unique mechanism, inducing metacaspase-dependent apoptosis and causing ROS accumulation without DNA fragmentation. When incorporated into the XHC film, DE-CQDs improve UV-blocking by 30 % at 400 nm, enhance water vapor transmission, and increase water contact angle. The XHC film significantly reduces mango decay (decay index: 0.35 ± 0.05 to 0.21 ± 0.05) and boosts vitamin C retention (from 30 % to 61 % over 7 days), effectively extending shelf life and preserving nutritional quality. Among the XHC films, XHC6 shows the best overall performance. Thus, DE-CQDs serve as functional fillers in biodegradable, environmentally friendly packaging films, offering a novel solution for mango disease prevention and control.
研究领域:
食品科学
·
植物病理学
·
材料科学
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PubMed
高影响因子
Advanced Materials Technologies
·
2025
·
IF 6.2
Jianfei Liu,Xiaolong An,Hui Yang,Kun Han
Overcoming the inherent density-strength-stability trade-off in ceramic aerogels remains challenging. Herein, we present HAlCAs, an ultralight aerogel fabricated by integrating hollow glass microspheres and alumina microfibers within a nano-hydroxypropyl methylcellulose (HPMC) matrix. Utilizing a sol-gel process followed by directional freeze-casting, we construct a deliberately engineered, 3D interwoven scaffold with uniformly dispersed fibers and microspheres. This unique “rigid-yet-flexible” architecture achieves a record porosity of 96% and an ultralow density of 20 mg cm −3 . Critically, it endows HAlCAs with fully recoverable superelasticity across an extreme temperature range (−196°C to 1200°C), while simultaneously suppressing structural collapse and thermal-conductivity surges. The resultant aerogel exhibits exceptional thermal insulation, with a room-temperature conductivity of 0.028 W m −1 K −1 that rises minimally to only 0.046 W m −1 K −1 even at 1200°C. Remarkably, a 20 mm-thick HAlCAs sample reduces the backside temperature by 1000°C when exposed to a 1200°C flame, highlighting its outstanding flame barrier performance. This green, scalable process routinely yields monoliths from abundant, low-cost precursors. Combining ultralow density, high temperature superelasticity, superior thermal insulation, and intrinsic flame retardancy. HAlCAs aerogels offer opportunities for next-generation thermal super-insulators in extreme environments, including hypersonic thermal-protection systems, deep-space insulation cabins, industrial furnaces, and battery packs.
研究领域:
材料科学
·
热工工程
·
气凝胶技术
·
高温材料
·
能源效率
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高影响因子
ACS Applied Polymer Materials
·
2021
·
IF 4.089
Xinran Wei,Daijun Chen,Xiaoli Zhao,Jinni Luo,Huanxia Wang,Pengxiang Jia
A reusable, underwater adhesive, self-healing, and conductive hydrogel was developed by the construction of an interpenetrating network structure consisting of a tungstosilicic acid (SiW) cross-linked hydroxypropyl methylcellulose (HPMC) network and a ferric ion cross-linked poly(dimethylaminoethyl methacrylate) (PDMAEMA) network. The impacts of HPMC, SiW, DMAEMA, and ferric chloride content on adhesion properties were carefully evaluated. The results demonstrated that the 3–2–0.5–60 hydrogel showed the optimal shear adhesion strength. The obtained HPMC/SiW-PDMAEMA/Fe3+ hydrogels exhibited reusable adhesion on the surfaces of various materials such as glass, wood, metals, agate, plastics, ceramics, and rubber. It was noticed that the HPMC/SiW-PDMAEMA/Fe3+ hydrogels also displayed attractive underwater adhesion performance, and they could be adhered to various substrates underwater without any pretreatment or long curing time. In addition, the HPMC/SiW-PDMAEMA/Fe3+ hydrogel showed strain-responsive conductivity and outstanding self-healing performance. Therefore, this work developed a simple method to fabricate reusable, underwater adhesive, conductive, and self-healing hydrogels, which ensure the hydrogel’s broad applicability.
研究领域:
材料科学
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化学工程
·
高分子化学
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DRUG DEVELOPMENT RESEARCH
·
2019
·Vol. 80
·期 7
·958-969
·
IF 1.742
Ying Huang,Zhengwei Huang,Mingjun Wu,Yanpeng Liu,Cheng Ma,Xuejuan Zhang,Ziyu Zhao,Xuequn Bai,Hu Liu,Lili Wang,Xin Pan,Chuanbin Wu
To minimize the gastric and esophageal injury effect, a system to deliver doxycycline hyclate (DOXY) to the duodenum area is needed. DOXY-containing modified-release oral pellets (DMOP) coated with hydroxypropyl methylcellulose phthalate HP-55 (HPMCP HP-55) and hydroxypropyl methylcellulose E15 (HPMC E15) appear to be a reasonable choice. This coating layer dissolves at pH 5.5, which is the pH of the duodenum, but not at a gastric pH (1.2). The formulation and preparation of DMOP were optimized, and a scale-up test was performed. The results showed that the production reproducibility was acceptable, and the quality of DMOP well met the standards of Chinese Pharmacopeia (Ch.P, 2015 edition). Notably, the accumulated DOXY release was lower than 50% at pH 1.2 (20 min) and higher than 85% at pH 5.5, which met the USP40-NF35 standard for DOXY modified-release formulations. Moreover, the storage stability of DMOP with different packages was investigated by stress testing, accelerated and long-term testings. The stability of DMOP was maintained up to 12 months, in terms of DOXY content and in vitro release behavior. The results seem to suggest that DMOP could be a promising duodenum delivery system.
研究领域:
药剂学
·
药物释放系统
·
生物医学工程
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PubMed
高影响因子
Foods
·
2025
·Vol. 14
·期 15
·2729
·
IF 5.1
Youwei Yu,Tian Li,Shengwang Li,Silong Jia,Xinyu Yang,Yaxuan Cui,Hui Ma,Shuaishuai Yan,Shaoying Zhang
To improve the postharvest preservation of cherry tomatoes and combat pathogenic, both bacterial and fungal contamination (particularlyAlternaria alternata), a novel biodegradable coating was developed based on a water-in-water (W/W) Pickering emulsion system. The emulsion was stabilized byL. plantarum(Lactobacillus plantarum), with maltodextrin (MD) as the dispersed phase and hydroxypropyl methylcellulose (HPMC) as the continuous phase. Characterization of emulsions at varying concentrations revealed that the optimized W/W-PL^8 film exhibited superior stability, smooth morphology, and low water vapor permeability (WVP = 220.437 g/(m2·24 h)), making it a promising candidate for fruit and vegetable preservation. Furthermore, the coating demonstrated strong antioxidant activity, with scavenging rates of 58.99% (ABTS) and 94.23% (DPPH), along with potent antimicrobial effects, showing inhibition rates of 12.8% againstEscherichia coliand 23.7% againstStaphylococcus aureus. Applied to cherry tomatoes, the W/W-PL^8 coating significantly reduced respiration rates, minimized decay incidence, and maintained nutritional quality during storage. Remarkably, the coating successfully controlledAlternaria alternatacontamination, enhancing the storage duration of cherry tomatoes. These findings highlight the potential of W/W-PL^8 as an eco-friendly and functional packaging material for fresh produce preservation.
研究领域:
食品科学
·
生物技术
·
采后技术
·
微生物学
·
材料科学
·
农业工程
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Jing Yin,Yue Fang,Lan Xu,Adnan Ahmed
Silk fibroin (SF) is a natural macromolecule material with good biocompatibility, which can be used to prepare a variety of biological materials. In this study, hydroxypropyl methylcellulose (HPMC) was applied to improve the properties of SF nanofibrous scaffolds (NFS) for skin tissue engineering applications. SF/HPMC NFS with varying weight ratios of SF: HPMC were prepared in batches by a modified free surface electrospinning. The effects of the varying weight ratio of SF: HPMC on the morphology, property and yield of SF/HPMC NFS were investigated. The results revealed that with the increase of HPMC contents, the hydrophilicity of SF/HPMC NFS would be improved, but the yield of that would decrease. Considering its effects on the morphology, property and yield of SF/HPMC NFS, the optimal weight ratio of SF: HPMC was 7:1. And SF/HPMC NFS with the weight ratio of 7:1 (SF/HPMC-7:1 NFS) had good mechanical property, hydrophilicity, porosity, swelling property and water vapor transmission rate (WVTR). In addition, the viability test results of human umbilical vein endothelial cells demonstrated that SF/HPMC-7:1 NFS maintained excellent biocompatibility for cell adhesion and proliferation.
研究领域:
生物材料学
·
组织工程学
·
医学材料
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 16
·7862-7872
·
IF 3.3
Zhuhui Chen,Yue Xiong,Ranran Ma,Pei Chen,Le Duan,Shuying Yang,Ineza Urujeni Gisèle,Linjun You,Deli Xiao
To overcome the low concentration and matrix complexity of N1-methylnicotinamide (MeNam) in biological samples, this work developed a method for the detection of MeNam in urine samples using a Fe3O4@hydroxypropylmethylcellulose@2,3-dimercaptosuccinic acid (Fe3O4@HPMC@DMSA) magnetic fluid as a pre-treatment material in combination with high performance liquid chromatography. The novel adsorbent material exhibited ultra-fast adsorption kinetics and a large adsorption capacity because Fe3O4@HPMC@DMSA NPs acted as a homogeneous magnetic fluid with more varieties and quantities of interaction sites (hydrogen-bonding interaction and electrostatic interaction). The limit of determination for MeNam was 0.05 μg mL−1 with Fe3O4@HPMC@DMSA NPs. Recoveries of spiked urine samples ranged between 95.49% and 106.4%, indicating that the developed method was promising for the accurate quantification of trace amounts of MeNam in urine samples. It provides research value for the rapid assessment of the nutritional effects of NMN dietary supplements and offers a sensitive assay for metabolism studies of related functional foods.
研究领域:
分析化学
·
生物医学
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高影响因子
危险品化学品经营许可证（带存储）