BIOMEDICAL CHROMATOGRAPHY
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2023
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IF 1.8
Tao Zhang,Yating Xie,Tao Li,Yaling Deng,Quan Wan,Tingting Bai,Qing Zhang,Zhongxi Cai,Mingxia Chen,Jinlian Zhang
Polygoni Multiflori Radix (PMR) is a medicinal herb commonly used in China and Eastern Asia. Recently, the discovery of hepatotoxicity in PMR has received considerable attention from scientists. Processing is a traditional Chinese medicine technique used for the effective reduction of toxicity. One uncommon technique is the braising method—also known as ‘Wen-Fa’ in Chinese—which is used to prepare tonics or poisonous medications. Braised PMR (BPMR)—also known as ‘Wen-He-Shou-Wu’—is one of the processed products of the braising method. However, the non-volatile components of BPMR have not been identified and examined in detail, and therefore, the hepatotoxic advantage of BPMR remains unknown. In this study, we compared the microscopic characteristics of different samples in powder form using scanning electron microscopy (SEM), investigated the non-volatile components, assessed the effects of different processed PMR products on the liver, and compared the differences between BPMR and PMR Praeparata recorded in the Chinese Pharmacopoeia (2020 edition). We found that the hepatotoxicity of BPMR was dramatically decreased, which may be related to an increase in polysaccharide content and a decrease in toxic substances. The present study provides an important foundation for future investigations of the processing mechanisms of BPMR.
研究领域:
药理学
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毒理学
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中医药
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植物化学
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Li-Ping Zhang,Zhen-Guo Zhao,Yuan-Yuan Huang,Xing Cao,Xin-Yu Tian,Yan-Peng Ni,Yu-Zhong Wang
The cationic waterborne polyurethanes (CWPU) exhibit excellent affinity towards various materials possessing negative surface charges owing to its positive charge. However, its limited heat resistance and flame retardancy greatly restrict its practical application. In this work, we synthesized a flame retardant , 2-(6-oxido-6H-dibenz〈c,e〉〈1,2〉oxaphosphorin-6-yl)-1,4-hydroxyethoxyphenylene (DOPO-HQ-HE), and incorporated it into the skeleton of cationic waterborne polyurethanes to prepare flame-retardant cationic waterborne polyurethanes (CWPU-DHHxs). The obtained CWPU-DHHxs showed excellent flame retardancy, in which the LOI value of CWPU-DHH 12 reached over 26.9 vol% and passed UL-94 V-0 rating. The findings showed that CWPU-DHHxs exhibited remarkable efficacy in both the vapor and condensed phase during combustion. Moreover, the incorporation of DOPO-HQ-HE led to a significant improvement in heat resistance performance by facilitating enhanced microphase separation . Meanwhile, the major comprehensive performance of CWPU-DHHxs, including emulsion storage stability, thermal stability, mechanical performance, and transparency were effectively preserved.
研究领域:
材料科学
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高分子化学
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产品关联
DOI
高影响因子
Radiation Effects and Defects in Solids
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2024
·
IF 1.1
X.L. Ren,G. Yao,L.M. Luo,Y. Xu,A. Yabuuchi,Q. Xu
In the present study, we developed Mo- and Zr-added W-Y2O3 composites, and investigated their surface damage, including commercially available W induced by He and D as well as He and D mixture plasmas. Blistering was not observed in the D-plasma-irradiated W and W composites. The thickness of the damaged surface layer due to He plasma exposure of the W-Mo-Y2O3 composite was similar to that of W. However, the thickness of the damaged surface layer of the W-Y2O3 composite was half that of W. In addition, the thickness of the damaged surface layer of the W-Zr-Y2O3 composite was further improved by 5 times. Y2O3 nanoparticles, especially refined Zr-Y-O nanoparticles, act as He trap sites to suppress the formation and growth of He bubbles. Furthermore, the W-O-Y and W-O-Zr-Y nanoparticles increased the solubility of He and delayed He diffusion, hindering the formation of He bubbles.
研究领域:
材料科学
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核能工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2020
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IF 3.69
Jun Li,Ming Li,Ke Ye,Qixin Jiang,Mi Wang,Xiaodong Wen,Jie Yang
Ethnopharmacological relevance Xian-He-Cao-Chang-Yan formula (XHCF) is consisting of six crude drugs including Agrimoniae Herba, Coptidis Rhizoma , Aucklandiae Radix, Cicadae Periostracum, Acori Tatarinowii Rhizoma, and Platycodonis Radix at the ratio of 5:1.5:1.5:1.5:1.5:1. It has been used to improve syndromes of ulcerative colitis (UC) for many years. Aim of the study This study was designed to study the bioactive ingredients and therapeutic mechanisms of XHCF. Materials and methods The chemical profile of XHCF was characterized by UHPLC-QTOF-MS/MS. The effects and mechanisms of XHCF on UC were investigated in colitis mice induced by dextran sulfate sodium (DSS) and LPS-stimulated RAW 264.7 cells. Results A total of 103 compounds were characterized in XHCF. XHCF could effectively improve acute colitis induced by DSS. More importantly, XHCF significantly decreased M1 macrophage markers (CD11c, IL-6 and IL-1β) whereas increased M2 macrophage markers (CD206) in colitis mice, suggesting it could regulate macrophage polarization. Furthermore, the levels of HK2 and lactic acid in colon tissues were significantly reduced by XHCF, indicating that XHCF could inhibit glycolysis. It also down-regulated HK2 expression in macrophages challenged by LPS. In addition, XHCF enhanced the phosphorylation of AMPK both in vivo and in vitro , suggesting the involvement of AMPK in XHCF function. Conclusions XHCF ameliorated DSS-induced colitis in mice via inhibition of M1 macrophage polarization, probably by the modulation of macrophage metabolic reprogramming via AMPK, contributing to its anti-inflammatory activity. The synergistic actions of multiple ingredients might be responsible for the therapeutic benefits of XHCF on UC.
研究领域:
药理学
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免疫学
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胃肠病学
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中医
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产品关联
DOI
PubMed
高影响因子
Small
·
2025
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IF 12.1
Yuxing Luo,Yehui Ding,Xin Zhu,Meng He,Weiqun Shi,Xiangdong Ding,Xue Liu
2D coordination polymer membranes, characterized by ultrathin thickness and nanoscale porosity, exhibit exceptional selectivity and permeability for molecular separations. While amorphous coordination polymer (aCP) monolayers are particularly attractive for scalable fabrication, as their separation performance is less dependent on crystallinity, aCP monolayers have never been synthesized and their gas separation capabilities have been completely unexplored. Herein, we report an amphiphilic polyaromatic hydrocarbon (PAH) assisted interfacial assembly strategy to fabricate nanometer thick aCP monolayer. An amphiphilic hexa(terpyridine)hexaphenylbenzene (HTPHPB) monolayer is first formed at the air/water interface, which adsorbed pyrazine and coordinated with Co 2 ⁺ to generate an active layer, subsequently inducing the interfacial co-assembly of water-soluble pyrazine and tetracyanonickelate into continuous aCP films with a thickness of 2.2 nm. Remarkably, the six layer stacking aCP membranes exhibit unprecedented He/CH 4 separation performance with a He permeance of 136.6 GPU and a He/CH 4 separation factor of 110, representing a nearly threefold improvement in separation factor over the best-performing MOF materials reported to date. Furthermore, the membrane maintains its separation efficiency without significant performance loss under 50 times bending, demonstrating excellent structure stability. This work not only establishes a facile strategy for synthesizing aCP monolayers but also opens new avenues for designing high-performance gas separation membranes.
研究领域:
材料科学
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膜技术
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气体分离
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配位聚合物
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纳米材料
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Jialin Wang,Wenxiao Qiao,Meng He,Xiangdong Ding,Weiqun Shi,Xue Liu
Interunit linkage flexibility regulates irradiation responses of ultrathin polymer membranes. • Diaryl ether linkages enable structural accommodation under γ irradiation. • PX-BPO membranes retain He and Kr/Xe separation after 50 kGy irradiation. • Crack formation causes nonselective transport pathways in rigid-linkage membranes. Efficient membrane separation of He/Kr/Xe noble gas mixtures is essential for He recycling and radioactive off-gas treatment in advanced nuclear reactors. Nevertheless, radiation induced structural degradation greatly limits the practical application of polymeric membranes in radioactive service conditions, especially for high-performance thin film composite membranes. Establishing valid molecular design strategies to suppress such nanoscale structural damage still poses a major obstacle to the development of radiation resistant separation membranes. Here, we show that ultrathin polyxanthene membranes containing different interunit linkages exhibit markedly different responses to γ irradiation. Three approximately 100 nm selective layers containing biphenyl (PX-BP), diaryl ether (PX-BPO), and hexafluoroisopropylidene (PX-HFP) linkages were evaluated for He/Kr/Xe separation after irradiation in air up to 50 kGy. At 50 kGy, PX-BP and PX-HFP developed severe cracking accompanied by substantial losses in selectivity, whereas PX-BPO underwent pronounced wrinkling while retaining selective-layer continuity and over 74% of its initial He/Kr and He/Xe separation factors. Structural characterization and molecular calculations further showed that PX-BPO underwent pronounced structural reorganization while retaining selective-layer continuity. Its diaryl ether linkage exhibited the lowest torsional barrier and a more distributed electronic and geometric response to one-electron ionization. These results identify linkage conformational flexibility as an important molecular factor associated with the distinct irradiation response of PX-BPO within this PX series. Download: Download high-res image (417KB) Download: Download full-size image
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2025
·
IF 9
Yanmei Li,Wufeng Wu,Yali Zhao,Yanying Wei,Haihui Wang
Interfacial incompatibility between inorganic fillers and polymer matrix remains a major challenge in developing high-performance zeolite-based mixed matrix membranes (MMMs), especially for the ones employing high-aspect-ratio two-dimensional (2D) nanosheets as fillers owing to the consequently enlarged interfacial area. Herein, a thermally induced crosslinking strategy is proposed to construct covalent Si– O –C linkages between RUB-15 nanosheets with abundant hydroxy groups and a polyimide (PI) matrix, effectively eliminating interfacial defects. Due to the improved interfacial compatibility, the membrane gas separation performance is significantly enhanced, presenting a He permeability of 87 Barrer with an impressive He/CH 4 selectivity of 357, ∼3.2 times as high as that before crosslinking. Furthermore, excellent separation stability is maintained over ten thermal cycling tests, demonstrating superior durability. This study presents a universal and efficient interfacial engineering strategy for fabrication of robust high-aspect-ratio 2D zeolite-based MMMs and highlights its significant potential in advancing next-generation gas separation technologies.
✓ 已验证
产品关联
DOI
高影响因子
Membranes
·
2025
·Vol. 15
·期 7
·197
·
IF 3.6
Jiale Zhang,Huixin Dong,Fei Guo,Huijun Yi,Xiaobin Jiang,Gaohong He,Wu Xiao
In this work, HNTs@ZIF-67 composites were synthesized using the in situ growth method and incorporated into 6FDA-TFMB to prepare mixed-matrix membranes (MMMs). Scanning electron microscope (SEM) and transmission electron microscope (TEM) proved that the HNTs@ZIF-67 composite not only retained the hollow structure of HNTs, but also formed a continuous ZIF-67 transport layer on the surface of HNTs. The results of gas permeability experiments showed that with the increase in HNTs@ZIF-67 incorporation, the He permeability and He/CH4selectivity of MMMs showed a trend of increasing first and then decreasing. When the loading is 5 wt%, the He permeability and He/CH4selectivity of MMMs reach 116 Barrer and 305, which are 22.11% and 79.41% higher than the pure 6FDA-TFMB membrane. The results of density functional theory (DFT) and Monte Carlo (MC) calculations reveal that He diffuses more easily inside ZIF-67, HNTs and 6FDA-TFMB than CH4, and ZIF-67 shows larger adsorption energy with He than HNTs and 6FDA-TFMB, indicating that He is easily adsorbed by ZIF-67 in MMMs. Based on experimental and molecular simulation results, the mechanism of HNTs@ZIF-67 improving the He/CH4separation performance of MMMs was summarized. With the advantage of a smaller molecular kinetic diameter, He can diffuse through ZIF-67 on the tube orifice of HNTs@ZIF-67 and enter the HNTs’ hollow tube for rapid transmission. At the same time, He can also be rapidly transferred in the continuous ZIF-67 transport channel layer, which improves the He permeability and the He/CH4selectivity of MMMs.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2024
·
IF 5.8
Kunqi Liu,Junxia Wang,Jin Wang,Die Liu,Long Kang,Haiyuan Wei,Junjun Zhou
In this study, the 500 keV He–ion irradiation effects were systematically analyzed in Sr 0.5 Zr 2 (PO 4 ) 3 –Ce 0.5 Sm 0.5 PO 4 composite ceramics used for nuclear waste form. The phase evolution was investigated at various ion doses of 1 × 10 16 , 1 × 10 17 , and 5 × 10 17 ions/cm² using GIXRD, Raman. Meanwhile, the irradiation effects at various depths of 100 nm, 1500 nm and 3000 nm in the typical sample with an ions dose of 5 × 10 17 ions/cm 2 were further observed through FIB–TEM and SEM. The results indicated that Sr 0.5 Zr 2 (PO 4 ) 3 phase transitioned from crystalline to amorphous state, while Ce 0.5 Sm 0.5 PO 4 phase exhibited crystalline–disorder transition. Furthermore, the microscopic strain changes of both post–irradiated phases were assessed by a geometric phase analysis (GPA) method, which revealed that Sr 0.5 Zr 2 (PO 4 ) 3 phase accumulated more lattice stress than Ce 0.5 Sm 0.5 PO 4 phase. Ultimately, this study confirmed that the irradiation resistance of Sr 0.5 Zr 2 (PO 4 ) 3 phase under He–ion irradiation was inferior to that of Ce 0.5 Sm 0.5 PO 4 phase.
研究领域:
材料科学
·
核能工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2024
·Vol. 45
·期 1
·116855
·
IF 5.8
Jintao Zhang,Shuai Xu,Chunmei Wen,Jiale Huang,Jiaqi Li,Zhongzheng Wu,Renda Wang,Fangfang Ge,Gaowei Zhang,Zhongqiang Fang,Jun Li,Tongmin Zhang,Xuan Meng,Bingsheng Li
High-entropy carbide ceramics (Ti 0.25 Zr 0.25 Nb 0.25 Ta 0.25 )C with a single-phase rock-salt structure were prepared by hot-pressed sintering. These ceramics were irradiated with 500 keV He 2+ ions to fluences of 5 × 10 16 ions·cm −2 and 1 × 10 17 ions·cm −2 at room temperature to 700 °C. The investigation into irradiation-induced lattice swelling was conducted using grazing incident X-ray diffraction, while microstructure evolution was characterized through transmission electron microscopy . Lattice expansion induced by the He ion irradiation was identified, which highly depends on the irradiation temperature and fluence. Notably, the lattice expansion diminishes with rising irradiation temperature primarily as a result of the dynamic annealing effect . Nano-sized He bubbles , with an average diameter of less than 1 nm were uniformly dispersed within the grain interior. Notably, He bubble nucleation does not exhibit a preference for grain boundaries at 700 °C irradiation. Following He ion irradiation at 350 °C and 700 °C, dislocation loops of 1/3<111> and 1/2<110> with sizes in the ranges of several nanometers were observed. The present study provides insights into high-entropy carbide ceramics with potential applications in the field of nuclear energy.
研究领域:
材料科学
·
核材料
·
辐照损伤
·
陶瓷
·
微观结构表征
✓ 已验证
DOI
高影响因子
Nuclear Materials and Energy
·
2024
·
IF 2.3
Y.J. Fu,H. Wang,Z.M. Xie,R. Liu,X.P. Wang,Q.F. Fang,C.S. Liu,X.B. Wu
Bulk W-0.5 wt%ZrC (W-ZrC), W-1 wt%Re-0.5 wt%ZrC (W-1Re-ZrC), and W-3 wt%Re-0.5 wt%ZrC (W-3Re-ZrC) alloys were prepared and exposed to He 2+ ion irradiation with an incident energy of 500 keV at 400 °C. Post-irradiation analysis revealed the formation of He bubbles, with consistent number density and average size across all alloys. However, the W-3Re-ZrC alloy exhibited a notably higher density of dislocation loops within grain interiors compared to W-ZrC and W-1Re-ZrC. This led to a significant increase in the hardening rate of W-3Re-ZrC to 61.5 %, nearly twice that of the other alloys. By considering the binding energies of He-vacancy, He-He, and Re-He, the formation and growth behavior of irradiation-induced defects, including He bubbles and dislocation loops, were also discussed. This work provides valuable insight into the relationships among Re alloying, He-induced defects, and irradiation hardening in Re-alloyed W materials, thus offering valuable guidance for the design of W-based plasma-facing materials.
研究领域:
材料科学
·
核能工程
✓ 已验证
DOI
高影响因子
COMBUSTION AND FLAME
·
2018
·
IF 4.494
Guoqing Wang,Yuyang Li,Wenhao Yuan,Yizun Wang,Zhenbiao Zhou,Yingzheng Liu,Jianghuai Cai
Bio-butanol is an important alternative fuel and has many advantages in engine combustion . In the present work, laminar flame propagation of n- butanol/air and n- butanol/(14% O 2 /86% He) mixtures was investigated using a constant-volume combustion vessel at the unburnt temperature of 423 K, initial pressures of 1–20 atm and a series of equivalence ratios. Flame instabilities of n -butanol, including cellular instability and pulsating instability, were studied based on flame morphology. The unsteady transition from weak flame to normal flame was investigated based on the flame trajectories and this phenomenon became less perceptible in the flame with stronger combustion intensity and smaller Lewis number. The accelerated laminar burning velocity (LBV), thickened flame thickness, larger Markstein length and Markstein number indicate that the thermal diffusivity of n- butanol/O 2 /He flames are greatly enhanced by helium addition. The smaller densities and lower reactant concentrations result in the smaller laminar burning fluxes of n- butanol/O 2 /He flames than those of n -butanol/air flames. The high temperature kinetic model of n -butanol reported by Cai et al. was further developed with recent theoretical progresses on n -butanol reactions. The updated high temperature model was validated on the present experimental data and a vast amount of previous n -butanol combustion data . Sensitivity analysis was performed using the updated model under wide pressure and equivalence ratio ranges. The similarity in the sensitivities indicates that the sensitive reactions in n- butanol/air flames can be validated by using n- butanol/O 2 /He flames, which greatly compensates the problem that the n- butanol/air flames are susceptible to flame instabilities at high pressures. The weaker pressure dependence of the LBVs of n -butanol/O 2 /He flames indicates that their flame chemistry changes less to resist the pressure variation.
研究领域:
燃烧学
·
化学反应动力学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）