Regenerative Biomaterials
·
2025
·
IF 8.1
Zhang Ting,Yu Yameng,Yuan Wei,Ren Zeqi,Cheng Yan,Wu Shuilin,Zheng Yufeng,Xia Dandan
Biodegradable Zn alloy have recently gained considerable attention for use in bone implants considering their biodegradability, attractive mechanical properties, and bioactivity. However, excessive corrosion of Zn alloy at the early stage of implantation may cause severe cytotoxicity, resulting in insufficient osseointegration, which hinders the clinical use of the Zn alloy. In this study, we designed a photothermal-controlled degradative hybrid coating as corrosion-protective barrier with the intention of preventing Zn ion burst release during the early stages of implantation and regaining the alloy's corrosion advantage later on. The coating consisting of Zeolite imidazole skeleton-encapsulated indocyanine green core-shell structured nanoparticles and polylactic coglycolic acid (ICG@ZIF-8/PLGA) on pristine Zn-0.8 (wt.%) Li (ZL) alloy. The electrochemical test results indicated that coating ZL with ICG@ZIF-8/PLGA might effectively reduce its corrosion current density (icorr) from 2.48 × 1 0 −5 A•cm−2 to 2.10 × 1 0 −8 A•cm−2. After near-infrared light irradiation, ICG@ZIF-8 heated PLGA coating to reach Tg, so that the coating was degrading, and the icorr of coated ZL alloy decreased to 2.50 × 1 0 −7 A•cm−2, thus restoring corrosion advantage. Both in vitro and in vivo investigations showed that coated ZL alloy had acceptable biocompatibility. Overall, the development of the photothermally controlled coating improved the Zn alloy's resistance to corrosion and allowed for the adjustment of the coated ZL alloy's rate of degradation through the use of 808 nm NIR laser irradiation.
研究领域:
生物医学工程
·
材料科学
·
生物材料
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Cancer Nanotechnology
·
2022
·Vol. 13
·期 1
·1-13
·
IF 7.917
Liu Bei,Liu Xiaoning,Zhang Xiangyu,Wu Xi,Li Chuanbo,Sun Zhaogang,Chu Hongqian
Background Despite the increasing interest in combination therapy for the treatment of cancer, controlled delivery of different therapeutics with high body-clearance efficacy and cancer cell specificity remained a great challenge. In this study, a novel codelivery system was synthesized through one-pot coordination-driven self-assembly of 2-methylimidazole, zinc ion and chemotherapeutic drug (doxorubicin, DOX), followed by a surface decoration of photothermal agent (indocyanine green, ICG). To improve the targeting specificity performance, folic acid-conjugated polyethylene glycol (FA-PEG) antennas was connected on the surface of nanoparticles.Results The hybrid nanoparticles keep stable under neutral physiological condition but decompose when exposed to acidic environment, resulting in the on-demand release of DOX and ICG for chemo-photothermal combined therapy. Moreover, by switching the initial large size (~ 94 nm) to an ultrasmall size (∼10 nm) in cancer cells, the nanoparticles hold great potential to avoid nanotoxicity for clinical applications.Conclusion sThis work provides a new strategy for co-delivery of different therapeutics for combined cancer therapy with high cancer cell specificity and low nanotoxicity.
研究领域:
癌症治疗
·
纳米技术
·
药物递送系统
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2023
·Vol. 15
·期 33
·13617-13627
·
IF 6.7
Lei Li,Guoqing Zhu,Wencheng Xu,Man Wang,Yulin Xie,Zixian Bao,Manlin Qi,Minghong Gao,Chunxia Li
The emergence of multidrug-resistant (MDR) bacterial infections calls for novel strategies for effective bacterial inhibition and wound healing. Phototherapeutic approaches are promising in treating bacterial infection because of their high efficiency, noninvasiveness, and few side effects; however, their antibacterial effect is limited by the formation of biofilms in wounds. Herein, we report novel composite nanoparticles (mPt/ICG-αA NPs) combining mesoporous platinum (mPt) nanoparticles, indocyanine green (ICG) and α-amylase (αA) for combating MDR bacteria and treating wound infection, which integrates a triple bacterial inhibition mechanism arising from the combination of photodynamic therapy (PDT), photothermal therapy (PTT) and α-amylase enzymatic activities. The combination of mPt and ICG significantly enhances the effect of PTT and the temperature can be increased up to 80.8 °C to induce efficacious bacterial degeneration. Meanwhile, mPt/ICG-αA (mPIA) NPs with a low concentration of 25 μg mL−1 exhibited a remarkable catalase activity (CAT) and could continuously decompose endogenous H2O2 into O2 in a hypoxic microenvironment, thereby enhancing the PDT effect to achieve broad-spectrum bactericidal activity. mPIA NPs showed excellent MDR antibacterial efficiency against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli), and the bactericidal rate reached up to 99.0% and 97.2% with single 808 nm near-infrared light irradiation, respectively. mPIA NPs also exhibited an excellent ability to destroy biofilms and biocompatibility. Animal experiments further suggested that mPIA NPs could achieve the successful repairment of wounds infected with S. aureus in living systems, while this platform demonstrated negligible toxicity towards mice. Considering the superior performances of mPIA NPs, the synergistic αA-CAT-PDT-PTT boosted therapeutic activity presented in the current work provides a promising method to effectively fight against biofilm-related infectious diseases and wound healing.
研究领域:
纳米技术
·
光疗
·
抗菌治疗
·
伤口愈合
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Yanyan Zheng,Yueyue Xie,Xu Dong,Shulin Shen,Gensuo Zheng,Jiaqi Weng,Qinying Yan
Biofilms, which are dense bacterial aggregates that form protective adhesion layers on surfaces, are associated with chronic wound infections, severe acne, and various other bacterial infection sites. However, the increasing antibiotic resistance of bacteria within biofilms and the limited penetration capacity of conventional treatments pose significant therapeutic challenges. To address these issues, we engineered a freeze-drying microneedle system integrating indocyanine green-loaded ZIF-8/hyaluronic acid nanoparticles (ICG@ZIF@HA NPs) and graphene oxide (GO) for dual-modal phototherapy. Notably, the microneedles demonstrated robust mechanical strength, enabling penetration through 140 μm-thick Staphylococcus aureus biofilms. Subsequently, the disruption of the biofilm’s structural integrity facilitated the release of ICG@ZIF@HA NPs from the microneedle tips into deeper biofilm regions. Moreover, the nanoparticles exhibited pH-triggered release kinetics, with over 80% of ICG released at pH 5.5 within 2 h, and generated reactive oxygen species (ROS) under 808 nm near-infrared (NIR) irradiation. Meanwhile, the GO in the backing provided localized hyperthermia, reaching 55 °C within 500 s under NIR exposure. By combining ROS generation and bacterial membrane disruption, the microneedle system achieved a synergistic antimicrobial effect, effectively inhibiting bacterial growth and eliminating biofilms under NIR irradiation. Thus, this study establishes a robust foundation for integrating antimicrobial therapy with microneedle technology, offering a safer and more efficient strategy for biofilm eradication.
研究领域:
纳米医学
·
光疗
·
抗菌治疗
·
药物递送系统
·
生物材料
·
生物膜研究
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2018
·
IF 4.432
Lixia Yu,Anjie Dong,Ruiwei Guo,Muyang Yang,Liandong Deng,Jianhua Zhang
Chemo-photothermal therapy has shown enormous potential in treating cancer. To achieve the chemo-photothermal synergistic effect, an efficient nanoparticulate system with the ability for simultaneous codelivery of chemotherapeutic drug and photothermal agent as well as photothermal-triggered drug release is highly desirable. Herein, an in situ polymerization within liposome template was designed to prepare liposome-coated poly(N-isopropylacrylamide-co-acrylamide) (P(NIPAM-co-AAM)) nanogels, which can efficiently coencapsulate a NIR dye indocyanine green (ICG) and high amount of doxorubicin hydrochloride (DOX). The DOX/ICG coloaded hybrid nanogels, denoted as DI-NGs@lipo, integrated the desirable functions of PEGylated liposomes and thermosensitive nanogels. The PEGylated liposome shell provided excellent storage stability, hemodynamic stability, and fluorescence stability. Meanwhile, the thermosensitive P(NIPAM-co-AAM) nanogels core endowed DI-NGs@lipo with volume phase transition temperature (VPTT) at about 40 °C, allowing for thermo-controlled transformation and drug release. The significant photothermal effect of DI-NGs@lipo and the simultaneous hyperthermia-triggered DOX release were observed under NIR light irradiation. The DI-NGs@lipo was demonstrated to be uptaken by 4T1 murine breast cancer cells via endocytosis, enhancing the distribution of DOX in the cell nucleus. Compared with chemo or photothermal treatment alone, the combination treatment of DI-NGs@lipo with NIR light irradiation induced significantly higher cytotoxicity to 4T1 cells, demonstrating the chemo-photothermal synergistic therapeutic effects on tumor cells. In a word, the strategy provided here offers a facile approach to develop a multifunctional nanoplatform for codelivery of DOX and ICG, which can synergistically improve the cancer-cell-killing efficiency, demonstrating great potential in chemo-photothermal therapy.
研究领域:
纳米技术
·
癌症治疗
·
药物递送系统
·
光热疗法
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2024
·
IF 5.8
Xinru Kong,Yanxi Yang,Xueli Ren,Yandai Lin,Yu Shi,Zhe Liu
The concept of combining external medical stimuli with internal functional biomaterials to serve cancer-oriented treatments is emergingly developed. Optical and acoustical activations have shown special promises as non-invasive regulation modalities in cancer treatment and intervention. It is always challenging to leverage their contributions between optical and acoustical stimuli and find the appropriate biomaterials to optimally match them. Herein, a type of hybrid nanomicelles (ICG@PEP@HA) containing ICG as photo/sonosensitizers, an amphiphilic peptide for membrane penetration and hyaluronic acid for cluster determinant 44 (CD44) targeting were fabricated. Triggered by external stimuli of laser and US irradiations, their photo/sonothermal performances, in vitro reactive oxygen species (ROS) production capabilities and tumor-targeting efficiency have been systematically evaluated. It was interestingly found that the external stimulus of laser induced more quantity of ROS which resulted in a significant cell apoptosis and tumor growth inhibition in the presence of ICG@PEP@HA. The individual analysis and corresponding rationales have been investigated. In the meanwhile, these hybrid nanomicelles were administered into the MDA-MB-231 tumor-bearing nude mice for PDT and SDT therapies and their biocompatibility assessment, and a PDT prevailing efficacy and reliable bio-safety have been evidenced based on the hematological analysis and histochemical stainings. In summary, this study has validated a novel pathway to utilize these hybrid nanomicelles for laser/US-triggered localized tumor treatments, and the treatment efficiency may be leveraged by different external stimuli sources. It is also expected to give birth to full accessibility to clinical translations for human cancer treatments by means of as-reported laser/US-nanomicelles combination strategy.
研究领域:
纳米技术
·
癌症治疗
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POROUS MATERIALS
·
2024
·
IF 2.5
Cai Xiaoqin,Wu Nian,Song Fangxiang,Luo Honghuan,Li Tingxian,Yan Yibing,Li Songye,Li Yan
Combination therapy for cancers can fully utilize each treatment method’s benefits in order to maximize anti-tumor actions and hence produce superior therapeutic outcomes. In this study, HMTNs@PMO@HA composite nanoparticles, a pH/NIR dual-responsive chemo-photothermal platform, were constructed. The hollow mesoporous titanium dioxide nanoparticles (HMTNs) were prepared by silica-protected calcination and alkali etching, and the periodic mesoporous organosilica (PMO) was coated on top of them to improve the biocompatibility, and then modified by hyaluronic acid (HA) to improve the targeting and cellular uptake of the nanoparticles. This chemo-photothermal platform combined the chemotherapeutic drug doxorubicin (DOX) with the photothermal agent indocyanine green (ICG) to investigate their inhibitory effects on breast cancer cells (MCF-7). Drug loading and release experiments revealed that the platform had a high loading rate of doxorubicin and indocyanine green (DOX: 40.21%; ICG: 25.78%), and the cumulative release rate of the drugs increased in an acidic environment. The results of the photothermal effect evaluation in vitro indicated that the nano-platform had a good photothermal effect. Cytotoxicity and apoptosis assays showed that the nanoparticles combined with NIR had a good inhibitory effect on breast cancer cells (cell viability: 27.68%; apoptosis rate: 43.4%). The above results indicated that the combination therapy used by this nano platform provided high therapeutic efficiency for treating tumors and offered a feasible strategy for combining tumor-targeting with chemo-photothermal therapy.
研究领域:
纳米技术
·
癌症治疗
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Xiaolei Zhang,Yangsai Lyu,Jia Li,Xiaohan Yang,Ziwei Lan,Zhixu Chen
Nanocatalytic therapeutic agents with triple synergistic treatment modes of chemodynamic therapy (CDT), photothermal therapy (PTT) and photodynamic therapy (PDT) are emerging nanomaterials in malignancy treatment. Nevertheless, the passive diffusion and transport of nanomaterials result in poor permeability in tumor lesions, severely affecting the effectiveness of synergistic therapy. Herein, a dual-source-driven parachute-like Au 2 Pt@PMO@ICG Janus nanomotor (APIJNS) is prepared by an interfacial energy-mediated anisotropic growth strategy for PTT-mediated CDT/PDT triple synergistic cancer therapy. Such nanomotor can realize self-thermophoresis drive under the trigger of near-infrared light, which can effectively enhance the active permeability and uptake of the APIJNS in the tumor tissue, thus achieving efficient PTT/PDT/CDT synergistic therapeutic effect. In addition, parachute-like APIJNS exhibits high-efficiency catalase (CAT)-like activity and can catalyze the overexpressed H 2 O 2 in the tumor microenvironment (TME) to generate oxygen (O 2 ), not only alleviating the hypoxia in the tumor lesion, but also converting it into singlet oxygen ( 1 O 2 ) to activate the photosensitizer ICG, achieving PDT. This work provides new ideas for enhancing triple synergistic cancer therapy by improving tumor permeability with dual-drive Janus nanomotors based on dual noble metal nanozymes.
研究领域:
纳米技术
·
生物医学工程
·
癌症治疗
·
材料科学
·
光热治疗
·
光动力治疗
·
化学动力治疗
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2020
·
IF 7.727
Hu Chen,Hongwei Cheng,Qixuan Dai,Yi Cheng,Yang Zhang,Dengfeng Li,Yang Sun,Jingsong Mao,Ke Ren,Chengchao Chu,Gang Liu
Accurate identification of surgical margins for malignancy remains a challenge in the surgical therapy of cancer, and this encountered interoperative difficulties which directly contribute to the prognosis of patients. In recent years, indocyanine green (ICG) has been approved and applied in clinical settings for lesions detection, especially for the precise surgical resection. However, rapid clearance and poor stability greatly limit its clinical practicality. Herein, a super-stable homogeneous iodinated formulation technology (SHIFT) is designed to realize sufficient dispersion of ICG into lipiodol (SHIFTs) for transcatheter embolization (TAE) synergistic fluorescence-guided resection. Particularly, SHIFTs is prepared in a green physical mixture via a carrier-free manner, which possesses controlled morphology, long-term stability, and improved optical characteristics of ICG (fluorescence/photoacoustic/photothermal activities). Furthermore, the viscosity of the synthetic solvent is comparable to lipiodol, and further assessment demonstrated the same efficacy in computed tomography . The performance of SHIFTs in the fluorescence navigation was further evaluated in vivo by TAE therapy to the rabbit VX2 tumor model for a two-week monitor. The integration of near-infrared fluorescence surgery navigation and TAE could effectively guarantee the precise resection for hepatocellular carcinoma . This SHIFT system provides good potentials for ameliorating the dilemma of precise fluorescent navigation for surgical resection after arterial embolization in clinical practice.
研究领域:
医学影像学
·
肿瘤学
·
外科手术
✓ 已验证
DOI
PubMed
高影响因子
Applied Materials Today
·
2019
·
IF 8.013
Chao Fang,Peijian Yan,Zhaohui Ren,Yifan Wang,Xiujun Cai,Xiang Li,Gaorong Han
A variety of approaches have been investigated in the development of photothermal (PTT) and photodynamic (PDT) therapies for cancer treatment. However, when used in isolation, both PTT and PDT suffer from intrinsic drawbacks, resulting in unsatisfactory therapeutic efficacy. We describe here, a multifunctional nanoplatform, enabling the effective combination of PTT and PDT, triggered by a single 808nm-NIR light. This platform is based on MoO 2 nanoparticles, which can effectively transform NIR light into heat. By attaching molecules of indocyanine green (ICG), a hydrophilic and biocompatible NIR-mediated photosensitizer, to the surface of the particles, both photothermal and photodynamic effects can be achieved. Using an in vitro study with 4T1 cancer cells, we have demonstrated that irradiating the particles with 808nm NIR can trigger ROS production and create heat within cells. Both mechanisms acting synchronously are likely to result in superior in vivo efficacy in tumor phototherapy.
研究领域:
肿瘤学
·
纳米医学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2023
·
IF 3.9
Xiang Wang,Jinchang Yin,Lu Shen,Ruiran Lai,Zizhou Mao,Haonan Wu,Li Tian,Fuli Zhao,Yuanzhi Shao
Combining photothermal/photodynamic effect of a nanocomposite with photosensitizer can work out a key component of the theranostic nanoplatform of physical therapy for tumors. Herein, we report a type of rare earth-doped core-dual-shell nanoparticles (CDSNPs) conjugated with indocyanine green (ICG), CDSNPs-ICG, which possess an enhancement of optical properties under 980 nm excitation. A relevant energy transfer mechanism underlying rare earth nanoparticles with ICG was proposed to interpret the enhancement of visible light , NIR-I and NIR-II luminescent properties. The excitation behavior of CDSNPs-ICG was theoretically addressed through the hole-electron analysis based on time-dependent density functional theory, and the approach reveal the charge transfer of ICG after compositing rare earth. Photothermal/photodynamic therapy capabilities of CDSNPs-ICG were appraised in vitro and in vivo , indicating that CDSNPs-ICG have a high potential to be applied to optical theranostics of tumor.
✓ 已验证
产品关联
DOI
高影响因子
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
·
2024
·
IF 2.7
Li-Hong Liu,Yu-Feng Liu,Hong-Bo Zhang,Xiao-Lei Liu,Han-Wen Zhang,Biao Huang,Fan Lin,Wei-Hua Li
PurposeDevelop an albumin nanoparticle-based nanoprobe for targeted glioblastoma (GBM) diagnosis and treatment, utilizing Angopep-2 for low-density lipoprotein receptor-related protein (LRP) targeting.MethodsCombined albumin-coated superparamagnetic iron oxide (SPIO), Carmustine (BCNU), and indocyanine green (ICG). Assessed morphology, size, Zeta potential, fluorescence, and drug encapsulation. Conducted in vitro fluorescence/MRI imaging and cell viability assays, and in vivo nanoprobe accumulation evaluation in brain tumors.ResultsANG-BSA/BCNU/ICG MNPs exhibited superior targeting and cytotoxicity against GBM cells in vitro. In vivo, enhanced brain tumor accumulation during imaging was observed.ConclusionThis targeted imaging and drug delivery system holds promise for efficient GBM therapy and intraoperative localization, addressing Blood-brain barrier (BBB) limitations with precise drug delivery and imaging capabilities.
研究领域:
纳米技术
·
神经肿瘤学
·
药物递送系统
·
医学成像
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）