XENOBIOTICA
·
2024
·
IF 1.3
Li Shao,Jiajia Mo,Qinlong Xu,Guangwei He,Chunyu Xing,Zhaoxing Chu
HY-072808 is a novel phosphodiesterase 4 inhibitor clinically used for topical atopic dermatitis treatment. Cytochrome P450 enzymes are involved in transforming it into major metabolite ZZ-24. An efficient UPLC–MS/MS method was established to detect HY-072808 and ZZ-24 in plasma and skin tissues of minipigs.One-step protein precipitation was performed with acetonitrile. Subsequently, elution was served with a methanol and water gradient containing 0.1% formic acid for 3.5 min. The plasma and skin tissue concentrations of HY-072808 and ZZ-24 showed good linearity from 0.200 to 200 ng/mL.The experimental minipigs exhibited low systemic exposure and bioavailability of 3.1–7.6% after transdermal application of 1–4% HY-072808 ointment. Multiple topical administrations over seven consecutive days showed a minor accumulation in systemic exposure, with accumulation factors of 2.3 and 4.0 for HY-072808 and ZZ-24, respectively.The distribution of HY-072808 ointment among different cortical layers in minipigs was studied for the first time. Following transdermal application of 2% HY-072808 ointment, the concentration in plasma and skin tissues in the order of epidermis > dermis > subcutaneous tissue ≈ subcutaneous muscle ≈ plasma; at 48 h after the administration, the epidermis and dermis still had a high concentration of the drug.
研究领域:
药理学
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皮肤病学
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产品关联
DOI
PubMed
高影响因子
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2018
·Vol. 96
·期 12
·2586-2592
·
IF 1.265
Renjie Deng,Kuiyi You,Fangfang Zhao,Pingle Liu,He'an Luo
In this work, a simple method for the highly selective preparation of valuable dinitronaphthalene from 1-nitronaphthalene employing NO 2 as a nitrating agent has been developed. The results demonstrated that HY zeolite as an eco-friendly and stable catalyst exhibits good catalytic performances. The total selectivity to valuable dinitronaphthalene compounds including 1,5-, 1,4-, and 1,3-dinitronaphthalene can reach 87.6 % in our present nitration reaction. Meanwhile, the physico-chemical properties of catalysts were characterized by XRD, FTIR, TG/DTG, BET, and NH 3 -TPD, and the probable nitration reaction mechanism was also suggested in this paper. The present nitration process seems to be a mild, eco-friendly, and economical route for the preparation of valuable dinitronaphthalene compounds.
研究领域:
化学工程
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催化
·
环境化学
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DOI
高影响因子
JOURNAL OF POROUS MATERIALS
·
2022
·Vol. 29
·期 4
·1039-1047
·
IF 2.523
Yang Zhigang,Li Yanru,Wang Dongliang,Long Xuefeng,Li Hongwei,Zhao Xinhong
Currently, synthesizing zeolites with specific physicochemical properties in a more environmentally benign and safe way is challenging. Herein we report a novel ionothermal route of preparing HZSM-5 zeolite, which is featured by the direct interzeolite transformation of HY to HZSM-5. The appropriate synthetic conditions of this HZSM-5 material are refined. Although performing a series of optimization, the resultant product still contains minor (NH 4 ) 3 AlF 6 impurity. Pure HZSM-5 phase with high relative crystallinity can be obtained through successive calcination and acid-washing treatments towards the as-made sample. SEM–EDS characterization and nitrogen physisorption measurement reveal that this pure HZSM-5 sample is composed of classical coffin-like crystals with a low Si/Al ratio and evident hierarchical micro-mesoporous structure. Benefiting from its unique physicochemical properties, this pure HZSM-5 catalyst exhibits more superior methanol-to-aromatics performance than those of the state-of-the-art HZSM-5 and Metal/ZSM-5 catalysts evaluated under similar reaction conditions. It can be anticipated that this HZSM-5 material may be applied in other industrially relevant reactions owing to its particular structure and properties.
研究领域:
材料科学
·
催化化学
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产品关联
DOI
高影响因子
ENERGY & FUELS
·
2023
·
IF 5.3
Yuxiang Mao,Jun Cheng,Hao Guo,Lei Qian,Weijuan Yang,Ji-Yeon Park
To improve Co-LDH nanosheet utilization in catalytic conversion of microalgal lipids to biodiesel, an efficient bifunctional catalyst with synergetic acid and base sites was synthesized by in situ growth of Co-LDH nanosheets on HY zeolite. The bifunctional catalyst with a molar ratio of Co-LDH nanosheets to HY zeolite at 4 exhibited synergistic catalysis of acid sites in the HY zeolite and base sites Co(OH)x (x = 2, 3) in the Co-LDH nanosheets, which promoted esterification of free fatty acids and transesterification of triglycerides in microalgal lipids. Co-LDH nanosheets were dispersed on the HY zeolite surface through generated Si–O–Co bonds to enhance Co(OH)x (x = 2, 3) utilization, while the specific surface area of the catalyst increased from 107.9 m2/g (Co-LDH) to 272.5 m2/g. Therefore, the optimal catalyst promoted conversion efficiency from 87.8 to 96.1%, and the conversion efficiency remained at 87.6% after six reusability cycles.
研究领域:
催化化学
·
可再生能源
·
材料科学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Zhengkun Hou,Qiuyan Ding,Hongbin Wang,Yilai Jiao,Peng Jin,Hong Li,Xin Gao
In reactive distillation processes constrained by the efficiency of vapor–liquid mass transfer, reducing the physical dimensions of simultaneous reaction and separation operations can significantly enhance overall process efficiency. To achieve this, HY@SiC, a structured catalytic packing was developed, allowing for concurrent catalytic reactions and vapor–liquid mass transfer on its surface. This innovative catalytic packing was employed in a pilot reactive distillation column to experimentally investigate the production of dimethyl maleate via reactive distillation, marking the first validation of its performance. Additionally, a reactive distillation model incorporating HY@SiC structured catalytic packing was established. Ultimately, a new double-column reactive distillation process for producing dimethyl maleate was proposed, with plans for optimization aimed at minimizing total annual cost, which was 4.08 × 10 5 $/y, utilizing a sequential iterative algorithm as the core focus for design improvements, while achieving DMM yield and purity levels of 99.42 % and 99.0 wt%, respectively.
研究领域:
化学工程
·
工艺设计
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催化
·
反应精馏
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产品关联
DOI
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Renjie Deng,Yiming She,Botao Cao,Lele Huang,Junjie Zhu,Huajie Liu,Haishuai Cui,Yao Tian,Fangfang Zhao
Zeolites are used in the field of toluene nitrification reactions, but their intrinsic mechanism is not well explained. In this work, three typical zeolites including HZSM-5, HY, and Hβ are selected as catalysts and used for the nitration of toluene and typical monosubstituted benzenes with NO2, and it explores the intrinsic influences on the nitrification of toluene on various zeolites through experimental and theoretical methods. The acidic properties and pore structures of three different zeolites were investigated through appropriate characterization techniques. Hβ zeolite exhibited the highest catalytic performance among the three zeolites, attributable to its unique pore structure and acidic properties. The theoretical analysis of various zeolites indicates that the Hβ zeolite can effectively reduce the activation energy barrier, thereby significantly enhancing the transfer nitration performance. The theoretical calculations also suggest that the para-nitration product is more readily formed within the pores of Hβ zeolite, resulting in high para-selectivity. This study provides a theoretical basis for the selective catalysis of aromatics on zeolites.
研究领域:
化学工程
·
催化科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2024
·
IF 6.7
Zi-Chun Fan,Zhuang Li,Xiang Bai,Xian-Yong Wei,Yierxiati Dilixiati,Qian-Qian Kong,Ji Zhao,Yong-Hui Feng,Zhi-Min Zong,Jun-Long Wang
The catalytic hydroconversion (CHC) of benzyloxybenzene (BOB) and oxydibenzene (ODB), two typical lignite-related model compounds (LRMCs) representing α-Ο-4 and 4-O-5 model linkages , have been investigated using uniformly dispersed Ni 15 /HY prepared by a three-step method. The cleavage of >CH-O- bridged bonds in BOB and partial hydrogenation of ODB are considered as a crucial first step, and the target reactions in this work are to produce complete hydrodeoxidized ring saturation products. Through the exploration of reaction mechanism, H + /H - and biatomic active hydrogen, as the main hydrogen species involved in the reaction, play an important role in the CHC of BOB and ODB. Herein, the synergic effect between the hydrogenation of nickel nanoparticles and the acidic function of Y -type zeolite improves the CHC performance, resulting in Ni 15 /HY displaying proficient catalytic activity and selectivity for the CHC of BOB and ODB. Under the optimal reaction conditions, BOB and ODB can be completely converted to cyclanes over Ni 15 /HY, and the main products are dicyclohexylmethane (57.6 %) and cyclohexane (92.4 %), respectively. The developed Ni 15 /HY can not only promote the hydroconversion of BOB and ODB to produce ring-saturated products, but also undergo the rearrangement reaction to produce two- or three-ring cyclanes, which is desirable to upgrade LRMCs to high-density hydrocarbon fuels .
研究领域:
化学工程
·
燃料化学
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产品关联
DOI
高影响因子
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2016
·
IF 3.652
Kuan Ding,Zhaoping Zhong,Bo Zhang,Jia Wang,Addy Min,Roger Ruan
Pyrolysis of waste tire with HY, HZSM-5 (HZ) and purified attapulgite (PA) catalysts to produce valuable aromatic hydrocarbons has been carried out in a Pyrolyzer- Gas Chromatograph/Mass Spectrum (Py-GC/MS) reactor. Likewise, d -limonene and polybutadiene rubber (BR), which played important roles in the pyrolysis process of waste tire, has also been pyrolyzed in the Py-GC/MS reactor with these catalysts. Based on the product distribution, the catalytic pyrolysis mechanisms of d -limonene were proposed, while those of BR were extended. With these mechanisms, the catalytic pyrolysis characteristics of waste tire could be explained reasonably. Results showed that HY promoted a dramatic increase of aromatics from pyrolysis of d -limonene and BR, leading to the considerable growth of aromatics in the degraded products of waste tire. The shape selectivity of HZ to mono-cyclic aromatics performed effectively in the pyrolysis of BR, yet it exhibited a weak performance in the pyrolysis of d -limonene. As a result, upon the catalytic pyrolysis of waste tire, HZ was inferior to HY in the aromatization ability. However, the selectivity of HZ to BTXE (benzene, toluene, xylene and ethylbenzene) was superior to that of HY. PA performed a weaker catalytic ability in promoting the production of aromatics during the pyrolysis of d -limonene, BR and waste tire.
研究领域:
化学工程
·
环境科学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2012
·
IF 5.228
Erdan Hu,Hefa Cheng,Yuanan Hu
The herbicide atrazine is a common pollutant in reservoirs and other sources of drinking water worldwide. The adsorption of atrazine from water onto zeolites CBV-720 and 4A, mesoporous silica MCM-41, quartz sand, and diatomite, and its microwave-induced degradation when sorbed on these minerals, were studied. Dealuminated HY zeolite CBV-720 exhibited the highest atrazine sorption capacity among the mineral sorbents because of its high micropore volume, suitable pore sizes, and surface hydrophobicity. Atrazine sorbed on the minerals degraded under microwave irradiation due to interfacial selective heating by the microwave, while atrazine in aqueous solution and associated with PTFE powder was not affected. Atrazine degraded rapidly in the micropores of CBV-720 under microwave irradiation and its degradation intermediates also decomposed with further irradiation, suggesting atrazine could be fully mineralized. Two new degradation intermediates of atrazine, 3,5-diamino-1,2,4-triazole and guanidine, were first identified in this study. The evolution of degradation intermediates and changes in infrared spectra of CBV-720 after microwave irradiation consistently indicate the creation of microscale hot spots in the micropores and the degradation of atrazine following a pyrolysis mechanism. These results indicate that microporous mineral sorption coupled with microwave-induced degradation could serve as an efficient treatment technology for removing atrazine from drinking water.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2025
·
IF 7.5
Yongheng Jia,Hao Li,Jie Feng,Wenfeng Lang,Longzhou Zhang,Young Dok Kim,Jingtao Wang,Zhongyi Liu,Zhikun Peng
The Friedel-Crafts alkylation of benzene with cyclohexene is crucial for producing high value cyclohexylbenzene industrially. Zeolites are effective solid acid catalysts, but enhancing strong acid site density can further improve cyclohexene activation, especially under low benzene-to-cyclohexene ratios. This study presents an innovative strategy of grafting sulfonic acid groups onto the pore openings of HY zeolite (HY-SO 3 H), which boosts strong acid sites and offers enhanced Brønsted acid sites for alkylation. Remarkably, under a 7:1 benzene-cyclohexene volume ratio, the HY-SO 3 H-2.5 catalyst achieves a cyclohexene conversion of 93.9 % and a cyclohexylbenzene selectivity of 99.3 %, outperforming the conventional HY catalyst (44.5 % conversion, 98.2 % selectivity). Additionally, HY-SO 3 H-2.5 maintaining stable catalytic performance over five consecutive cycles without significant sulfonic acid group loss. This indicates the zeolite matrix effectively stabilizes the sulfonic acid groups. This work provides insights for addressing the activation of key reactive species by tuning the strength and density of strong acidity in zeolite-based catalysts, offering guidance for designing more efficient catalytic systems.
研究领域:
化学工程
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE ENERGY INSTITUTE
·
2026
·
IF 6.5
Siwei Yan,Kezhen Qian,Dezhen Chen
The catalytic conversion of plastic waste is often complicated by additives. This study systematically investigates the influence of nonylphenol, a common oxygenated additive, on the catalytic performance of HY (FAU-type) and HZSM-5 (MFI-type) zeolites using high-density polyethylene (HDPE) and n -octane. The research revealed that nonylphenol exhibits a dual role: it provides an initial activity enhancement via bimolecular hydride transfer but more significantly acts as a potent coke precursor, driving rapid deactivation through pore-mouth blockage. Although nonylphenol accelerated deactivation, it did not alter the fundamental cracking pathway of n -octane on either zeolite. There are significant differences in deactivation behavior and selectivity trends between HDPE raw materials and n -octane model compounds. This discrepancy reveals the limitations of using n -octane as models to predict catalyst behavior in polyethylene catalytic cracking.
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS TODAY
·
2018
·
IF 4.667
Dongxi Zhang,Lei Shi,Yan Wang,Fei Chen,Jie Yao,Xinyu Li,Youming Ni,Wenliang Zhu,Zhongmin Liu
A series of hierarchical HY zeolites were prepared by using sequential acid (H 4 EDTA) and alkaline (NaOH and NH 4 OH) solution treatments. The nitrogen adsorption-desorption analysis proved that the mesoporous structure was definitely formed with the pore diameter at about 3.5 and 17.5 nm, and the external surface area and mesopore volume significantly increased. The XRD , XRF , and NH 3 -TPD characterization results disclosed that the relative crystallinity , crystalline sizes, and acidity of as-treated HY zeolites decreased as compared with parent HY although their Si/Al ratios were higher. The zeolites were conducted in vapor phase carbonylation of dimethoxymethane (DMM) to methoxyacetate (MMAc) at 5.0 MPa and different temperatures. As compared with reference HY, the DMM conversion and MMAc selectivity obviously increased from 50.41% to 90.91% and from 34.79% to 84.57% at 383 K, respectively. The DMM conversion were closely related to the medium-strong acid amount and greater amount of medium-strong acid sites resulted in higher DMM conversion. The catalytic stability of HY-DAl 0.11 -DSi NaOH 0.05 was carried out at 393 K and 5.0 MPa for 100 h. The DMM conversion (about 97%) and products selectivity (MMAc: 84%) kept unchanged during the whole carbonylation process, exhibiting excellent catalytic stability, which was also supported by the TG-DTA analysis that the carbon deposition was effectively suppressed. In a word, as-treated HY zeolites with larger external surface area and mesopore volume that contributed to promoting the mass transfer efficiency exhibited much higher DMM conversion, MMAc selectivity and excellent catalytic stability than parent HY.
研究领域:
催化化学
·
化学工程
·
材料科学
·
多孔材料
·
反应工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）